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The map label for this gene is mutL

Identifier: 89056538

GI number: 89056538

Start: 4150797

End: 4152629

Strand: Direct

Name: mutL

Synonym: Jann_4047

Alternate gene names: 89056538

Gene position: 4150797-4152629 (Clockwise)

Preceding gene: 89056537

Following gene: 89056539

Centisome position: 96.13

GC content: 65.63

Gene sequence:

>1833_bases
ATGGCCCAAGCGCACCCCAACATATCCACAAACCCACGCCCGGTGATCCGTCAGCTGGACGAGGCTGCGATCAACCGCAT
CGCGGCGGGGGAAGTGGTGGAACGCCCCGCCTCTGCTGTCAAAGAACTGGTGGAAAACGCGATAGATGCCGATGCGCGGC
GCATCGTGATTGAGGTGGCCCACGGCGGCAAAACCCTGATCCGCGTGACAGATGACGGCTGCGGGATGGAGGCGGCGGAC
CTGCCGCTGGCCCTGTCGCGCCACGCGACCTCCAAGATCGACGGCACAGATCTGCTCAATATCCATTCCTTCGGGTTTCG
GGGGGAGGCGTTGCCGTCCCTGGGGTCTGTCGGGCGGTTGTCGATCACCTCGCGGGCATCGGATGCGGGCCACATGATCC
GCGTGACCGGCGGTGCCCATGATGCCGTGAAGCCCGCCGCGCTGAACCGGGGCACTCTTGTGGAGCTGCGCGATCTCTTC
TTCGCCACGCCCGCACGCCTGAAGTTCCTGCGCACGGATCGGGCCGAGATGCAGGCGATCACCGATGTGGTGAAGCGTCT
GGCGATGGCGGAGCCTGCGGTAGGTTTCACGTTGAAAGACGTGAGTGACGGCGAACGGGTGACGTTCCGCGTCGACCCGG
AACAGGGCGATCTGTTCGACGCGCTGCGGGGGCGGCTGACGGCGATCATGGGGCGTGACTTCACCGACAATGCGCTGGCG
ATTGATGCGGAGCGCGAGGGGCTGCGGCTGACGGGCTACGCCGCCCTGCCCACCTATTCGCGCGGGTCAGCGGTGGCCCA
ATTCCTGTTCGTGAATGGCAGGCCTGTACGGGACAAACTGCTGATCGGGGCGTTGCGCGCGGCATATATGGATGTATTGA
GCCGCGACCGGCATCCGGCGGCGGTGTTGTTCATCGGCTGCCCGTCGGAGCGGGTGGATGTGAACGTGCATCCGGCGAAA
TCTGAAGTGCGCTTCCGGGAACCTGGCGTTGCCCGATCCCTGATCGTGACGGGGCTGCGCCATGCACTGGCCGAAGCCGG
ACACCGGGCCTCCTCCACCGTCGCGGACGCGACGCTGTCTGCCATGCAACCGGCTTATTCAGAGCCTCCTTCGGAACCTC
TGGCTGCGCCGCGCATCTATCAGATGGACCGGTTGGGGCAGCAGCGGGGCTTTGCCCCTGTCCGGGGCCTGGAAGAAGCT
GCACCGCAATGGTCCGCGCCATCGGCGCGCGTGGATGAGGCGGTGATCGACAGCGACGGCCCATTGGGGGCTGCGCGGGC
GCAGGTCCATGAAAATTACATCATCGCGCAGACGCCAGGCGGGATTGTGTTGGTGGATCAGCACGCCGCCCATGAACGGT
TGGTTTATGAGCGGTTGAAGACACAGATGGCAGAGCGGGGCGTGGCGCGGCAGGCGTTGTTAATCCCGGAGATCCTGACG
CTGGGAGCTGATGCGGACCGCTTGCTGGACCACGCGGCGGAGTTGGAGCGGTTCGGTCTGGTGATTGAGGCGTTTGGCCC
CGGCACCGTCGCCGTGCGCGAGACCCCCGCAATCCTGGGAGAGATCAACGCCGAGGCGCTGTTGCGCGACATCCTTGATG
AGCTGTCCGATCTGGGCGACAGCCAGACGCTTCAGGCAAGGGTGGAGGCGGTGTTGTCCCGTGTCGCCTGCCACGGCTCC
ATCCGGTCGGGCCGTCAGATGCGCGCCGATGAGATGAACGCGCTGCTGCGCGAGATGGAGGCCACGCCGCTGTCGGGCCA
ATGCAACCACGGGCGGCCCACCTATGTGGAGCTGAAACTGGCCGATATCGAACGGCTGTTCGGGCGCACGTGA

Upstream 100 bases:

>100_bases
TACGGATGGCCTGTAGGGGGGGCGACCCGCCGGACGATTCCGATGCCGGGCACATGGGAATCGGTTCCCCGGACATCCAT
GTCATGCTACAGATAGCGTC

Downstream 100 bases:

>100_bases
TACAGGTCGATGAGATCGTGGTGGATCTGAGCGATCCGATGACGCTGGCCGCCATAGCGGCGGGCGTTGTGTTTGTTGTG
CTGATTGTCCTTGCTCTGCA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MAQAHPNISTNPRPVIRQLDEAAINRIAAGEVVERPASAVKELVENAIDADARRIVIEVAHGGKTLIRVTDDGCGMEAAD
LPLALSRHATSKIDGTDLLNIHSFGFRGEALPSLGSVGRLSITSRASDAGHMIRVTGGAHDAVKPAALNRGTLVELRDLF
FATPARLKFLRTDRAEMQAITDVVKRLAMAEPAVGFTLKDVSDGERVTFRVDPEQGDLFDALRGRLTAIMGRDFTDNALA
IDAEREGLRLTGYAALPTYSRGSAVAQFLFVNGRPVRDKLLIGALRAAYMDVLSRDRHPAAVLFIGCPSERVDVNVHPAK
SEVRFREPGVARSLIVTGLRHALAEAGHRASSTVADATLSAMQPAYSEPPSEPLAAPRIYQMDRLGQQRGFAPVRGLEEA
APQWSAPSARVDEAVIDSDGPLGAARAQVHENYIIAQTPGGIVLVDQHAAHERLVYERLKTQMAERGVARQALLIPEILT
LGADADRLLDHAAELERFGLVIEAFGPGTVAVRETPAILGEINAEALLRDILDELSDLGDSQTLQARVEAVLSRVACHGS
IRSGRQMRADEMNALLREMEATPLSGQCNHGRPTYVELKLADIERLFGRT

Sequences:

>Translated_610_residues
MAQAHPNISTNPRPVIRQLDEAAINRIAAGEVVERPASAVKELVENAIDADARRIVIEVAHGGKTLIRVTDDGCGMEAAD
LPLALSRHATSKIDGTDLLNIHSFGFRGEALPSLGSVGRLSITSRASDAGHMIRVTGGAHDAVKPAALNRGTLVELRDLF
FATPARLKFLRTDRAEMQAITDVVKRLAMAEPAVGFTLKDVSDGERVTFRVDPEQGDLFDALRGRLTAIMGRDFTDNALA
IDAEREGLRLTGYAALPTYSRGSAVAQFLFVNGRPVRDKLLIGALRAAYMDVLSRDRHPAAVLFIGCPSERVDVNVHPAK
SEVRFREPGVARSLIVTGLRHALAEAGHRASSTVADATLSAMQPAYSEPPSEPLAAPRIYQMDRLGQQRGFAPVRGLEEA
APQWSAPSARVDEAVIDSDGPLGAARAQVHENYIIAQTPGGIVLVDQHAAHERLVYERLKTQMAERGVARQALLIPEILT
LGADADRLLDHAAELERFGLVIEAFGPGTVAVRETPAILGEINAEALLRDILDELSDLGDSQTLQARVEAVLSRVACHGS
IRSGRQMRADEMNALLREMEATPLSGQCNHGRPTYVELKLADIERLFGRT
>Mature_609_residues
AQAHPNISTNPRPVIRQLDEAAINRIAAGEVVERPASAVKELVENAIDADARRIVIEVAHGGKTLIRVTDDGCGMEAADL
PLALSRHATSKIDGTDLLNIHSFGFRGEALPSLGSVGRLSITSRASDAGHMIRVTGGAHDAVKPAALNRGTLVELRDLFF
ATPARLKFLRTDRAEMQAITDVVKRLAMAEPAVGFTLKDVSDGERVTFRVDPEQGDLFDALRGRLTAIMGRDFTDNALAI
DAEREGLRLTGYAALPTYSRGSAVAQFLFVNGRPVRDKLLIGALRAAYMDVLSRDRHPAAVLFIGCPSERVDVNVHPAKS
EVRFREPGVARSLIVTGLRHALAEAGHRASSTVADATLSAMQPAYSEPPSEPLAAPRIYQMDRLGQQRGFAPVRGLEEAA
PQWSAPSARVDEAVIDSDGPLGAARAQVHENYIIAQTPGGIVLVDQHAAHERLVYERLKTQMAERGVARQALLIPEILTL
GADADRLLDHAAELERFGLVIEAFGPGTVAVRETPAILGEINAEALLRDILDELSDLGDSQTLQARVEAVLSRVACHGSI
RSGRQMRADEMNALLREMEATPLSGQCNHGRPTYVELKLADIERLFGRT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=318, Percent_Identity=35.8490566037736, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4505913, Length=353, Percent_Identity=28.6118980169972, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI310128478, Length=353, Percent_Identity=28.6118980169972, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4505911, Length=330, Percent_Identity=28.1818181818182, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI189458898, Length=330, Percent_Identity=28.1818181818182, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=27.9874213836478, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI263191589, Length=223, Percent_Identity=30.4932735426009, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI91992162, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI91992160, Length=350, Percent_Identity=24.8571428571429, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790612, Length=546, Percent_Identity=35.7142857142857, Blast_Score=254, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=35.3658536585366, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=338, Percent_Identity=26.9230769230769, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=371, Percent_Identity=32.3450134770889, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=333, Percent_Identity=28.2282282282282, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=382, Percent_Identity=23.5602094240838, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136968, Length=324, Percent_Identity=34.8765432098765, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17136970, Length=352, Percent_Identity=28.4090909090909, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 65882; Mature: 65751

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQAHPNISTNPRPVIRQLDEAAINRIAAGEVVERPASAVKELVENAIDADARRIVIEVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
HGGKTLIRVTDDGCGMEAADLPLALSRHATSKIDGTDLLNIHSFGFRGEALPSLGSVGRL
CCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEE
SITSRASDAGHMIRVTGGAHDAVKPAALNRGTLVELRDLFFATPARLKFLRTDRAEMQAI
EEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCHHHHHHH
TDVVKRLAMAEPAVGFTLKDVSDGERVTFRVDPEQGDLFDALRGRLTAIMGRDFTDNALA
HHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEE
IDAEREGLRLTGYAALPTYSRGSAVAQFLFVNGRPVRDKLLIGALRAAYMDVLSRDRHPA
EECCCCCEEEEEEEECCCCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCE
AVLFIGCPSERVDVNVHPAKSEVRFREPGVARSLIVTGLRHALAEAGHRASSTVADATLS
EEEEEECCCCCEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AMQPAYSEPPSEPLAAPRIYQMDRLGQQRGFAPVRGLEEAAPQWSAPSARVDEAVIDSDG
HHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCHHHHCCCCCCCCCHHCHHHCCCCC
PLGAARAQVHENYIIAQTPGGIVLVDQHAAHERLVYERLKTQMAERGVARQALLIPEILT
CCCHHHHHHHCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LGADADRLLDHAAELERFGLVIEAFGPGTVAVRETPAILGEINAEALLRDILDELSDLGD
CCCCHHHHHHHHHHHHHHCEEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCC
SQTLQARVEAVLSRVACHGSIRSGRQMRADEMNALLREMEATPLSGQCNHGRPTYVELKL
CHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEH
ADIERLFGRT
HHHHHHHCCC
>Mature Secondary Structure 
AQAHPNISTNPRPVIRQLDEAAINRIAAGEVVERPASAVKELVENAIDADARRIVIEVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
HGGKTLIRVTDDGCGMEAADLPLALSRHATSKIDGTDLLNIHSFGFRGEALPSLGSVGRL
CCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEE
SITSRASDAGHMIRVTGGAHDAVKPAALNRGTLVELRDLFFATPARLKFLRTDRAEMQAI
EEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCHHHHHHH
TDVVKRLAMAEPAVGFTLKDVSDGERVTFRVDPEQGDLFDALRGRLTAIMGRDFTDNALA
HHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEE
IDAEREGLRLTGYAALPTYSRGSAVAQFLFVNGRPVRDKLLIGALRAAYMDVLSRDRHPA
EECCCCCEEEEEEEECCCCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCE
AVLFIGCPSERVDVNVHPAKSEVRFREPGVARSLIVTGLRHALAEAGHRASSTVADATLS
EEEEEECCCCCEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AMQPAYSEPPSEPLAAPRIYQMDRLGQQRGFAPVRGLEEAAPQWSAPSARVDEAVIDSDG
HHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCHHHHCCCCCCCCCHHCHHHCCCCC
PLGAARAQVHENYIIAQTPGGIVLVDQHAAHERLVYERLKTQMAERGVARQALLIPEILT
CCCHHHHHHHCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LGADADRLLDHAAELERFGLVIEAFGPGTVAVRETPAILGEINAEALLRDILDELSDLGD
CCCCHHHHHHHHHHHHHHCEEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCC
SQTLQARVEAVLSRVACHGSIRSGRQMRADEMNALLREMEATPLSGQCNHGRPTYVELKL
CHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEH
ADIERLFGRT
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA