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The map label for this gene is xasA [C]

Identifier: 89898317

GI number: 89898317

Start: 597614

End: 599014

Strand: Direct

Name: xasA [C]

Synonym: CF0510

Alternate gene names: 89898317

Gene position: 597614-599014 (Clockwise)

Preceding gene: 89898316

Following gene: 89898321

Centisome position: 51.24

GC content: 38.33

Gene sequence:

>1401_bases
ATGCATACCCATACAAAACCCTCAAAACCTCTGGGAACATTTACTGTTGGAATGTTATCTCTAGCAGTAGTTATTAGTTT
AAGGAACTTGCCCCTAACAGCAAAACACGGATTATCGACTCTTTTCTTTTATGCTCTAGCCGTGGGCTGTTTTATGATCC
CCTATGCGCTTATTTCAGCTGAATTAGCGTCTTTTAAACCCCAAGGAATTTATATTTGGACTCGCGATGCCTTGGGAAAG
TGGTGGGGATTTTTCTCTATATGGATGCAATGGTTCCATAACATGACATGGTACCCTGCAATGCTCGCATTTATTGCAAG
TACGCTAGTGTACAAAATTAATCCAGAACTAGCCCATAACAAAGTCTATTTGGCAATAGTTATTCTTGCCGGATTTTGGG
GACTGACTTTTTTTAATTTCTTTGGGATTAGTACATCAGCTTTATTTAGTTCGATTTGCGTTATCGTAGGAACTTTGATC
CCAGGAGTAATTTTAGTTGCCTTGGCTATTTTTTGGATCATGACGGGAAATCCTATAGCCATTTCCTTGTCGTGGAGAGA
TTTACTTCCTGATATTAATGGTATGTCTTCCTTTGTATTACTCGCAGGAATGCTTCTAGCTCTCTGCGGATTAGAAGCCA
ATGCGAACCTGGCCTCGGATATGGTAAATCCTAGAAAGAACTACCCTAAAGCTGTACTTATTGGAGCGATTTCTACATTA
GCTATTCTAGTTTTGGGATCGCTGTCTATAGCCATTGTGATTCCGAAAGAAGAGATCAGTTTAGTTTCTGGGCTAGTCAA
AGCTTTTTCTCTATTCTTTGATAAGTATAATCTTTCTTGGATGACTAGCATCATTGTTGTTATGACGATTGCTGGATCTT
TAGGAGAGCTTAATGCTTGGATGTTTGCTGGAACCAAGGGCTTATTTGTTTCCACACAAAATGACTGCCTCCCTAGAATG
TTTAAAAAAGTAAACGCAAAAAATGTCCCTACAAACCTAATGCTATTTCAAGCAATCGTAGTGACTTTATTTACTTTGAT
ATTCCTATGTCTAGACTCTGCAGATCTGGCGTATTGGATTCTTAGTGCATTGAGCATACAAATGTATTTAGCTATGTACA
TTTGCTTATTTATTGCAGGTCCAATTTTGCGTATTAAAGAGCCAAAGGCTCAACGTCTCTATTCTGTTCCCGGAAAATTT
TTCGGCATCTGTCTACTTTCTATCTTGGGAATACTTTCTTGCTTATTTGTTTTATGGATTAGCTTTTTACCTCCTCAAGG
AGTCTCTTTGTTATCTGGAGCGGGTAAAATAGGGTACTCAGCCTTTCTACTATTGGCTTTCTCTATAAATTGTATGATAC
CTTTTGGCATCTACTACGCACATAAAAAACTCGTCAAATAA

Upstream 100 bases:

>100_bases
TCAAAGACCTCTTACTGAAGGCGTACAATTATTAAACTTGGTTCAAGACATTTATTTAGATCCGAGCATCACAATAGCGT
AATCTAAAGAAAAGGCTTTT

Downstream 100 bases:

>100_bases
GCCTGATAGAAAACATCGAAGCAGTTCCTTAAAAATCTTTTAAGAAGCTGCTTTGATATTCTTCAAAAAAGCAAGGTTGC
TCCCCTAAAGAATGAAGGAA

Product: amino acid antiporter

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MHTHTKPSKPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYALAVGCFMIPYALISAELASFKPQGIYIWTRDALGK
WWGFFSIWMQWFHNMTWYPAMLAFIASTLVYKINPELAHNKVYLAIVILAGFWGLTFFNFFGISTSALFSSICVIVGTLI
PGVILVALAIFWIMTGNPIAISLSWRDLLPDINGMSSFVLLAGMLLALCGLEANANLASDMVNPRKNYPKAVLIGAISTL
AILVLGSLSIAIVIPKEEISLVSGLVKAFSLFFDKYNLSWMTSIIVVMTIAGSLGELNAWMFAGTKGLFVSTQNDCLPRM
FKKVNAKNVPTNLMLFQAIVVTLFTLIFLCLDSADLAYWILSALSIQMYLAMYICLFIAGPILRIKEPKAQRLYSVPGKF
FGICLLSILGILSCLFVLWISFLPPQGVSLLSGAGKIGYSAFLLLAFSINCMIPFGIYYAHKKLVK

Sequences:

>Translated_466_residues
MHTHTKPSKPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYALAVGCFMIPYALISAELASFKPQGIYIWTRDALGK
WWGFFSIWMQWFHNMTWYPAMLAFIASTLVYKINPELAHNKVYLAIVILAGFWGLTFFNFFGISTSALFSSICVIVGTLI
PGVILVALAIFWIMTGNPIAISLSWRDLLPDINGMSSFVLLAGMLLALCGLEANANLASDMVNPRKNYPKAVLIGAISTL
AILVLGSLSIAIVIPKEEISLVSGLVKAFSLFFDKYNLSWMTSIIVVMTIAGSLGELNAWMFAGTKGLFVSTQNDCLPRM
FKKVNAKNVPTNLMLFQAIVVTLFTLIFLCLDSADLAYWILSALSIQMYLAMYICLFIAGPILRIKEPKAQRLYSVPGKF
FGICLLSILGILSCLFVLWISFLPPQGVSLLSGAGKIGYSAFLLLAFSINCMIPFGIYYAHKKLVK
>Mature_466_residues
MHTHTKPSKPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYALAVGCFMIPYALISAELASFKPQGIYIWTRDALGK
WWGFFSIWMQWFHNMTWYPAMLAFIASTLVYKINPELAHNKVYLAIVILAGFWGLTFFNFFGISTSALFSSICVIVGTLI
PGVILVALAIFWIMTGNPIAISLSWRDLLPDINGMSSFVLLAGMLLALCGLEANANLASDMVNPRKNYPKAVLIGAISTL
AILVLGSLSIAIVIPKEEISLVSGLVKAFSLFFDKYNLSWMTSIIVVMTIAGSLGELNAWMFAGTKGLFVSTQNDCLPRM
FKKVNAKNVPTNLMLFQAIVVTLFTLIFLCLDSADLAYWILSALSIQMYLAMYICLFIAGPILRIKEPKAQRLYSVPGKF
FGICLLSILGILSCLFVLWISFLPPQGVSLLSGAGKIGYSAFLLLAFSINCMIPFGIYYAHKKLVK

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787768, Length=471, Percent_Identity=28.4501061571125, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081798, Length=393, Percent_Identity=22.64631043257, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51288; Mature: 51288

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTHTKPSKPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYALAVGCFMIPYALISA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELASFKPQGIYIWTRDALGKWWGFFSIWMQWFHNMTWYPAMLAFIASTLVYKINPELAHN
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHC
KVYLAIVILAGFWGLTFFNFFGISTSALFSSICVIVGTLIPGVILVALAIFWIMTGNPIA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ISLSWRDLLPDINGMSSFVLLAGMLLALCGLEANANLASDMVNPRKNYPKAVLIGAISTL
EEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHH
AILVLGSLSIAIVIPKEEISLVSGLVKAFSLFFDKYNLSWMTSIIVVMTIAGSLGELNAW
HHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHH
MFAGTKGLFVSTQNDCLPRMFKKVNAKNVPTNLMLFQAIVVTLFTLIFLCLDSADLAYWI
EEECCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSALSIQMYLAMYICLFIAGPILRIKEPKAQRLYSVPGKFFGICLLSILGILSCLFVLWI
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
SFLPPQGVSLLSGAGKIGYSAFLLLAFSINCMIPFGIYYAHKKLVK
HCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTHTKPSKPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYALAVGCFMIPYALISA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELASFKPQGIYIWTRDALGKWWGFFSIWMQWFHNMTWYPAMLAFIASTLVYKINPELAHN
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHC
KVYLAIVILAGFWGLTFFNFFGISTSALFSSICVIVGTLIPGVILVALAIFWIMTGNPIA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ISLSWRDLLPDINGMSSFVLLAGMLLALCGLEANANLASDMVNPRKNYPKAVLIGAISTL
EEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHH
AILVLGSLSIAIVIPKEEISLVSGLVKAFSLFFDKYNLSWMTSIIVVMTIAGSLGELNAW
HHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHH
MFAGTKGLFVSTQNDCLPRMFKKVNAKNVPTNLMLFQAIVVTLFTLIFLCLDSADLAYWI
EEECCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSALSIQMYLAMYICLFIAGPILRIKEPKAQRLYSVPGKFFGICLLSILGILSCLFVLWI
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
SFLPPQGVSLLSGAGKIGYSAFLLLAFSINCMIPFGIYYAHKKLVK
HCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]