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The map label for this gene is argH2 [H]

Identifier: 89055075

GI number: 89055075

Start: 2593675

End: 2595165

Strand: Reverse

Name: argH2 [H]

Synonym: Jann_2584

Alternate gene names: 89055075

Gene position: 2595165-2593675 (Counterclockwise)

Preceding gene: 89055076

Following gene: 89055074

Centisome position: 60.1

GC content: 63.11

Gene sequence:

>1491_bases
ATGACGGACACAAGCACCTTCCCCGATCCCACTTACCGCGACACCGTCCTTGCGCCGCTGTTTGAAGGCGTGAAGATCCA
TTTCGCGGACCACATGGACCGCATCAACCGCGCCCATCTGGTGATGTTGGTCGAGACCGGAATAGTGCTGCGAGAAGATG
GCGAAGCCATCGCCGAGGCACTGGCGGATATCGAGACGAATGTCGACCGGCAAGCGCTTGACTACACAGGAGAACATGAG
GATTGGTTCTTCCTGGTTGAGGCCGAGTTGCGCGCCCGTCTGGGCGACCTGGGCGGGGCGCTGCACACGGCACGGTCGCG
CAACGACATGGATCACACCATGTTCAAGATGGCCCTTCGCGACCGGGCGGAGAACGCTTTGGCGCGCATGTTGACCCTCG
CGCAGGCTCTGTTGGACAAGGCGCGGGCGGAGCGGGACACGCTCATTGTCGCCTACACCCACGGCCAGCCCGCGCAGCCC
GCCACCTTCGGCCATTATCTCTCTGCGGTGATCGAAGTGCTTGTATCCGACGCCAGGCGCCTGGAGACGGCGATAACGCA
TGTCGACCATTGCCCCATGGGCGCGGCGGCCATCACCACCTCTGGCTTCCCGATTGATCGAGAGCGGATGGCGGAGCTGT
TGGGTTTCGCGGGCGTTCGGGTCAATGCCTACGGGTGTATCGCCGGTGTGGATTATGTCACGGGTCTTTACTCGGCGTTG
AAACTGCCAATGATCCATCTGGGCCGAGTGGTGCAGGATATGGCGTTCTGGTCCGCGTTTGAGGTGGGGCAGCTGTATGT
GCCACGCGCTTTGGTCCAGATCAGCTCCATCATGCCGCAGAAGCGCAACCCGGTGCCGATTGAGCATTTGCGCCACCTTG
CGTCAGTGGCGGCCGGGCGGTGCGATGCCATGATCAACACGATGCACAACACGCCCTTCACGGACATGAACGACAGCGAA
GGCGAGGTGCAGCAGGCGGGGTACGGCGCGTTTGATCATGCGACCCGCGTATTTGATCTGCTGACGGCGTTTCTGCCAGC
CTGCTCCATCAATGCGGACCGTGTGGCACAGACGACGGATGCGGCTTGTATCACGATTACCGAATTGGCCGACACACTGG
TGCGCGATGAGGGGCTGAGCTTCCGCCTGGCCCATGACATTGCATCGCAAACGGCGCGCGCCGTGATCGCTGACGCTCGG
CCCCTCGGCGGCGGCTACGCCGCCTTCTCGCAGGCGTTTGAGGCGGCCACGGGCAAGCCGCCGAAGCTGAACGCGGCAGA
GTTTGCCGAAGCGGTAGACGCGCGCACCTTTGTTTCGCGCCGGGATCGCACCGGCGGACCTGCACCCGCCGCTCTGGACG
CAGCGTTCGAGATCTATTCGAGTGATATCAACGCCCTGAAAGGCGACCTTAAAGCACGCCTCACCCGTCGTGACGCCGCC
GCCGGCGCCCTCGACACCGCATTCGACGCCCTCCTGAAAGGCCCCCGATGA

Upstream 100 bases:

>100_bases
ATTACGGTTTGGCGATGACGCTCGACTTCCTTGATCCCGATGGCAACGAGTTGGAACTTGTGTGCTATGATGCGGGCGCG
GTTCGGGCAGGTCTGGGACG

Downstream 100 bases:

>100_bases
CCGATCTGATCCTTCGCGACCTCGTCAAGACATTCGGCGAGACCGAGGTCCTGCACTCGATCAACCTGACCGTGAACCCC
GGCGAGTTCGTCGTGCTGGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTDTSTFPDPTYRDTVLAPLFEGVKIHFADHMDRINRAHLVMLVETGIVLREDGEAIAEALADIETNVDRQALDYTGEHE
DWFFLVEAELRARLGDLGGALHTARSRNDMDHTMFKMALRDRAENALARMLTLAQALLDKARAERDTLIVAYTHGQPAQP
ATFGHYLSAVIEVLVSDARRLETAITHVDHCPMGAAAITTSGFPIDRERMAELLGFAGVRVNAYGCIAGVDYVTGLYSAL
KLPMIHLGRVVQDMAFWSAFEVGQLYVPRALVQISSIMPQKRNPVPIEHLRHLASVAAGRCDAMINTMHNTPFTDMNDSE
GEVQQAGYGAFDHATRVFDLLTAFLPACSINADRVAQTTDAACITITELADTLVRDEGLSFRLAHDIASQTARAVIADAR
PLGGGYAAFSQAFEAATGKPPKLNAAEFAEAVDARTFVSRRDRTGGPAPAALDAAFEIYSSDINALKGDLKARLTRRDAA
AGALDTAFDALLKGPR

Sequences:

>Translated_496_residues
MTDTSTFPDPTYRDTVLAPLFEGVKIHFADHMDRINRAHLVMLVETGIVLREDGEAIAEALADIETNVDRQALDYTGEHE
DWFFLVEAELRARLGDLGGALHTARSRNDMDHTMFKMALRDRAENALARMLTLAQALLDKARAERDTLIVAYTHGQPAQP
ATFGHYLSAVIEVLVSDARRLETAITHVDHCPMGAAAITTSGFPIDRERMAELLGFAGVRVNAYGCIAGVDYVTGLYSAL
KLPMIHLGRVVQDMAFWSAFEVGQLYVPRALVQISSIMPQKRNPVPIEHLRHLASVAAGRCDAMINTMHNTPFTDMNDSE
GEVQQAGYGAFDHATRVFDLLTAFLPACSINADRVAQTTDAACITITELADTLVRDEGLSFRLAHDIASQTARAVIADAR
PLGGGYAAFSQAFEAATGKPPKLNAAEFAEAVDARTFVSRRDRTGGPAPAALDAAFEIYSSDINALKGDLKARLTRRDAA
AGALDTAFDALLKGPR
>Mature_495_residues
TDTSTFPDPTYRDTVLAPLFEGVKIHFADHMDRINRAHLVMLVETGIVLREDGEAIAEALADIETNVDRQALDYTGEHED
WFFLVEAELRARLGDLGGALHTARSRNDMDHTMFKMALRDRAENALARMLTLAQALLDKARAERDTLIVAYTHGQPAQPA
TFGHYLSAVIEVLVSDARRLETAITHVDHCPMGAAAITTSGFPIDRERMAELLGFAGVRVNAYGCIAGVDYVTGLYSALK
LPMIHLGRVVQDMAFWSAFEVGQLYVPRALVQISSIMPQKRNPVPIEHLRHLASVAAGRCDAMINTMHNTPFTDMNDSEG
EVQQAGYGAFDHATRVFDLLTAFLPACSINADRVAQTTDAACITITELADTLVRDEGLSFRLAHDIASQTARAVIADARP
LGGGYAAFSQAFEAATGKPPKLNAAEFAEAVDARTFVSRRDRTGGPAPAALDAAFEIYSSDINALKGDLKARLTRRDAAA
GALDTAFDALLKGPR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=355, Percent_Identity=27.3239436619718, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI68303542, Length=355, Percent_Identity=27.3239436619718, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI68303547, Length=355, Percent_Identity=25.9154929577465, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI68303549, Length=355, Percent_Identity=25.6338028169014, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1790398, Length=363, Percent_Identity=31.6804407713499, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321806, Length=429, Percent_Identity=28.6713286713287, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221473854, Length=316, Percent_Identity=30.0632911392405, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI78706858, Length=316, Percent_Identity=30.0632911392405, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53883; Mature: 53751

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTSTFPDPTYRDTVLAPLFEGVKIHFADHMDRINRAHLVMLVETGIVLREDGEAIAEA
CCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHCHHHEEEEEECCEEEECCCHHHHHH
LADIETNVDRQALDYTGEHEDWFFLVEAELRARLGDLGGALHTARSRNDMDHTMFKMALR
HHHHHHCCCHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DRAENALARMLTLAQALLDKARAERDTLIVAYTHGQPAQPATFGHYLSAVIEVLVSDARR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LETAITHVDHCPMGAAAITTSGFPIDRERMAELLGFAGVRVNAYGCIAGVDYVTGLYSAL
HHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHH
KLPMIHLGRVVQDMAFWSAFEVGQLYVPRALVQISSIMPQKRNPVPIEHLRHLASVAAGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
CDAMINTMHNTPFTDMNDSEGEVQQAGYGAFDHATRVFDLLTAFLPACSINADRVAQTTD
HHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
AACITITELADTLVRDEGLSFRLAHDIASQTARAVIADARPLGGGYAAFSQAFEAATGKP
CHHEEHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
PKLNAAEFAEAVDARTFVSRRDRTGGPAPAALDAAFEIYSSDINALKGDLKARLTRRDAA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGALDTAFDALLKGPR
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDTSTFPDPTYRDTVLAPLFEGVKIHFADHMDRINRAHLVMLVETGIVLREDGEAIAEA
CCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHCHHHEEEEEECCEEEECCCHHHHHH
LADIETNVDRQALDYTGEHEDWFFLVEAELRARLGDLGGALHTARSRNDMDHTMFKMALR
HHHHHHCCCHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DRAENALARMLTLAQALLDKARAERDTLIVAYTHGQPAQPATFGHYLSAVIEVLVSDARR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LETAITHVDHCPMGAAAITTSGFPIDRERMAELLGFAGVRVNAYGCIAGVDYVTGLYSAL
HHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHH
KLPMIHLGRVVQDMAFWSAFEVGQLYVPRALVQISSIMPQKRNPVPIEHLRHLASVAAGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
CDAMINTMHNTPFTDMNDSEGEVQQAGYGAFDHATRVFDLLTAFLPACSINADRVAQTTD
HHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
AACITITELADTLVRDEGLSFRLAHDIASQTARAVIADARPLGGGYAAFSQAFEAATGKP
CHHEEHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
PKLNAAEFAEAVDARTFVSRRDRTGGPAPAALDAAFEIYSSDINALKGDLKARLTRRDAA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGALDTAFDALLKGPR
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]