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The map label for this gene is ywrD [H]

Identifier: 89056545

GI number: 89056545

Start: 4157144

End: 4158712

Strand: Direct

Name: ywrD [H]

Synonym: Jann_4054

Alternate gene names: 89056545

Gene position: 4157144-4158712 (Clockwise)

Preceding gene: 89056544

Following gene: 89056547

Centisome position: 96.28

GC content: 64.56

Gene sequence:

>1569_bases
ATGCGCGATTTTCACCAACCCGGACGGTCCACTGTCTATGCAGACCAGGGCATGTGCGCCACATCCCACCCGTTGGCCGC
GCAAACCGCGATCTCTATCCTTCAACAGGGCGGGAACGCCGTGGATGCGGCCATCGGCGCCGCTATTTTGTTGGGTCTGT
GTGAGCCCCAGAGCACCGGCATCGGCGGTGATATGTTCGCCCTTGTCGCGCAGCCCGATGGGGAGAACTTGGGCCTCAAC
GCTTCGGGGCGCGCGCCTGCCGGCCTGAATGCGGACGCCATTCGCGCCAACCACGACACCATGCCGCTCTATGACATCAG
CGCCATCACCGTGCCCGGCGCGATTGATGGATTTTGTCGTCTGCATGGCGACCACGGCCAATTGCCGCTGGACCAGGTGC
TTGCCCCCTCCATCCATTATGCCGAGGCTGGAATTCCCATCGCGCCGCGCGTGGCGATGGATTACGCGACCTCCGGCCAT
CTGCTGCAAGGCGCGGGGCGTCGGCATTACCTGCAGGATGACGCGCCCCTGCCCATTGGCGCGCGGTTCAAGGCCCCCGG
TCAGGCCGAGGTGTTGCGCCGCATCGCCGAGCAAGGGCGCGCGGGCTTTTATGAAGGCGAAGTGCTGGACGACATGCTGG
CGTCTCTTCAGGCGCATGGCGGCACCCATACGGCCGAGGATTTCGCCAACACCAAGTGCGATTACGTCACCCCGCTGCGG
TCCGGTTACCGCGATGCGGAGCTGATTGAACTTCCGCCCAATGGTCAGGGGGCAACGGCGATGTTGATCCTCAACATCCT
GGAAACGATGACGCCGCAAGACGACCCCTTCGGTCCTCAGCGCGCGCATCTGGAGGCCGAGGCGACCAAACTTGGCTATG
ACGCCCGCGACCGGTTCCTGGCCGATCCCGATCACGTGACCCGTCTGGATCACATGCTGTCCAAGCAGACCGCCGCAGAC
CTTGCCGCGCTGATTGATCCCAACGCCGCGATGCCCGATCCCCGCGCCGCGTCCGACAATGTTCACAAGGACACCGTCTA
TCTCACCGTCGTCGACAAGGACCGCCGCGCCGTCAGCCTGATCTATTCGATTTTCCATTCATTTGGCTCCGGGATGGCCT
CCGACAGATTCGGCATATTGTTTCAGAACCGGGGCGGCGGCTTCACGCTGGAGGCGGGCCACGCGAATGAGGCAGGTCCC
GGCAAGCGCCCGATGCACACGATCATCCCCGGCATGTTGAAGCTGGCCGACGGGTCGCTGATGCCCTTCGGCGTCATGGG
CGGGGCGTATCAGTCGACCGGCCACGCGCGGTTCGTGTCCAATTTGGTGGACTACGGTATGGACCCGCAGGCGGCCATCG
ACGGCCCGCGCGCCTTTGCCGAGGCCGGAGCGCTGAAGATCGAGCGTGGCTATGGCGATGATACTCGCGACGATCTGGCC
GCCAAGGGCCACACGCTTACCACGCCGGACACGCCGATTGGCGGGGCCCAGGCCATTCGCATTCGCCCCGACGGTGTGTT
GGAAGGCGGCTCAGACCCCCGGAAGGACGGCATCGCGTTGGGGTATTAG

Upstream 100 bases:

>100_bases
GACCTCTGCAGCCACATCTCTCCCCCGGAAAGACCGCACCAGACCTTGCCCCTGCGTCCCCGCGCATTAAGGTCTCCGCT
CTAGTTGTCGGAGGGGACGT

Downstream 100 bases:

>100_bases
GGACGTCGGTGGGGTACCGCCGCCCAAGCCCGCGCGCGCTTGGCACACCGGGTGGGCGGCACAGACCCTCTTATTGCCTG
GGGCCGAAGATCCGACCAAG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MRDFHQPGRSTVYADQGMCATSHPLAAQTAISILQQGGNAVDAAIGAAILLGLCEPQSTGIGGDMFALVAQPDGENLGLN
ASGRAPAGLNADAIRANHDTMPLYDISAITVPGAIDGFCRLHGDHGQLPLDQVLAPSIHYAEAGIPIAPRVAMDYATSGH
LLQGAGRRHYLQDDAPLPIGARFKAPGQAEVLRRIAEQGRAGFYEGEVLDDMLASLQAHGGTHTAEDFANTKCDYVTPLR
SGYRDAELIELPPNGQGATAMLILNILETMTPQDDPFGPQRAHLEAEATKLGYDARDRFLADPDHVTRLDHMLSKQTAAD
LAALIDPNAAMPDPRAASDNVHKDTVYLTVVDKDRRAVSLIYSIFHSFGSGMASDRFGILFQNRGGGFTLEAGHANEAGP
GKRPMHTIIPGMLKLADGSLMPFGVMGGAYQSTGHARFVSNLVDYGMDPQAAIDGPRAFAEAGALKIERGYGDDTRDDLA
AKGHTLTTPDTPIGGAQAIRIRPDGVLEGGSDPRKDGIALGY

Sequences:

>Translated_522_residues
MRDFHQPGRSTVYADQGMCATSHPLAAQTAISILQQGGNAVDAAIGAAILLGLCEPQSTGIGGDMFALVAQPDGENLGLN
ASGRAPAGLNADAIRANHDTMPLYDISAITVPGAIDGFCRLHGDHGQLPLDQVLAPSIHYAEAGIPIAPRVAMDYATSGH
LLQGAGRRHYLQDDAPLPIGARFKAPGQAEVLRRIAEQGRAGFYEGEVLDDMLASLQAHGGTHTAEDFANTKCDYVTPLR
SGYRDAELIELPPNGQGATAMLILNILETMTPQDDPFGPQRAHLEAEATKLGYDARDRFLADPDHVTRLDHMLSKQTAAD
LAALIDPNAAMPDPRAASDNVHKDTVYLTVVDKDRRAVSLIYSIFHSFGSGMASDRFGILFQNRGGGFTLEAGHANEAGP
GKRPMHTIIPGMLKLADGSLMPFGVMGGAYQSTGHARFVSNLVDYGMDPQAAIDGPRAFAEAGALKIERGYGDDTRDDLA
AKGHTLTTPDTPIGGAQAIRIRPDGVLEGGSDPRKDGIALGY
>Mature_522_residues
MRDFHQPGRSTVYADQGMCATSHPLAAQTAISILQQGGNAVDAAIGAAILLGLCEPQSTGIGGDMFALVAQPDGENLGLN
ASGRAPAGLNADAIRANHDTMPLYDISAITVPGAIDGFCRLHGDHGQLPLDQVLAPSIHYAEAGIPIAPRVAMDYATSGH
LLQGAGRRHYLQDDAPLPIGARFKAPGQAEVLRRIAEQGRAGFYEGEVLDDMLASLQAHGGTHTAEDFANTKCDYVTPLR
SGYRDAELIELPPNGQGATAMLILNILETMTPQDDPFGPQRAHLEAEATKLGYDARDRFLADPDHVTRLDHMLSKQTAAD
LAALIDPNAAMPDPRAASDNVHKDTVYLTVVDKDRRAVSLIYSIFHSFGSGMASDRFGILFQNRGGGFTLEAGHANEAGP
GKRPMHTIIPGMLKLADGSLMPFGVMGGAYQSTGHARFVSNLVDYGMDPQAAIDGPRAFAEAGALKIERGYGDDTRDDLA
AKGHTLTTPDTPIGGAQAIRIRPDGVLEGGSDPRKDGIALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=554, Percent_Identity=28.5198555956679, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI73915090, Length=554, Percent_Identity=28.5198555956679, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI73915096, Length=554, Percent_Identity=28.5198555956679, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI73915094, Length=554, Percent_Identity=28.5198555956679, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI113429324, Length=550, Percent_Identity=28.5454545454545, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI113429326, Length=555, Percent_Identity=28.1081081081081, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI153266885, Length=533, Percent_Identity=25.515947467167, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI109148539, Length=522, Percent_Identity=26.6283524904215, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI153266901, Length=534, Percent_Identity=25.4681647940075, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI153266907, Length=535, Percent_Identity=24.1121495327103, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1789856, Length=538, Percent_Identity=31.2267657992565, Blast_Score=226, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI212646519, Length=460, Percent_Identity=25.4347826086956, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=460, Percent_Identity=25.8695652173913, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=491, Percent_Identity=24.847250509165, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193208245, Length=491, Percent_Identity=24.847250509165, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=24.5960502692998, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077878, Length=524, Percent_Identity=26.9083969465649, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551474, Length=524, Percent_Identity=26.9083969465649, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077880, Length=524, Percent_Identity=26.9083969465649, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642670, Length=524, Percent_Identity=26.9083969465649, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642666, Length=524, Percent_Identity=26.9083969465649, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18859741, Length=511, Percent_Identity=25.6360078277886, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI18859893, Length=538, Percent_Identity=26.5799256505576, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161077496, Length=444, Percent_Identity=25.2252252252252, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55166; Mature: 55166

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFHQPGRSTVYADQGMCATSHPLAAQTAISILQQGGNAVDAAIGAAILLGLCEPQSTG
CCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
IGGDMFALVAQPDGENLGLNASGRAPAGLNADAIRANHDTMPLYDISAITVPGAIDGFCR
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECEEEECCCCCCCEEE
LHGDHGQLPLDQVLAPSIHYAEAGIPIAPRVAMDYATSGHLLQGAGRRHYLQDDAPLPIG
ECCCCCCCCHHHHHCCCCEECCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCC
ARFKAPGQAEVLRRIAEQGRAGFYEGEVLDDMLASLQAHGGTHTAEDFANTKCDYVTPLR
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECHHH
SGYRDAELIELPPNGQGATAMLILNILETMTPQDDPFGPQRAHLEAEATKLGYDARDRFL
CCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHCCCCHHHCCC
ADPDHVTRLDHMLSKQTAADLAALIDPNAAMPDPRAASDNVHKDTVYLTVVDKDRRAVSL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHH
IYSIFHSFGSGMASDRFGILFQNRGGGFTLEAGHANEAGPGKRPMHTIIPGMLKLADGSL
HHHHHHHHCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
MPFGVMGGAYQSTGHARFVSNLVDYGMDPQAAIDGPRAFAEAGALKIERGYGDDTRDDLA
CCHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHCCCEEEECCCCCCCHHHHH
AKGHTLTTPDTPIGGAQAIRIRPDGVLEGGSDPRKDGIALGY
HCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDFHQPGRSTVYADQGMCATSHPLAAQTAISILQQGGNAVDAAIGAAILLGLCEPQSTG
CCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
IGGDMFALVAQPDGENLGLNASGRAPAGLNADAIRANHDTMPLYDISAITVPGAIDGFCR
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECEEEECCCCCCCEEE
LHGDHGQLPLDQVLAPSIHYAEAGIPIAPRVAMDYATSGHLLQGAGRRHYLQDDAPLPIG
ECCCCCCCCHHHHHCCCCEECCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCC
ARFKAPGQAEVLRRIAEQGRAGFYEGEVLDDMLASLQAHGGTHTAEDFANTKCDYVTPLR
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECHHH
SGYRDAELIELPPNGQGATAMLILNILETMTPQDDPFGPQRAHLEAEATKLGYDARDRFL
CCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHCCCCHHHCCC
ADPDHVTRLDHMLSKQTAADLAALIDPNAAMPDPRAASDNVHKDTVYLTVVDKDRRAVSL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHH
IYSIFHSFGSGMASDRFGILFQNRGGGFTLEAGHANEAGPGKRPMHTIIPGMLKLADGSL
HHHHHHHHCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
MPFGVMGGAYQSTGHARFVSNLVDYGMDPQAAIDGPRAFAEAGALKIERGYGDDTRDDLA
CCHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHCCCEEEECCCCCCCHHHHH
AKGHTLTTPDTPIGGAQAIRIRPDGVLEGGSDPRKDGIALGY
HCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]