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The map label for this gene is purE [H]

Identifier: 89255809

GI number: 89255809

Start: 368675

End: 369166

Strand: Direct

Name: purE [H]

Synonym: FTL_0398

Alternate gene names: 89255809

Gene position: 368675-369166 (Clockwise)

Preceding gene: 89255808

Following gene: 89255810

Centisome position: 19.44

GC content: 39.43

Gene sequence:

>492_bases
ATGAGTGTACAAGTTGGTGTAATAATGGGCTCTAAATCTGATTGGAGTACAATGAAAGAATGTTGTGATATCTTGGATAA
TTTAGGTATTGGTTATGAATGTGAAGTAGTGTCTGCTCATCGAACTCCAGATAAGATGTTTGACTATGCCAAAACTGCTA
AAGAAAGAGGCCTTAAGGTTATAATAGCAGGAGCTGGCGGTGCTGCACATTTACCTGGAATGGTTGCGGCAAAAACTGCT
TTACCAGTATTAGGTGTACCAGTTAAATCAAGTACACTTAATGGCCAAGATAGTTTATTATCAATAGTACAGATGCCAGC
GGGTATTCCAGTAGCTACTTTTGCAATTGGTATGGCAGGAGCAAAAAACGCGGCGCTTTTTGCTGCAAGTATCTTGCAAC
ATACAGATATAAATATTGCAAAAGCACTAGCTGAGTTTAGAGCTGAGCAAACACGATTTGTTTTGGAAAATCCTGATCCT
AGGGAGCACTAA

Upstream 100 bases:

>100_bases
TACTACGATTTGAGCGTAGAATCTATTGATAGATATGGTGAATGGATCCTATAGTTTAAGCATAGGATGACTGATTTGTG
GGTTAAAGTGGAGAAAAGAG

Downstream 100 bases:

>100_bases
ATAATGAAAATAGGTATTATCGGAGCTGGACAACTTGCCAGGATGCTAAGCTTAGCAGGTACACCTTTAGGTTTAGAGTT
TCATTGTCTTGGTAAAAATG

Product: phosphoribosylaminoimidazole carboxylase,catalyic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSVQVGVIMGSKSDWSTMKECCDILDNLGIGYECEVVSAHRTPDKMFDYAKTAKERGLKVIIAGAGGAAHLPGMVAAKTA
LPVLGVPVKSSTLNGQDSLLSIVQMPAGIPVATFAIGMAGAKNAALFAASILQHTDINIAKALAEFRAEQTRFVLENPDP
REH

Sequences:

>Translated_163_residues
MSVQVGVIMGSKSDWSTMKECCDILDNLGIGYECEVVSAHRTPDKMFDYAKTAKERGLKVIIAGAGGAAHLPGMVAAKTA
LPVLGVPVKSSTLNGQDSLLSIVQMPAGIPVATFAIGMAGAKNAALFAASILQHTDINIAKALAEFRAEQTRFVLENPDP
REH
>Mature_162_residues
SVQVGVIMGSKSDWSTMKECCDILDNLGIGYECEVVSAHRTPDKMFDYAKTAKERGLKVIIAGAGGAAHLPGMVAAKTAL
PVLGVPVKSSTLNGQDSLLSIVQMPAGIPVATFAIGMAGAKNAALFAASILQHTDINIAKALAEFRAEQTRFVLENPDPR
EH

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=62.0253164556962, Blast_Score=172, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=54.9668874172185, Blast_Score=157, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17165; Mature: 17034

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQVGVIMGSKSDWSTMKECCDILDNLGIGYECEVVSAHRTPDKMFDYAKTAKERGLKV
CCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMVAAKTALPVLGVPVKSSTLNGQDSLLSIVQMPAGIPVATFAIGMAG
EEECCCCCCCCCCHHHHHHHCCEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCC
AKNAALFAASILQHTDINIAKALAEFRAEQTRFVLENPDPREH
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEECCCCCCCC
>Mature Secondary Structure 
SVQVGVIMGSKSDWSTMKECCDILDNLGIGYECEVVSAHRTPDKMFDYAKTAKERGLKV
CEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMVAAKTALPVLGVPVKSSTLNGQDSLLSIVQMPAGIPVATFAIGMAG
EEECCCCCCCCCCHHHHHHHCCEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCC
AKNAALFAASILQHTDINIAKALAEFRAEQTRFVLENPDPREH
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]