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The map label for this gene is pgi

Identifier: 89898087

GI number: 89898087

Start: 326955

End: 328562

Strand: Direct

Name: pgi

Synonym: CF0280

Alternate gene names: 89898087

Gene position: 326955-328562 (Clockwise)

Preceding gene: 89898085

Following gene: 89898088

Centisome position: 28.03

GC content: 41.73

Gene sequence:

>1608_bases
ATGAATGGAAAAAGCTTTTTAGATAGCTCATCAACGAAGATTTTACAAGATTTAGCAGTTGCTCCTATAGACCTAACATC
TCCTGGAATAATTTCTAAAGAACGAATAGAAAGGTTTTCCTTGTTCGTGGAAGGCTTTACGTTTAGCTATGCTATGGAAC
GTGTTGATGATGGAATTCTATCTGCATTAACAGGCTTAGCTTCTGAACGTGGCCTTCTTGCTTCTATGAAAGCTATGCAA
AATGGGGAAGTCGTAAATTATATTGATAATTTTCCTAGTGAATCACGACCCGCCCTACACACAGCTACGCGTGCTTGGGT
TAGGGGAATTTCCTTGACAGGCAATGCTGAAGATATTTCATTGAGATCGAAAATTGAAGTGCAACGTTTAAGAGATTTCC
TAAACAAGTATAGGGATGCTTTTACCACTATTGTACAAATTGGTATTGGGGGATCGGAACTCGGACCCAAAGCTCTACAT
TGTGCTTTAAAAGGTTGTTGCCCATCGGATAAGAAAGTGTATTTTGTTTCTAATGTGGACCCCGATAATGCTGCAGAGGT
TTTGCAAGAGATCGATTGCTCTAAAACACTAGTGGTTACTGTATCGAAGTCGGGAACAACATTGGAGACAGCGGTTAACG
AAGAATTATTCGCAGATCATTTCTTAAAACAGGGGTTAAGTTTTCGCGACCATTTTATTGCTGTTACCTGTGAGGGTAGC
CCCATGGATGATACAACTAGGTATCTCGAAGTTTTCCATATTTGGGACAGTATTGGTGGCCGGTTTTCTTCTACATCTAT
GGTAGGGGGAGTCGTTTTAGGATTTGCTTATGGGTTTGATGCTTTCATTCAGCTTCTTGAAGGAGCTGCAGCTATGGACT
TAGTGGCTTTAGAACCCCATATGAGCGAAAACCTCCCCATGTTATCTGCAATGCTCGGAATCTGGAATCGCAATTTCTTG
CGCTATCCTACTACCGCGGTCATTCCCTACTCTATGGGATTGGAATACTTTCCCGCGCATTTGCAGCAATGTGGTATGGA
ATCTAATGGAAAGAGCGTGGCTCAAACCGGAGAGTTGATTGGTTTTTCCACGAGTCCTATTCTTTGGGGTGAGTTAGGAA
CAAATAGTCAGCATTCCTTTTTCCAGGCCTTGCATCAAGGTAGCGATATTGTGCCTGTAGAATTTATTGGTTTTCTTAGG
AATCAACGAGGAAGGGATATTGAGATTTCCGGGTCTAGTTCCTCTCAGAAGCTTTTTGCTAATATGATAGCGCAATCGAT
AGCTTTAGCAAAGGGAAGAGAAAATGTGAATCCTAATAAGAATTTCAAGGGAAATCGTCCGTCCTCTCTTCTGGTATCTG
AAAGACTCACTCCCTACACCATGGGAGCTCTCTTGGCTTTCTATGAACATAAGATAGTCTTTCAAGGCTTTTGCTGGGGT
ATCAATTCCTTTGACCAGGAAGGAGTCACTCTAGGAAAAGACCTAGCTAATCAGGTTTTGCGCATTATGCAGGGACAACA
GGGAGGGGATAATGTTGTTATTGAAGCAGAGGCATTGTTAGGACTTTTTGACAAAAATAAAAAACTTAAAGAGTTTGGGG
AGGCGTAA

Upstream 100 bases:

>100_bases
TGTTATCGCAAAACTGGGCTGAGGTCATAAAATGTAACTTCGGCTGGTATGGTTTCAGTATAGGTACATAGGTAGTTTTT
AAGCTAGGACGAGGTAGATA

Downstream 100 bases:

>100_bases
CACCTTTTCATACAGTATTTTAATGGTTTTTGTGGTATAATAAGGGCCTTCATAGTTTAAGCGATGGATGAAAAGCTATG
TTTTTTATTCGTGTGCGTTC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MNGKSFLDSSSTKILQDLAVAPIDLTSPGIISKERIERFSLFVEGFTFSYAMERVDDGILSALTGLASERGLLASMKAMQ
NGEVVNYIDNFPSESRPALHTATRAWVRGISLTGNAEDISLRSKIEVQRLRDFLNKYRDAFTTIVQIGIGGSELGPKALH
CALKGCCPSDKKVYFVSNVDPDNAAEVLQEIDCSKTLVVTVSKSGTTLETAVNEELFADHFLKQGLSFRDHFIAVTCEGS
PMDDTTRYLEVFHIWDSIGGRFSSTSMVGGVVLGFAYGFDAFIQLLEGAAAMDLVALEPHMSENLPMLSAMLGIWNRNFL
RYPTTAVIPYSMGLEYFPAHLQQCGMESNGKSVAQTGELIGFSTSPILWGELGTNSQHSFFQALHQGSDIVPVEFIGFLR
NQRGRDIEISGSSSSQKLFANMIAQSIALAKGRENVNPNKNFKGNRPSSLLVSERLTPYTMGALLAFYEHKIVFQGFCWG
INSFDQEGVTLGKDLANQVLRIMQGQQGGDNVVIEAEALLGLFDKNKKLKEFGEA

Sequences:

>Translated_535_residues
MNGKSFLDSSSTKILQDLAVAPIDLTSPGIISKERIERFSLFVEGFTFSYAMERVDDGILSALTGLASERGLLASMKAMQ
NGEVVNYIDNFPSESRPALHTATRAWVRGISLTGNAEDISLRSKIEVQRLRDFLNKYRDAFTTIVQIGIGGSELGPKALH
CALKGCCPSDKKVYFVSNVDPDNAAEVLQEIDCSKTLVVTVSKSGTTLETAVNEELFADHFLKQGLSFRDHFIAVTCEGS
PMDDTTRYLEVFHIWDSIGGRFSSTSMVGGVVLGFAYGFDAFIQLLEGAAAMDLVALEPHMSENLPMLSAMLGIWNRNFL
RYPTTAVIPYSMGLEYFPAHLQQCGMESNGKSVAQTGELIGFSTSPILWGELGTNSQHSFFQALHQGSDIVPVEFIGFLR
NQRGRDIEISGSSSSQKLFANMIAQSIALAKGRENVNPNKNFKGNRPSSLLVSERLTPYTMGALLAFYEHKIVFQGFCWG
INSFDQEGVTLGKDLANQVLRIMQGQQGGDNVVIEAEALLGLFDKNKKLKEFGEA
>Mature_535_residues
MNGKSFLDSSSTKILQDLAVAPIDLTSPGIISKERIERFSLFVEGFTFSYAMERVDDGILSALTGLASERGLLASMKAMQ
NGEVVNYIDNFPSESRPALHTATRAWVRGISLTGNAEDISLRSKIEVQRLRDFLNKYRDAFTTIVQIGIGGSELGPKALH
CALKGCCPSDKKVYFVSNVDPDNAAEVLQEIDCSKTLVVTVSKSGTTLETAVNEELFADHFLKQGLSFRDHFIAVTCEGS
PMDDTTRYLEVFHIWDSIGGRFSSTSMVGGVVLGFAYGFDAFIQLLEGAAAMDLVALEPHMSENLPMLSAMLGIWNRNFL
RYPTTAVIPYSMGLEYFPAHLQQCGMESNGKSVAQTGELIGFSTSPILWGELGTNSQHSFFQALHQGSDIVPVEFIGFLR
NQRGRDIEISGSSSSQKLFANMIAQSIALAKGRENVNPNKNFKGNRPSSLLVSERLTPYTMGALLAFYEHKIVFQGFCWG
INSFDQEGVTLGKDLANQVLRIMQGQQGGDNVVIEAEALLGLFDKNKKLKEFGEA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=509, Percent_Identity=35.3634577603143, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI296080693, Length=501, Percent_Identity=33.9321357285429, Blast_Score=261, Evalue=1e-69,
Organism=Escherichia coli, GI1790457, Length=515, Percent_Identity=35.3398058252427, Blast_Score=277, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71996708, Length=527, Percent_Identity=33.965844402277, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71996703, Length=527, Percent_Identity=33.965844402277, Blast_Score=272, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6319673, Length=483, Percent_Identity=35.1966873706004, Blast_Score=253, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24651916, Length=490, Percent_Identity=36.1224489795918, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24651914, Length=490, Percent_Identity=36.1224489795918, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI17737445, Length=490, Percent_Identity=36.1224489795918, Blast_Score=282, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CHLFF (Q255I6)

Other databases:

- EMBL:   AP006861
- RefSeq:   YP_515197.1
- HSSP:   Q3TEE7
- STRING:   Q255I6
- GeneID:   3958533
- GenomeReviews:   AP006861_GR
- KEGG:   cfe:CF0280
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- ProtClustDB:   PRK14095
- BioCyc:   CFEL264202:CF0280-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 58639; Mature: 58639

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 347-347 ACT_SITE 378-378 ACT_SITE 493-493

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKSFLDSSSTKILQDLAVAPIDLTSPGIISKERIERFSLFVEGFTFSYAMERVDDGIL
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALTGLASERGLLASMKAMQNGEVVNYIDNFPSESRPALHTATRAWVRGISLTGNAEDIS
HHHHHHHHCCCHHHHHHHHCCCCEEEHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
LRSKIEVQRLRDFLNKYRDAFTTIVQIGIGGSELGPKALHCALKGCCPSDKKVYFVSNVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
PDNAAEVLQEIDCSKTLVVTVSKSGTTLETAVNEELFADHFLKQGLSFRDHFIAVTCEGS
CCHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
PMDDTTRYLEVFHIWDSIGGRFSSTSMVGGVVLGFAYGFDAFIQLLEGAAAMDLVALEPH
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCC
MSENLPMLSAMLGIWNRNFLRYPTTAVIPYSMGLEYFPAHLQQCGMESNGKSVAQTGELI
CCCCCHHHHHHHHHHCCCCEECCCCEEEEHHCCHHHHHHHHHHCCCCCCCCHHHHCCCEE
GFSTSPILWGELGTNSQHSFFQALHQGSDIVPVEFIGFLRNQRGRDIEISGSSSSQKLFA
ECCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHH
NMIAQSIALAKGRENVNPNKNFKGNRPSSLLVSERLTPYTMGALLAFYEHKIVFQGFCWG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECC
INSFDQEGVTLGKDLANQVLRIMQGQQGGDNVVIEAEALLGLFDKNKKLKEFGEA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MNGKSFLDSSSTKILQDLAVAPIDLTSPGIISKERIERFSLFVEGFTFSYAMERVDDGIL
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALTGLASERGLLASMKAMQNGEVVNYIDNFPSESRPALHTATRAWVRGISLTGNAEDIS
HHHHHHHHCCCHHHHHHHHCCCCEEEHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
LRSKIEVQRLRDFLNKYRDAFTTIVQIGIGGSELGPKALHCALKGCCPSDKKVYFVSNVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
PDNAAEVLQEIDCSKTLVVTVSKSGTTLETAVNEELFADHFLKQGLSFRDHFIAVTCEGS
CCHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
PMDDTTRYLEVFHIWDSIGGRFSSTSMVGGVVLGFAYGFDAFIQLLEGAAAMDLVALEPH
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCC
MSENLPMLSAMLGIWNRNFLRYPTTAVIPYSMGLEYFPAHLQQCGMESNGKSVAQTGELI
CCCCCHHHHHHHHHHCCCCEECCCCEEEEHHCCHHHHHHHHHHCCCCCCCCHHHHCCCEE
GFSTSPILWGELGTNSQHSFFQALHQGSDIVPVEFIGFLRNQRGRDIEISGSSSSQKLFA
ECCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHH
NMIAQSIALAKGRENVNPNKNFKGNRPSSLLVSERLTPYTMGALLAFYEHKIVFQGFCWG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECC
INSFDQEGVTLGKDLANQVLRIMQGQQGGDNVVIEAEALLGLFDKNKKLKEFGEA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA