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The map label for this gene is pkn2 [H]

Identifier: 89898193

GI number: 89898193

Start: 451200

End: 453056

Strand: Direct

Name: pkn2 [H]

Synonym: CF0386

Alternate gene names: 89898193

Gene position: 451200-453056 (Clockwise)

Preceding gene: 89898192

Following gene: 89898194

Centisome position: 38.69

GC content: 40.76

Gene sequence:

>1857_bases
ATGGTAAACGAGCAAGATATAGGGGTTGAGTTTTTAGGTGATTATAAGATTCTCTGTTATTTGCGAAGGGGCTTATGGTG
CCAAGATATTCTTGCCGAGCATCGTTTTATAAAAAAACGTTATATTTTAAAAATACCCCACGCTGAGCTTACTTCATCAG
AAGCGTTCATGAATGCTTTTCATGAAACTATTGTTAAATTGGCAACCATAAAACATCCTGGGATTATTTCTATAGAAAAT
GTTTCACAGGTAGATGGAAGGTACTTTTTAGTAACTGAAGAAAGAGAGGTGCCTACTCTTTCTTTAACGCAATATCTTGC
TAGTCGCCCTCAGGGATTATCAGAATTAGAAATTCAAGACCTTGTCTGTCAGCTTGCCGAGATTTTAGATTACGCGCACG
CTAGAGGATTAGTTCATGGCGGACTAAGTTTGGATTCCGTGCATGTAGACCTTTCTGGACCATCCCCGAAAGTATTTTTG
CCTGAGATTGGATTTTCTTTTTTACTTAAGGATCAGTATGCCCAGCATCTTTTAGCAGAGTTATCAGAGAAATCTTCTTT
CGATAAGTTAAAGCAGATGTTGTTGTTTCAGGCTCCAGAACCCACATCAGGAACAGTTGTTGAAGATATTTATGCTTTCG
GGGTAGTTGTTTATGTTCTGTTGCTGAGACAGTTTCCTCAAGGCGTGTTTCCTTTGCCTTCTGAAGCGTTCCCTAATTAT
ATTTATGATTGGGATTCATTAATTAAATCCTGCTTGAGTTATTCCATTAATCAAAGGCCCAAGAAGCTATCTCCCTTACT
TGTGAAAAAAACTGCGGGAGAACTGTTTGTTACTGCTAAAGCACAATGTGTAGAAGAAGAATTAAGAGAAATAGGTGAGG
AACCCCAAATTCCGAGCGTAGCGAATATTATTCAAGAGAGTGAGAATCAAATAATCGAAGAATCTTCTGATCATTTAGCA
TTTGTCCTTGTAGAAGCAAAATCTATAGATGAGGCCATGAATACTTCCGTAGATTCTACGGAAGAAGTCATCAGAGAAGA
TGAAAGCTATTCCAATGCTTTGCAGTCTTTATTAATACGAGAACCTGTTGTTAGCCGTTATGTAGAGGAAGAAAAGGAAG
AAATCAAACCTCAACCCTTATTCACAGAAATGGTGTTTATTGAGGGAGGCGGATTTTTTCGAGGGGGGCGCGAGGGACAA
CGTGATGAACATCCCGTGCATGAGATTTTTCTAGAGAGCTTTTTCTTAGATATTCATCCTGTGACTAATGAGCAATTTGT
TCGTTATTTAGAATGCGCGGGTAGCGAGCAGGATAAATATTACAATGAGCTTATCCGTCTTAAGGATTCGCGAATTCAAC
GACGTTCCGGAAAGCTTGTTATAGAACCAGGTTATGCTAAACATCCCGTGGTTGGTGTTACGTGGTACGGAGCTTCCGGC
TATGCTTCCTGGGTTGGAAAACGTCTTCCCACAGAAGCTGAATGGGAGGTCGCTGCTTATGGAGGGATTGCTCAACAACG
TTATCCTTGCGGCGAAGAAATAGATAAAAGTCAGGCAAACTTTTTTAGTTCTGATACAACAGCAGTGATGAGTTATCCCG
CAAATCCCTATGGATTATATGATATGGCGGGAAACGTGTATGAGTGGTGTGAAGATTGGTATGGTTATGATTTCTATGAA
ATTTCCGCTCAAGAGTCTCACTGCCCTCGTGGTCCTGCTCAAGGTGTTTATCGTGTTTTGCGAGGAGGATGCTGGAAAAG
TTTAAAAGATGATCTTCGCTGTGCTCATCGTCACCGAAATAATCCCGGTGCGGTAAATAGTACCTACGGATTCCGCTGCG
CAAAAGGAGTTAAGTAG

Upstream 100 bases:

>100_bases
TGTTGTTCTTTGTGTGTTGCAATCATCCCCTTCCCTTACTATAGTTAGCTCAATGTAAGCAGAAGATAGAAAATCTAAAA
AAAGGCAAGGAGTTTGCTCA

Downstream 100 bases:

>100_bases
ACACTGTATGCACAATATGTATACCAGGGAACAATATTTAGCTCTGTGTAAAGATATCGAAGAAGATGATTACCGCTATT
ATGTTCTTCATGATCCTATA

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MVNEQDIGVEFLGDYKILCYLRRGLWCQDILAEHRFIKKRYILKIPHAELTSSEAFMNAFHETIVKLATIKHPGIISIEN
VSQVDGRYFLVTEEREVPTLSLTQYLASRPQGLSELEIQDLVCQLAEILDYAHARGLVHGGLSLDSVHVDLSGPSPKVFL
PEIGFSFLLKDQYAQHLLAELSEKSSFDKLKQMLLFQAPEPTSGTVVEDIYAFGVVVYVLLLRQFPQGVFPLPSEAFPNY
IYDWDSLIKSCLSYSINQRPKKLSPLLVKKTAGELFVTAKAQCVEEELREIGEEPQIPSVANIIQESENQIIEESSDHLA
FVLVEAKSIDEAMNTSVDSTEEVIREDESYSNALQSLLIREPVVSRYVEEEKEEIKPQPLFTEMVFIEGGGFFRGGREGQ
RDEHPVHEIFLESFFLDIHPVTNEQFVRYLECAGSEQDKYYNELIRLKDSRIQRRSGKLVIEPGYAKHPVVGVTWYGASG
YASWVGKRLPTEAEWEVAAYGGIAQQRYPCGEEIDKSQANFFSSDTTAVMSYPANPYGLYDMAGNVYEWCEDWYGYDFYE
ISAQESHCPRGPAQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAVNSTYGFRCAKGVK

Sequences:

>Translated_618_residues
MVNEQDIGVEFLGDYKILCYLRRGLWCQDILAEHRFIKKRYILKIPHAELTSSEAFMNAFHETIVKLATIKHPGIISIEN
VSQVDGRYFLVTEEREVPTLSLTQYLASRPQGLSELEIQDLVCQLAEILDYAHARGLVHGGLSLDSVHVDLSGPSPKVFL
PEIGFSFLLKDQYAQHLLAELSEKSSFDKLKQMLLFQAPEPTSGTVVEDIYAFGVVVYVLLLRQFPQGVFPLPSEAFPNY
IYDWDSLIKSCLSYSINQRPKKLSPLLVKKTAGELFVTAKAQCVEEELREIGEEPQIPSVANIIQESENQIIEESSDHLA
FVLVEAKSIDEAMNTSVDSTEEVIREDESYSNALQSLLIREPVVSRYVEEEKEEIKPQPLFTEMVFIEGGGFFRGGREGQ
RDEHPVHEIFLESFFLDIHPVTNEQFVRYLECAGSEQDKYYNELIRLKDSRIQRRSGKLVIEPGYAKHPVVGVTWYGASG
YASWVGKRLPTEAEWEVAAYGGIAQQRYPCGEEIDKSQANFFSSDTTAVMSYPANPYGLYDMAGNVYEWCEDWYGYDFYE
ISAQESHCPRGPAQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAVNSTYGFRCAKGVK
>Mature_618_residues
MVNEQDIGVEFLGDYKILCYLRRGLWCQDILAEHRFIKKRYILKIPHAELTSSEAFMNAFHETIVKLATIKHPGIISIEN
VSQVDGRYFLVTEEREVPTLSLTQYLASRPQGLSELEIQDLVCQLAEILDYAHARGLVHGGLSLDSVHVDLSGPSPKVFL
PEIGFSFLLKDQYAQHLLAELSEKSSFDKLKQMLLFQAPEPTSGTVVEDIYAFGVVVYVLLLRQFPQGVFPLPSEAFPNY
IYDWDSLIKSCLSYSINQRPKKLSPLLVKKTAGELFVTAKAQCVEEELREIGEEPQIPSVANIIQESENQIIEESSDHLA
FVLVEAKSIDEAMNTSVDSTEEVIREDESYSNALQSLLIREPVVSRYVEEEKEEIKPQPLFTEMVFIEGGGFFRGGREGQ
RDEHPVHEIFLESFFLDIHPVTNEQFVRYLECAGSEQDKYYNELIRLKDSRIQRRSGKLVIEPGYAKHPVVGVTWYGASG
YASWVGKRLPTEAEWEVAAYGGIAQQRYPCGEEIDKSQANFFSSDTTAVMSYPANPYGLYDMAGNVYEWCEDWYGYDFYE
ISAQESHCPRGPAQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAVNSTYGFRCAKGVK

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=261, Percent_Identity=32.183908045977, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI38202250, Length=281, Percent_Identity=29.8932384341637, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI194248087, Length=275, Percent_Identity=31.2727272727273, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI194248088, Length=285, Percent_Identity=29.8245614035088, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI257470977, Length=279, Percent_Identity=27.5985663082437, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI226437577, Length=167, Percent_Identity=35.3293413173653, Blast_Score=94, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20130397, Length=286, Percent_Identity=26.5734265734266, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 70111; Mature: 70111

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNEQDIGVEFLGDYKILCYLRRGLWCQDILAEHRFIKKRYILKIPHAELTSSEAFMNAF
CCCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCHHCHHHHHHHHH
HETIVKLATIKHPGIISIENVSQVDGRYFLVTEEREVPTLSLTQYLASRPQGLSELEIQD
HHHHHHHHHCCCCCEEEECCHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
LVCQLAEILDYAHARGLVHGGLSLDSVHVDLSGPSPKVFLPEIGFSFLLKDQYAQHLLAE
HHHHHHHHHHHHHHCCHHCCCCEEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHH
LSEKSSFDKLKQMLLFQAPEPTSGTVVEDIYAFGVVVYVLLLRQFPQGVFPLPSEAFPNY
HHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCH
IYDWDSLIKSCLSYSINQRPKKLSPLLVKKTAGELFVTAKAQCVEEELREIGEEPQIPSV
HHHHHHHHHHHHHHHHCCCCCCCCCHHEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCHH
ANIIQESENQIIEESSDHLAFVLVEAKSIDEAMNTSVDSTEEVIREDESYSNALQSLLIR
HHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHH
EPVVSRYVEEEKEEIKPQPLFTEMVFIEGGGFFRGGREGQRDEHPVHEIFLESFFLDIHP
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
VTNEQFVRYLECAGSEQDKYYNELIRLKDSRIQRRSGKLVIEPGYAKHPVVGVTWYGASG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCC
YASWVGKRLPTEAEWEVAAYGGIAQQRYPCGEEIDKSQANFFSSDTTAVMSYPANPYGLY
HHHHHHHCCCCCCCEEEHECCCCHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHH
DMAGNVYEWCEDWYGYDFYEISAQESHCPRGPAQGVYRVLRGGCWKSLKDDLRCAHRHRN
HHCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPGAVNSTYGFRCAKGVK
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVNEQDIGVEFLGDYKILCYLRRGLWCQDILAEHRFIKKRYILKIPHAELTSSEAFMNAF
CCCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCHHCHHHHHHHHH
HETIVKLATIKHPGIISIENVSQVDGRYFLVTEEREVPTLSLTQYLASRPQGLSELEIQD
HHHHHHHHHCCCCCEEEECCHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
LVCQLAEILDYAHARGLVHGGLSLDSVHVDLSGPSPKVFLPEIGFSFLLKDQYAQHLLAE
HHHHHHHHHHHHHHCCHHCCCCEEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHH
LSEKSSFDKLKQMLLFQAPEPTSGTVVEDIYAFGVVVYVLLLRQFPQGVFPLPSEAFPNY
HHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCH
IYDWDSLIKSCLSYSINQRPKKLSPLLVKKTAGELFVTAKAQCVEEELREIGEEPQIPSV
HHHHHHHHHHHHHHHHCCCCCCCCCHHEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCHH
ANIIQESENQIIEESSDHLAFVLVEAKSIDEAMNTSVDSTEEVIREDESYSNALQSLLIR
HHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHH
EPVVSRYVEEEKEEIKPQPLFTEMVFIEGGGFFRGGREGQRDEHPVHEIFLESFFLDIHP
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
VTNEQFVRYLECAGSEQDKYYNELIRLKDSRIQRRSGKLVIEPGYAKHPVVGVTWYGASG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCC
YASWVGKRLPTEAEWEVAAYGGIAQQRYPCGEEIDKSQANFFSSDTTAVMSYPANPYGLY
HHHHHHHCCCCCCCEEEHECCCCHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHH
DMAGNVYEWCEDWYGYDFYEISAQESHCPRGPAQGVYRVLRGGCWKSLKDDLRCAHRHRN
HHCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPGAVNSTYGFRCAKGVK
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]