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The map label for this gene is fumC [H]

Identifier: 89898074

GI number: 89898074

Start: 312050

End: 313432

Strand: Direct

Name: fumC [H]

Synonym: CF0267

Alternate gene names: 89898074

Gene position: 312050-313432 (Clockwise)

Preceding gene: 89898072

Following gene: 89898076

Centisome position: 26.76

GC content: 39.91

Gene sequence:

>1383_bases
ATGCGGCAAGAAAATGATAGTTTGGGAGTTATAGAAGTCCCTGAAGATAAGTTGTATGGTGCGCAAACCGCGCGTTCTCA
AAAGTATTTTTCTTGGGCTCCTGAGGTTATGCCTCGAGAAGTTATCCAAGCTTTAGTATGGATTAAAAAATGTTCTGCTA
AGGCCAATCGTGATCTAGGATTCTTAGATTCAAAATATTGTGATATGATTGTCTCTGCTGCTGACGAGATTTTAGAAGGT
AATTTTGATGAACATTTTCCTTTAAGGGTGTGGCAAACGGGAAGCGGGACGCAATCTAATATGAATGTGAATGAAGTGAT
CGCGAATCTAGCCATTCAACGTCACGGAGGAGTCGTTGGCAGTAAAACACCGATACATCCTAATGATCATGTGAATAAAT
CTCAGTCTTCTAATGATGTGTTTCCAACAGCTATGCATATGGCGGCTGTGATTAGCATTAAGAAGAAATTGATTCCTTCT
ATGGATCATTTACAACGGGCTTTGGATGCTAAGGTTGCTGAATTTCGAGACTGCGTTAAGATAGGAAGAACCCATTTAAT
GGATGCTGTTCCTATGACATTAGGTCAGGAATTTTCTGGTTACAGTAGTCAGATTCGTCAGTGTTTAGAAAGAGTCGCCT
TTTCTCTTACACATATGTATGAGTTAGCTATAGGGGGAACCGCTGTAGGTACAGGATTAAATGTTCCTGATGGATTTATA
GATAAAGTGATTCACTATTTGCGTCAGGAAGTAGGAGAGCCTTTTATTGCAGCGTCGAATTATTTTTCAGCACTGTCTAA
TCACGATACCCTAGTGAATGCGCACGGAACTCTGGCTACTTTAGCTTGTGCTTTAACAAAGATGGCTACGGATTTAAGTT
TTTTGGGATCTGGTCCTCGCTGTGGTTTAGGGGAGTTATTATTTCCTGAGAATGAACCTGGATCGTCGATAATGCCAGGG
AAGATAAACCCTACGCAATGCGAAGCTTTGCAAATGGTTTGTGCTCAGGTTATCGGAAATAACCAGGCGGTAGTTATTGG
TGGGAGTCGAGGAAACTTCGAACTCAATGTTATGAAACCTGTAATAATATATAATTTTTTACAGTCAGTGGATATCCTTT
CAGGAGGAATGCGAGCTTTTGCTGATTACTTTGTATCGGGTTTACGTGTGAATAAGCTTCGTCTTAAAGAATACTTAGAC
AATTCTTTAATGCTCGTTACAGCTTTAACCCCTGTCTTAGGATACGATAAGTGTTCTAAAATGGCGTTAAAAGCTTTTCA
CGATAATATAAGCTTAAAAGAAGCTTGTATACAGATGGGGTACCTATCTGAAGAAGAGTTTGACCGACTTGTTGTCCCAG
AATCTATGGTAGGAAAACATTAG

Upstream 100 bases:

>100_bases
AAGGAAAAATGAAATTGTTAGAAAATAACACGCGAATTTTTTTTTCATTTTGTAACTGTGGTAGTAGAAACAATAAAAAA
TCATAAGGGAAATAGAATAT

Downstream 100 bases:

>100_bases
TGAGACGATTTGCTCTCTAGATTAATCAGTGCTTGAGCAAATAAGAGAGCACTCTTCGTAGTTGAAAAGATATGATCAAC
ACCGATAAGTTCATCTAAAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MRQENDSLGVIEVPEDKLYGAQTARSQKYFSWAPEVMPREVIQALVWIKKCSAKANRDLGFLDSKYCDMIVSAADEILEG
NFDEHFPLRVWQTGSGTQSNMNVNEVIANLAIQRHGGVVGSKTPIHPNDHVNKSQSSNDVFPTAMHMAAVISIKKKLIPS
MDHLQRALDAKVAEFRDCVKIGRTHLMDAVPMTLGQEFSGYSSQIRQCLERVAFSLTHMYELAIGGTAVGTGLNVPDGFI
DKVIHYLRQEVGEPFIAASNYFSALSNHDTLVNAHGTLATLACALTKMATDLSFLGSGPRCGLGELLFPENEPGSSIMPG
KINPTQCEALQMVCAQVIGNNQAVVIGGSRGNFELNVMKPVIIYNFLQSVDILSGGMRAFADYFVSGLRVNKLRLKEYLD
NSLMLVTALTPVLGYDKCSKMALKAFHDNISLKEACIQMGYLSEEEFDRLVVPESMVGKH

Sequences:

>Translated_460_residues
MRQENDSLGVIEVPEDKLYGAQTARSQKYFSWAPEVMPREVIQALVWIKKCSAKANRDLGFLDSKYCDMIVSAADEILEG
NFDEHFPLRVWQTGSGTQSNMNVNEVIANLAIQRHGGVVGSKTPIHPNDHVNKSQSSNDVFPTAMHMAAVISIKKKLIPS
MDHLQRALDAKVAEFRDCVKIGRTHLMDAVPMTLGQEFSGYSSQIRQCLERVAFSLTHMYELAIGGTAVGTGLNVPDGFI
DKVIHYLRQEVGEPFIAASNYFSALSNHDTLVNAHGTLATLACALTKMATDLSFLGSGPRCGLGELLFPENEPGSSIMPG
KINPTQCEALQMVCAQVIGNNQAVVIGGSRGNFELNVMKPVIIYNFLQSVDILSGGMRAFADYFVSGLRVNKLRLKEYLD
NSLMLVTALTPVLGYDKCSKMALKAFHDNISLKEACIQMGYLSEEEFDRLVVPESMVGKH
>Mature_460_residues
MRQENDSLGVIEVPEDKLYGAQTARSQKYFSWAPEVMPREVIQALVWIKKCSAKANRDLGFLDSKYCDMIVSAADEILEG
NFDEHFPLRVWQTGSGTQSNMNVNEVIANLAIQRHGGVVGSKTPIHPNDHVNKSQSSNDVFPTAMHMAAVISIKKKLIPS
MDHLQRALDAKVAEFRDCVKIGRTHLMDAVPMTLGQEFSGYSSQIRQCLERVAFSLTHMYELAIGGTAVGTGLNVPDGFI
DKVIHYLRQEVGEPFIAASNYFSALSNHDTLVNAHGTLATLACALTKMATDLSFLGSGPRCGLGELLFPENEPGSSIMPG
KINPTQCEALQMVCAQVIGNNQAVVIGGSRGNFELNVMKPVIIYNFLQSVDILSGGMRAFADYFVSGLRVNKLRLKEYLD
NSLMLVTALTPVLGYDKCSKMALKAFHDNISLKEACIQMGYLSEEEFDRLVVPESMVGKH

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=54.6840958605665, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=53.968253968254, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=53.9301310043668, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI87082375, Length=453, Percent_Identity=36.644591611479, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=54.3478260869565, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=52.6153846153846, Blast_Score=360, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=53.9130434782609, Blast_Score=491, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=55, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=55, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=53.3622559652928, Blast_Score=505, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=52.7114967462039, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=44.6854663774403, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50545; Mature: 50545

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQENDSLGVIEVPEDKLYGAQTARSQKYFSWAPEVMPREVIQALVWIKKCSAKANRDLG
CCCCCCCCCEEECCCHHHCCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FLDSKYCDMIVSAADEILEGNFDEHFPLRVWQTGSGTQSNMNVNEVIANLAIQRHGGVVG
CCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SKTPIHPNDHVNKSQSSNDVFPTAMHMAAVISIKKKLIPSMDHLQRALDAKVAEFRDCVK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGRTHLMDAVPMTLGQEFSGYSSQIRQCLERVAFSLTHMYELAIGGTAVGTGLNVPDGFI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHH
DKVIHYLRQEVGEPFIAASNYFSALSNHDTLVNAHGTLATLACALTKMATDLSFLGSGPR
HHHHHHHHHHHCCCEEEHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCC
CGLGELLFPENEPGSSIMPGKINPTQCEALQMVCAQVIGNNQAVVIGGSRGNFELNVMKP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHH
VIIYNFLQSVDILSGGMRAFADYFVSGLRVNKLRLKEYLDNSLMLVTALTPVLGYDKCSK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEHHHHHHHHHCHHHHHH
MALKAFHDNISLKEACIQMGYLSEEEFDRLVVPESMVGKH
HHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHCCC
>Mature Secondary Structure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HHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]