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The map label for this gene is kdpD [H]

Identifier: 89257129

GI number: 89257129

Start: 1810079

End: 1811656

Strand: Reverse

Name: kdpD [H]

Synonym: FTL_1878

Alternate gene names: 89257129

Gene position: 1811656-1810079 (Counterclockwise)

Preceding gene: 89257130

Following gene: 89257128

Centisome position: 95.55

GC content: 31.88

Gene sequence:

>1578_bases
ATGCAAGTACACATTGTTTCGATAAATAAAAAAGAGCACAAGCTTCAGGAACAGCCACGTCATAGTAAAATTAAGACAAA
AGGCTTGATTATTGATGTGATAAAATCAGCATTAATAGCAGCAGTATCAGGAGTATTTATCTTCTTTAGTCTTAGTATTG
CAGGTTTAGTTTCACAAACTCTATGTTTTTTGATGGTTTTAGCAGCATGTGCTTATAGATATGGATTAATACCATCGATA
ATATCTTCATTAGTTGGGTTATTTTTGTATATCTATCTTTATTTAGAACCAAATTTTGTTTTTCATATTTCTAGTTTAGC
AGGGATAATTACTTTTGCTTTCTTTATGACTATAGTTATATTCTCTAGCCATGTGATTCTAAGAACTAAAAGAGCTTTTA
CACTTCTAAAAGAACGAGAAAATAATATTTCGGTATTATACCGCTTTACAAAAATATTTAATGAAAAGAGTTTAGATAAA
GATCTACGCTCAGTATTTTTACATGCTTTAGAAGAGTATTTCAAGTGTGACTTTGTTTTTTTAAGTGTTTCAGATGGTGA
GCTTGATTCAGCAGCTTTTCCGCAACACTCAAATTTTAATCAAAAAGAATTAGCAGCCGCTAAATGGAGTTTTAAGTATA
AGGACAGCTGTGGTAAAGGTACTAATACCTTTGCTGGTTTAGATTGGGCAGTAGAACCATTAGTGATAGAAAATCGAGTC
CTAGGAGTAATAGCAATATATTTAAGTTCAGAAACAGCAGTAGAGCGCATAACTACAGATAGTGTCATTCTAAGTAGTAT
GCTTTCGCATATTTCACATATTCTTTTGAAAAGAAATCTTGAAAAAGAGGAGAAGAAATCCTTACTTCTTGATGAGCAAA
GACGCCTACAAAAATCGATGTTATCATCGGTTTCTCATGATCTTAAAACACCGTTGGCTTCTATAATGGGTGCATTAAGT
AGTATTAAGTCATACAAAGATTCATTTAATCCAGAACAGCAGGTTGAGATGTTAGATTTAGCGCTAACAGAGTCAAAAAG
ACTTGATAGTTACATTGATAATATAATCCAAATGCTTAAGGTTGATTCAGGAAAGCTTTCATTAAATATTCAAAATGTTA
ATAGTAATTTTTTCCTAACTGAAATACAAGAAACTTGCGCAAGAGTATATAATAAACAGAAGTTCAGGTTTATAATGCCT
AAGGAGCCATTTGAAATTGAGCTTGATCCAGTTTTATTCCAACAGGTAATTCTCAATTTGATTGATAATGCTGTTAAGTT
TACGTGTGATTTTGAAAAAGAGATTATAATTTCTCTTAAGAGAAAGAAAGCTGCATTCTGTCTTTTTGAGGTTCAAAACA
AAGGCATTGGCTTAAGAGAATCAGATATGGAAAAAATATTTACAATATTTCATAGAATTGAAAAGAGAGATAGCTATACA
CATGGTAATGGTTTAGGCTTAGCTATATGTAAGGGCATAGTGACAGCGCACAATGGTAAGATCAGGGTGTATAGTGATGG
CGAGGGTAAAGGCAGTGTTTTCAAAATTACATTACCTTTAAAATCAAGTACAAATTAG

Upstream 100 bases:

>100_bases
TGCAACTGATTTAGTAATCGGTAAATCGATACGACCAAAATGGAAAGATAAACTTTTTGGTTCTGTTGTCTACGATATTA
TCCGTAATAATAACAATGGT

Downstream 100 bases:

>100_bases
CTATCAAGTGATCACAATATAACTAAATTTATATAGTTAGGATGATAAGAAAAATATTAATAGTAGAAGATGAACCACAG
ATTAAAAAACTTTTTTAGTT

Product: two component sensor protein kdpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MQVHIVSINKKEHKLQEQPRHSKIKTKGLIIDVIKSALIAAVSGVFIFFSLSIAGLVSQTLCFLMVLAACAYRYGLIPSI
ISSLVGLFLYIYLYLEPNFVFHISSLAGIITFAFFMTIVIFSSHVILRTKRAFTLLKERENNISVLYRFTKIFNEKSLDK
DLRSVFLHALEEYFKCDFVFLSVSDGELDSAAFPQHSNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRV
LGVIAIYLSSETAVERITTDSVILSSMLSHISHILLKRNLEKEEKKSLLLDEQRRLQKSMLSSVSHDLKTPLASIMGALS
SIKSYKDSFNPEQQVEMLDLALTESKRLDSYIDNIIQMLKVDSGKLSLNIQNVNSNFFLTEIQETCARVYNKQKFRFIMP
KEPFEIELDPVLFQQVILNLIDNAVKFTCDFEKEIIISLKRKKAAFCLFEVQNKGIGLRESDMEKIFTIFHRIEKRDSYT
HGNGLGLAICKGIVTAHNGKIRVYSDGEGKGSVFKITLPLKSSTN

Sequences:

>Translated_525_residues
MQVHIVSINKKEHKLQEQPRHSKIKTKGLIIDVIKSALIAAVSGVFIFFSLSIAGLVSQTLCFLMVLAACAYRYGLIPSI
ISSLVGLFLYIYLYLEPNFVFHISSLAGIITFAFFMTIVIFSSHVILRTKRAFTLLKERENNISVLYRFTKIFNEKSLDK
DLRSVFLHALEEYFKCDFVFLSVSDGELDSAAFPQHSNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRV
LGVIAIYLSSETAVERITTDSVILSSMLSHISHILLKRNLEKEEKKSLLLDEQRRLQKSMLSSVSHDLKTPLASIMGALS
SIKSYKDSFNPEQQVEMLDLALTESKRLDSYIDNIIQMLKVDSGKLSLNIQNVNSNFFLTEIQETCARVYNKQKFRFIMP
KEPFEIELDPVLFQQVILNLIDNAVKFTCDFEKEIIISLKRKKAAFCLFEVQNKGIGLRESDMEKIFTIFHRIEKRDSYT
HGNGLGLAICKGIVTAHNGKIRVYSDGEGKGSVFKITLPLKSSTN
>Mature_525_residues
MQVHIVSINKKEHKLQEQPRHSKIKTKGLIIDVIKSALIAAVSGVFIFFSLSIAGLVSQTLCFLMVLAACAYRYGLIPSI
ISSLVGLFLYIYLYLEPNFVFHISSLAGIITFAFFMTIVIFSSHVILRTKRAFTLLKERENNISVLYRFTKIFNEKSLDK
DLRSVFLHALEEYFKCDFVFLSVSDGELDSAAFPQHSNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRV
LGVIAIYLSSETAVERITTDSVILSSMLSHISHILLKRNLEKEEKKSLLLDEQRRLQKSMLSSVSHDLKTPLASIMGALS
SIKSYKDSFNPEQQVEMLDLALTESKRLDSYIDNIIQMLKVDSGKLSLNIQNVNSNFFLTEIQETCARVYNKQKFRFIMP
KEPFEIELDPVLFQQVILNLIDNAVKFTCDFEKEIIISLKRKKAAFCLFEVQNKGIGLRESDMEKIFTIFHRIEKRDSYT
HGNGLGLAICKGIVTAHNGKIRVYSDGEGKGSVFKITLPLKSSTN

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=512, Percent_Identity=23.046875, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=28.2258064516129, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=29.8701298701299, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=28.6324786324786, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=26.3598326359833, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789149, Length=252, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=26.9662921348315, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=25.5506607929515, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=27.1551724137931, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=25.9574468085106, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=28.0487804878049, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=24.3697478991597, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=209, Percent_Identity=23.9234449760766, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59520; Mature: 59520

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVHIVSINKKEHKLQEQPRHSKIKTKGLIIDVIKSALIAAVSGVFIFFSLSIAGLVSQT
CEEEEEECCCHHHHHHCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCFLMVLAACAYRYGLIPSIISSLVGLFLYIYLYLEPNFVFHISSLAGIITFAFFMTIVI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
FSSHVILRTKRAFTLLKERENNISVLYRFTKIFNEKSLDKDLRSVFLHALEEYFKCDFVF
HHCHHHEEHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEE
LSVSDGELDSAAFPQHSNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRV
EEECCCCCCCCCCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEECCHH
LGVIAIYLSSETAVERITTDSVILSSMLSHISHILLKRNLEKEEKKSLLLDEQRRLQKSM
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LSSVSHDLKTPLASIMGALSSIKSYKDSFNPEQQVEMLDLALTESKRLDSYIDNIIQMLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDSGKLSLNIQNVNSNFFLTEIQETCARVYNKQKFRFIMPKEPFEIELDPVLFQQVILNL
CCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCEEEECCCCCCEEEECHHHHHHHHHHH
IDNAVKFTCDFEKEIIISLKRKKAAFCLFEVQNKGIGLRESDMEKIFTIFHRIEKRDSYT
HHHHHEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
HGNGLGLAICKGIVTAHNGKIRVYSDGEGKGSVFKITLPLKSSTN
CCCCCHHHHHHHHHEECCCEEEEEECCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MQVHIVSINKKEHKLQEQPRHSKIKTKGLIIDVIKSALIAAVSGVFIFFSLSIAGLVSQT
CEEEEEECCCHHHHHHCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCFLMVLAACAYRYGLIPSIISSLVGLFLYIYLYLEPNFVFHISSLAGIITFAFFMTIVI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
FSSHVILRTKRAFTLLKERENNISVLYRFTKIFNEKSLDKDLRSVFLHALEEYFKCDFVF
HHCHHHEEHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEE
LSVSDGELDSAAFPQHSNFNQKELAAAKWSFKYKDSCGKGTNTFAGLDWAVEPLVIENRV
EEECCCCCCCCCCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEECCHH
LGVIAIYLSSETAVERITTDSVILSSMLSHISHILLKRNLEKEEKKSLLLDEQRRLQKSM
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LSSVSHDLKTPLASIMGALSSIKSYKDSFNPEQQVEMLDLALTESKRLDSYIDNIIQMLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDSGKLSLNIQNVNSNFFLTEIQETCARVYNKQKFRFIMPKEPFEIELDPVLFQQVILNL
CCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCEEEECCCCCCEEEECHHHHHHHHHHH
IDNAVKFTCDFEKEIIISLKRKKAAFCLFEVQNKGIGLRESDMEKIFTIFHRIEKRDSYT
HHHHHEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
HGNGLGLAICKGIVTAHNGKIRVYSDGEGKGSVFKITLPLKSSTN
CCCCCHHHHHHHHHEECCCEEEEEECCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9226259; 11466286 [H]