Click here to switch to the map view.

The map label for this gene is msrAB [H]

Identifier: 89255793

GI number: 89255793

Start: 350509

End: 351021

Strand: Reverse

Name: msrAB [H]

Synonym: FTL_0379

Alternate gene names: 89255793

Gene position: 351021-350509 (Counterclockwise)

Preceding gene: 89255796

Following gene: 89255792

Centisome position: 18.51

GC content: 35.28

Gene sequence:

>513_bases
ATGAAAAAAATTATTCTCATATTAGCATTTATACCGATTATCACTTTAGCTGATACGCAAAACTGGCAAAGCTTTGATAA
GACACAAGCATTAGCTAAACTAACTAGGCTGCAATATTATGTGACTCAAAAAGGCGGTACTGAAAGAGCGTTTAATAATA
AATACTGGAATAATCATAGGCAAGGCATCTATGTCGACGTTGTCTCTGGAGAGCCACTTTTTAGTTCTACTGATAAATAC
GATTCTGGCACAGGTTGGCCAAGTTTTACTAAACCTATTGATAACTCATTTATAAAAACAAAAACTGATAATAGCTGGTT
TATGACTCGTACAGAAGTTCTCTCACGCTATGCTAATTCGCACTTAGGCCATGTCTTCGATGATGGTCCTCAACCTACTG
GCAAGAGATACTGTATGAATTCTGCGGCTCTTAAATTTATCCCTAAAGAAGACATGCAGAAAGATGGTTATGGTAAGTAT
CTATATTTATTTACTAACAAAAACTTACAATAG

Upstream 100 bases:

>100_bases
TCTATATTAAAATACGATTAAACAGCTATATATTATCTAAAAATCAAACCTAGGATGTTAAAATATTAATCAACATGTTC
ATTTTGAAGATTAGATTCTC

Downstream 100 bases:

>100_bases
TTGTCAAAAAACTAATACATGATATTATTAAATCAATTTATCAGAAGCTGGAGCTGTACTATTAATACTCATTTTTTTGG
ACAAATAGCACTTAATGCTT

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MKKIILILAFIPIITLADTQNWQSFDKTQALAKLTRLQYYVTQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKY
DSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANSHLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKY
LYLFTNKNLQ

Sequences:

>Translated_170_residues
MKKIILILAFIPIITLADTQNWQSFDKTQALAKLTRLQYYVTQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKY
DSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANSHLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKY
LYLFTNKNLQ
>Mature_170_residues
MKKIILILAFIPIITLADTQNWQSFDKTQALAKLTRLQYYVTQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKY
DSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANSHLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKY
LYLFTNKNLQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=150, Percent_Identity=46.6666666666667, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI301336162, Length=150, Percent_Identity=46.6666666666667, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI73089054, Length=150, Percent_Identity=46.6666666666667, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI37620216, Length=126, Percent_Identity=50.7936507936508, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI117606353, Length=125, Percent_Identity=48, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1788077, Length=121, Percent_Identity=47.1074380165289, Blast_Score=126, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17553450, Length=143, Percent_Identity=33.5664335664336, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115532676, Length=142, Percent_Identity=33.8028169014084, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319816, Length=119, Percent_Identity=34.453781512605, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24645799, Length=137, Percent_Identity=42.3357664233577, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45553335, Length=125, Percent_Identity=44.8, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21356369, Length=125, Percent_Identity=44.8, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24645801, Length=148, Percent_Identity=39.1891891891892, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221378664, Length=125, Percent_Identity=43.2, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24645804, Length=136, Percent_Identity=41.1764705882353, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI221378662, Length=132, Percent_Identity=40.9090909090909, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 19632; Mature: 19632

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIILILAFIPIITLADTQNWQSFDKTQALAKLTRLQYYVTQKGGTERAFNNKYWNNHR
CCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
QGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANS
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEHHHHHHHHHHC
HLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKYLYLFTNKNLQ
CCCCCCCCCCCCCCHHHHCCCHHEEECCHHHCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MKKIILILAFIPIITLADTQNWQSFDKTQALAKLTRLQYYVTQKGGTERAFNNKYWNNHR
CCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
QGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANS
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEHHHHHHHHHHC
HLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKYLYLFTNKNLQ
CCCCCCCCCCCCCCHHHHCCCHHEEECCHHHCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]