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The map label for this gene is fabG [H]

Identifier: 89056267

GI number: 89056267

Start: 3860660

End: 3861439

Strand: Direct

Name: fabG [H]

Synonym: Jann_3776

Alternate gene names: 89056267

Gene position: 3860660-3861439 (Clockwise)

Preceding gene: 89056266

Following gene: 89056272

Centisome position: 89.41

GC content: 65.9

Gene sequence:

>780_bases
GTGACCGGGCCGGACGGGCTGCGCCTGACACCCGCGCCGGGCGCCCGGATCGCCGTGATCGGTGCGGCGGGGGGCATCGG
GCGCGCGACGGTCACAGCACTGGCCAATGCCGGATGCCGGGTCTTTGCGCTGGACCGGTCCGACCCACTATCAACCATGT
CGAACAAATGGCCCGATGCGGTCATACCGATTGCACTTGATGCAACAGACCCTGCCTCAGTCGACGCAGCTTTCTCGCAG
ATCTCAGCCGAAGTGTCCGGGCTTGACGGACTGGTTCATCTGGCCGGGTTCGCCAATCCACGCGCACCTGTTGCCGAAAC
CGACCTGGCTGACTGGCGCGAGGTGGTTGAAGGCAATCTCGACAGCGGTTTCCTGTGTGTCCGCGCCGCGATCCCCTTGC
TGCGCGCGTCTCCCGCATCCTCCGTGGTTCTGGCAGCCTCGGGCCTCGCCGTGAAACCTGCCCCCGGATATGGCCCCTAT
GCCGCCGCAAAGGCCGGTCTTCTCGCGTTCATGCGGGTCCTCGCTGCGGAACTGGCGCCACAGGTGCGCGTCAATGCTGT
CGCACCCTCAGCCGTCGAAACGCCCTTCCTGACCGGAGGCACCGGACGCGCGGAGCGATCACTGGGCTTCGACCGGGACG
CCTACGTGCAAAGCGTTCCGTTGGGCCGCATGGCGATTGCAGAGGATATCGTTGGGCCCATCGTATTCCTGCTGGGCCCG
GCCTCGGGCTATCTGACCGGGCAAACCTTGCACGTGAACGGTGGGTTGGTGATGTCGTGA

Upstream 100 bases:

>100_bases
TCGGGCGCGAAGGTGGCGAGGCCTGCGAACGCTTCTATACCGAGCCGAAGACAGTGACCGTGCCGTCCTCTCCGATCACC
CCGCGCCGTATGGGCCTCTC

Downstream 100 bases:

>100_bases
ACCCGCCGATCTGGCGAAAGTCACCCGTCTGCGACGTTTAGCATCAGGGCCGGATCGCAAAAGCGACCGCACGAACCGGA
ATATTACCAGGGTCGTCTGA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTGPDGLRLTPAPGARIAVIGAAGGIGRATVTALANAGCRVFALDRSDPLSTMSNKWPDAVIPIALDATDPASVDAAFSQ
ISAEVSGLDGLVHLAGFANPRAPVAETDLADWREVVEGNLDSGFLCVRAAIPLLRASPASSVVLAASGLAVKPAPGYGPY
AAAKAGLLAFMRVLAAELAPQVRVNAVAPSAVETPFLTGGTGRAERSLGFDRDAYVQSVPLGRMAIAEDIVGPIVFLLGP
ASGYLTGQTLHVNGGLVMS

Sequences:

>Translated_259_residues
MTGPDGLRLTPAPGARIAVIGAAGGIGRATVTALANAGCRVFALDRSDPLSTMSNKWPDAVIPIALDATDPASVDAAFSQ
ISAEVSGLDGLVHLAGFANPRAPVAETDLADWREVVEGNLDSGFLCVRAAIPLLRASPASSVVLAASGLAVKPAPGYGPY
AAAKAGLLAFMRVLAAELAPQVRVNAVAPSAVETPFLTGGTGRAERSLGFDRDAYVQSVPLGRMAIAEDIVGPIVFLLGP
ASGYLTGQTLHVNGGLVMS
>Mature_258_residues
TGPDGLRLTPAPGARIAVIGAAGGIGRATVTALANAGCRVFALDRSDPLSTMSNKWPDAVIPIALDATDPASVDAAFSQI
SAEVSGLDGLVHLAGFANPRAPVAETDLADWREVVEGNLDSGFLCVRAAIPLLRASPASSVVLAASGLAVKPAPGYGPYA
AAKAGLLAFMRVLAAELAPQVRVNAVAPSAVETPFLTGGTGRAERSLGFDRDAYVQSVPLGRMAIAEDIVGPIVFLLGPA
SGYLTGQTLHVNGGLVMS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=228, Percent_Identity=27.6315789473684, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=28.2157676348548, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=31.3725490196078, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI32483357, Length=148, Percent_Identity=31.7567567567568, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI126723750, Length=148, Percent_Identity=32.4324324324324, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=28.740157480315, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=28.6343612334802, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=25.8964143426295, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=26.9387755102041, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=27.9352226720648, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=28.2258064516129, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1787526, Length=247, Percent_Identity=27.9352226720648, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788459, Length=185, Percent_Identity=29.1891891891892, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=25.0996015936255, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=27.1653543307087, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=26.7206477732794, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=28.8973384030418, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=29.6875, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=31.1538461538462, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=26.4822134387352, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=29.3893129770992, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=24.1106719367589, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=28.8617886178862, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=28.5185185185185, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=28.735632183908, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=27.3076923076923, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322227, Length=191, Percent_Identity=29.8429319371728, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=28.125, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.1255060728745, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=29.3650793650794, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=27.1604938271605, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=28.8, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644337, Length=194, Percent_Identity=30.9278350515464, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=28.1746031746032, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26207; Mature: 26076

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPDGLRLTPAPGARIAVIGAAGGIGRATVTALANAGCRVFALDRSDPLSTMSNKWPDA
CCCCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCE
VIPIALDATDPASVDAAFSQISAEVSGLDGLVHLAGFANPRAPVAETDLADWREVVEGNL
EEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCC
DSGFLCVRAAIPLLRASPASSVVLAASGLAVKPAPGYGPYAAAKAGLLAFMRVLAAELAP
CCCEEHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
QVRVNAVAPSAVETPFLTGGTGRAERSLGFDRDAYVQSVPLGRMAIAEDIVGPIVFLLGP
CEEEEEECCCHHCCCEEECCCCCCHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHEEEECC
ASGYLTGQTLHVNGGLVMS
CCCCEECEEEEECCCEEEC
>Mature Secondary Structure 
TGPDGLRLTPAPGARIAVIGAAGGIGRATVTALANAGCRVFALDRSDPLSTMSNKWPDA
CCCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCE
VIPIALDATDPASVDAAFSQISAEVSGLDGLVHLAGFANPRAPVAETDLADWREVVEGNL
EEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCC
DSGFLCVRAAIPLLRASPASSVVLAASGLAVKPAPGYGPYAAAKAGLLAFMRVLAAELAP
CCCEEHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
QVRVNAVAPSAVETPFLTGGTGRAERSLGFDRDAYVQSVPLGRMAIAEDIVGPIVFLLGP
CEEEEEECCCHHCCCEEECCCCCCHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHEEEECC
ASGYLTGQTLHVNGGLVMS
CCCCEECEEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1556094; 8905232; 9278503; 1314802 [H]