Click here to switch to the map view.

The map label for this gene is tyrP [H]

Identifier: 89255715

GI number: 89255715

Start: 268066

End: 269262

Strand: Direct

Name: tyrP [H]

Synonym: FTL_0283

Alternate gene names: 89255715

Gene position: 268066-269262 (Clockwise)

Preceding gene: 89255713

Following gene: 89255716

Centisome position: 14.14

GC content: 32.92

Gene sequence:

>1197_bases
ATGAAACGAGTCTCAAAAGTTAAGCTAATTGGCGCTATAGCAATTATAGCTGGAACAGCTATTGGCGCAGGTATGCTTGG
GATTCCTTTTGCAGTAGCAGCAGTCGGGTTTAATTATGCAGTTGCGGCTTTATTTCTTGTTTGGATAATTATGTATGCAA
CTGCTTTATTGATTATCGAGGCGAATATTTCTCAGCCTTTAGGTACAGATATGGATTCTATTACACATAATATATTAGGC
AAGCCTGGTAGAGTATTGAATTTGTTATTTTATCTATTATTGTTATATTCGTTACTTACGGCTTATATTTTTATGGGCGG
GCAACTTTTTCAAACATACATACTTTGTTGGTTAAATCTAGAGAATGCTAGCTTAGCAAAGTTACTATTCTGTTTGATAT
TTGGTTTTTTTATATATAAAGGTATCAAAGTAGTATTTAGTGTTAATGAATTATTTTTAAGTTTAAAAGTATTAGCTTTT
ATTTTATTTATTGCATTTGTTGCACCACAAATTAGCACTTCTTTACTAGAAAATAAAGCTTTAGGAGTAGAGTATGTTTG
GTTTGCTATTCCAATACTTGTCACATCATTTGGTTTTCATATTGTTATCCCAGCAATTAGGAACTACTTTGAGAATGATA
TTGTCTTCAAAAGAACAGTCGCTATTGGAGCACTAGCACCATTGCTTGTTTATTTGGTATGGGTTGTAGCTACGCTTGGA
ACTGTAAGTCTATATGGAAACAATGGCTTCATAGCGTTGAGTAAAGCAGGAGAGACTTTAGCCGAAGCGTACCAAGGTTT
AGGACAGAATGGTCCATTAGTATTTATAAGACTTTTTGAGAACTTTGCAATTATTACATCTTTTTTGGGAGTTGCTTTAG
CTTTATTCTCTTTTAACAGAGATCTTTATGGTTTAGATATCAGGAAAAAATTACTGACTTTGGTGATAACATTATTACCA
CCGCTTATATTTGCGATATATTTTGTCAATAGTTTTATAGCTGCTCTAGGTTATGCTAGTATCTTTGTTTCAGTGTTACT
GATAGTGCAGCCTGCGATGATGGTTTGGGCTATAAGAACTAAACAGGGTAAAAATGATATTCTTAGTAAACTATATTTAT
CTTTGATATTATTTAGCGGTCTTGGTATTATTGCGTTGCAATTATTAGTAGCCTTTGGTAGATTACCTCATATATAA

Upstream 100 bases:

>100_bases
TTGACTTAATTTCCTATGTAATTAGAATAAGTGATTGGTTGATGTTTATTTACATTAAATTATTAAAATTGGTATAATTT
AGTGTTTTTAAGGTTAAATA

Downstream 100 bases:

>100_bases
TTTCATTAACTTTCAAATCCTTGATTATTTTCTATGAAGAAACCTAATTTTGATATTAATAAAAAATCTTTTCCTAATGA
TGATTTAGTAGGCGATGAGT

Product: aromatic amino acid HAAP transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKRVSKVKLIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIEANISQPLGTDMDSITHNILG
KPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNLENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAF
ILFIAFVAPQISTSLLENKALGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNRDLYGLDIRKKLLTLVITLLP
PLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRTKQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI

Sequences:

>Translated_398_residues
MKRVSKVKLIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIEANISQPLGTDMDSITHNILG
KPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNLENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAF
ILFIAFVAPQISTSLLENKALGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNRDLYGLDIRKKLLTLVITLLP
PLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRTKQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI
>Mature_398_residues
MKRVSKVKLIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIEANISQPLGTDMDSITHNILG
KPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNLENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAF
ILFIAFVAPQISTSLLENKALGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNRDLYGLDIRKKLLTLVITLLP
PLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRTKQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789552, Length=387, Percent_Identity=29.9741602067183, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790145, Length=361, Percent_Identity=27.4238227146814, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43649; Mature: 43649

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVSKVKLIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIE
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANISQPLGTDMDSITHNILGKPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNL
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
ENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAFILFIAFVAPQISTSLLENKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNR
HEEEECCCCEEEEECCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DLYGLDIRKKLLTLVITLLPPLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRVSKVKLIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIE
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANISQPLGTDMDSITHNILGKPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNL
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
ENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAFILFIAFVAPQISTSLLENKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNR
HEEEECCCCEEEEECCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DLYGLDIRKKLLTLVITLLPPLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]