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The map label for this gene is dnaX [H]

Identifier: 89257153

GI number: 89257153

Start: 1837363

End: 1839000

Strand: Direct

Name: dnaX [H]

Synonym: FTL_1905

Alternate gene names: 89257153

Gene position: 1837363-1839000 (Clockwise)

Preceding gene: 89257150

Following gene: 89257160

Centisome position: 96.91

GC content: 32.6

Gene sequence:

>1638_bases
ATGTCATATCAAGCATTAGCAAGAAAATATCGTCCACAATCATTCGCAGAAGTTGCTGGACAACAACATGCTCTTAACAG
TTTAGTACATGCTTTAGAAACTCAAAAAGTTCACCATGCCTACTTATTTACAGGTACGCGTGGGGTTGGTAAGACAACAC
TTGGTAGACTCTTAGCAAAATGTCTAAATTGTAAAACTGGTGTTACTGCTGAGCCTTGCAACAAATGTGAAAACTGTGTA
GCAATCAATAATAACAGCTTTATAGATTTGATCGAGATTGATGCTGCTTCACGTACAGGTGTTGAAGAGACTAAAGAAAT
CTTAGATAATATCCAATATATGCCTTCACAAGGACGCTATAAAGTCTATCTAATCGATGAGGTACATATGCTATCTAAGC
AAAGTTTCAATGCTTTGCTAAAGACTCTCGAAGAGCCACCAGAATATGTCAAATTTATCCTAGCTACAACAGATTATCAC
AAAATCCCTGTTACGATACTTTCTAGATGTATCCAACTTCATCTCAAACATATCTCACAGACTGATATCAAAGATCAACT
AAAAATAATTCTAGCTAAAGAGAATATAAATTCAGATGAGCAATCACTTGAATACATAGCTTATCATGCTAAAGGCAGTT
TAAGAGATGCTTTAAGCTTACTTGATCAGGCTATTAGCTTTTGTGGTGGTGAACTTAAGCAAGCTCAGATCAAACAAATG
CTTGGAATTATCGATAGTGAAGAAGTATATAGTATTATCAATGCAATTATTGATAATGATCCAAAAGCTATATTGCCAGC
CATCAAAAATTTAGCACTTACAGAAAGTAGTGCTAATGCTGTACTAGATAGAATTGCTGAAATTTGGTTCGCTTGCTGTA
TATATAGCTTTACCCAATCACTAGATGCTGTTAATGATATTGATGTTGATATAATCAATAATATTTTGGCAAAAATATCA
ATCGAACAAGCACATTTTTTGTATCAACTAACGATAACCGCCAAAAAAGATATTGCTTTAGCACCAAATTTCGAAACTGG
TGTAACTATGGCTATACTTAGACTTATAGCGTTTCAAAAAAAAAATCTAATTGATAAAATCCAAACCTCTAAGTCAAATA
TTAGCCCAATAGTTTCTAAAAATGATATAAATCTGCTTAAAAACACATTTAAGTCAGAACAACCTAAACAGACTGTAAAA
GCTGTAGCACAAAATAATGATTCAACAGCTAGTGAAAATACTCAAGAACAATCATTAGATAAAAAATGGTTTAATCTGCT
TAATAGAATAAAACTGAAAGGCTTCACAAAAACGCTCGCTTTTAATAGTCACCTTATTAGTGATAATAGTGAAACATTTG
TAATCCATCTAAATGAAGATGCCAAAAAAATCCTTGAGCTTGATCCTCAAAGCATAGCTAAACTTCAAGCAAGTATTAGT
GAGTATCTTAACAACCCTAGTTTTAGGTTAGATATCAAAAACCTAGCTATGGATAAAGTCTCAACTGATCAAAAGTCTCC
TGCTGAAATTAAGCGTGAAAATGCTATAAGTAAAATTCATAATGATGAGAATACAAAGCTTATTAAACAAGCTCTCGCAA
TTGATATAAAGGATCAAAATATAATTTTAACAGATTAG

Upstream 100 bases:

>100_bases
ACAAACAAAGACTATTGAAAGTTATCTAAATACCCTCTTATTCTTTTAGCCTAACTCTGTTATTATTTAATATAAGATTT
TCTAATATATTAATTTGTAA

Downstream 100 bases:

>100_bases
AAGTTTAAAAAACCTAAATGTATTCCCACGCATCTTTATCAGCAAAGACAGCATGTAGAAGTTTGTTATTAAGAGTATGT
CCAGACTTAAAACAGTTGAA

Product: DNA polymerase III, gamma/tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MSYQALARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFTGTRGVGKTTLGRLLAKCLNCKTGVTAEPCNKCENCV
AINNNSFIDLIEIDAASRTGVEETKEILDNIQYMPSQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYH
KIPVTILSRCIQLHLKHISQTDIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISFCGGELKQAQIKQM
LGIIDSEEVYSIINAIIDNDPKAILPAIKNLALTESSANAVLDRIAEIWFACCIYSFTQSLDAVNDIDVDIINNILAKIS
IEQAHFLYQLTITAKKDIALAPNFETGVTMAILRLIAFQKKNLIDKIQTSKSNISPIVSKNDINLLKNTFKSEQPKQTVK
AVAQNNDSTASENTQEQSLDKKWFNLLNRIKLKGFTKTLAFNSHLISDNSETFVIHLNEDAKKILELDPQSIAKLQASIS
EYLNNPSFRLDIKNLAMDKVSTDQKSPAEIKRENAISKIHNDENTKLIKQALAIDIKDQNIILTD

Sequences:

>Translated_545_residues
MSYQALARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFTGTRGVGKTTLGRLLAKCLNCKTGVTAEPCNKCENCV
AINNNSFIDLIEIDAASRTGVEETKEILDNIQYMPSQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYH
KIPVTILSRCIQLHLKHISQTDIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISFCGGELKQAQIKQM
LGIIDSEEVYSIINAIIDNDPKAILPAIKNLALTESSANAVLDRIAEIWFACCIYSFTQSLDAVNDIDVDIINNILAKIS
IEQAHFLYQLTITAKKDIALAPNFETGVTMAILRLIAFQKKNLIDKIQTSKSNISPIVSKNDINLLKNTFKSEQPKQTVK
AVAQNNDSTASENTQEQSLDKKWFNLLNRIKLKGFTKTLAFNSHLISDNSETFVIHLNEDAKKILELDPQSIAKLQASIS
EYLNNPSFRLDIKNLAMDKVSTDQKSPAEIKRENAISKIHNDENTKLIKQALAIDIKDQNIILTD
>Mature_544_residues
SYQALARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFTGTRGVGKTTLGRLLAKCLNCKTGVTAEPCNKCENCVA
INNNSFIDLIEIDAASRTGVEETKEILDNIQYMPSQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHK
IPVTILSRCIQLHLKHISQTDIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISFCGGELKQAQIKQML
GIIDSEEVYSIINAIIDNDPKAILPAIKNLALTESSANAVLDRIAEIWFACCIYSFTQSLDAVNDIDVDIINNILAKISI
EQAHFLYQLTITAKKDIALAPNFETGVTMAILRLIAFQKKNLIDKIQTSKSNISPIVSKNDINLLKNTFKSEQPKQTVKA
VAQNNDSTASENTQEQSLDKKWFNLLNRIKLKGFTKTLAFNSHLISDNSETFVIHLNEDAKKILELDPQSIAKLQASISE
YLNNPSFRLDIKNLAMDKVSTDQKSPAEIKRENAISKIHNDENTKLIKQALAIDIKDQNIILTD

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=258, Percent_Identity=24.031007751938, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI31881687, Length=258, Percent_Identity=24.031007751938, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786676, Length=378, Percent_Identity=45.5026455026455, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1787119, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=221, Percent_Identity=24.4343891402715, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322528, Length=306, Percent_Identity=22.8758169934641, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=226, Percent_Identity=23.8938053097345, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647857, Length=221, Percent_Identity=24.8868778280543, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61074; Mature: 60943

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQALARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFTGTRGVGKTTLGRLLAK
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
CLNCKTGVTAEPCNKCENCVAINNNSFIDLIEIDAASRTGVEETKEILDNIQYMPSQGRY
HHCCCCCCCCCHHHHCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHKIPVTILSRCIQLHLKHISQ
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
TDIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISFCGGELKQAQIKQM
CCHHHHHEEEEEECCCCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGIIDSEEVYSIINAIIDNDPKAILPAIKNLALTESSANAVLDRIAEIWFACCIYSFTQS
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDAVNDIDVDIINNILAKISIEQAHFLYQLTITAKKDIALAPNFETGVTMAILRLIAFQK
HCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEEEECCCEEECCCCCCHHHHHHHHHHHHHH
KNLIDKIQTSKSNISPIVSKNDINLLKNTFKSEQPKQTVKAVAQNNDSTASENTQEQSLD
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
KKWFNLLNRIKLKGFTKTLAFNSHLISDNSETFVIHLNEDAKKILELDPQSIAKLQASIS
HHHHHHHHHHHHCCHHHHHEECCEEECCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHH
EYLNNPSFRLDIKNLAMDKVSTDQKSPAEIKRENAISKIHNDENTKLIKQALAIDIKDQN
HHHCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCE
IILTD
EEECC
>Mature Secondary Structure 
SYQALARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFTGTRGVGKTTLGRLLAK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
CLNCKTGVTAEPCNKCENCVAINNNSFIDLIEIDAASRTGVEETKEILDNIQYMPSQGRY
HHCCCCCCCCCHHHHCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHKIPVTILSRCIQLHLKHISQ
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
TDIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISFCGGELKQAQIKQM
CCHHHHHEEEEEECCCCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGIIDSEEVYSIINAIIDNDPKAILPAIKNLALTESSANAVLDRIAEIWFACCIYSFTQS
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDAVNDIDVDIINNILAKISIEQAHFLYQLTITAKKDIALAPNFETGVTMAILRLIAFQK
HCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEEEECCCEEECCCCCCHHHHHHHHHHHHHH
KNLIDKIQTSKSNISPIVSKNDINLLKNTFKSEQPKQTVKAVAQNNDSTASENTQEQSLD
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
KKWFNLLNRIKLKGFTKTLAFNSHLISDNSETFVIHLNEDAKKILELDPQSIAKLQASIS
HHHHHHHHHHHHCCHHHHHEECCEEECCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHH
EYLNNPSFRLDIKNLAMDKVSTDQKSPAEIKRENAISKIHNDENTKLIKQALAIDIKDQN
HHHCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCE
IILTD
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]