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The map label for this gene is dut [H]

Identifier: 89255664

GI number: 89255664

Start: 229774

End: 230220

Strand: Direct

Name: dut [H]

Synonym: FTL_0230

Alternate gene names: 89255664

Gene position: 229774-230220 (Clockwise)

Preceding gene: 89255663

Following gene: 89255665

Centisome position: 12.12

GC content: 37.14

Gene sequence:

>447_bases
ATGAAGGTAGAGCTAAAAATTTTAAATAAAGAACTTATAAAAGAGTTACCCGGTTATGCGACTGAAGGTTCAGCAGCTAT
TGACTTAAGAGCATGTATCTCTGAGAGTATTTATCTTAAATCGGGTGAATGTAAACTTATTGCAACTGGTATAGCTATTA
ATATTGCTAATCCAAATTATGCGGCAATGATTTTACCAAGATCTGGTTTGGGACATAAAAAAGGTTTGGTGCTAGGAAAT
GGTACGGGGCTTATAGATTCTGATTATCAAGGTGAGCTTATGGTTTCTTGTTTTAATCGCTCACAAGAGACTATTGAAAT
AGAACCGCTAATGAGATTCGCTCAGCTTGTAATTGTTCCTGTGGTACAAGCAAATTTTGAGATTGTTGAAGATTTTTCAC
AGCAAAGTGTCCGAGCTACTGGCGGCTTTGGACATACAGGGGTTTGA

Upstream 100 bases:

>100_bases
TGGTGGAGTGCTTGATAGGTTGGATGGATATATGCCAACTTTACCAATATTTGTGCTGTTTGGTTATTTAGCGGGAGTTT
TTGTTTTTTAGGGGGAAGAT

Downstream 100 bases:

>100_bases
TTTATGTTTTTTAATATCCCTAATATTCTGACTTTTGGTCGTTTGATATTAATTCCTTTTATAGTTATATGTTATTATTT
TGAGTTTCCACACCATCATG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKVELKILNKELIKELPGYATEGSAAIDLRACISESIYLKSGECKLIATGIAINIANPNYAAMILPRSGLGHKKGLVLGN
GTGLIDSDYQGELMVSCFNRSQETIEIEPLMRFAQLVIVPVVQANFEIVEDFSQQSVRATGGFGHTGV

Sequences:

>Translated_148_residues
MKVELKILNKELIKELPGYATEGSAAIDLRACISESIYLKSGECKLIATGIAINIANPNYAAMILPRSGLGHKKGLVLGN
GTGLIDSDYQGELMVSCFNRSQETIEIEPLMRFAQLVIVPVVQANFEIVEDFSQQSVRATGGFGHTGV
>Mature_148_residues
MKVELKILNKELIKELPGYATEGSAAIDLRACISESIYLKSGECKLIATGIAINIANPNYAAMILPRSGLGHKKGLVLGN
GTGLIDSDYQGELMVSCFNRSQETIEIEPLMRFAQLVIVPVVQANFEIVEDFSQQSVRATGGFGHTGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=56.7567567567568, Blast_Score=178, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71988561, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319729, Length=143, Percent_Identity=33.5664335664336, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15957; Mature: 15957

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVELKILNKELIKELPGYATEGSAAIDLRACISESIYLKSGECKLIATGIAINIANPNY
CEEEEEECCHHHHHHCCCCCCCCCCEEEHHHHHCCCEEEECCCEEEEEEEEEEEECCCCE
AAMILPRSGLGHKKGLVLGNGTGLIDSDYQGELMVSCFNRSQETIEIEPLMRFAQLVIVP
EEEEEECCCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHH
VVQANFEIVEDFSQQSVRATGGFGHTGV
HHHCCHHHHHHHHHHCEEECCCCCCCCC
>Mature Secondary Structure
MKVELKILNKELIKELPGYATEGSAAIDLRACISESIYLKSGECKLIATGIAINIANPNY
CEEEEEECCHHHHHHCCCCCCCCCCEEEHHHHHCCCEEEECCCEEEEEEEEEEEECCCCE
AAMILPRSGLGHKKGLVLGNGTGLIDSDYQGELMVSCFNRSQETIEIEPLMRFAQLVIVP
EEEEEECCCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHH
VVQANFEIVEDFSQQSVRATGGFGHTGV
HHHCCHHHHHHHHHHCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA