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The map label for this gene is hemE

Identifier: 89056337

GI number: 89056337

Start: 3941169

End: 3942200

Strand: Direct

Name: hemE

Synonym: Jann_3846

Alternate gene names: 89056337

Gene position: 3941169-3942200 (Clockwise)

Preceding gene: 89056331

Following gene: 89056340

Centisome position: 91.27

GC content: 61.63

Gene sequence:

>1032_bases
ATGGCCGACAAGAAAAAACTTCTGCGCTCGCTCGCGGGCGAGGCCATGGACGTGCCGCCCGTATGGTTGATGCGCCAGGC
CGGGCGCTATTTGCCGGAATATCGCGCCACCCGCGCGCAGGCAGGCGACTTCCTGTCACTGTGCTATAACCCTGAATTGG
CAGCGGAAGTTACGCTGCAACCGATCCGGCGCTTTGATTTTGATGCGTCGATCTTGTTCGCCGACATCCTGCTCATCCCG
CAGGCACTTGGCGCCAACCTGTGGTTCGTCACTGGTGAGGGGCCGCGTTTGTCGACCATCACTGACGCGTCTGGCATGGC
GCGGATGAAGACGGCGGACGACATTCATGAGACGCTGAACCCCATCTACGAGACGGTAAAGATCCTGGCGCAGGAACTGC
CGAAGGAGACCACGCTGATCGGTTTCGCGGGCGCGCCCTGGACAGTGGCTACCTACATGATCGCGGGTCGCGGCACGCCG
GACCAAGCCCCCGCCCATAAGCTGCGCGAAGGCGACCCGGAGACCTTCGACAAGCTGATGGACCTGATCACCGCCGCAAC
GATTGAATATCTGGATATGCAGGTTCAGGCGGGCGCTGAAGTCGTGAAGCTCTTCGACTCCTGGGCCGGGTCCCTCAAGG
GCGAGGCGTTCGATAAATACGCGCTCGCCCCCGCGAAACGCATCATCTCAGAGCTGAAGTCACGCCACCCCGATCTGCCG
ATCATCGCCTTCCCGCGCGAGGCGGGAGAGAAATACATCGGTTTCGCCAACGCCGTGGGAGCCGATTGTCTGGCCATCGA
CACCTCCGTCGACGCCATCTGGGCGGCAGAAAACCTACAGACAGACGGCTGTGTGCAGGGCAACCTTGATCCCAAATTGA
TGGTGACCGGAGGCGAGGCTTTGGCATCCGAGGCCCGGCGTATCCGCGATGCCCTGAAGGGTGGGCCGCATATCTTCAAT
CTGGGCCACGGCATCACGCCGGACGCGGACCCGGAGAATGTGCATATTCTGCTGGATGCGATCCGGAGCTAA

Upstream 100 bases:

>100_bases
GTCCTCTTTAGATGTGTCAACTTGGCTTGACAACGCTGTTCCGTGTGACACTCATGAGGCGAGTAATCTGATCCCGACGA
CGACCCTGAGGATATCTGAC

Downstream 100 bases:

>100_bases
CGACGCGCCTGTCCCGTAGCAAGCAAGCGGCGGTAGATCGCCATGATGGCCTCAGCCTCCCGCTCGATGCGGAAGTTCTG
TTCGACATGCGCCCGAGCGG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MADKKKLLRSLAGEAMDVPPVWLMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRFDFDASILFADILLIP
QALGANLWFVTGEGPRLSTITDASGMARMKTADDIHETLNPIYETVKILAQELPKETTLIGFAGAPWTVATYMIAGRGTP
DQAPAHKLREGDPETFDKLMDLITAATIEYLDMQVQAGAEVVKLFDSWAGSLKGEAFDKYALAPAKRIISELKSRHPDLP
IIAFPREAGEKYIGFANAVGADCLAIDTSVDAIWAAENLQTDGCVQGNLDPKLMVTGGEALASEARRIRDALKGGPHIFN
LGHGITPDADPENVHILLDAIRS

Sequences:

>Translated_343_residues
MADKKKLLRSLAGEAMDVPPVWLMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRFDFDASILFADILLIP
QALGANLWFVTGEGPRLSTITDASGMARMKTADDIHETLNPIYETVKILAQELPKETTLIGFAGAPWTVATYMIAGRGTP
DQAPAHKLREGDPETFDKLMDLITAATIEYLDMQVQAGAEVVKLFDSWAGSLKGEAFDKYALAPAKRIISELKSRHPDLP
IIAFPREAGEKYIGFANAVGADCLAIDTSVDAIWAAENLQTDGCVQGNLDPKLMVTGGEALASEARRIRDALKGGPHIFN
LGHGITPDADPENVHILLDAIRS
>Mature_342_residues
ADKKKLLRSLAGEAMDVPPVWLMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRFDFDASILFADILLIPQ
ALGANLWFVTGEGPRLSTITDASGMARMKTADDIHETLNPIYETVKILAQELPKETTLIGFAGAPWTVATYMIAGRGTPD
QAPAHKLREGDPETFDKLMDLITAATIEYLDMQVQAGAEVVKLFDSWAGSLKGEAFDKYALAPAKRIISELKSRHPDLPI
IAFPREAGEKYIGFANAVGADCLAIDTSVDAIWAAENLQTDGCVQGNLDPKLMVTGGEALASEARRIRDALKGGPHIFNL
GHGITPDADPENVHILLDAIRS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=345, Percent_Identity=38.2608695652174, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=38.5294117647059, Blast_Score=252, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6320252, Length=348, Percent_Identity=33.9080459770115, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=37.7906976744186, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=37.7906976744186, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_JANSC (Q28KJ9)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_511788.1
- ProteinModelPortal:   Q28KJ9
- SMR:   Q28KJ9
- STRING:   Q28KJ9
- GeneID:   3936326
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_3846
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q28KJ9
- ProtClustDB:   PRK00115
- BioCyc:   JSP290400:JANN_3846-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37315; Mature: 37184

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 75-75 BINDING 152-152 BINDING 207-207 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKKLLRSLAGEAMDVPPVWLMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
PIRRFDFDASILFADILLIPQALGANLWFVTGEGPRLSTITDASGMARMKTADDIHETLN
HHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHH
PIYETVKILAQELPKETTLIGFAGAPWTVATYMIAGRGTPDQAPAHKLREGDPETFDKLM
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHH
DLITAATIEYLDMQVQAGAEVVKLFDSWAGSLKGEAFDKYALAPAKRIISELKSRHPDLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
IIAFPREAGEKYIGFANAVGADCLAIDTSVDAIWAAENLQTDGCVQGNLDPKLMVTGGEA
EEECCHHHCHHHHCHHHHCCCCEEEEECCCHHHEECCCCCCCCCEECCCCCEEEEECCHH
LASEARRIRDALKGGPHIFNLGHGITPDADPENVHILLDAIRS
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEHHHHHCC
>Mature Secondary Structure 
ADKKKLLRSLAGEAMDVPPVWLMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQ
CCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
PIRRFDFDASILFADILLIPQALGANLWFVTGEGPRLSTITDASGMARMKTADDIHETLN
HHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHH
PIYETVKILAQELPKETTLIGFAGAPWTVATYMIAGRGTPDQAPAHKLREGDPETFDKLM
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHH
DLITAATIEYLDMQVQAGAEVVKLFDSWAGSLKGEAFDKYALAPAKRIISELKSRHPDLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
IIAFPREAGEKYIGFANAVGADCLAIDTSVDAIWAAENLQTDGCVQGNLDPKLMVTGGEA
EEECCHHHCHHHHCHHHHCCCCEEEEECCCHHHEECCCCCCCCCEECCCCCEEEEECCHH
LASEARRIRDALKGGPHIFNLGHGITPDADPENVHILLDAIRS
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA