Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 89056111

GI number: 89056111

Start: 3692221

End: 3693321

Strand: Direct

Name: gcvT [H]

Synonym: Jann_3620

Alternate gene names: 89056111

Gene position: 3692221-3693321 (Clockwise)

Preceding gene: 89056109

Following gene: 89056112

Centisome position: 85.51

GC content: 64.4

Gene sequence:

>1101_bases
ATGGCCGACGGCGATCTGAAGACACTGGCCTTGGCCGATCTGCATAAGGAGCTTGGCGGCAAATTCGTCGGCTTTGCGGG
CTATTCCATGCCCGTCCAATACCCAACCGGCGTCATGGCCGAGCATCTGTGGACACGCGAAAACGCCGGCCTGTTTGACG
TCAGTCACATGGGCCAAGTCGTGCTGCCCGCCGATGCGGATCTTGAGGCGCTGGTGCCGGTGGATGTGCTTGGCCTTGCA
GAGGGTCGCCAGCGATACGGTTTTTTCACAAATGACACGGGCGGTGTGCTCGACGATCTGATGATTGCACGCGGTCCTGA
TGGATTGTTCCTGGTTGTGAATGCCGGGTGCAAAGCGGCCGACATTGCCCATCTACGCGCGCATATGAACGGGGTGGAGG
TGATCGAGGACCGCGCCCTTCTGGCCCTGCAAGGGCCCAAGGCAGATGCGGCGCTGGCCAAGCTGATCCCCGGTGCCGCC
GATATGCGCTTCATGGATTCCACGCGGATGGCGTGGGACGGGGCGGAGCTGTGGATCAGCCGATCCGGCTACACCAGCGA
AGACGGGTTCGAGATATCGATCCCGGATAAGCGGGCTGAGGCCTTTGCGCGCGCGTTATTGGCGGACGACCGTGTCCAGC
CCATCGGTCTTGGGGCGCGGGACTCGCTCCGTTTGGAAGCGGGCCTGCCGCTTTACGGCCAGGACATGACACCGTCCATC
AGCCCCGTCGAGGCCGGACAGGCCTGGGCCATCGGCAAGGTCCGGCGCACAGGCGGTGACCGTGCCGGCGGGTTCCCCGG
TGCGGAGGTCTTGTTGGATCAACTGGCTAATGGCGCGCCCCGTCGCCGCGCGGGTCTTTTGCCAGAAGGTCGCGCGCCGA
TGCGCGCAGGCGTGGAGATTTTCGCGAGCCCGGACACACAGACACCCATCGGCGTTGTCACGTCCGGCGGCTTTGGCCCA
ACCCTCGGCGCGCCCATGGCGTTGGCGCTGATCGCCGCCGACACGCCCAAAGACATCCCCTTGTTTGGTGACGTGCGCGG
CAAACGCCTGCCCGTCGCACAGACCAAACTTCCTTTCACACCCCCCGGCTACAAACGCTGA

Upstream 100 bases:

>100_bases
CGATCTCAGGCCGAAGGACAGAGGGGGCATCAGGAGGGCGCAGCGGAGGGCTGCGTTTGCATGATGCCGGGCCACACGCG
TCCCGGATAAGGAGGCGGCG

Downstream 100 bases:

>100_bases
CATCGACGAAACACGACGGAGACACCGATGAAATTCACTGAAGACCACGAATGGCTGAACGCCGACGGCGACGTTATCAC
TGTTGGCATCACCGAACACG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MADGDLKTLALADLHKELGGKFVGFAGYSMPVQYPTGVMAEHLWTRENAGLFDVSHMGQVVLPADADLEALVPVDVLGLA
EGRQRYGFFTNDTGGVLDDLMIARGPDGLFLVVNAGCKAADIAHLRAHMNGVEVIEDRALLALQGPKADAALAKLIPGAA
DMRFMDSTRMAWDGAELWISRSGYTSEDGFEISIPDKRAEAFARALLADDRVQPIGLGARDSLRLEAGLPLYGQDMTPSI
SPVEAGQAWAIGKVRRTGGDRAGGFPGAEVLLDQLANGAPRRRAGLLPEGRAPMRAGVEIFASPDTQTPIGVVTSGGFGP
TLGAPMALALIAADTPKDIPLFGDVRGKRLPVAQTKLPFTPPGYKR

Sequences:

>Translated_366_residues
MADGDLKTLALADLHKELGGKFVGFAGYSMPVQYPTGVMAEHLWTRENAGLFDVSHMGQVVLPADADLEALVPVDVLGLA
EGRQRYGFFTNDTGGVLDDLMIARGPDGLFLVVNAGCKAADIAHLRAHMNGVEVIEDRALLALQGPKADAALAKLIPGAA
DMRFMDSTRMAWDGAELWISRSGYTSEDGFEISIPDKRAEAFARALLADDRVQPIGLGARDSLRLEAGLPLYGQDMTPSI
SPVEAGQAWAIGKVRRTGGDRAGGFPGAEVLLDQLANGAPRRRAGLLPEGRAPMRAGVEIFASPDTQTPIGVVTSGGFGP
TLGAPMALALIAADTPKDIPLFGDVRGKRLPVAQTKLPFTPPGYKR
>Mature_365_residues
ADGDLKTLALADLHKELGGKFVGFAGYSMPVQYPTGVMAEHLWTRENAGLFDVSHMGQVVLPADADLEALVPVDVLGLAE
GRQRYGFFTNDTGGVLDDLMIARGPDGLFLVVNAGCKAADIAHLRAHMNGVEVIEDRALLALQGPKADAALAKLIPGAAD
MRFMDSTRMAWDGAELWISRSGYTSEDGFEISIPDKRAEAFARALLADDRVQPIGLGARDSLRLEAGLPLYGQDMTPSIS
PVEAGQAWAIGKVRRTGGDRAGGFPGAEVLLDQLANGAPRRRAGLLPEGRAPMRAGVEIFASPDTQTPIGVVTSGGFGPT
LGAPMALALIAADTPKDIPLFGDVRGKRLPVAQTKLPFTPPGYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=377, Percent_Identity=41.3793103448276, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI257796258, Length=349, Percent_Identity=42.1203438395415, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI257796254, Length=367, Percent_Identity=38.1471389645777, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI257796256, Length=312, Percent_Identity=40.3846153846154, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=35.2941176470588, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=390, Percent_Identity=39.4871794871795, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=41.2371134020619, Blast_Score=240, Evalue=2e-64,
Organism=Drosophila melanogaster, GI20129441, Length=387, Percent_Identity=39.5348837209302, Blast_Score=231, Evalue=8e-61,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38677; Mature: 38546

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGDLKTLALADLHKELGGKFVGFAGYSMPVQYPTGVMAEHLWTRENAGLFDVSHMGQV
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHCCCE
VLPADADLEALVPVDVLGLAEGRQRYGFFTNDTGGVLDDLMIARGPDGLFLVVNAGCKAA
EECCCCCCEEECCCCEEECCCCHHHCCEEECCCCCHHHHHHHHCCCCCEEEEEECCCCHH
DIAHLRAHMNGVEVIEDRALLALQGPKADAALAKLIPGAADMRFMDSTRMAWDGAELWIS
HHHHHHHHCCCCEEECCCEEEEEECCCCHHHHHHHCCCCCCEEECCCCCCEECCCEEEEE
RSGYTSEDGFEISIPDKRAEAFARALLADDRVQPIGLGARDSLRLEAGLPLYGQDMTPSI
CCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEECCCCCCCCCCCCCC
SPVEAGQAWAIGKVRRTGGDRAGGFPGAEVLLDQLANGAPRRRAGLLPEGRAPMRAGVEI
CCCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCCCHHCCEEE
FASPDTQTPIGVVTSGGFGPTLGAPMALALIAADTPKDIPLFGDVRGKRLPVAQTKLPFT
EECCCCCCCEEEEECCCCCCCCCHHHEEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCC
PPGYKR
CCCCCC
>Mature Secondary Structure 
ADGDLKTLALADLHKELGGKFVGFAGYSMPVQYPTGVMAEHLWTRENAGLFDVSHMGQV
CCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHCCCE
VLPADADLEALVPVDVLGLAEGRQRYGFFTNDTGGVLDDLMIARGPDGLFLVVNAGCKAA
EECCCCCCEEECCCCEEECCCCHHHCCEEECCCCCHHHHHHHHCCCCCEEEEEECCCCHH
DIAHLRAHMNGVEVIEDRALLALQGPKADAALAKLIPGAADMRFMDSTRMAWDGAELWIS
HHHHHHHHCCCCEEECCCEEEEEECCCCHHHHHHHCCCCCCEEECCCCCCEECCCEEEEE
RSGYTSEDGFEISIPDKRAEAFARALLADDRVQPIGLGARDSLRLEAGLPLYGQDMTPSI
CCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEECCCCCCCCCCCCCC
SPVEAGQAWAIGKVRRTGGDRAGGFPGAEVLLDQLANGAPRRRAGLLPEGRAPMRAGVEI
CCCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCCCHHCCEEE
FASPDTQTPIGVVTSGGFGPTLGAPMALALIAADTPKDIPLFGDVRGKRLPVAQTKLPFT
EECCCCCCCEEEEECCCCCCCCCHHHEEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCC
PPGYKR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA