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The map label for this gene is bioA [C]

Identifier: 89055200

GI number: 89055200

Start: 2718231

End: 2719562

Strand: Reverse

Name: bioA [C]

Synonym: Jann_2709

Alternate gene names: 89055200

Gene position: 2719562-2718231 (Counterclockwise)

Preceding gene: 89055202

Following gene: 89055199

Centisome position: 62.98

GC content: 61.19

Gene sequence:

>1332_bases
ATGGCTCTCGACCGCAGCAACCCGGTCCCCAATGACCTGAGCGCATTTTGGATGCCGTTCACGGCGAACCGGCAGTTCAA
GCAGACGCCGCGCATGTTCGTGGGTGCAGACAAGATGCACTACACCACCGCCGATGGGCGGCAGGTGCTGGACGGAACGG
CGGGCCTGTGGTGCTGCAATGCGGGCCACAATCAGCCCCGCATCGTGGAGGCGATCCAGAAACAGGCGGCTGAGATGGAT
TATGCGCCCGCCTTTCAAATGGGCCATCCGAAGGCGTTCGAGCTGGCCAACCGCTTGCGGGATATGGCCCCGGACCCGTT
TGAGCATGTATTCTACACCAATTCTGGCTCGGAAAGTGTTGAGACCGCGTTAAAGATCGCCATCGCCTATCAACGCGCCA
TCGGGCAGGGGAGCCGGACCCGCCTGATCGGGCGCGAGCGCGGGTATCACGGGGTGAACTTCGGCGGCATCTCCGTGGGC
GGGATCGTGAACAACCGCAAGGTGTTCGGGTCCTTGCTGACCGGTGTGGACCATCTGCCCGCCACGCATCTGCCTGACCA
GAACCGTTTCGTGAAGGGCCAGCCCGAGCATGGCGCGCATCTGGCCGAGGAATTGGAGCGCATCGTGGCCCTGCATGGCG
CGGAGACGATCGCGGCCTGCATCGTGGAGCCGATGGCAGGCTCCACCGGCGTGCTGATGCCGCCCAAAGGCTATCTGGAA
CGCCTGCGGGAGATCTGTACCAAACACGGTATTATTCTTATTTTTGATGAGGTTATCACCGGTTTTGGCCGTCTGGGCTC
CAGCTTTGCGGCCGCCCATTACAACGTTATGCCCGATCTGATCACCACCGCGAAGGGCCTGACCAATGGTGTGATCCCCA
TGGGCGCGGTCCTGGCCACGAAAGAGATACACGATGCCTTCATGCAGGGGCCCGAGCATCTGATCGAGCTGTTCCACGGC
TACACCTATTCCGGCAATCCCATCGCCTCCGCCGCCGGTCTGGCCACTTTGGAGACCTACAAAGAAGATGGCCTGTTCGA
GCGCGCGGCAGAGTTGGCCCCCTATTGGGCCGATGGCGTGCATTCCCTGCGCGATTGCCCCAATGTGATCGATATCCGCA
GCGAGGGGCTGATCGGCGCGGTGGAACTTGAACCCATCGCGGGCGAGCCCACAAAGCGCGCCTTCCAGGCCTTCCTCGAC
TGCTATGACAAGGGCGTCCTGATCCGCACGACAGGCGACATCATCGCCATGTCACCGCCGCTGATCATCTCGAAAGATGA
GATAGATCAATTGTTTGGCACCTTGCGCGATGTCCTCAAGGGATTGCACTAA

Upstream 100 bases:

>100_bases
TGGATCGTTAACATTGACTGGCACGATTCATTTGCTAGCGTGTCCTTGACCGTTTGGTCAAAAGATTTCGCGCCCGTTTG
GCGCCGCAAGGGGAATAGCC

Downstream 100 bases:

>100_bases
ATGGCTGAGGCGACAGTAGAAACCTTGATTGACGATGCCCGTGTCCGTGTCACGCGGTTTGACTTCGAACCGGGCGATGA
GACGGGCTGGCACACCCACG

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MALDRSNPVPNDLSAFWMPFTANRQFKQTPRMFVGADKMHYTTADGRQVLDGTAGLWCCNAGHNQPRIVEAIQKQAAEMD
YAPAFQMGHPKAFELANRLRDMAPDPFEHVFYTNSGSESVETALKIAIAYQRAIGQGSRTRLIGRERGYHGVNFGGISVG
GIVNNRKVFGSLLTGVDHLPATHLPDQNRFVKGQPEHGAHLAEELERIVALHGAETIAACIVEPMAGSTGVLMPPKGYLE
RLREICTKHGIILIFDEVITGFGRLGSSFAAAHYNVMPDLITTAKGLTNGVIPMGAVLATKEIHDAFMQGPEHLIELFHG
YTYSGNPIASAAGLATLETYKEDGLFERAAELAPYWADGVHSLRDCPNVIDIRSEGLIGAVELEPIAGEPTKRAFQAFLD
CYDKGVLIRTTGDIIAMSPPLIISKDEIDQLFGTLRDVLKGLH

Sequences:

>Translated_443_residues
MALDRSNPVPNDLSAFWMPFTANRQFKQTPRMFVGADKMHYTTADGRQVLDGTAGLWCCNAGHNQPRIVEAIQKQAAEMD
YAPAFQMGHPKAFELANRLRDMAPDPFEHVFYTNSGSESVETALKIAIAYQRAIGQGSRTRLIGRERGYHGVNFGGISVG
GIVNNRKVFGSLLTGVDHLPATHLPDQNRFVKGQPEHGAHLAEELERIVALHGAETIAACIVEPMAGSTGVLMPPKGYLE
RLREICTKHGIILIFDEVITGFGRLGSSFAAAHYNVMPDLITTAKGLTNGVIPMGAVLATKEIHDAFMQGPEHLIELFHG
YTYSGNPIASAAGLATLETYKEDGLFERAAELAPYWADGVHSLRDCPNVIDIRSEGLIGAVELEPIAGEPTKRAFQAFLD
CYDKGVLIRTTGDIIAMSPPLIISKDEIDQLFGTLRDVLKGLH
>Mature_442_residues
ALDRSNPVPNDLSAFWMPFTANRQFKQTPRMFVGADKMHYTTADGRQVLDGTAGLWCCNAGHNQPRIVEAIQKQAAEMDY
APAFQMGHPKAFELANRLRDMAPDPFEHVFYTNSGSESVETALKIAIAYQRAIGQGSRTRLIGRERGYHGVNFGGISVGG
IVNNRKVFGSLLTGVDHLPATHLPDQNRFVKGQPEHGAHLAEELERIVALHGAETIAACIVEPMAGSTGVLMPPKGYLER
LREICTKHGIILIFDEVITGFGRLGSSFAAAHYNVMPDLITTAKGLTNGVIPMGAVLATKEIHDAFMQGPEHLIELFHGY
TYSGNPIASAAGLATLETYKEDGLFERAAELAPYWADGVHSLRDCPNVIDIRSEGLIGAVELEPIAGEPTKRAFQAFLDC
YDKGVLIRTTGDIIAMSPPLIISKDEIDQLFGTLRDVLKGLH

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=30.2325581395349, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=27.9596977329975, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=29.6875, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=26.6666666666667, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=27.0676691729323, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=26.4367816091954, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI24119277, Length=441, Percent_Identity=25.8503401360544, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=33.0188679245283, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI145693181, Length=404, Percent_Identity=30.4455445544554, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=29.0243902439024, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=29.4573643410853, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=439, Percent_Identity=29.8405466970387, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788044, Length=386, Percent_Identity=28.2383419689119, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=28.0346820809249, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=30.0236406619385, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25144271, Length=412, Percent_Identity=26.4563106796117, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=218, Percent_Identity=33.4862385321101, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=25.6818181818182, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=23.6658932714617, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=30.0947867298578, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324386, Length=427, Percent_Identity=26.2295081967213, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=26.980198019802, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=288, Percent_Identity=26.0416666666667, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161085790, Length=466, Percent_Identity=27.8969957081545, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI28574759, Length=450, Percent_Identity=28, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357415, Length=401, Percent_Identity=26.4339152119701, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI21356575, Length=442, Percent_Identity=28.2805429864253, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48289; Mature: 48158

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDRSNPVPNDLSAFWMPFTANRQFKQTPRMFVGADKMHYTTADGRQVLDGTAGLWCCN
CCCCCCCCCCCCCHHEEECCCCCCCHHHCCCCEECCCCEEEECCCCCHHHCCCCCEEEEC
AGHNQPRIVEAIQKQAAEMDYAPAFQMGHPKAFELANRLRDMAPDPFEHVFYTNSGSESV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEEECCCCHHH
ETALKIAIAYQRAIGQGSRTRLIGRERGYHGVNFGGISVGGIVNNRKVFGSLLTGVDHLP
HHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCEEECCEECCHHHHHHHHHHHHCCC
ATHLPDQNRFVKGQPEHGAHLAEELERIVALHGAETIAACIVEPMAGSTGVLMPPKGYLE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCHHHHH
RLREICTKHGIILIFDEVITGFGRLGSSFAAAHYNVMPDLITTAKGLTNGVIPMGAVLAT
HHHHHHHHCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KEIHDAFMQGPEHLIELFHGYTYSGNPIASAAGLATLETYKEDGLFERAAELAPYWADGV
HHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHH
HSLRDCPNVIDIRSEGLIGAVELEPIAGEPTKRAFQAFLDCYDKGVLIRTTGDIIAMSPP
HHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCC
LIISKDEIDQLFGTLRDVLKGLH
EEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALDRSNPVPNDLSAFWMPFTANRQFKQTPRMFVGADKMHYTTADGRQVLDGTAGLWCCN
CCCCCCCCCCCCHHEEECCCCCCCHHHCCCCEECCCCEEEECCCCCHHHCCCCCEEEEC
AGHNQPRIVEAIQKQAAEMDYAPAFQMGHPKAFELANRLRDMAPDPFEHVFYTNSGSESV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEEECCCCHHH
ETALKIAIAYQRAIGQGSRTRLIGRERGYHGVNFGGISVGGIVNNRKVFGSLLTGVDHLP
HHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCEEECCEECCHHHHHHHHHHHHCCC
ATHLPDQNRFVKGQPEHGAHLAEELERIVALHGAETIAACIVEPMAGSTGVLMPPKGYLE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCHHHHH
RLREICTKHGIILIFDEVITGFGRLGSSFAAAHYNVMPDLITTAKGLTNGVIPMGAVLAT
HHHHHHHHCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KEIHDAFMQGPEHLIELFHGYTYSGNPIASAAGLATLETYKEDGLFERAAELAPYWADGV
HHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHH
HSLRDCPNVIDIRSEGLIGAVELEPIAGEPTKRAFQAFLDCYDKGVLIRTTGDIIAMSPP
HHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCC
LIISKDEIDQLFGTLRDVLKGLH
EEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]