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The map label for this gene is tmk [H]

Identifier: 89256933

GI number: 89256933

Start: 1590922

End: 1591551

Strand: Reverse

Name: tmk [H]

Synonym: FTL_1660

Alternate gene names: 89256933

Gene position: 1591551-1590922 (Counterclockwise)

Preceding gene: 89256934

Following gene: 89256932

Centisome position: 83.94

GC content: 32.22

Gene sequence:

>630_bases
ATGCAAAGTAAATTTATTGTAATAGAAGGTCTTGATGGTGCTGGTAAAAGTACAGCTATTAGCTTTGTTAGGAAATATTT
AGAAAAAAATAATCTAGCAGCAATTTATACTCGTGAACCAGGCGGAACTAAAATAGCTGAAGAATTAAGAAACTTAGTTC
TACATAATAAGTATGATGAAGAAATCCATTCAGATAGTGAGCTATTGATGATTTATGCTGGAAGAGTACAGCATTATAGA
AACCTTATCGCACCAGCTTTAGAAAAGGGTATTAATGTGGTTTCAGATAGATTTTACTGGTCAAGCATGGCTTATCAAGG
TGGTGGTCGTGGGGTTGAGCTAAGCAAAATCAGAGCGTTAAATGATAATTTTCTTAATGGTTGTGAGCCAGATTTAGTAA
TCTATCTTGATATTGATCCAATATTGGGGCTACAAAGAGCTCAAAAAGTTGGAAGTCCTGATAGGATTGAAAAAGCTGGG
CTAGAATTTTTTAATAGAACCCGTAAAGTTTTCAAAGATCTTGTCAAAGATTTAGATAATGCTATTGAAATTGATGCTGC
AAAGTCTATTCAAGAAGTTGAAAAGCAAATATATCTAATATTAGATAAACATTTTAATTTTCAAAATTAA

Upstream 100 bases:

>100_bases
TAAAGTTGCAAGATTTAGTTTAAAAATTCTCTATGGTGCGGTTTTAGTTAGTATACTATCTGCATGTGTTGTCGGATTTA
TTGTTTAGTAAGCCAAAAAA

Downstream 100 bases:

>100_bases
TCTATTTCTAGTAAACTTCTCTTCATTAAATATTATCTTCAAATAGTTAGAAAGAATTATTATGAGTGAATATCTACAAC
AAATCGCTAAGCGTAGGACT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYR
NLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAG
LEFFNRTRKVFKDLVKDLDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN

Sequences:

>Translated_209_residues
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYR
NLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAG
LEFFNRTRKVFKDLVKDLDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN
>Mature_209_residues
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDEEIHSDSELLMIYAGRVQHYR
NLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRALNDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAG
LEFFNRTRKVFKDLVKDLDNAIEIDAAKSIQEVEKQIYLILDKHFNFQN

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=200, Percent_Identity=46, Blast_Score=167, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23752; Mature: 23752

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDE
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHH
EIHSDSELLMIYAGRVQHYRNLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRAL
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
NDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAGLEFFNRTRKVFKDLVKDLDN
CCHHCCCCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEIDAAKSIQEVEKQIYLILDKHFNFQN
HEEHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MQSKFIVIEGLDGAGKSTAISFVRKYLEKNNLAAIYTREPGGTKIAEELRNLVLHNKYDE
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHH
EIHSDSELLMIYAGRVQHYRNLIAPALEKGINVVSDRFYWSSMAYQGGGRGVELSKIRAL
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
NDNFLNGCEPDLVIYLDIDPILGLQRAQKVGSPDRIEKAGLEFFNRTRKVFKDLVKDLDN
CCHHCCCCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEIDAAKSIQEVEKQIYLILDKHFNFQN
HEEHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA