Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 89054570

GI number: 89054570

Start: 2087343

End: 2088680

Strand: Direct

Name: glyA [H]

Synonym: Jann_2079

Alternate gene names: 89054570

Gene position: 2087343-2088680 (Clockwise)

Preceding gene: 89054569

Following gene: 89054571

Centisome position: 48.34

GC content: 62.86

Gene sequence:

>1338_bases
ATGGTATTGGCAAAACGCGACTGGGTGCCCGCAGACAGTGACGCCCTGGTTCAATCCATCGCCGCACGCACGTCGGCGTC
GGACGGCGCCACCATCGCCGCGCGGCTTACGGCTTTGGGGGCCGAGAACCGCCGCATTCATGAGGACGCCTGCTTCAACC
TCAACCCCGCCACCAATGTGATGAACCCGGCGGCGGAGGCGCTTTTGTCCAACGGCATGGGCACGCGCCCGTCCCTTGGC
TACCCCGGCGACAAATATGAGATGGGGCTGGAGGCGGTGGAGGAGGCGGAGGTCATCGCCGCAGAACTGGCCGCTGAGGT
CTTCCGCGCGCGCTTTGCTGAGATTCGCGTGGCCTCCGGCGCGATGGCCAACCTCTACGCCTTTATGGCGACCTGCCAAC
CCGGCGACACAATCATCGTGCCGCCCGCATCCATCGGCGGCCATGTCACCCACCACGGGGCTGGATGCGCGGGCCTTTTC
GGATTGCGGATCGTGGAGGCCCCCGTTTATCCAAATTGTTATACCATTGATATACCCGGCCTCGCGGATCTGGCGGCAAA
AGAGCGCCCGGCGCTGATCACTTTGGGTGGGTCCCTGAACCTGTTGCCCCATCCTGTGGCGGAGGTGCGGGCTATTGCCG
ACGACGTCGGGGCCTATCTGCTGATGGATGCCGCGCATCAATGCGGCCTCTTTGCTGGGCAGGCCTGGCCTGATCCACTG
GCCTCTGAAAATGGGGCAGAGGGCGCGCATCTGATGACGATGAGCACCTATAAATCCCTCGGCGGACCTGCGGGCGGGTT
AATCGTGACCAACGACGCCGAGATCGCCAAGCGTCTGGATTCCATTGCTTTTCCCGGCATGACGGCCAATTTCGATGCCT
CCAAATCCGCCGCCCTCGCGCGCAGCCTGTTGGATTGGCGCGACCATGGCCGGGCCTACGCCGCCAAGATGGTGGAGGTG
GCGAAGGCGCTGTCCGATGCGCTGAAGGCACAGGGCATTCCGCTGTTTGAAACGGCACGCGGTGCCACGCAAAGCCACCA
ATTTGCCGTGCCAGCCTATGAGCTCGGGGGCGGGCAGGCGGCCTCCAAACACCTTTACCGCGCGGGGATCATCGCCTGTG
GGATCGGCATCCCGGGCCCAGAAGTTCCCAATGATATGAATGCGATACGTTTTGGGACACCCGAAATTGTCCGCTTTGGC
GTGGGGCAGGGGTCGGATGATGTCACCACCCTGGCAGGCCTCATTGCGCGGGCTCTGCGCAGTGATCGACCAGAGGATCT
TGCCGGGGAAACAGCCGCCTTTCGGAGCAATTTCAAAGCCTTGCACTATGTATCTTAA

Upstream 100 bases:

>100_bases
TAACCGCCGTCTCTGACATCCTCACGGCGACCTTTAGATTTCCGTTGCGCCCGCAGGCCTGCCGCTGTCTCCTTCCGTAA
AAGATCGGAAGGGGACGGAT

Downstream 100 bases:

>100_bases
TCTGTTTTTGCAACTCACTCGCAAGTGACTTGCTTTCTTGCGAATAAGTCGCATATACACTTCTGACGGCACCGCCATCA
GGAGTTCCCCAGATATGAAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MVLAKRDWVPADSDALVQSIAARTSASDGATIAARLTALGAENRRIHEDACFNLNPATNVMNPAAEALLSNGMGTRPSLG
YPGDKYEMGLEAVEEAEVIAAELAAEVFRARFAEIRVASGAMANLYAFMATCQPGDTIIVPPASIGGHVTHHGAGCAGLF
GLRIVEAPVYPNCYTIDIPGLADLAAKERPALITLGGSLNLLPHPVAEVRAIADDVGAYLLMDAAHQCGLFAGQAWPDPL
ASENGAEGAHLMTMSTYKSLGGPAGGLIVTNDAEIAKRLDSIAFPGMTANFDASKSAALARSLLDWRDHGRAYAAKMVEV
AKALSDALKAQGIPLFETARGATQSHQFAVPAYELGGGQAASKHLYRAGIIACGIGIPGPEVPNDMNAIRFGTPEIVRFG
VGQGSDDVTTLAGLIARALRSDRPEDLAGETAAFRSNFKALHYVS

Sequences:

>Translated_445_residues
MVLAKRDWVPADSDALVQSIAARTSASDGATIAARLTALGAENRRIHEDACFNLNPATNVMNPAAEALLSNGMGTRPSLG
YPGDKYEMGLEAVEEAEVIAAELAAEVFRARFAEIRVASGAMANLYAFMATCQPGDTIIVPPASIGGHVTHHGAGCAGLF
GLRIVEAPVYPNCYTIDIPGLADLAAKERPALITLGGSLNLLPHPVAEVRAIADDVGAYLLMDAAHQCGLFAGQAWPDPL
ASENGAEGAHLMTMSTYKSLGGPAGGLIVTNDAEIAKRLDSIAFPGMTANFDASKSAALARSLLDWRDHGRAYAAKMVEV
AKALSDALKAQGIPLFETARGATQSHQFAVPAYELGGGQAASKHLYRAGIIACGIGIPGPEVPNDMNAIRFGTPEIVRFG
VGQGSDDVTTLAGLIARALRSDRPEDLAGETAAFRSNFKALHYVS
>Mature_445_residues
MVLAKRDWVPADSDALVQSIAARTSASDGATIAARLTALGAENRRIHEDACFNLNPATNVMNPAAEALLSNGMGTRPSLG
YPGDKYEMGLEAVEEAEVIAAELAAEVFRARFAEIRVASGAMANLYAFMATCQPGDTIIVPPASIGGHVTHHGAGCAGLF
GLRIVEAPVYPNCYTIDIPGLADLAAKERPALITLGGSLNLLPHPVAEVRAIADDVGAYLLMDAAHQCGLFAGQAWPDPL
ASENGAEGAHLMTMSTYKSLGGPAGGLIVTNDAEIAKRLDSIAFPGMTANFDASKSAALARSLLDWRDHGRAYAAKMVEV
AKALSDALKAQGIPLFETARGATQSHQFAVPAYELGGGQAASKHLYRAGIIACGIGIPGPEVPNDMNAIRFGTPEIVRFG
VGQGSDDVTTLAGLIARALRSDRPEDLAGETAAFRSNFKALHYVS

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=367, Percent_Identity=27.7929155313352, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI261862350, Length=367, Percent_Identity=27.7929155313352, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI261862348, Length=367, Percent_Identity=27.7929155313352, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI19923315, Length=367, Percent_Identity=27.7929155313352, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI261862346, Length=361, Percent_Identity=27.7008310249307, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI22547186, Length=378, Percent_Identity=24.6031746031746, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI22547189, Length=374, Percent_Identity=25.4010695187166, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788902, Length=394, Percent_Identity=29.9492385786802, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI25144729, Length=396, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319739, Length=408, Percent_Identity=25.9803921568627, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323087, Length=376, Percent_Identity=25.7978723404255, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221329721, Length=389, Percent_Identity=27.2493573264781, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24640005, Length=377, Percent_Identity=27.5862068965517, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46402; Mature: 46402

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLAKRDWVPADSDALVQSIAARTSASDGATIAARLTALGAENRRIHEDACFNLNPATNV
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCHHHH
MNPAAEALLSNGMGTRPSLGYPGDKYEMGLEAVEEAEVIAAELAAEVFRARFAEIRVASG
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AMANLYAFMATCQPGDTIIVPPASIGGHVTHHGAGCAGLFGLRIVEAPVYPNCYTIDIPG
HHHHHHHHHHCCCCCCEEEECCCCCCCCCEECCCCHHHHHHHEEEECCCCCCEEEEECCC
LADLAAKERPALITLGGSLNLLPHPVAEVRAIADDVGAYLLMDAAHQCGLFAGQAWPDPL
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ASENGAEGAHLMTMSTYKSLGGPAGGLIVTNDAEIAKRLDSIAFPGMTANFDASKSAALA
CCCCCCCCEEEEEHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RSLLDWRDHGRAYAAKMVEVAKALSDALKAQGIPLFETARGATQSHQFAVPAYELGGGQA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEECCCCCCCCCHH
ASKHLYRAGIIACGIGIPGPEVPNDMNAIRFGTPEIVRFGVGQGSDDVTTLAGLIARALR
HHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCHHHEEECCCCCCCHHHHHHHHHHHHHH
SDRPEDLAGETAAFRSNFKALHYVS
CCCCHHHCCCHHHHHHCCCEEEECC
>Mature Secondary Structure
MVLAKRDWVPADSDALVQSIAARTSASDGATIAARLTALGAENRRIHEDACFNLNPATNV
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCHHHH
MNPAAEALLSNGMGTRPSLGYPGDKYEMGLEAVEEAEVIAAELAAEVFRARFAEIRVASG
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AMANLYAFMATCQPGDTIIVPPASIGGHVTHHGAGCAGLFGLRIVEAPVYPNCYTIDIPG
HHHHHHHHHHCCCCCCEEEECCCCCCCCCEECCCCHHHHHHHEEEECCCCCCEEEEECCC
LADLAAKERPALITLGGSLNLLPHPVAEVRAIADDVGAYLLMDAAHQCGLFAGQAWPDPL
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ASENGAEGAHLMTMSTYKSLGGPAGGLIVTNDAEIAKRLDSIAFPGMTANFDASKSAALA
CCCCCCCCEEEEEHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RSLLDWRDHGRAYAAKMVEVAKALSDALKAQGIPLFETARGATQSHQFAVPAYELGGGQA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEECCCCCCCCCHH
ASKHLYRAGIIACGIGIPGPEVPNDMNAIRFGTPEIVRFGVGQGSDDVTTLAGLIARALR
HHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCHHHEEECCCCCCCHHHHHHHHHHHHHH
SDRPEDLAGETAAFRSNFKALHYVS
CCCCHHHCCCHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA