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The map label for this gene is hisS [H]

Identifier: 89257070

GI number: 89257070

Start: 1739886

End: 1741151

Strand: Reverse

Name: hisS [H]

Synonym: FTL_1807

Alternate gene names: 89257070

Gene position: 1741151-1739886 (Counterclockwise)

Preceding gene: 89257071

Following gene: 89257069

Centisome position: 91.83

GC content: 34.6

Gene sequence:

>1266_bases
ATGAGTAAGCTTACTATTGTTCGTGGATTTAATGATGTATTGCCACTAGACAGTTATAAATGGCAATTCTTGGAATCAAA
AGTAAAACTCATACTTGATAGATATAACTACAGTGAAACAAGATTGCCTATTGTTGAGAGGAGCGAATTGTTTCATAGAA
GTGTAGGTGAAAGTTCTGATATAGTTTCAAAAGAGACTTATGACTTTCAAGATCGTAATGGTGATAGCCTGACATTGCGT
CCAGAAGGAACAGCTGGCTGTGTTAGGATGGTTATTGAAAATAATTTGGCTACTCGAGGCCAAACACAGAAACTATGGTA
TTGTGGACCTATGTTTCGCTATGAGCGCCCACAAAAAGGCCGCTATAGACAATTTTATCAGCTTGGGGTTGAGGCTTATG
GCTTTGATGGTATAGCTATTGATTTAGAGGTTATTGCTATAGCTTGGAGTCTTTTCAAAGAGCTTGGGATTTCTGAGTAT
GTAACTTTAGAACTAAATAGCCTTGGTTCTAGTCTTAACAGACAAGAGTATACTCAAGCGCTATTACAATACCTAAAACC
ATATCATGCTGAGCTTGATGAAGATTCTATCAAGAGGTTGGATAAAAATCCTCTAAGAATATTAGATTCTAAGATAGAAA
AAACACAAAAAATCTTAGCAAACGCACCTAAACTTATTGATTTTATAGATCATGATTTGCGTTTGAGATTTAAACAAACT
TGTCAATATTTAGATGCCTTGGGTGTCAGATATAAATTAAATGAAAATCTTGTTAGAGGTTTGGATTATTATACTGGTTT
AGTTTTTGAATGGACTACTGATAAACTTGGTTCACAGAGTGCAATCTGTGCAGGTGGTCGTTATGATGGTCTTGTAGATA
ATCTTGGTGGTCAGAAAACTGCTGCGATAGGATTTGCTATAGGTATGGAGCGTTTGTTACTCTTATTAGAAGATTTAGGT
AAATTACCTAATCAAGATAATGCTTGTGATGTGTTTTTCATATTAGATAGTGCCCAGCTGCATCAATCTCTTGCTATAGT
AGAGAATATTCGCCAAGAGCTTCCCCAACTTAAAATAGATATGGATCTAAAGTTTGGTAGTTTTAAATCACAATTTAAGA
AAGCGGATAAATCTGGAGCTAAAGTTGCTATAATAATCGGCCAAGATGAGTTAGATAATGGCTTTGCTGGTATAAAATTT
CTTCAACAAAATGAAGAACAACAACAAGTTGCTTTTAATGAGTTAATAAATTTTTTAGAAAGATAG

Upstream 100 bases:

>100_bases
GCTGACTCAAAAATTATCAAGCAAGATGATAAATCTTTACAAGAAAATTATAAGCAAAACGATAAAGAAACTAAAGCTGA
GAAGTTAAGGTAGGTAGCTT

Downstream 100 bases:

>100_bases
AGGTTTATGAAATTACATAATATAAAGGGCTATGCTTGGATTGTAGTTGGGTTAAGCTCATTTCTACTAATCGATAAATA
TATAATGAATGTTTCTCCTA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSKLTIVRGFNDVLPLDSYKWQFLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLR
PEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGISEY
VTLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVDNLGGQKTAAIGFAIGMERLLLLLEDLG
KLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKF
LQQNEEQQQVAFNELINFLER

Sequences:

>Translated_421_residues
MSKLTIVRGFNDVLPLDSYKWQFLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLR
PEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGISEY
VTLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVDNLGGQKTAAIGFAIGMERLLLLLEDLG
KLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKF
LQQNEEQQQVAFNELINFLER
>Mature_420_residues
SKLTIVRGFNDVLPLDSYKWQFLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSDIVSKETYDFQDRNGDSLTLRP
EGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKGRYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGISEYV
TLELNSLGSSLNRQEYTQALLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQTC
QYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVDNLGGQKTAAIGFAIGMERLLLLLEDLGK
LPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKIDMDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFL
QQNEEQQQVAFNELINFLER

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=425, Percent_Identity=24.9411764705882, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI15029520, Length=426, Percent_Identity=24.1784037558685, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788861, Length=408, Percent_Identity=50, Blast_Score=420, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48171; Mature: 48039

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLTIVRGFNDVLPLDSYKWQFLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSD
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
IVSKETYDFQDRNGDSLTLRPEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKG
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCHHHCCCCCCC
RYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGISEYVTLELNSLGSSLNRQEYTQA
HHHHHHHHCCHHCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCHHHHHHH
LLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
HHHHHCHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHH
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVDNLGGQKT
HHHHHHCCCEEEECHHHHHHHHHHHCEEEEECCCCCCCCCCEECCCCCCCHHHCCCCCHH
AAIGFAIGMERLLLLLEDLGKLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEE
MDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFLQQNEEQQQVAFNELINFLE
EEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
R
C
>Mature Secondary Structure 
SKLTIVRGFNDVLPLDSYKWQFLESKVKLILDRYNYSETRLPIVERSELFHRSVGESSD
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
IVSKETYDFQDRNGDSLTLRPEGTAGCVRMVIENNLATRGQTQKLWYCGPMFRYERPQKG
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCHHHCCCCCCC
RYRQFYQLGVEAYGFDGIAIDLEVIAIAWSLFKELGISEYVTLELNSLGSSLNRQEYTQA
HHHHHHHHCCHHCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCHHHHHHH
LLQYLKPYHAELDEDSIKRLDKNPLRILDSKIEKTQKILANAPKLIDFIDHDLRLRFKQT
HHHHHCHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHH
CQYLDALGVRYKLNENLVRGLDYYTGLVFEWTTDKLGSQSAICAGGRYDGLVDNLGGQKT
HHHHHHCCCEEEECHHHHHHHHHHHCEEEEECCCCCCCCCCEECCCCCCCHHHCCCCCHH
AAIGFAIGMERLLLLLEDLGKLPNQDNACDVFFILDSAQLHQSLAIVENIRQELPQLKID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEE
MDLKFGSFKSQFKKADKSGAKVAIIIGQDELDNGFAGIKFLQQNEEQQQVAFNELINFLE
EEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA