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The map label for this gene is lpxB [H]

Identifier: 89054939

GI number: 89054939

Start: 2440844

End: 2441998

Strand: Reverse

Name: lpxB [H]

Synonym: Jann_2448

Alternate gene names: 89054939

Gene position: 2441998-2440844 (Counterclockwise)

Preceding gene: 89054940

Following gene: 89054937

Centisome position: 56.55

GC content: 65.71

Gene sequence:

>1155_bases
ATGACCACGCTGTTTCTTGTGGCCGGGGAACCCTCTGGCGACAGTTTGGGCGCATCACTGATGGACGGGTTTGATGGGAT
TGGCGAGGACGTGACCTTTGCGGGTGTCGGTGGGCCGAAGATGGCGTCCCGTGGCCTGCATTCGCTGTTCCCCTATGAAG
AGCTTGCGGTGATGGGCATCGCGGAAGTGCTGCCGAAATATCGCGCGCTGAGACGGCGGATCACCCAGACGGCCCAGGCC
TTTCTGGAGAGCGGCGCGGAGGCGTTGATCACCATCGATAGCCCTGATTTCGGCCTGCGGGTCGCGAGGATCGTGAAGGG
CGCGCGACCCGAGGCCAAGACGATCCACTACGTGGCCCCGTCGGTCTGGGCCTGGCGCCCCAAGCGGGCGCAAAAGATGG
CGCGCGTGATCGACCATGTTCTGGCGCTGCTGCCGTTCGAGCCGCCCTACATGGAAGCGGCGGGGATGAGCTGCGATTTC
GTGGGGCACCCCATCGCCGCGCACGCCCCCGCAGGGGAGGTTGAAACGACTGCATGCCGCAAGGAATTTGGGGTGGAAGA
GACGGACAACGTGATCCTCGTCCTGCCCGGCTCCCGCGTGTCCGAGGTCACGCGGCTTGCGCCCGTTTTCGGGGAGGCGC
TCCGTGACATCGACGCCAGGCTGGTGCTGCCGACGACGCCGAACGTGGCGCCATTGATGGCGGATCTGACCAAAGACTGG
TCCCCGCGTCCTATCGTTATTGACCCACGGGAGCATAGCACGGCCAAATTTGCGTTCCTGAAACACGGCGCTTTCGGTGT
GGCAGAGGCTGCGCTTGCAGCATCCGGGACCGTGTCGTTGGAACTGGCGCAGGCCCGGACGCCCATGGTCATCGCCTACG
ACATGCACTGGCTGACGCGGCAGATCATGCGGCTGGCCATGCGCGTGGACACCGTGACCCTGGTCAATCTGGTGTCGGAG
ACGCGGGCCGTGCCGGAATTCCTTGGCCTCAATTGCCGCCCGGGACCGATCCGGGCCGCGTTGGATGGCATTCGGACCGG
GTCCGCGCAAGACCAAATCGCGGCGATGGCGGCCACGATGGCGCGTCTGGGCGCAGGCGGTCCGCCGCCGGGGGAACGGG
CCGCACGGTCTGTCCTCAGCTTCCTTAACCGGTGA

Upstream 100 bases:

>100_bases
TGTCCGGCATTGAAATCGCACCGGGGAACGTTCTGCTTCTGGACCGTCCCGCAATCCTTGCGGCCTGCGCCGAGACTGGC
CTGAACCTTTGGGCCGGTCC

Downstream 100 bases:

>100_bases
AGTCTGCGGGGGCCGCGCCCGCAAGCGCGACCAGAACGGTCGGATCTATCGCAAAGATATGGCGCGGCGTACCTGCGGCG
GCATAGACCACGTCGAAGTC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTTLFLVAGEPSGDSLGASLMDGFDGIGEDVTFAGVGGPKMASRGLHSLFPYEELAVMGIAEVLPKYRALRRRITQTAQA
FLESGAEALITIDSPDFGLRVARIVKGARPEAKTIHYVAPSVWAWRPKRAQKMARVIDHVLALLPFEPPYMEAAGMSCDF
VGHPIAAHAPAGEVETTACRKEFGVEETDNVILVLPGSRVSEVTRLAPVFGEALRDIDARLVLPTTPNVAPLMADLTKDW
SPRPIVIDPREHSTAKFAFLKHGAFGVAEAALAASGTVSLELAQARTPMVIAYDMHWLTRQIMRLAMRVDTVTLVNLVSE
TRAVPEFLGLNCRPGPIRAALDGIRTGSAQDQIAAMAATMARLGAGGPPPGERAARSVLSFLNR

Sequences:

>Translated_384_residues
MTTLFLVAGEPSGDSLGASLMDGFDGIGEDVTFAGVGGPKMASRGLHSLFPYEELAVMGIAEVLPKYRALRRRITQTAQA
FLESGAEALITIDSPDFGLRVARIVKGARPEAKTIHYVAPSVWAWRPKRAQKMARVIDHVLALLPFEPPYMEAAGMSCDF
VGHPIAAHAPAGEVETTACRKEFGVEETDNVILVLPGSRVSEVTRLAPVFGEALRDIDARLVLPTTPNVAPLMADLTKDW
SPRPIVIDPREHSTAKFAFLKHGAFGVAEAALAASGTVSLELAQARTPMVIAYDMHWLTRQIMRLAMRVDTVTLVNLVSE
TRAVPEFLGLNCRPGPIRAALDGIRTGSAQDQIAAMAATMARLGAGGPPPGERAARSVLSFLNR
>Mature_383_residues
TTLFLVAGEPSGDSLGASLMDGFDGIGEDVTFAGVGGPKMASRGLHSLFPYEELAVMGIAEVLPKYRALRRRITQTAQAF
LESGAEALITIDSPDFGLRVARIVKGARPEAKTIHYVAPSVWAWRPKRAQKMARVIDHVLALLPFEPPYMEAAGMSCDFV
GHPIAAHAPAGEVETTACRKEFGVEETDNVILVLPGSRVSEVTRLAPVFGEALRDIDARLVLPTTPNVAPLMADLTKDWS
PRPIVIDPREHSTAKFAFLKHGAFGVAEAALAASGTVSLELAQARTPMVIAYDMHWLTRQIMRLAMRVDTVTLVNLVSET
RAVPEFLGLNCRPGPIRAALDGIRTGSAQDQIAAMAATMARLGAGGPPPGERAARSVLSFLNR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=335, Percent_Identity=35.8208955223881, Blast_Score=181, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41180; Mature: 41049

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLFLVAGEPSGDSLGASLMDGFDGIGEDVTFAGVGGPKMASRGLHSLFPYEELAVMGI
CCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCHHHHCCHHHHHHHHH
AEVLPKYRALRRRITQTAQAFLESGAEALITIDSPDFGLRVARIVKGARPEAKTIHYVAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECC
SVWAWRPKRAQKMARVIDHVLALLPFEPPYMEAAGMSCDFVGHPIAAHAPAGEVETTACR
CHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
KEFGVEETDNVILVLPGSRVSEVTRLAPVFGEALRDIDARLVLPTTPNVAPLMADLTKDW
HHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCC
SPRPIVIDPREHSTAKFAFLKHGAFGVAEAALAASGTVSLELAQARTPMVIAYDMHWLTR
CCCCEEECCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHH
QIMRLAMRVDTVTLVNLVSETRAVPEFLGLNCRPGPIRAALDGIRTGSAQDQIAAMAATM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ARLGAGGPPPGERAARSVLSFLNR
HHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTLFLVAGEPSGDSLGASLMDGFDGIGEDVTFAGVGGPKMASRGLHSLFPYEELAVMGI
CEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCHHHHCCHHHHHHHHH
AEVLPKYRALRRRITQTAQAFLESGAEALITIDSPDFGLRVARIVKGARPEAKTIHYVAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECC
SVWAWRPKRAQKMARVIDHVLALLPFEPPYMEAAGMSCDFVGHPIAAHAPAGEVETTACR
CHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
KEFGVEETDNVILVLPGSRVSEVTRLAPVFGEALRDIDARLVLPTTPNVAPLMADLTKDW
HHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCC
SPRPIVIDPREHSTAKFAFLKHGAFGVAEAALAASGTVSLELAQARTPMVIAYDMHWLTR
CCCCEEECCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHH
QIMRLAMRVDTVTLVNLVSETRAVPEFLGLNCRPGPIRAALDGIRTGSAQDQIAAMAATM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ARLGAGGPPPGERAARSVLSFLNR
HHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA