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The map label for this gene is hmuU [H]

Identifier: 89054626

GI number: 89054626

Start: 2143178

End: 2144251

Strand: Direct

Name: hmuU [H]

Synonym: Jann_2135

Alternate gene names: 89054626

Gene position: 2143178-2144251 (Clockwise)

Preceding gene: 89054625

Following gene: 89054627

Centisome position: 49.63

GC content: 64.62

Gene sequence:

>1074_bases
ATGGCCGAGGCCGTTCAACAGATCGCAATCCCGGTTGAGGGCGACCGGGAAACACGGGCGCGGATGTGCTTTTTCGGGTT
GTTGGGGCTGTTGGGCGTCGTCAGTCTTGCCAGTCTCACCACCGGTGCGTCGGGGATCTCCCTGGGGGAGGTGTTCAGTA
CCTGGACCCGCGGGGAGGAGTTGGACCGTGTCACCCGCGCAGTGCTGTTCGACATTCGCATGCCGCGCCTGATCATGGGC
ATTCTAGTCGGGGCCGCGCTGGCGGTCTCGGGGGCCGTGATGCAGGGCCTGTTCCGCAACCCGCTGGCGGACCCGGGCCT
TGTGGGCGTCGGCGCAGGGGCGGGTCTCGGCGCGATCATCGCAATCGTTTTGGGGGGGCTGTTGCCAGTCGCGATGCGGG
ATGTCATCGGCCTCTACCTCGTGCCGCTGGCCGCGTTCTTTGGCGGATGGGTCACGACGATCCTGCTTTATGTTGTGTCC
ACGAACCGGGGCAAAACCTCCGTTGCCGTGATGCTTCTGGCCGGGATCGCGCTTGGCGCGCTGACGGGGGCTTTGTCGGG
CATCCTCGTCTATATGGCCGACGATCAGCAATTGCGCGACCTGACGTTTTGGGGCCTTGGGTCCCTTGCTGGGGCGACAT
GGGTCAAGCTGTTCATTGCCGCACCGCTGATCATTGCCGCCCTCGCCGCAGCACCGTTTCTGGCCCGCAGTCTCAACGGG
TTGGCCCTGGGAGAAGCCGCTGCATCGCATCTCGGCATTCCCGTCCAGCGCATGAAAGCCATCGCGATCCTCACCGTCGC
CGCCGCCGTCGGTGCGGCTGTGGCCGTTTCGGGCGGCATAGGCTTCATCGGCATCGTCGTGCCGCACCTCCTGCGCATTG
CCGTGGGGCCGGACCACCGCTTTCTTCTGCCCAACGCGGCGCTTCTTGGGGCATCGCTGCTGATCGTGGCGGACATGATC
TCGCGCACCATTATTGCTCCGGCAGAGCTGCCCATCGGGATCGTTACGGCAGTCATTGGGGGTCCGTTCTTCCTTTGGAT
CTTGCTGCGCAACCGATCCCTTCTGGATCTGTGA

Upstream 100 bases:

>100_bases
GTGCGGATCAACGGGTTGCTTCTTCTCGGGTTTGGTCCCCGCACGCCGGAGGCTGTCGCGCGGCTGTCGGCGGCGCTTGG
CACCGTCGGGGGCTAGGATC

Downstream 100 bases:

>100_bases
GGGCCCCGTGCTGACCGTTGAAAACATCGAAGTGACCCTAGGTGCCACGCCAGTCCTCCACGGCATCGACATGGTGGCGC
AGCCGGGGCAGGTGACGGCG

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MAEAVQQIAIPVEGDRETRARMCFFGLLGLLGVVSLASLTTGASGISLGEVFSTWTRGEELDRVTRAVLFDIRMPRLIMG
ILVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAIIAIVLGGLLPVAMRDVIGLYLVPLAAFFGGWVTTILLYVVS
TNRGKTSVAVMLLAGIALGALTGALSGILVYMADDQQLRDLTFWGLGSLAGATWVKLFIAAPLIIAALAAAPFLARSLNG
LALGEAAASHLGIPVQRMKAIAILTVAAAVGAAVAVSGGIGFIGIVVPHLLRIAVGPDHRFLLPNAALLGASLLIVADMI
SRTIIAPAELPIGIVTAVIGGPFFLWILLRNRSLLDL

Sequences:

>Translated_357_residues
MAEAVQQIAIPVEGDRETRARMCFFGLLGLLGVVSLASLTTGASGISLGEVFSTWTRGEELDRVTRAVLFDIRMPRLIMG
ILVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAIIAIVLGGLLPVAMRDVIGLYLVPLAAFFGGWVTTILLYVVS
TNRGKTSVAVMLLAGIALGALTGALSGILVYMADDQQLRDLTFWGLGSLAGATWVKLFIAAPLIIAALAAAPFLARSLNG
LALGEAAASHLGIPVQRMKAIAILTVAAAVGAAVAVSGGIGFIGIVVPHLLRIAVGPDHRFLLPNAALLGASLLIVADMI
SRTIIAPAELPIGIVTAVIGGPFFLWILLRNRSLLDL
>Mature_356_residues
AEAVQQIAIPVEGDRETRARMCFFGLLGLLGVVSLASLTTGASGISLGEVFSTWTRGEELDRVTRAVLFDIRMPRLIMGI
LVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAIIAIVLGGLLPVAMRDVIGLYLVPLAAFFGGWVTTILLYVVST
NRGKTSVAVMLLAGIALGALTGALSGILVYMADDQQLRDLTFWGLGSLAGATWVKLFIAAPLIIAALAAAPFLARSLNGL
ALGEAAASHLGIPVQRMKAIAILTVAAAVGAAVAVSGGIGFIGIVVPHLLRIAVGPDHRFLLPNAALLGASLLIVADMIS
RTIIAPAELPIGIVTAVIGGPFFLWILLRNRSLLDL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=319, Percent_Identity=39.4984326018809, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1788004, Length=312, Percent_Identity=41.9871794871795, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790741, Length=292, Percent_Identity=33.9041095890411, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1786805, Length=307, Percent_Identity=38.1107491856677, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786804, Length=313, Percent_Identity=34.8242811501597, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786347, Length=312, Percent_Identity=29.8076923076923, Blast_Score=101, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36645; Mature: 36514

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAVQQIAIPVEGDRETRARMCFFGLLGLLGVVSLASLTTGASGISLGEVFSTWTRGEE
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHH
LDRVTRAVLFDIRMPRLIMGILVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHH
AIVLGGLLPVAMRDVIGLYLVPLAAFFGGWVTTILLYVVSTNRGKTSVAVMLLAGIALGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LTGALSGILVYMADDQQLRDLTFWGLGSLAGATWVKLFIAAPLIIAALAAAPFLARSLNG
HHHHHHHEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LALGEAAASHLGIPVQRMKAIAILTVAAAVGAAVAVSGGIGFIGIVVPHLLRIAVGPDHR
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
FLLPNAALLGASLLIVADMISRTIIAPAELPIGIVTAVIGGPFFLWILLRNRSLLDL
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure 
AEAVQQIAIPVEGDRETRARMCFFGLLGLLGVVSLASLTTGASGISLGEVFSTWTRGEE
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHH
LDRVTRAVLFDIRMPRLIMGILVGAALAVSGAVMQGLFRNPLADPGLVGVGAGAGLGAII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHH
AIVLGGLLPVAMRDVIGLYLVPLAAFFGGWVTTILLYVVSTNRGKTSVAVMLLAGIALGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LTGALSGILVYMADDQQLRDLTFWGLGSLAGATWVKLFIAAPLIIAALAAAPFLARSLNG
HHHHHHHEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LALGEAAASHLGIPVQRMKAIAILTVAAAVGAAVAVSGGIGFIGIVVPHLLRIAVGPDHR
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
FLLPNAALLGASLLIVADMISRTIIAPAELPIGIVTAVIGGPFFLWILLRNRSLLDL
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]