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The map label for this gene is ldhA [C]

Identifier: 89255564

GI number: 89255564

Start: 129871

End: 130587

Strand: Direct

Name: ldhA [C]

Synonym: FTL_0127

Alternate gene names: 89255564

Gene position: 129871-130587 (Clockwise)

Preceding gene: 89255551

Following gene: 89255565

Centisome position: 6.85

GC content: 33.33

Gene sequence:

>717_bases
ATGAAGATATTATGTATTTTATATGATGATCCTAAAACTGGAATGCCAAAAGATTATCCATTAGCTCAAATACCAAAATT
AAGCAATTATCCTGACGGCTCATCCTTGCCTACTCCTCAAGCAATAGATTTTAGACCGGGTGAATTGCTTGGTTGTGTTT
CTGGTGAGCTGGGTCTGCGTAAGTTTTTAGAAGAACTAGGACATGAACTTGTAGTTACATCGGATAAGGATGGTGATGGT
TGTAAAGCAGAGCAAGAGTTGATTGATGCTGATATCGTTATATCTCAACCATTTTGGCCATTTTATTTAACAAAAGAAAG
AATACAAAAAGCTAAAAAACTTAAGCTAGCAATTACAGCTAGTATTGGTTTTGATCATGTTGATTTAGATGCAGCTAAAG
AGCATAAGATTGATGTTGTTGAAGTAACGTATTCTAACTCAATTTCAGTATCTGAGCATATTGTTATGATGATTTTATCT
ATAGTTAGAGATTATTTGACCCAACATGAAATAGCTAAGTCAGGTGGTTGGAATATTGCAGATGCAGTAAAAAGATCTTA
TGATCTTGAGGGTATGAACGTTGGGACAGTTGCAGCAGGTAGAATAGGACTTTCTGTATTAAGAAAATTAAAACCGTTTA
ATACAAAACTTCATTATTTTGATAAATATAGATTACCAAAGAATGTAGAGCAAGAGCTCAATTTAACTTATAGTTAA

Upstream 100 bases:

>100_bases
ATTTATATATCAAAATAATAAATTTTATTGTATAAAGGAAATATAAATTAGTTTGTATTCTTCTTTACTGCAAAAAAATA
AACAACAAGGAATAGATATA

Downstream 100 bases:

>100_bases
TCCGAAAGATATTTGTAGAAAAAGATATTTGTAGAAATGTTATAATGTCTAATAAAAATGCCATCATATAGCCAAGATTT
TAGAGACATCGTAATTAATA

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKILCILYDDPKTGMPKDYPLAQIPKLSNYPDGSSLPTPQAIDFRPGELLGCVSGELGLRKFLEELGHELVVTSDKDGDG
CKAEQELIDADIVISQPFWPFYLTKERIQKAKKLKLAITASIGFDHVDLDAAKEHKIDVVEVTYSNSISVSEHIVMMILS
IVRDYLTQHEIAKSGGWNIADAVKRSYDLEGMNVGTVAAGRIGLSVLRKLKPFNTKLHYFDKYRLPKNVEQELNLTYS

Sequences:

>Translated_238_residues
MKILCILYDDPKTGMPKDYPLAQIPKLSNYPDGSSLPTPQAIDFRPGELLGCVSGELGLRKFLEELGHELVVTSDKDGDG
CKAEQELIDADIVISQPFWPFYLTKERIQKAKKLKLAITASIGFDHVDLDAAKEHKIDVVEVTYSNSISVSEHIVMMILS
IVRDYLTQHEIAKSGGWNIADAVKRSYDLEGMNVGTVAAGRIGLSVLRKLKPFNTKLHYFDKYRLPKNVEQELNLTYS
>Mature_238_residues
MKILCILYDDPKTGMPKDYPLAQIPKLSNYPDGSSLPTPQAIDFRPGELLGCVSGELGLRKFLEELGHELVVTSDKDGDG
CKAEQELIDADIVISQPFWPFYLTKERIQKAKKLKLAITASIGFDHVDLDAAKEHKIDVVEVTYSNSISVSEHIVMMILS
IVRDYLTQHEIAKSGGWNIADAVKRSYDLEGMNVGTVAAGRIGLSVLRKLKPFNTKLHYFDKYRLPKNVEQELNLTYS

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787645, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324964, Length=189, Percent_Identity=49.7354497354497, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324979, Length=123, Percent_Identity=52.0325203252033, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 26642; Mature: 26642

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILCILYDDPKTGMPKDYPLAQIPKLSNYPDGSSLPTPQAIDFRPGELLGCVSGELGLR
CEEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHH
KFLEELGHELVVTSDKDGDGCKAEQELIDADIVISQPFWPFYLTKERIQKAKKLKLAITA
HHHHHCCCEEEEECCCCCCCCCHHHHHHCCEEEEECCCCCCEECHHHHHHHHHEEEEEEE
SIGFDHVDLDAAKEHKIDVVEVTYSNSISVSEHIVMMILSIVRDYLTQHEIAKSGGWNIA
ECCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DAVKRSYDLEGMNVGTVAAGRIGLSVLRKLKPFNTKLHYFDKYRLPKNVEQELNLTYS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCCCC
>Mature Secondary Structure
MKILCILYDDPKTGMPKDYPLAQIPKLSNYPDGSSLPTPQAIDFRPGELLGCVSGELGLR
CEEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHH
KFLEELGHELVVTSDKDGDGCKAEQELIDADIVISQPFWPFYLTKERIQKAKKLKLAITA
HHHHHCCCEEEEECCCCCCCCCHHHHHHCCEEEEECCCCCCEECHHHHHHHHHEEEEEEE
SIGFDHVDLDAAKEHKIDVVEVTYSNSISVSEHIVMMILSIVRDYLTQHEIAKSGGWNIA
ECCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DAVKRSYDLEGMNVGTVAAGRIGLSVLRKLKPFNTKLHYFDKYRLPKNVEQELNLTYS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]