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The map label for this gene is cpx [H]

Identifier: 89055097

GI number: 89055097

Start: 2621913

End: 2623349

Strand: Reverse

Name: cpx [H]

Synonym: Jann_2606

Alternate gene names: 89055097

Gene position: 2623349-2621913 (Counterclockwise)

Preceding gene: 89055098

Following gene: 89055083

Centisome position: 60.75

GC content: 61.8

Gene sequence:

>1437_bases
ATGGCCGATCATTCACTCGGAACGCCGGAGCAGCTCCGCGATCCAAATTTCACACCACCGCTCTACAAAGCGGTGCCGCT
CGGCATTCAGCACGTTCTGGCGATGTTCGTGTCCAACGTGACGCCTGCAATTATCGTGGCGGGCGCAGCGGGCTTCGGCT
TTGGGTCCAACAGCCCCGACTTCCCCGAACTTCTGTACCTGATCCAGATGTCGATGCTGTTTGCGGGCGTGGCGACCCTG
CTGCAAACGATCTCCATCGGTCCAATTGGGGCGAAATTGCCCATCGTACAGGGCACGTCATTTGCCTTCCTGCCGATCAT
GATCCCGCTGGTGGCGGGGCAGGGTGTGGACGCATTGGCCGCGCTCTTCACCGGTGTCATCATCGGGGGCCTGTTCCACG
GCTTCCTCGGTCTGTTCATTGGCAAGATACGGTTCGCGCTGCCGCCGCTGGTCACCGGCCTTGTCGTGACGATGATCGGT
CTGGCGCTGGTGCGCGTGGGCATCCAGTACGCCGCAGGTGGGGTGCCTGCCATCGGTACGCCGGAATATGGCTCGCTCGG
CAACTGGATCGTGGCGTGCATCGTGATCGCTGTGACCCTGGGCCTGAAGTTCTTTGCCCGCGGTATGCTGTCGATCTCGG
CGGTTCTGATCGGTTTGGCCGTGGGTTACGCCTACTGCCTGTTTTTCACCGATATGCTCAGCTTTGAGGCCATCGCCACA
TCCTGGGATCGCGCCGCCGTCTTCGCGCTGCCGCGCCCGTTTGCCTATGGGTTTGAATTCTCCGTCGCGGCCATCCTCGG
TTTCTGCCTGATGTCTTTCGTCTCTGCCGTTGAAACGGTGGGCGACGTGTCGGGCATCACCAAGGGCGGCGCCGGTCGTG
AAGCAACGGATGAAGAGATCCAGGGCGCGACCTTCGCCGATGGTGTCGGTACGGCGTTTGCGGGCCTCTTTGGTGGCTTC
CCGAACACGAGCTTCTCTCAGAATGTTGGTCTGATTGCGATGACCGGCGTGATGAGCCGCCACGTTGTAACCTGCGGTGC
GATCTTCCTGATCATCTGCGGCCTCGTGCCCAAGGTGGGTGGTTTGATCCGCACCATCCCGATCGAGGTTCTGGGCGGCG
GCGTCATCGTCATGTTCGGCATGGTCGTGGCCGCCGGTATTTCCATGCTGTCAGACGTGAACTGGAACCGGCGCAATATG
GTGATCTTCGCGGTCGCTTTGTCGATAGGTCTTGGCCTGCAGCTGGAGCCGGGGGCCGTGCAATACCTGCCCGATTGGGG
GCGTGTGCTGATGGTTTCGGGTCTGTTGCCCGCCGCCTTCATCGCGATTGTGCTGAACCTGATCCTGCCGGAGGAATTGT
CCGGTGAGGCCACCGAGGAAGTCTCGGGCGGCATGGCGGGCCACGGGTCCGGCAGCCTTCCGGGATCAGACAGCTAG

Upstream 100 bases:

>100_bases
AACCTGGAAGAACACCGGCTCGACACCCCGTATTCGGTCGAGCCGGGACTACACTGCATCAGCGCGGGGCTGGTTTAGGG
CTATCTTGGGAGGGACACAA

Downstream 100 bases:

>100_bases
GCCGTTCTGAAGACATGAAAAAGGGGCGTGGCGCTGTTTGGCCCCACGCCCCTTCTTGTATTCTGTTGTCGCGCTCTAGA
AGTCGACCTCAATCGCCACG

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MADHSLGTPEQLRDPNFTPPLYKAVPLGIQHVLAMFVSNVTPAIIVAGAAGFGFGSNSPDFPELLYLIQMSMLFAGVATL
LQTISIGPIGAKLPIVQGTSFAFLPIMIPLVAGQGVDALAALFTGVIIGGLFHGFLGLFIGKIRFALPPLVTGLVVTMIG
LALVRVGIQYAAGGVPAIGTPEYGSLGNWIVACIVIAVTLGLKFFARGMLSISAVLIGLAVGYAYCLFFTDMLSFEAIAT
SWDRAAVFALPRPFAYGFEFSVAAILGFCLMSFVSAVETVGDVSGITKGGAGREATDEEIQGATFADGVGTAFAGLFGGF
PNTSFSQNVGLIAMTGVMSRHVVTCGAIFLIICGLVPKVGGLIRTIPIEVLGGGVIVMFGMVVAAGISMLSDVNWNRRNM
VIFAVALSIGLGLQLEPGAVQYLPDWGRVLMVSGLLPAAFIAIVLNLILPEELSGEATEEVSGGMAGHGSGSLPGSDS

Sequences:

>Translated_478_residues
MADHSLGTPEQLRDPNFTPPLYKAVPLGIQHVLAMFVSNVTPAIIVAGAAGFGFGSNSPDFPELLYLIQMSMLFAGVATL
LQTISIGPIGAKLPIVQGTSFAFLPIMIPLVAGQGVDALAALFTGVIIGGLFHGFLGLFIGKIRFALPPLVTGLVVTMIG
LALVRVGIQYAAGGVPAIGTPEYGSLGNWIVACIVIAVTLGLKFFARGMLSISAVLIGLAVGYAYCLFFTDMLSFEAIAT
SWDRAAVFALPRPFAYGFEFSVAAILGFCLMSFVSAVETVGDVSGITKGGAGREATDEEIQGATFADGVGTAFAGLFGGF
PNTSFSQNVGLIAMTGVMSRHVVTCGAIFLIICGLVPKVGGLIRTIPIEVLGGGVIVMFGMVVAAGISMLSDVNWNRRNM
VIFAVALSIGLGLQLEPGAVQYLPDWGRVLMVSGLLPAAFIAIVLNLILPEELSGEATEEVSGGMAGHGSGSLPGSDS
>Mature_477_residues
ADHSLGTPEQLRDPNFTPPLYKAVPLGIQHVLAMFVSNVTPAIIVAGAAGFGFGSNSPDFPELLYLIQMSMLFAGVATLL
QTISIGPIGAKLPIVQGTSFAFLPIMIPLVAGQGVDALAALFTGVIIGGLFHGFLGLFIGKIRFALPPLVTGLVVTMIGL
ALVRVGIQYAAGGVPAIGTPEYGSLGNWIVACIVIAVTLGLKFFARGMLSISAVLIGLAVGYAYCLFFTDMLSFEAIATS
WDRAAVFALPRPFAYGFEFSVAAILGFCLMSFVSAVETVGDVSGITKGGAGREATDEEIQGATFADGVGTAFAGLFGGFP
NTSFSQNVGLIAMTGVMSRHVVTCGAIFLIICGLVPKVGGLIRTIPIEVLGGGVIVMFGMVVAAGISMLSDVNWNRRNMV
IFAVALSIGLGLQLEPGAVQYLPDWGRVLMVSGLLPAAFIAIVLNLILPEELSGEATEEVSGGMAGHGSGSLPGSDS

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=525, Percent_Identity=24.7619047619048, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI40316845, Length=525, Percent_Identity=24.7619047619048, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI44680143, Length=236, Percent_Identity=28.8135593220339, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI44680145, Length=236, Percent_Identity=28.8135593220339, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790087, Length=446, Percent_Identity=32.9596412556054, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI87082178, Length=461, Percent_Identity=32.7548806941432, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082181, Length=430, Percent_Identity=34.8837209302326, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788843, Length=478, Percent_Identity=29.2887029288703, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI87081818, Length=482, Percent_Identity=28.0082987551867, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558856, Length=501, Percent_Identity=25.5489021956088, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17541904, Length=397, Percent_Identity=26.1964735516373, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=390, Percent_Identity=23.5897435897436, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356175, Length=458, Percent_Identity=24.8908296943231, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49316; Mature: 49185

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADHSLGTPEQLRDPNFTPPLYKAVPLGIQHVLAMFVSNVTPAIIVAGAAGFGFGSNSPD
CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCC
FPELLYLIQMSMLFAGVATLLQTISIGPIGAKLPIVQGTSFAFLPIMIPLVAGQGVDALA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCHHHHH
ALFTGVIIGGLFHGFLGLFIGKIRFALPPLVTGLVVTMIGLALVRVGIQYAAGGVPAIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEYGSLGNWIVACIVIAVTLGLKFFARGMLSISAVLIGLAVGYAYCLFFTDMLSFEAIAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWDRAAVFALPRPFAYGFEFSVAAILGFCLMSFVSAVETVGDVSGITKGGAGREATDEEI
CCCCCEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
QGATFADGVGTAFAGLFGGFPNTSFSQNVGLIAMTGVMSRHVVTCGAIFLIICGLVPKVG
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLIRTIPIEVLGGGVIVMFGMVVAAGISMLSDVNWNRRNMVIFAVALSIGLGLQLEPGAV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCCC
QYLPDWGRVLMVSGLLPAAFIAIVLNLILPEELSGEATEEVSGGMAGHGSGSLPGSDS
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]