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The map label for this gene is helC [H]

Identifier: 89055140

GI number: 89055140

Start: 2663292

End: 2664035

Strand: Direct

Name: helC [H]

Synonym: Jann_2649

Alternate gene names: 89055140

Gene position: 2663292-2664035 (Clockwise)

Preceding gene: 89055139

Following gene: 89055141

Centisome position: 61.68

GC content: 61.69

Gene sequence:

>744_bases
ATGTTCCCGCCCATGTCCTCGATCTGGGAATACGCGAACCCGCGACGGTTCATGGCCACGTCCGGCGCGATCCTTCCCTG
GGTCTCGGCGCTTGCCGCATTGGTCCTGGGTGTTGGTCTGATCTGGGGATTTTTCTTCACGCCCGATGACTTCCGCATGG
GTTCCACCGTGAAGATCATCTACATCCATGTGCCCGCCGCGATCATGGCGACGTCCGCTTGGTTCATGATGCTGGTGACA
TCGCTGATCTGGGTGATCCGCCGCCATCACGTCAGCGCTCTGGCAGCAAAGGCCGCCGCGCCCATTGGTCTGGTCTTCAC
TCTGATCGGGCTGTTTACCGGCGCTGTCTGGGGGCAACCGATGTGGGGCACCTGGTGGGCCTGGGATCCGCGCCTGACCT
CATTCCTGATCCTGTTCCTCTTTTATCTGGGCTACATCGCGCTGTGGGAGGCAGTTGAAAACCCCGATGCGGCAGCTGAT
CTGACCTCGGTCCTGTGCCTCGTGGGGACGGTCTTTGCCGTCATCTCGCGCTACGCGATCCTGTTCTGGAACCAGGGCCT
GCATCAGGGCGCGTCGCTGAGCATGGACGCGGAGGAGAACGTGGCCGATGTCTTCGCCTATCCGCTGTGGACCTGTATCG
GCGGGTTTTTCCTGCTGTTCGTGGCGCTGGTGCTGTACCGGACCAGAACCGAAATCCGCGCGCGCCGCCTCAAGGCGTTG
ATTGCGCAGGAGCAAATGGCCTGA

Upstream 100 bases:

>100_bases
GCCTGCGCCGTCCTGCCCTTTGCAGCCGCCGCCGCGCTCCGCGTCAATCTGCGCTAGTTTGCGTCCGATCGCCCCATTGT
GACGCGCAAATCTCCCGCCT

Downstream 100 bases:

>100_bases
TGGTGGATCTGGGGCAATATGCGGGGCCGGTGCTGGCGGCCTATGCTGGCACGATTGCGTGCCTGATCGGGCTTGTGGGG
GCGTCCGTCATGCGCGCCCG

Product: heme exporter protein CcmC

Products: NA

Alternate protein names: Cytochrome c-type biogenesis protein HelC [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MFPPMSSIWEYANPRRFMATSGAILPWVSALAALVLGVGLIWGFFFTPDDFRMGSTVKIIYIHVPAAIMATSAWFMMLVT
SLIWVIRRHHVSALAAKAAAPIGLVFTLIGLFTGAVWGQPMWGTWWAWDPRLTSFLILFLFYLGYIALWEAVENPDAAAD
LTSVLCLVGTVFAVISRYAILFWNQGLHQGASLSMDAEENVADVFAYPLWTCIGGFFLLFVALVLYRTRTEIRARRLKAL
IAQEQMA

Sequences:

>Translated_247_residues
MFPPMSSIWEYANPRRFMATSGAILPWVSALAALVLGVGLIWGFFFTPDDFRMGSTVKIIYIHVPAAIMATSAWFMMLVT
SLIWVIRRHHVSALAAKAAAPIGLVFTLIGLFTGAVWGQPMWGTWWAWDPRLTSFLILFLFYLGYIALWEAVENPDAAAD
LTSVLCLVGTVFAVISRYAILFWNQGLHQGASLSMDAEENVADVFAYPLWTCIGGFFLLFVALVLYRTRTEIRARRLKAL
IAQEQMA
>Mature_247_residues
MFPPMSSIWEYANPRRFMATSGAILPWVSALAALVLGVGLIWGFFFTPDDFRMGSTVKIIYIHVPAAIMATSAWFMMLVT
SLIWVIRRHHVSALAAKAAAPIGLVFTLIGLFTGAVWGQPMWGTWWAWDPRLTSFLILFLFYLGYIALWEAVENPDAAAD
LTSVLCLVGTVFAVISRYAILFWNQGLHQGASLSMDAEENVADVFAYPLWTCIGGFFLLFVALVLYRTRTEIRARRLKAL
IAQEQMA

Specific function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes [H]

COG id: COG0755

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmC/CycZ/HelC family [H]

Homologues:

Organism=Escherichia coli, GI1788527, Length=223, Percent_Identity=42.152466367713, Blast_Score=167, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002541
- InterPro:   IPR003557 [H]

Pfam domain/function: PF01578 Cytochrom_C_asm [H]

EC number: NA

Molecular weight: Translated: 27623; Mature: 27623

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCC
>Mature Secondary Structure
MFPPMSSIWEYANPRRFMATSGAILPWVSALAALVLGVGLIWGFFFTPDDFRMGSTVKII
CCCCHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
YIHVPAAIMATSAWFMMLVTSLIWVIRRHHVSALAAKAAAPIGLVFTLIGLFTGAVWGQP
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
MWGTWWAWDPRLTSFLILFLFYLGYIALWEAVENPDAAADLTSVLCLVGTVFAVISRYAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFWNQGLHQGASLSMDAEENVADVFAYPLWTCIGGFFLLFVALVLYRTRTEIRARRLKAL
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAQEQMA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1310666 [H]