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The map label for this gene is pyrH

Identifier: 89054951

GI number: 89054951

Start: 2453861

End: 2454610

Strand: Reverse

Name: pyrH

Synonym: Jann_2460

Alternate gene names: 89054951

Gene position: 2454610-2453861 (Counterclockwise)

Preceding gene: 89054959

Following gene: 89054950

Centisome position: 56.85

GC content: 62.93

Gene sequence:

>750_bases
ATGCCAAATGATGTCACCCCAGGTCACCCAGCCGGGGACGACGCAAAATACGCCCGCGTCATGCTGAAGATATCGGGCGA
GGCGCTGATGGGCGATCAGGGGTTCGGGCTGCACCCGCCCACGGTGGAGCGGATCGCACGGGAGATCCAATCCGTCCATG
ATATGGGGGTGGAGATCTGTCTGGTAATCGGCGGCGGCAACATCTTTCGCGGCTTGCAGGGCAGCGCCCAGGGGATGGAG
CGGACGACCGCCGATTATATGGGGATGCTGGCCACGGTGATGAACGCGCTGGCGATGCAGGGCGCGTTGGAGAGCCTGGG
CGTCTACACCCGGGTGATCTCAGCCATCACGATGAATGAGGTAGCGGAGCCTTATATCCGCCGCCGGGCCATTCGGCACC
TTGAGAAAAAGCGCGTCTGCATTTTCGCGGCGGGCACGGGCAACCCTTATTTCACCACCGATACGGCGGCGACCCTGCGG
GCCTCGGAAATGGATTGCGAGGCGATCTTCAAGGGCACCAAGGTGGACGGCGTCTACGACAAGGACCCCGCCAAACATGC
CGACGCCAAGCGGTACGAGACGGTGACCTATGACGAGGTGCTGGCGCAGCATCTGGGCGTGATGGACGCCTCGGCCATCG
CATTGGCGCGGGAGAACAAGCTGCCGATCATGGTGTTCTCGCTCGACGAGCCGGGCGGGTTCCGGTCCATTCTGGACGGG
ACGGGGACCTATACGAAGGTCGTGGAATAG

Upstream 100 bases:

>100_bases
GGTCGTTCTTCAAGTTGCGCGGAGTGTGGCGGATGGGGCGTTGAACCGGCGCGCCATTTAGACCATTCTCGCGCCGCAAG
ATCAAACAAGGATGAGCCCC

Downstream 100 bases:

>100_bases
GCGCGTCCTTGCGGGAGGATGCGTGAAAGCAGCGGCTGACTGTGCGCCTTGAGGGCCCGCATCGCGCTGTTGTCGAGCCC
GGCACCGAAGGTCGCCTGAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPNDVTPGHPAGDDAKYARVMLKISGEALMGDQGFGLHPPTVERIAREIQSVHDMGVEICLVIGGGNIFRGLQGSAQGME
RTTADYMGMLATVMNALAMQGALESLGVYTRVISAITMNEVAEPYIRRRAIRHLEKKRVCIFAAGTGNPYFTTDTAATLR
ASEMDCEAIFKGTKVDGVYDKDPAKHADAKRYETVTYDEVLAQHLGVMDASAIALARENKLPIMVFSLDEPGGFRSILDG
TGTYTKVVE

Sequences:

>Translated_249_residues
MPNDVTPGHPAGDDAKYARVMLKISGEALMGDQGFGLHPPTVERIAREIQSVHDMGVEICLVIGGGNIFRGLQGSAQGME
RTTADYMGMLATVMNALAMQGALESLGVYTRVISAITMNEVAEPYIRRRAIRHLEKKRVCIFAAGTGNPYFTTDTAATLR
ASEMDCEAIFKGTKVDGVYDKDPAKHADAKRYETVTYDEVLAQHLGVMDASAIALARENKLPIMVFSLDEPGGFRSILDG
TGTYTKVVE
>Mature_248_residues
PNDVTPGHPAGDDAKYARVMLKISGEALMGDQGFGLHPPTVERIAREIQSVHDMGVEICLVIGGGNIFRGLQGSAQGMER
TTADYMGMLATVMNALAMQGALESLGVYTRVISAITMNEVAEPYIRRRAIRHLEKKRVCIFAAGTGNPYFTTDTAATLRA
SEMDCEAIFKGTKVDGVYDKDPAKHADAKRYETVTYDEVLAQHLGVMDASAIALARENKLPIMVFSLDEPGGFRSILDGT
GTYTKVVE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=48.4978540772532, Blast_Score=230, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_JANSC (Q28PI5)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510402.1
- ProteinModelPortal:   Q28PI5
- SMR:   Q28PI5
- STRING:   Q28PI5
- GeneID:   3934917
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2460
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q28PI5
- ProtClustDB:   PRK00358
- BioCyc:   JSP290400:JANN_2460-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26964; Mature: 26833

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: BINDING 65-65 BINDING 66-66 BINDING 70-70 BINDING 85-85 BINDING 173-173 BINDING 179-179 BINDING 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNDVTPGHPAGDDAKYARVMLKISGEALMGDQGFGLHPPTVERIAREIQSVHDMGVEIC
CCCCCCCCCCCCCCHHHHEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
LVIGGGNIFRGLQGSAQGMERTTADYMGMLATVMNALAMQGALESLGVYTRVISAITMNE
EEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAEPYIRRRAIRHLEKKRVCIFAAGTGNPYFTTDTAATLRASEMDCEAIFKGTKVDGVYD
HHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCHHHHHHCCCCHHHHHCCCCCCCCCC
KDPAKHADAKRYETVTYDEVLAQHLGVMDASAIALARENKLPIMVFSLDEPGGFRSILDG
CCCCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHECCCCCCEEEEECCCCCCHHHHHCC
TGTYTKVVE
CCCEEEECC
>Mature Secondary Structure 
PNDVTPGHPAGDDAKYARVMLKISGEALMGDQGFGLHPPTVERIAREIQSVHDMGVEIC
CCCCCCCCCCCCCHHHHEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
LVIGGGNIFRGLQGSAQGMERTTADYMGMLATVMNALAMQGALESLGVYTRVISAITMNE
EEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAEPYIRRRAIRHLEKKRVCIFAAGTGNPYFTTDTAATLRASEMDCEAIFKGTKVDGVYD
HHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCHHHHHHCCCCHHHHHCCCCCCCCCC
KDPAKHADAKRYETVTYDEVLAQHLGVMDASAIALARENKLPIMVFSLDEPGGFRSILDG
CCCCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHECCCCCCEEEEECCCCCCHHHHHCC
TGTYTKVVE
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA