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The map label for this gene is msrA [H]

Identifier: 89257196

GI number: 89257196

Start: 1888335

End: 1889024

Strand: Reverse

Name: msrA [H]

Synonym: FTL_1960

Alternate gene names: 89257196

Gene position: 1889024-1888335 (Counterclockwise)

Preceding gene: 89257197

Following gene: 89257195

Centisome position: 99.63

GC content: 28.26

Gene sequence:

>690_bases
ATGATTAAGAAGATTATTTATAGTTTATCAATACTATCTTGTAGTTTAGGTTTCTCAGCTAATAGTGATACTAAATATGA
AAAAGCTATATTTGCAGGTGGTTGTTTTTGGTGTTTAGAATCAGATTTTGAATATATGCAAAAACATCAAGATCTAAGTC
ATAATGGTATTATAAAGGTTATCTCTGGTTATGATGGTGGTTTGCAAAAAGATCCTACCTACAAAACAGTATCTGCAGGT
ATTACAAATTATAAAGAATCAGTTGAAGTCATATATGATCCTACTAAAATTAGCTATCAAGAGCTTGTAGAGTATTTTTA
TCGCCGTATAGATCCTACAGACTTTAAAGGACAATTTTGTGATAAAGGCAAGCAATATCAATCAGCTATATATTACAACA
ATGACAAACAAAAACAGGTTGCTGAAGAGGTTACTAAAAAATTAAAAGAAGAATTTAAAAAACATAATCAATCTGTATAT
ACTCAAATTTTACCATCTACACATTTTTATAAAGCTGAAAGTTACCATCAAGATTATCATCATAAAAATCCTAAAAGATA
TTGCTATTATCGTACCGGATGTGGTCGTGATCTAACAATAAATAAAGTTTGGCAAAATATAGATTGTAAATATAGTAATG
TAGTTCCATTTGATATACCATCTAGCTATGCAGAATGTTTAATAAGATAA

Upstream 100 bases:

>100_bases
ATTTAGAAAATTCTTAATATTTTAATCATCATCAAATTTATTTATTCAACATTTGTTTATATAATTTTTTAGTATCATAA
TTAAAATTAAGGATTATATT

Downstream 100 bases:

>100_bases
TAAAATGAAAGTAGTTGGTATAGCATCAAAAGTTTCTAATGATAGAGAAGATTTGCTTGAATAAGCTTGGGAGCTTTTCT
TTAATAGTGAGGTATTAGAG

Product: peptide methionine sulfoxide reductase msrA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MIKKIIYSLSILSCSLGFSANSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKVISGYDGGLQKDPTYKTVSAG
ITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFCDKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVY
TQILPSTHFYKAESYHQDYHHKNPKRYCYYRTGCGRDLTINKVWQNIDCKYSNVVPFDIPSSYAECLIR

Sequences:

>Translated_229_residues
MIKKIIYSLSILSCSLGFSANSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKVISGYDGGLQKDPTYKTVSAG
ITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFCDKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVY
TQILPSTHFYKAESYHQDYHHKNPKRYCYYRTGCGRDLTINKVWQNIDCKYSNVVPFDIPSSYAECLIR
>Mature_229_residues
MIKKIIYSLSILSCSLGFSANSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKVISGYDGGLQKDPTYKTVSAG
ITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFCDKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVY
TQILPSTHFYKAESYHQDYHHKNPKRYCYYRTGCGRDLTINKVWQNIDCKYSNVVPFDIPSSYAECLIR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=35.5828220858896, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=35.5828220858896, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=37.962962962963, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790665, Length=166, Percent_Identity=36.144578313253, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533973, Length=159, Percent_Identity=37.7358490566038, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=35.5421686746988, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664627, Length=151, Percent_Identity=33.7748344370861, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45553131, Length=152, Percent_Identity=32.8947368421053, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24664631, Length=151, Percent_Identity=33.112582781457, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26809; Mature: 26809

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIIYSLSILSCSLGFSANSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKV
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHEEHHHHHHHHHHHCCCCCCCEEEE
ISGYDGGLQKDPTYKTVSAGITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFC
EECCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHH
DKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVYTQILPSTHFYKAESYHQDYH
CCCHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHH
HKNPKRYCYYRTGCGRDLTINKVWQNIDCKYSNVVPFDIPSSYAECLIR
CCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MIKKIIYSLSILSCSLGFSANSDTKYEKAIFAGGCFWCLESDFEYMQKHQDLSHNGIIKV
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHEEHHHHHHHHHHHCCCCCCCEEEE
ISGYDGGLQKDPTYKTVSAGITNYKESVEVIYDPTKISYQELVEYFYRRIDPTDFKGQFC
EECCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHH
DKGKQYQSAIYYNNDKQKQVAEEVTKKLKEEFKKHNQSVYTQILPSTHFYKAESYHQDYH
CCCHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHH
HKNPKRYCYYRTGCGRDLTINKVWQNIDCKYSNVVPFDIPSSYAECLIR
CCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA