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The map label for this gene is lutR [H]

Identifier: 89056042

GI number: 89056042

Start: 3614565

End: 3615329

Strand: Direct

Name: lutR [H]

Synonym: Jann_3551

Alternate gene names: 89056042

Gene position: 3614565-3615329 (Clockwise)

Preceding gene: 89056039

Following gene: 89056043

Centisome position: 83.71

GC content: 60.78

Gene sequence:

>765_bases
TTGACCTCCCTCGACAAATCCCTCTCCGACCCAGTCAGCGCCAATCCGGTCGACGCGTTGAGCCTGTTGCCCGCGCGCAG
TTCCAGCCGGGATGTGCTGGAGGCGCTGTCGCTGATGATCGAGACGCAAGGGTTAAAGGTCGGCGACCGACTGCCACCCG
AAGTCGAAATCGCGAAGCATCTGGGGATCGGACGCGCCAAGGTGCGCGAGGCGCTCACCGGGTGGCAAAACATGGGTATT
GTGACGCGGAACAAGAAGGCCGGTACAGTACTGGCGACGGAAGTGTCGTCCAATGCCATCCAGCTTCCCGTGACGGTGAA
GTTGGAGGCCGAGAGCCTGCTGCGCACCCACGCCGTGCGCCGCCCGCTAGAGATTGAGACCGTCCGCCTCGCCGCACAGA
ATTGCGATGTGCACCACAAACGGATGATCCGCGCGCGATCCGCCGAATTGATGGCTGTTTATGAGGCTGGGGAAGATTGG
CGAGCCGCCGATTACCGGTTCCACGCCGCTTTGCAGGACGCCAGCGGCAATCCACTTTTCGGTCAGTTGATCCGGCAAAT
TCAACAGGGGTTCAACGAGGTCTATGAAGCGCCCTTTGGCCAGGCCCACCTGGGACAGGCATCCATCCCGATGCACCAGG
ACATTGCCGACGCGGTTGTTGCGGGGGACGCTGATAAAGCCGCAGCGCTCATGGATGAAATCTTGTCGATGGTGGAAGAT
GAAATCCGGCAGGTGATGCAAGACATGGGTGCGCGTGATGTCTGA

Upstream 100 bases:

>100_bases
AATCATCATTAAAATCTCACTTCAGATAATGTCCGACAATATAGTTGATTTTGTCGGACATTATTGCCTATCCTTCTCGT
AGCAGAACTGGACACATCCA

Downstream 100 bases:

>100_bases
TGGACCGGACATTGCGACCGTCCTCGCGTCGGTGCTGGCCGACGATGGTGGGTCCATGACGCCGCCAATCGTGCAGACGT
CCCTGTTCGCCTTCGACAAC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: L-lactate utilization operon repressor [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTSLDKSLSDPVSANPVDALSLLPARSSSRDVLEALSLMIETQGLKVGDRLPPEVEIAKHLGIGRAKVREALTGWQNMGI
VTRNKKAGTVLATEVSSNAIQLPVTVKLEAESLLRTHAVRRPLEIETVRLAAQNCDVHHKRMIRARSAELMAVYEAGEDW
RAADYRFHAALQDASGNPLFGQLIRQIQQGFNEVYEAPFGQAHLGQASIPMHQDIADAVVAGDADKAAALMDEILSMVED
EIRQVMQDMGARDV

Sequences:

>Translated_254_residues
MTSLDKSLSDPVSANPVDALSLLPARSSSRDVLEALSLMIETQGLKVGDRLPPEVEIAKHLGIGRAKVREALTGWQNMGI
VTRNKKAGTVLATEVSSNAIQLPVTVKLEAESLLRTHAVRRPLEIETVRLAAQNCDVHHKRMIRARSAELMAVYEAGEDW
RAADYRFHAALQDASGNPLFGQLIRQIQQGFNEVYEAPFGQAHLGQASIPMHQDIADAVVAGDADKAAALMDEILSMVED
EIRQVMQDMGARDV
>Mature_253_residues
TSLDKSLSDPVSANPVDALSLLPARSSSRDVLEALSLMIETQGLKVGDRLPPEVEIAKHLGIGRAKVREALTGWQNMGIV
TRNKKAGTVLATEVSSNAIQLPVTVKLEAESLLRTHAVRRPLEIETVRLAAQNCDVHHKRMIRARSAELMAVYEAGEDWR
AADYRFHAALQDASGNPLFGQLIRQIQQGFNEVYEAPFGQAHLGQASIPMHQDIADAVVAGDADKAAALMDEILSMVEDE
IRQVMQDMGARDV

Specific function: Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to lutR, leads to derepression of the operon. Also appears to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 27724; Mature: 27593

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLDKSLSDPVSANPVDALSLLPARSSSRDVLEALSLMIETQGLKVGDRLPPEVEIAKH
CCCCCHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LGIGRAKVREALTGWQNMGIVTRNKKAGTVLATEVSSNAIQLPVTVKLEAESLLRTHAVR
CCCCHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCEEEEEEEEEECHHHHHHHHHHC
RPLEIETVRLAAQNCDVHHKRMIRARSAELMAVYEAGEDWRAADYRFHAALQDASGNPLF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHEHEEHEEECCCCCCHH
GQLIRQIQQGFNEVYEAPFGQAHLGQASIPMHQDIADAVVAGDADKAAALMDEILSMVED
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EIRQVMQDMGARDV
HHHHHHHHCCCCCC
>Mature Secondary Structure 
TSLDKSLSDPVSANPVDALSLLPARSSSRDVLEALSLMIETQGLKVGDRLPPEVEIAKH
CCCCHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LGIGRAKVREALTGWQNMGIVTRNKKAGTVLATEVSSNAIQLPVTVKLEAESLLRTHAVR
CCCCHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCEEEEEEEEEECHHHHHHHHHHC
RPLEIETVRLAAQNCDVHHKRMIRARSAELMAVYEAGEDWRAADYRFHAALQDASGNPLF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHEHEEHEEECCCCCCHH
GQLIRQIQQGFNEVYEAPFGQAHLGQASIPMHQDIADAVVAGDADKAAALMDEILSMVED
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EIRQVMQDMGARDV
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]