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The map label for this gene is lpd [H]

Identifier: 89054211

GI number: 89054211

Start: 1704227

End: 1705624

Strand: Direct

Name: lpd [H]

Synonym: Jann_1720

Alternate gene names: 89054211

Gene position: 1704227-1705624 (Clockwise)

Preceding gene: 89054210

Following gene: 89054213

Centisome position: 39.47

GC content: 60.59

Gene sequence:

>1398_bases
ATGGCCGCACAAAACTTCGACCTCATAGTCATCGGAGCGGGCCCGGGCGGCTACGTCGCGGCGATCCGGGCCAGCCAGCT
TGGCCTGAAGACGGCAATTGTCGAGCGCGAACATATGGGTGGGATCTGCCTGAACTGGGGCTGTATCCCCACCAAAGCCA
TGCTGCGCAGCTCCGAGGTCTTCCACCTGATGCACCGCGCGAAAGAGTTCGGACTGTCCGCCGATGGCATCGGGTATGAC
CTTGATAAGGTCGTGGACCGCTCCCGCAAGGTGGCCAAGCAGCTGTCGGGCGGCGTGGCGCATCTGATGAAGAAGAACAA
GATCACCACGATCATGGGGGAGGCGACGATCCCCGCCAAGGGCAAGGTTTCCGTCAAAACCGACAAGGGCACCGAAGAGC
TGACCGCCAAGAACATCATCCTCGCCACCGGCGCACGCGCCCGCGAACTTCCGGGGCTGGAGGCGGACGGCAAGCGGGTC
TGGACCTACAAGGCTGCCCTGACACCGCCGCACATGCCGAAGAAACTGCTGGTGATTGGCTCCGGCGCCATCGGCATCGA
GTTCGCCAGCTTCTACAACACGCTTGGCGCCGACACGACCGTGGTTGAGGTCATGGACCGCGTTCTGCCCGTGGAAGATG
CGGAGATCAGCGCGTTTGCCAAGAAGAGCTTTGAGAAGCAGGGGATGAAGATCCTGCAAAAGGCGATGGTCAAACAGCTG
GACCGCGCCGATGACAAGGTGACGGCGCATATCGAGATCGGCGGCAATGTCGAAAAGCAGGACTTTGATACCGTTATCTC
TGCCGTTGGTATCGTCGGCAATGTCGAAAATCTCGGGCTGGAAGACCTCGGCGTGAAGATCGACCGCACCCATGTGGTGA
CCGATGAATATTGCCGGACCGGCGTCGACGGGCTTTATGCCATAGGGGATATCGCGGGCGCGCCGTGGCTGGCGCATAAG
GCGTCCCACGAAGGGGTCATGGTGGCGGAGCTGATCTCCGGCAAGAACAATGTCCATCCGATCAAGCCCGAAAGCATCGC
GGGCTGCACCTATTGCCATCCCCAGGTCGCCTCTGTCGGGCTGACCGAGGCGAAGGCGAAGGAGCAGGGTTACAAGATCA
AGGTTGGTCGCTTCCCCTTCATCGGCAACGGCAAGGCGATTGCCCTGGGTGAGCCGGAGGGCATGATCAAGACGATTTTC
GACGAGAAAACCGGAGAACTTCTGGGCGCCCATATGGTCGGCGCGGAGGTGACGGAGCTGATCCAGGGCTATGTCGTGGG
TCGGCAGCTGGAGACCACGGAGCAGGACCTGATGGAGACGGTCTTCCCGCATCCGACCCTGTCAGAGATGATGCATGAAT
CGGTGCTGGATGCCTATGATCGCGTGGTTCATATTTGA

Upstream 100 bases:

>100_bases
CAACCCGGCCTGCGACCTAGCGTCAATTGTCGCCCTTGGGGAATTGGTTTAACGTTGAACAAACGCAGAAACTGATATTC
CAGACCCGGAGACTTCGCCA

Downstream 100 bases:

>100_bases
CCGGCCAAGCGGGGTCTCAAGGTTACAACAGGGGGTCAAGCCCCTGATACTAAAATATAATCGTATTATAGTATAAGAAT
AAAAGAAGGGCGCCAGGATC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MAAQNFDLIVIGAGPGGYVAAIRASQLGLKTAIVEREHMGGICLNWGCIPTKAMLRSSEVFHLMHRAKEFGLSADGIGYD
LDKVVDRSRKVAKQLSGGVAHLMKKNKITTIMGEATIPAKGKVSVKTDKGTEELTAKNIILATGARARELPGLEADGKRV
WTYKAALTPPHMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFEKQGMKILQKAMVKQL
DRADDKVTAHIEIGGNVEKQDFDTVISAVGIVGNVENLGLEDLGVKIDRTHVVTDEYCRTGVDGLYAIGDIAGAPWLAHK
ASHEGVMVAELISGKNNVHPIKPESIAGCTYCHPQVASVGLTEAKAKEQGYKIKVGRFPFIGNGKAIALGEPEGMIKTIF
DEKTGELLGAHMVGAEVTELIQGYVVGRQLETTEQDLMETVFPHPTLSEMMHESVLDAYDRVVHI

Sequences:

>Translated_465_residues
MAAQNFDLIVIGAGPGGYVAAIRASQLGLKTAIVEREHMGGICLNWGCIPTKAMLRSSEVFHLMHRAKEFGLSADGIGYD
LDKVVDRSRKVAKQLSGGVAHLMKKNKITTIMGEATIPAKGKVSVKTDKGTEELTAKNIILATGARARELPGLEADGKRV
WTYKAALTPPHMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFEKQGMKILQKAMVKQL
DRADDKVTAHIEIGGNVEKQDFDTVISAVGIVGNVENLGLEDLGVKIDRTHVVTDEYCRTGVDGLYAIGDIAGAPWLAHK
ASHEGVMVAELISGKNNVHPIKPESIAGCTYCHPQVASVGLTEAKAKEQGYKIKVGRFPFIGNGKAIALGEPEGMIKTIF
DEKTGELLGAHMVGAEVTELIQGYVVGRQLETTEQDLMETVFPHPTLSEMMHESVLDAYDRVVHI
>Mature_464_residues
AAQNFDLIVIGAGPGGYVAAIRASQLGLKTAIVEREHMGGICLNWGCIPTKAMLRSSEVFHLMHRAKEFGLSADGIGYDL
DKVVDRSRKVAKQLSGGVAHLMKKNKITTIMGEATIPAKGKVSVKTDKGTEELTAKNIILATGARARELPGLEADGKRVW
TYKAALTPPHMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFEKQGMKILQKAMVKQLD
RADDKVTAHIEIGGNVEKQDFDTVISAVGIVGNVENLGLEDLGVKIDRTHVVTDEYCRTGVDGLYAIGDIAGAPWLAHKA
SHEGVMVAELISGKNNVHPIKPESIAGCTYCHPQVASVGLTEAKAKEQGYKIKVGRFPFIGNGKAIALGEPEGMIKTIFD
EKTGELLGAHMVGAEVTELIQGYVVGRQLETTEQDLMETVFPHPTLSEMMHESVLDAYDRVVHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=37.8787878787879, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=26.7818574514039, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI22035672, Length=465, Percent_Identity=26.8817204301075, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI291045266, Length=428, Percent_Identity=25.4672897196262, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=24.295010845987, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=24.295010845987, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=24.295010845987, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=24.295010845987, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=24.295010845987, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI291045268, Length=424, Percent_Identity=25, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=36.3636363636364, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI87082354, Length=473, Percent_Identity=27.906976744186, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=27.5, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=25.1101321585903, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788892, Length=210, Percent_Identity=30, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=37.7682403433476, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=27.9166666666667, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=461, Percent_Identity=27.9826464208243, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=461, Percent_Identity=27.9826464208243, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=25.3638253638254, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=35.5042016806723, Blast_Score=272, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=26.9473684210526, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=27.5053304904051, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=39.1304347826087, Blast_Score=307, Evalue=8e-84,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=27.7542372881356, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=27.7542372881356, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=27.7542372881356, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=26.4705882352941, Blast_Score=125, Evalue=8e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50065; Mature: 49933

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQNFDLIVIGAGPGGYVAAIRASQLGLKTAIVEREHMGGICLNWGCIPTKAMLRSSEV
CCCCCCCEEEEECCCCCEEEEEEHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
FHLMHRAKEFGLSADGIGYDLDKVVDRSRKVAKQLSGGVAHLMKKNKITTIMGEATIPAK
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCC
GKVSVKTDKGTEELTAKNIILATGARARELPGLEADGKRVWTYKAALTPPHMPKKLLVIG
CEEEEECCCCCHHHHHCCEEEECCCCHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEE
SGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFEKQGMKILQKAMVKQL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRADDKVTAHIEIGGNVEKQDFDTVISAVGIVGNVENLGLEDLGVKIDRTHVVTDEYCRT
HCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHCCHHHHCEEEECEEECCHHHHHC
GVDGLYAIGDIAGAPWLAHKASHEGVMVAELISGKNNVHPIKPESIAGCTYCHPQVASVG
CCCHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCC
LTEAKAKEQGYKIKVGRFPFIGNGKAIALGEPEGMIKTIFDEKTGELLGAHMVGAEVTEL
CHHHHHHHCCCEEEECCCCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGYVVGRQLETTEQDLMETVFPHPTLSEMMHESVLDAYDRVVHI
HHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAQNFDLIVIGAGPGGYVAAIRASQLGLKTAIVEREHMGGICLNWGCIPTKAMLRSSEV
CCCCCCEEEEECCCCCEEEEEEHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
FHLMHRAKEFGLSADGIGYDLDKVVDRSRKVAKQLSGGVAHLMKKNKITTIMGEATIPAK
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCC
GKVSVKTDKGTEELTAKNIILATGARARELPGLEADGKRVWTYKAALTPPHMPKKLLVIG
CEEEEECCCCCHHHHHCCEEEECCCCHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEE
SGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFEKQGMKILQKAMVKQL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRADDKVTAHIEIGGNVEKQDFDTVISAVGIVGNVENLGLEDLGVKIDRTHVVTDEYCRT
HCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHCCHHHHCEEEECEEECCHHHHHC
GVDGLYAIGDIAGAPWLAHKASHEGVMVAELISGKNNVHPIKPESIAGCTYCHPQVASVG
CCCHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCC
LTEAKAKEQGYKIKVGRFPFIGNGKAIALGEPEGMIKTIFDEKTGELLGAHMVGAEVTEL
CHHHHHHHCCCEEEECCCCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGYVVGRQLETTEQDLMETVFPHPTLSEMMHESVLDAYDRVVHI
HHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]