Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 89056565

GI number: 89056565

Start: 4180682

End: 4182067

Strand: Direct

Name: ahcY [H]

Synonym: Jann_4074

Alternate gene names: 89056565

Gene position: 4180682-4182067 (Clockwise)

Preceding gene: 89056560

Following gene: 89056566

Centisome position: 96.82

GC content: 59.74

Gene sequence:

>1386_bases
ATGGACGATTATATCGTAAAAGATATCGCGCTGGCCGAGTTTGGCCGCAAGGAACTGGACATTGCCGAAACGGAGATGCC
CGGCTTGATGGCGCTGCGCGAGGAATATGGCGCGGAGAAGCCGCTCAAAGGCGCGCGGATTGTGGGCTCGCTCCACATGA
CGATCCAGACGGCGGTTCTGATTGAAACGCTGGTCGATCTGGGCGCGGATGTCCGGTGGGCGTCGTGCAACATCTTCTCC
ACCCAGGATCACGCGGCGGCGGCCATTGCCAAGGCGGGCGTGCCGGTCTTTGCGATCAAGGGCCAGTCGCTGGAGGAGCA
TTGGGATTATCTGGATAAGTCTTTCATGTTTGAAGACGGCCCGAACCTGATCCTGGACGATGGCGGGGACGCGACGCTGT
ATATCCTGTTGGGCGCGCGCGCCGAGGCGGGGGAAGATGTGATCGCCGTGCCCACATCCGAGGAAGAATTGGCGATCAAG
GCGCAGATCAAGAAGCGGCTTGAGGCGTCCCCCGGTTGGTTCACCAAGATGAAAGAGCAGATCGTTGGCGTGTCGGAGGA
GACGACGACCGGCGTGCACCGCCTCTATGACCTGCAAAAGAATGGCCAACTGCCGTTCCCTGCGATCAACGTGAATGACT
CCGTGACCAAGTCGAAGTTCGACAACAAATACGGCTGCAAGGAATCGCTGGTCGACGGCATCCGCCGCGCCACGGACACG
ATGATGGCCGGTAAGGTCGCCGTCGTGATGGGCTACGGCGATGTGGGCAAAGGCTCCGCCGCGTCTTTGGCCGGTGCCGG
CGCGCGGGTGAAGGTGACGGAAGCGGATCCGATCTGCGCGTTGCAGGCGGCCATGGACGGGTTCGAGGTTGTGCTGCTGG
AGGATGTGGTTGCCGACGCGGACGTCTTCATCACCACCACCGGAAACAAGGACGTGATCCGCATCGAGCATATGCGCGAG
ATGAAGGACATGGCGATTGTCGGCAACATCGGCCATTTCGACAATGAGATCCAGGTTGCCGCCCTGAAAAACCACAAGTG
GACCAATATCAAGGAACAGGTGGACATGATCGAGATGCCGTCTGGCAGCCGTTTGATCCTGTTGTCCGAGGGCCGTCTGC
TGAACCTGGGCAACGCCACCGGGCACCCGTCCTTCGTGATGTCCGCGTCCTTCACCAACCAGGTGCTGGCGCAGATGGAG
CTGTGGCTGCGGGGTGATGAGTACAAGAATGAGGTCTACATCCTGCCCAAGAAGCTCGACGAAAAGGTCGCGCGTCTGCA
TCTGGCAAAAATCGGCGTGAAGCTGACCCAGCTGGATAAGGAACAGGCCGATTACATCGGTGTGCCACAGGATGGCCCGT
TCAAGCCAGAGCATTACCGCTACTGA

Upstream 100 bases:

>100_bases
TTGGCTAACGCTGACATTTGCGCCGCATTGCAGGGGTGGGGACAGGCTGGTATGGCACCGGCAAATACCGCTTTTGATGG
ATGCCCGAGGAGGCAAGGAC

Downstream 100 bases:

>100_bases
TCTGACAGGCGATTTGCTTGCAACGGCCGGTCCTTCAGGGGCCGGTCGTTTGCGTTCGAGGCTCAAGGTGATGCAACCGA
TAGAGAAACGCGGCGCCGCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MDDYIVKDIALAEFGRKELDIAETEMPGLMALREEYGAEKPLKGARIVGSLHMTIQTAVLIETLVDLGADVRWASCNIFS
TQDHAAAAIAKAGVPVFAIKGQSLEEHWDYLDKSFMFEDGPNLILDDGGDATLYILLGARAEAGEDVIAVPTSEEELAIK
AQIKKRLEASPGWFTKMKEQIVGVSEETTTGVHRLYDLQKNGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT
MMAGKVAVVMGYGDVGKGSAASLAGAGARVKVTEADPICALQAAMDGFEVVLLEDVVADADVFITTTGNKDVIRIEHMRE
MKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMPSGSRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQME
LWLRGDEYKNEVYILPKKLDEKVARLHLAKIGVKLTQLDKEQADYIGVPQDGPFKPEHYRY

Sequences:

>Translated_461_residues
MDDYIVKDIALAEFGRKELDIAETEMPGLMALREEYGAEKPLKGARIVGSLHMTIQTAVLIETLVDLGADVRWASCNIFS
TQDHAAAAIAKAGVPVFAIKGQSLEEHWDYLDKSFMFEDGPNLILDDGGDATLYILLGARAEAGEDVIAVPTSEEELAIK
AQIKKRLEASPGWFTKMKEQIVGVSEETTTGVHRLYDLQKNGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT
MMAGKVAVVMGYGDVGKGSAASLAGAGARVKVTEADPICALQAAMDGFEVVLLEDVVADADVFITTTGNKDVIRIEHMRE
MKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMPSGSRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQME
LWLRGDEYKNEVYILPKKLDEKVARLHLAKIGVKLTQLDKEQADYIGVPQDGPFKPEHYRY
>Mature_461_residues
MDDYIVKDIALAEFGRKELDIAETEMPGLMALREEYGAEKPLKGARIVGSLHMTIQTAVLIETLVDLGADVRWASCNIFS
TQDHAAAAIAKAGVPVFAIKGQSLEEHWDYLDKSFMFEDGPNLILDDGGDATLYILLGARAEAGEDVIAVPTSEEELAIK
AQIKKRLEASPGWFTKMKEQIVGVSEETTTGVHRLYDLQKNGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT
MMAGKVAVVMGYGDVGKGSAASLAGAGARVKVTEADPICALQAAMDGFEVVLLEDVVADADVFITTTGNKDVIRIEHMRE
MKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMPSGSRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQME
LWLRGDEYKNEVYILPKKLDEKVARLHLAKIGVKLTQLDKEQADYIGVPQDGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=461, Percent_Identity=59.002169197397, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI239937451, Length=439, Percent_Identity=58.5421412300683, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI298286489, Length=463, Percent_Identity=50.1079913606911, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=463, Percent_Identity=50.1079913606911, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI195539337, Length=463, Percent_Identity=50.1079913606911, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=463, Percent_Identity=50.1079913606911, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=48.9224137931034, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=57.6344086021505, Blast_Score=505, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=56.6945606694561, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=58.2251082251082, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24656245, Length=464, Percent_Identity=48.9224137931034, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.3239740820734, Blast_Score=427, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.2164502164502, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50591; Mature: 50591

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDYIVKDIALAEFGRKELDIAETEMPGLMALREEYGAEKPLKGARIVGSLHMTIQTAVL
CCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHH
IETLVDLGADVRWASCNIFSTQDHAAAAIAKAGVPVFAIKGQSLEEHWDYLDKSFMFEDG
HHHHHHCCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCEECCC
PNLILDDGGDATLYILLGARAEAGEDVIAVPTSEEELAIKAQIKKRLEASPGWFTKMKEQ
CCEEEECCCCEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
IVGVSEETTTGVHRLYDLQKNGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT
HCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHH
MMAGKVAVVMGYGDVGKGSAASLAGAGARVKVTEADPICALQAAMDGFEVVLLEDVVADA
HHCCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCHHHHHHCCCEEEEEEEHHHCCC
DVFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMP
CEEEEECCCCCEEEHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHEEECC
SGSRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQMELWLRGDEYKNEVYILPKKLD
CCCEEEEEECCCEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEECHHHH
EKVARLHLAKIGVKLTQLDKEQADYIGVPQDGPFKPEHYRY
HHHHHHHHHHHCEEHHHCCCHHCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MDDYIVKDIALAEFGRKELDIAETEMPGLMALREEYGAEKPLKGARIVGSLHMTIQTAVL
CCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHH
IETLVDLGADVRWASCNIFSTQDHAAAAIAKAGVPVFAIKGQSLEEHWDYLDKSFMFEDG
HHHHHHCCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCEECCC
PNLILDDGGDATLYILLGARAEAGEDVIAVPTSEEELAIKAQIKKRLEASPGWFTKMKEQ
CCEEEECCCCEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
IVGVSEETTTGVHRLYDLQKNGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT
HCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHH
MMAGKVAVVMGYGDVGKGSAASLAGAGARVKVTEADPICALQAAMDGFEVVLLEDVVADA
HHCCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCHHHHHHCCCEEEEEEEHHHCCC
DVFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKEQVDMIEMP
CEEEEECCCCCEEEHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHEEECC
SGSRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQMELWLRGDEYKNEVYILPKKLD
CCCEEEEEECCCEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEECHHHH
EKVARLHLAKIGVKLTQLDKEQADYIGVPQDGPFKPEHYRY
HHHHHHHHHHHCEEHHHCCCHHCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA