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The map label for this gene is pyrC [H]

Identifier: 89056396

GI number: 89056396

Start: 4003214

End: 4004482

Strand: Direct

Name: pyrC [H]

Synonym: Jann_3905

Alternate gene names: 89056396

Gene position: 4003214-4004482 (Clockwise)

Preceding gene: 89056395

Following gene: 89056397

Centisome position: 92.71

GC content: 66.35

Gene sequence:

>1269_bases
ATGACCAACGCGCTGCTCCACAATGCCCGGCTGATTGACCCAGAGGCCGGAACAGAGACCCTCGGCTGGGTGCGGATTGA
GGCCGGTCTGATCGCCGAAGTGGGCGACGGTCCGCGCGCGGGCGGCCTTGATTGCGGTGGGCTGTGCCTTGCGCCCGGTA
TCGTTGATGTGGGCGTAAAGGTGGGCGAACCCGGCGAGCGTCACAAGGAAAGTTTCCGTACCGCTGGCCGCGCAGCGGCA
GCCGGTGGCGTGACGACCATGGTGACCCGCCCCGACACCACGACGCCGATTGATACGCCCGAAGTGCTGGATTTCGTGAC
CCGCCGGGGGCGCGATCATTCTGCCGTGCGTGTGGCGCCCATGGCCGCCCTGACCCGGGCCCGCGAAGGGCGTGAAATGG
TGGAGATCGGGTTCCTGCGCGACGCGGGCGCGGTGGCGTTTTCCGACGGCGATCAGGTCGTCACCAACACGAAGGTGCTG
TCGCGCTGCATGACCTATGCGCGGTCTCTGGGTGCGTTGATCGTGGGCCACCCGCAGGAACCGATCTTGAGCGACGGGGC
TGCCGTGACGTCTGGCAAATTCGCCTCGCTGCGTGGCCTGCCCGCCGCCTCGCCCATGGCCGAGCGGATGGGGTTGGAGC
GGGATCTGGCGCTGGTGGAGATGACGGGCGTGGCCTACCATGCCGACCAGATCTCCACCACCAATGCCCTGCCCGCACTG
GCGCGCGCAAAGGCGGCGCTGGATGTGACCGCCGGGGTCTCCATCCATCACCTGACGTTGAACGAATTTGACGTGGCGGA
CTACCGGACCTTCTTCAAGCTGAAACCGCCACTCCGATCCGAGGATGACCGAAGCGCGATGGTCGAGGCCGTGCGCGATG
GCACCATCGACATCATCTGCTCCATGCACACGCCCCAGGATGAGGAAAGCAAACGCCTGCCGTTTGAAGTCGCCGCCTCC
GGTGCCGTGGGCCTGGAGACGCTGCTGCCCGCCGCGATGCGCTTGGTGCATTCCGGCCAACTGACCCTGCCGGAGCTGTT
CCGGGCACTGTCCCTGAACCCCGCGCGCCGGTTCGGCCAGCCCTCCGGTCGGCTCAGCGCGGGTGCCCCGGCAGACTTGA
TCCTGTTTGACCCGGACAAGCCGTTTCAACTGGACCGTGCGACGTTGCGGTCAAAATCCAAGAATACGCCATTCGACGGG
GCCCGTATGCAAGGCCGCGTGATGCGCACCTGGGTCGGCGGAAACACCGTATTTGAGGCAGCTCCGTGA

Upstream 100 bases:

>100_bases
TTGATTGGCATGGCGATCCTGGCCGCCCTGATCTTCTTTGTGGGGTGGCGCTAGTGCCTGTGCCCTTGCAATCATCTGCC
CCACGCGGCAGGCACGCGCC

Downstream 100 bases:

>100_bases
TCCCACTGATTGAAACCTCCGCACTTCTTCTGGGGCTGACGGCGCTGCTGGCCTATCTGCTTGGGTCCGTGCCGTTTGGC
ATCATGATGGCACGTCTCTT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTNALLHNARLIDPEAGTETLGWVRIEAGLIAEVGDGPRAGGLDCGGLCLAPGIVDVGVKVGEPGERHKESFRTAGRAAA
AGGVTTMVTRPDTTTPIDTPEVLDFVTRRGRDHSAVRVAPMAALTRAREGREMVEIGFLRDAGAVAFSDGDQVVTNTKVL
SRCMTYARSLGALIVGHPQEPILSDGAAVTSGKFASLRGLPAASPMAERMGLERDLALVEMTGVAYHADQISTTNALPAL
ARAKAALDVTAGVSIHHLTLNEFDVADYRTFFKLKPPLRSEDDRSAMVEAVRDGTIDIICSMHTPQDEESKRLPFEVAAS
GAVGLETLLPAAMRLVHSGQLTLPELFRALSLNPARRFGQPSGRLSAGAPADLILFDPDKPFQLDRATLRSKSKNTPFDG
ARMQGRVMRTWVGGNTVFEAAP

Sequences:

>Translated_422_residues
MTNALLHNARLIDPEAGTETLGWVRIEAGLIAEVGDGPRAGGLDCGGLCLAPGIVDVGVKVGEPGERHKESFRTAGRAAA
AGGVTTMVTRPDTTTPIDTPEVLDFVTRRGRDHSAVRVAPMAALTRAREGREMVEIGFLRDAGAVAFSDGDQVVTNTKVL
SRCMTYARSLGALIVGHPQEPILSDGAAVTSGKFASLRGLPAASPMAERMGLERDLALVEMTGVAYHADQISTTNALPAL
ARAKAALDVTAGVSIHHLTLNEFDVADYRTFFKLKPPLRSEDDRSAMVEAVRDGTIDIICSMHTPQDEESKRLPFEVAAS
GAVGLETLLPAAMRLVHSGQLTLPELFRALSLNPARRFGQPSGRLSAGAPADLILFDPDKPFQLDRATLRSKSKNTPFDG
ARMQGRVMRTWVGGNTVFEAAP
>Mature_421_residues
TNALLHNARLIDPEAGTETLGWVRIEAGLIAEVGDGPRAGGLDCGGLCLAPGIVDVGVKVGEPGERHKESFRTAGRAAAA
GGVTTMVTRPDTTTPIDTPEVLDFVTRRGRDHSAVRVAPMAALTRAREGREMVEIGFLRDAGAVAFSDGDQVVTNTKVLS
RCMTYARSLGALIVGHPQEPILSDGAAVTSGKFASLRGLPAASPMAERMGLERDLALVEMTGVAYHADQISTTNALPALA
RAKAALDVTAGVSIHHLTLNEFDVADYRTFFKLKPPLRSEDDRSAMVEAVRDGTIDIICSMHTPQDEESKRLPFEVAASG
AVGLETLLPAAMRLVHSGQLTLPELFRALSLNPARRFGQPSGRLSAGAPADLILFDPDKPFQLDRATLRSKSKNTPFDGA
RMQGRVMRTWVGGNTVFEAAP

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786722, Length=436, Percent_Identity=25.2293577981651, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI87082175, Length=422, Percent_Identity=26.0663507109005, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=392, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=201, Percent_Identity=27.363184079602, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642586, Length=376, Percent_Identity=27.9255319148936, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI18859883, Length=484, Percent_Identity=26.6528925619835, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44893; Mature: 44762

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNALLHNARLIDPEAGTETLGWVRIEAGLIAEVGDGPRAGGLDCGGLCLAPGIVDVGVK
CCCCCCCCCEEECCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHCCCCEECCCC
VGEPGERHKESFRTAGRAAAAGGVTTMVTRPDTTTPIDTPEVLDFVTRRGRDHSAVRVAP
CCCCCHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEHH
MAALTRAREGREMVEIGFLRDAGAVAFSDGDQVVTNTKVLSRCMTYARSLGALIVGHPQE
HHHHHHHHCCCCEEEEEEEECCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCEEECCCCC
PILSDGAAVTSGKFASLRGLPAASPMAERMGLERDLALVEMTGVAYHADQISTTNALPAL
CCCCCCCEECCCCHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCEEECCCCCCCHHHHHH
ARAKAALDVTAGVSIHHLTLNEFDVADYRTFFKLKPPLRSEDDRSAMVEAVRDGTIDIIC
HHHHHHEEEECCCEEEEEECCCCCCHHHHEEEEECCCCCCCCHHHHHHHHHHCCCEEEEE
SMHTPQDEESKRLPFEVAASGAVGLETLLPAAMRLVHSGQLTLPELFRALSLNPARRFGQ
ECCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCC
PSGRLSAGAPADLILFDPDKPFQLDRATLRSKSKNTPFDGARMQGRVMRTWVGGNTVFEA
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCEEEEC
AP
CC
>Mature Secondary Structure 
TNALLHNARLIDPEAGTETLGWVRIEAGLIAEVGDGPRAGGLDCGGLCLAPGIVDVGVK
CCCCCCCCEEECCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHCCCCEECCCC
VGEPGERHKESFRTAGRAAAAGGVTTMVTRPDTTTPIDTPEVLDFVTRRGRDHSAVRVAP
CCCCCHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEHH
MAALTRAREGREMVEIGFLRDAGAVAFSDGDQVVTNTKVLSRCMTYARSLGALIVGHPQE
HHHHHHHHCCCCEEEEEEEECCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCEEECCCCC
PILSDGAAVTSGKFASLRGLPAASPMAERMGLERDLALVEMTGVAYHADQISTTNALPAL
CCCCCCCEECCCCHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCEEECCCCCCCHHHHHH
ARAKAALDVTAGVSIHHLTLNEFDVADYRTFFKLKPPLRSEDDRSAMVEAVRDGTIDIIC
HHHHHHEEEECCCEEEEEECCCCCCHHHHEEEEECCCCCCCCHHHHHHHHHHCCCEEEEE
SMHTPQDEESKRLPFEVAASGAVGLETLLPAAMRLVHSGQLTLPELFRALSLNPARRFGQ
ECCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCC
PSGRLSAGAPADLILFDPDKPFQLDRATLRSKSKNTPFDGARMQGRVMRTWVGGNTVFEA
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCEEEEC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA