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The map label for this gene is sdhB [H]

Identifier: 89257048

GI number: 89257048

Start: 1717674

End: 1718375

Strand: Reverse

Name: sdhB [H]

Synonym: FTL_1785

Alternate gene names: 89257048

Gene position: 1718375-1717674 (Counterclockwise)

Preceding gene: 89257049

Following gene: 89257047

Centisome position: 90.63

GC content: 35.9

Gene sequence:

>702_bases
ATGGAAGTAAGATTTAAAATTTATAGATATAATCCAGAAGTTGATAAAAAACCTTATTACGATGAGTATACAGTTGAAGT
AGAAAATGAAGGTGTTAAGGTTCTAACAGCTCTAGAATTAATTAAAGAGCAGGATCCTACCTTGGCTTTAAGAAGATCTT
GTCGTGAAGGTGTTTGTGGTTCTGATGGTATGAATATCAACGGCAAGAATCGTTTGGCGTGTATCACTTCGGTTGGTGAG
TTAAAGCAGCCTATTAAAGTTAATCCTTTACCAGGGTTGCCAGTTATTAGAGATTTAATCGTCAATATGAAACAGTTCTA
TAAGAATTATGAGAAAGTTAAACCATATCTTATCAATGATGATGAGCCGCCTGTTAAAGAGAGGTTACAATCACCAGAGG
ATAGGGCTAAACTTGATGGGCTGTATGAGTGTATTTTATGTGCTTGTTGTACTACATCGTGCCCTTCGTTTTGGTGGAAT
CCCGACAAATTTATAGGTCCTTCTGGATTGTTACAAGCTTATAGATTTATTGCCGACTCAAGAGATACTGCTACACAGCA
AAGACTTGAAGATCTAAAAGATCCATTTAGTCTTTTCAGATGTAGGACTATTATGAACTGTGTTTCTGTGTGTCCAAAAG
GTCTTAACCCTACAGAAGCAATAGGTAAGATTAGATCAGCATTATTAAAGAAGAGTGTATAA

Upstream 100 bases:

>100_bases
AAGGAGATAGAACATCTCTGCGTGATGTAAATATGTCTTCTACTAAAGTAAAAGCTTTTCAACCAGCAGAACGTAAGTAC
TAATACAAGGATTTAATATA

Downstream 100 bases:

>100_bases
AAATTAAAACCTGATATTTGGGTGCCTATATGAAAAAAAAACAACCAGATTTTAGTCAGTGGCTGGAGACTACCCAGTTC
TTTGGAGGTAATCTAGAATA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MEVRFKIYRYNPEVDKKPYYDEYTVEVENEGVKVLTALELIKEQDPTLALRRSCREGVCGSDGMNINGKNRLACITSVGE
LKQPIKVNPLPGLPVIRDLIVNMKQFYKNYEKVKPYLINDDEPPVKERLQSPEDRAKLDGLYECILCACCTTSCPSFWWN
PDKFIGPSGLLQAYRFIADSRDTATQQRLEDLKDPFSLFRCRTIMNCVSVCPKGLNPTEAIGKIRSALLKKSV

Sequences:

>Translated_233_residues
MEVRFKIYRYNPEVDKKPYYDEYTVEVENEGVKVLTALELIKEQDPTLALRRSCREGVCGSDGMNINGKNRLACITSVGE
LKQPIKVNPLPGLPVIRDLIVNMKQFYKNYEKVKPYLINDDEPPVKERLQSPEDRAKLDGLYECILCACCTTSCPSFWWN
PDKFIGPSGLLQAYRFIADSRDTATQQRLEDLKDPFSLFRCRTIMNCVSVCPKGLNPTEAIGKIRSALLKKSV
>Mature_233_residues
MEVRFKIYRYNPEVDKKPYYDEYTVEVENEGVKVLTALELIKEQDPTLALRRSCREGVCGSDGMNINGKNRLACITSVGE
LKQPIKVNPLPGLPVIRDLIVNMKQFYKNYEKVKPYLINDDEPPVKERLQSPEDRAKLDGLYECILCACCTTSCPSFWWN
PDKFIGPSGLLQAYRFIADSRDTATQQRLEDLKDPFSLFRCRTIMNCVSVCPKGLNPTEAIGKIRSALLKKSV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=230, Percent_Identity=53.0434782608696, Blast_Score=248, Evalue=3e-66,
Organism=Escherichia coli, GI1786943, Length=238, Percent_Identity=65.546218487395, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=36.6812227074236, Blast_Score=151, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17533915, Length=230, Percent_Identity=50.4347826086956, Blast_Score=240, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322987, Length=229, Percent_Identity=53.2751091703057, Blast_Score=244, Evalue=9e-66,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=54.3103448275862, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24643156, Length=230, Percent_Identity=52.6086956521739, Blast_Score=248, Evalue=2e-66,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26566; Mature: 26566

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVRFKIYRYNPEVDKKPYYDEYTVEVENEGVKVLTALELIKEQDPTLALRRSCREGVCG
CCEEEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SDGMNINGKNRLACITSVGELKQPIKVNPLPGLPVIRDLIVNMKQFYKNYEKVKPYLIND
CCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECC
DEPPVKERLQSPEDRAKLDGLYECILCACCTTSCPSFWWNPDKFIGPSGLLQAYRFIADS
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RDTATQQRLEDLKDPFSLFRCRTIMNCVSVCPKGLNPTEAIGKIRSALLKKSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEVRFKIYRYNPEVDKKPYYDEYTVEVENEGVKVLTALELIKEQDPTLALRRSCREGVCG
CCEEEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SDGMNINGKNRLACITSVGELKQPIKVNPLPGLPVIRDLIVNMKQFYKNYEKVKPYLIND
CCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECC
DEPPVKERLQSPEDRAKLDGLYECILCACCTTSCPSFWWNPDKFIGPSGLLQAYRFIADS
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RDTATQQRLEDLKDPFSLFRCRTIMNCVSVCPKGLNPTEAIGKIRSALLKKSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]