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The map label for this gene is dxr

Identifier: 89054946

GI number: 89054946

Start: 2449022

End: 2450203

Strand: Reverse

Name: dxr

Synonym: Jann_2455

Alternate gene names: 89054946

Gene position: 2450203-2449022 (Counterclockwise)

Preceding gene: 89054947

Following gene: 89054945

Centisome position: 56.74

GC content: 63.2

Gene sequence:

>1182_bases
GTGAGCCCCCGGCCCGAGAAGCGGCGGGTCAGCATTTTCGGGGCCACCGGCTCCATCGGCCAGAACACCATTGATCTGAT
CGCCCGCGCGCCGGAGGCCTATGATGTTGTGGCGCTGACCGGCGCGCGCAACATCGCCCAACTTGCCGCAGATGCGAGGA
GGCTTTCGGCGAGTATCGCCGTAACAGCCGAGGAGGAGCTGCTGCCCGATCTGCGCGCAGCGCTGGAGGGATCCGGGGTG
GAGGCCGCCGCAGGCGAGGCCGCGCTGCTGGAGGCCGCTGACCGTCCTGCCGACTGGATCATGTCTGCCATTGTCGGGGC
CGCCGGCCTTGCCCCCGGCTTCCGGGCGCTGCGCCACGGCACGACGCTTGCATTGGCGAACAAGGAAAGTCTGGTGACGG
CCGGGCCGCTCTTGCTGGCTGAGGCTGCGACACACGGGGCCACGATCCTACCCGTGGACAGTGAACATTCCGCCGTTTTT
CAAGCGCTTGTCGGCGAAGATATCGCCGCCGTTGAGCGTATCATCATCACTGCATCCGGCGGTGGCCTGCGCGATTGGCC
GGAGGATGATCTGGCCCGCGCCACCCCAGCGGATGCAGGCGCGCATCCGAATTGGGATATGGGCCAACGGATCACTATTG
ATTCAGCCTCCATGTTTAACAAAGCCATGGAGCTGATTGAAACGAAAGAGTTTTTCGGCGTTTCACCCGCAAGGATCGAG
GCCGTGGTCCATCCCCAATCGCTGATCCACGCCCTTGTGGGCTTCACCGACGGCGCGCTGATGGCGCATCTCGGGCCGCC
GGATATGCGCCACGCCATCGGATATGCGCTGAACTACCCCGACCGCGCGCATCTGCCTGTCGACCGCCTTGACCTGGCCC
AGATCGCCCGGCTGGAGTTTCATGCCCCCTCCGATACCCGATATCCGGCCCTTAAAATCGCCCGCGAGGTGATGCAGACG
GGCGGTCAATCGGGCTGCATCTTCAACGCCGCAAAGGAAATCGCGCTGGATGGGTTCCTGGCCGGGAAAATCGGGTTCAT
GGACATGTCAGGCATCGTTTCCGACACACTCGACGCTATGTCGTCAAAGAACAGCCTTTCAAATGCCCCAGAAACCCTTG
AGGACGTGCTGCAAACTGACCAAATGGCTAGGAACATAGCCAGCGCGCGCCTGGCGCGATAA

Upstream 100 bases:

>100_bases
TGCCCGGCCACGGCGGCGCACTGGACCGGTTTGACGGCATGCTTGGCGCCTTCACCGTGGCGGGCCTGATGTTCGTGCTG
GCGGGCTACACGGTGGTGTC

Downstream 100 bases:

>100_bases
TTCGAGCAACCCCGGGCCGTTCGCCCGAACATCCGCAGAAAAGAGATCGCTAAAGATGGAATTCCTCCCCGCCTTCGGCA
ATATCGGCTTCACGCTTGTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSPRPEKRRVSIFGATGSIGQNTIDLIARAPEAYDVVALTGARNIAQLAADARRLSASIAVTAEEELLPDLRAALEGSGV
EAAAGEAALLEAADRPADWIMSAIVGAAGLAPGFRALRHGTTLALANKESLVTAGPLLLAEAATHGATILPVDSEHSAVF
QALVGEDIAAVERIIITASGGGLRDWPEDDLARATPADAGAHPNWDMGQRITIDSASMFNKAMELIETKEFFGVSPARIE
AVVHPQSLIHALVGFTDGALMAHLGPPDMRHAIGYALNYPDRAHLPVDRLDLAQIARLEFHAPSDTRYPALKIAREVMQT
GGQSGCIFNAAKEIALDGFLAGKIGFMDMSGIVSDTLDAMSSKNSLSNAPETLEDVLQTDQMARNIASARLAR

Sequences:

>Translated_393_residues
MSPRPEKRRVSIFGATGSIGQNTIDLIARAPEAYDVVALTGARNIAQLAADARRLSASIAVTAEEELLPDLRAALEGSGV
EAAAGEAALLEAADRPADWIMSAIVGAAGLAPGFRALRHGTTLALANKESLVTAGPLLLAEAATHGATILPVDSEHSAVF
QALVGEDIAAVERIIITASGGGLRDWPEDDLARATPADAGAHPNWDMGQRITIDSASMFNKAMELIETKEFFGVSPARIE
AVVHPQSLIHALVGFTDGALMAHLGPPDMRHAIGYALNYPDRAHLPVDRLDLAQIARLEFHAPSDTRYPALKIAREVMQT
GGQSGCIFNAAKEIALDGFLAGKIGFMDMSGIVSDTLDAMSSKNSLSNAPETLEDVLQTDQMARNIASARLAR
>Mature_392_residues
SPRPEKRRVSIFGATGSIGQNTIDLIARAPEAYDVVALTGARNIAQLAADARRLSASIAVTAEEELLPDLRAALEGSGVE
AAAGEAALLEAADRPADWIMSAIVGAAGLAPGFRALRHGTTLALANKESLVTAGPLLLAEAATHGATILPVDSEHSAVFQ
ALVGEDIAAVERIIITASGGGLRDWPEDDLARATPADAGAHPNWDMGQRITIDSASMFNKAMELIETKEFFGVSPARIEA
VVHPQSLIHALVGFTDGALMAHLGPPDMRHAIGYALNYPDRAHLPVDRLDLAQIARLEFHAPSDTRYPALKIAREVMQTG
GQSGCIFNAAKEIALDGFLAGKIGFMDMSGIVSDTLDAMSSKNSLSNAPETLEDVLQTDQMARNIASARLAR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=399, Percent_Identity=39.0977443609023, Blast_Score=280, Evalue=9e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_JANSC (Q28PJ0)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510397.1
- ProteinModelPortal:   Q28PJ0
- SMR:   Q28PJ0
- STRING:   Q28PJ0
- GeneID:   3934912
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2455
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q28PJ0
- ProtClustDB:   PRK05447
- BioCyc:   JSP290400:JANN_2455-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41390; Mature: 41259

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: BINDING 128-128 BINDING 155-155 BINDING 179-179 BINDING 202-202 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRPEKRRVSIFGATGSIGQNTIDLIARAPEAYDVVALTGARNIAQLAADARRLSASIA
CCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHEEE
VTAEEELLPDLRAALEGSGVEAAAGEAALLEAADRPADWIMSAIVGAAGLAPGFRALRHG
EEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCC
TTLALANKESLVTAGPLLLAEAATHGATILPVDSEHSAVFQALVGEDIAAVERIIITASG
CEEEEECCCCHHHHCHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCHHHHHEEEEEEECC
GGLRDWPEDDLARATPADAGAHPNWDMGQRITIDSASMFNKAMELIETKEFFGVSPARIE
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHEE
AVVHPQSLIHALVGFTDGALMAHLGPPDMRHAIGYALNYPDRAHLPVDRLDLAQIARLEF
EEECHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEE
HAPSDTRYPALKIAREVMQTGGQSGCIFNAAKEIALDGFLAGKIGFMDMSGIVSDTLDAM
ECCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SSKNSLSNAPETLEDVLQTDQMARNIASARLAR
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPRPEKRRVSIFGATGSIGQNTIDLIARAPEAYDVVALTGARNIAQLAADARRLSASIA
CCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHEEE
VTAEEELLPDLRAALEGSGVEAAAGEAALLEAADRPADWIMSAIVGAAGLAPGFRALRHG
EEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCC
TTLALANKESLVTAGPLLLAEAATHGATILPVDSEHSAVFQALVGEDIAAVERIIITASG
CEEEEECCCCHHHHCHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCHHHHHEEEEEEECC
GGLRDWPEDDLARATPADAGAHPNWDMGQRITIDSASMFNKAMELIETKEFFGVSPARIE
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHEE
AVVHPQSLIHALVGFTDGALMAHLGPPDMRHAIGYALNYPDRAHLPVDRLDLAQIARLEF
EEECHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEE
HAPSDTRYPALKIAREVMQTGGQSGCIFNAAKEIALDGFLAGKIGFMDMSGIVSDTLDAM
ECCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SSKNSLSNAPETLEDVLQTDQMARNIASARLAR
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA