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The map label for this gene is accC [H]

Identifier: 89055206

GI number: 89055206

Start: 2724255

End: 2725601

Strand: Direct

Name: accC [H]

Synonym: Jann_2715

Alternate gene names: 89055206

Gene position: 2724255-2725601 (Clockwise)

Preceding gene: 89055205

Following gene: 89055207

Centisome position: 63.09

GC content: 62.21

Gene sequence:

>1347_bases
ATGTTCCGCAAGATTCTGATCGCCAACCGTGGCGAGATTGCCCTGCGCGTCATCCGCGCCGCCCGCGAGATGGGCATCGA
AAGCGTTGCCGTCCATTCCACCGCCGACGCGGATGCGATGCACGTGCGCATGGCCGACGAAAGCGTGTGTATCGGCCCGC
CGCCGGGCACTGACAGCTACCTGTCGATGTCCGCGATTCTGTCGGCCTGTGAAATCTCGGGCGCGGAGGCGATCCACCCG
GGCTATGGCTTCCTGTCTGAGAACGCGGCCTTCGTGCAAGCGGTAGAGGATCACGGGATCAAGTTCATCGGCCCGTCGGC
GGAACACATCCGCATGATGGGCGACAAGATCACCGCCAAGGAGACCGCTTTGCGGTTGGGCATTCCCTGTGTTCCCGGCT
CTGCCGGGGGCGTGCCCACGGTGGAGGAGGCCCGCCAGATCGGCGAGGAGTTCGGCTACCCGGTGATCGTGAAGGCCACA
GCCGGTGGCGGCGGGCGCGGCATGAAACTCGCGAAATCCGCGGACGAGATCGACACCGCCTTCAAATCCGCCCGGACCGA
GGCCAAGGCCGCCTTCGGCAATGACGAGGTCTATATCGAGAAGTACCTCGGCACGCCGCGCCATATTGAGGTGCAGGTGT
TTGGCGACGGCAAGGGCCATGCGGTACATCTGGGCGAGCGTGACTGCTCCCTCCAGCGGCGGCACCAGAAGGTGTTTGAG
GAAGCCCCCGGCCCCTCCATCACGCCGGAATTGCGCGACCATATCGGGATGATCTGCGCAAATGCGGTGGGCGAGCTAGG
ATATGAGGGCGCGGGCACCATTGAGTTCTTGTATGAGAATGGCGAGTTCTATTTCATCGAAATGAACACGCGTCTGCAGG
TCGAGCACCCGGTGACCGAGGCGATCATGGGCGTGGATCTGGTGCGCGAACAGATCCGCGTTGCAGCCGGAGAGCCGATG
TCGTTCCGGCAAGATGACCTCCAGGTCCAGGGCCATGCGATCGAGGTGCGGATCAACGCCGAAAAACTGCCCAACTTCTC
GCCCTGCCCTGGCACGATCACGCAATATCACGCGCCCGGTGGCCTTGGGGTGCGCATGGATAGCGCGCTTTATGACGGCT
ATCGCATCCCGCCCTACTACGATTCGCTGATTGCAAAGCTGATTGTCCACGGACGCGACCGGCCCGAGGCGCTTGCGCGG
CTCAACCGGGCGTTGGGCGAGTTGATCGTGGATGGAATCGACACAACGGTGCCGCTGTTTCACGAGCTTTTACAGGCCGA
TGCGGTTCAGACAGGTGATTACACCATCCATTGGCTGGAACATTGGCTGGACGAAAACCTGTCTTAA

Upstream 100 bases:

>100_bases
GGCACCGTCAAGCGCATCGTCGTGGGCGACGGCGCCCCGGTCGAGTTTGGCGCACCGTTGATGATCATCGAATAAGTCAC
AAATTCGGGGGGCCCTGCCC

Downstream 100 bases:

>100_bases
CGAAATTGGCGTAGGATGCGTCCAGCCGGTGCCTTCGAGAGAGGACACCGGCTGGTACACGATCACGTCACGGGGTGCAC
TTGGCGCGGGCGATCCAGCC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFRKILIANRGEIALRVIRAAREMGIESVAVHSTADADAMHVRMADESVCIGPPPGTDSYLSMSAILSACEISGAEAIHP
GYGFLSENAAFVQAVEDHGIKFIGPSAEHIRMMGDKITAKETALRLGIPCVPGSAGGVPTVEEARQIGEEFGYPVIVKAT
AGGGGRGMKLAKSADEIDTAFKSARTEAKAAFGNDEVYIEKYLGTPRHIEVQVFGDGKGHAVHLGERDCSLQRRHQKVFE
EAPGPSITPELRDHIGMICANAVGELGYEGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAIMGVDLVREQIRVAAGEPM
SFRQDDLQVQGHAIEVRINAEKLPNFSPCPGTITQYHAPGGLGVRMDSALYDGYRIPPYYDSLIAKLIVHGRDRPEALAR
LNRALGELIVDGIDTTVPLFHELLQADAVQTGDYTIHWLEHWLDENLS

Sequences:

>Translated_448_residues
MFRKILIANRGEIALRVIRAAREMGIESVAVHSTADADAMHVRMADESVCIGPPPGTDSYLSMSAILSACEISGAEAIHP
GYGFLSENAAFVQAVEDHGIKFIGPSAEHIRMMGDKITAKETALRLGIPCVPGSAGGVPTVEEARQIGEEFGYPVIVKAT
AGGGGRGMKLAKSADEIDTAFKSARTEAKAAFGNDEVYIEKYLGTPRHIEVQVFGDGKGHAVHLGERDCSLQRRHQKVFE
EAPGPSITPELRDHIGMICANAVGELGYEGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAIMGVDLVREQIRVAAGEPM
SFRQDDLQVQGHAIEVRINAEKLPNFSPCPGTITQYHAPGGLGVRMDSALYDGYRIPPYYDSLIAKLIVHGRDRPEALAR
LNRALGELIVDGIDTTVPLFHELLQADAVQTGDYTIHWLEHWLDENLS
>Mature_448_residues
MFRKILIANRGEIALRVIRAAREMGIESVAVHSTADADAMHVRMADESVCIGPPPGTDSYLSMSAILSACEISGAEAIHP
GYGFLSENAAFVQAVEDHGIKFIGPSAEHIRMMGDKITAKETALRLGIPCVPGSAGGVPTVEEARQIGEEFGYPVIVKAT
AGGGGRGMKLAKSADEIDTAFKSARTEAKAAFGNDEVYIEKYLGTPRHIEVQVFGDGKGHAVHLGERDCSLQRRHQKVFE
EAPGPSITPELRDHIGMICANAVGELGYEGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAIMGVDLVREQIRVAAGEPM
SFRQDDLQVQGHAIEVRINAEKLPNFSPCPGTITQYHAPGGLGVRMDSALYDGYRIPPYYDSLIAKLIVHGRDRPEALAR
LNRALGELIVDGIDTTVPLFHELLQADAVQTGDYTIHWLEHWLDENLS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=47.2850678733032, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=47.2850678733032, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=47.2850678733032, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI116805327, Length=423, Percent_Identity=46.8085106382979, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=43.2372505543237, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=43.2372505543237, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=43.2372505543237, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=30.1556420233463, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=30.1556420233463, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=30.1556420233463, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=30.1556420233463, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=30.1556420233463, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI134142062, Length=519, Percent_Identity=30.0578034682081, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=59.009009009009, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=45.2488687782805, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=425, Percent_Identity=46.5882352941176, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=41.7040358744395, Blast_Score=348, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=28.8065843621399, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=25.1968503937008, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=25.1968503937008, Blast_Score=175, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319685, Length=430, Percent_Identity=43.7209302325581, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=42.4107142857143, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=43.0803571428571, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=30.5609284332689, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323863, Length=465, Percent_Identity=30.5376344086021, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=46.5168539325843, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=46.5168539325843, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=46.5168539325843, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=46.5168539325843, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=46.5168539325843, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=46.4125560538117, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=46.4125560538117, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=46.4125560538117, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=46.4125560538117, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=46.4125560538117, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=44.2696629213483, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=42.7872860635697, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=27.8656126482213, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=27.8656126482213, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=27.8656126482213, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=27.8656126482213, Blast_Score=198, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48772; Mature: 48772

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKILIANRGEIALRVIRAAREMGIESVAVHSTADADAMHVRMADESVCIGPPPGTDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEEECCCCCCCHH
LSMSAILSACEISGAEAIHPGYGFLSENAAFVQAVEDHGIKFIGPSAEHIRMMGDKITAK
HHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCCHHHH
ETALRLGIPCVPGSAGGVPTVEEARQIGEEFGYPVIVKATAGGGGRGMKLAKSADEIDTA
HHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCHHHHHHH
FKSARTEAKAAFGNDEVYIEKYLGTPRHIEVQVFGDGKGHAVHLGERDCSLQRRHQKVFE
HHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPGPSITPELRDHIGMICANAVGELGYEGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AIMGVDLVREQIRVAAGEPMSFRQDDLQVQGHAIEVRINAEKLPNFSPCPGTITQYHAPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEEEHHHCCCCCCCCCCCEEEECCC
GLGVRMDSALYDGYRIPPYYDSLIAKLIVHGRDRPEALARLNRALGELIVDGIDTTVPLF
CCCEEECHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
HELLQADAVQTGDYTIHWLEHWLDENLS
HHHHHHCCCCCCCEEHHHHHHHHCCCCC
>Mature Secondary Structure
MFRKILIANRGEIALRVIRAAREMGIESVAVHSTADADAMHVRMADESVCIGPPPGTDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEEECCCCCCCHH
LSMSAILSACEISGAEAIHPGYGFLSENAAFVQAVEDHGIKFIGPSAEHIRMMGDKITAK
HHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCCHHHH
ETALRLGIPCVPGSAGGVPTVEEARQIGEEFGYPVIVKATAGGGGRGMKLAKSADEIDTA
HHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCHHHHHHH
FKSARTEAKAAFGNDEVYIEKYLGTPRHIEVQVFGDGKGHAVHLGERDCSLQRRHQKVFE
HHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPGPSITPELRDHIGMICANAVGELGYEGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AIMGVDLVREQIRVAAGEPMSFRQDDLQVQGHAIEVRINAEKLPNFSPCPGTITQYHAPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEEEHHHCCCCCCCCCCCEEEECCC
GLGVRMDSALYDGYRIPPYYDSLIAKLIVHGRDRPEALARLNRALGELIVDGIDTTVPLF
CCCEEECHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
HELLQADAVQTGDYTIHWLEHWLDENLS
HHHHHHCCCCCCCEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]