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The map label for this gene is degA [H]

Identifier: 89054053

GI number: 89054053

Start: 1537748

End: 1538764

Strand: Reverse

Name: degA [H]

Synonym: Jann_1562

Alternate gene names: 89054053

Gene position: 1538764-1537748 (Counterclockwise)

Preceding gene: 89054059

Following gene: 89054051

Centisome position: 35.64

GC content: 62.44

Gene sequence:

>1017_bases
ATGAAAGTGAAAAAAGCGGATATCTTCAGTGTATCAAAGGCCGCGCGGGTGTCGCCTTCGACCGTGTCGCGCTACTTCAA
CCACCCTGAACTGGTCAAACTCGCGACCCGCAAGAAGATAGATGCTGCCGTCCGTAAACAGGGCTACATCCGCAACCGCG
CGGCCCAGACGATCCATGGCATTCGCTCCGGCACAATCGGCGTTGTCGTCCCCACGCTGGACCACGCGATCTTTGCAGAG
GTTGTGCAGGCCTTCTCCGACACGGTGGCGGACTTGGGGTTCACGATCCTCCTGGCCTCCCACGGCTACGACCAGCAGCG
GGAATACGCGATCCTGCGCAAAATGCTGGAGCATCGGGTGGATGGCGTGGTGCTGACCGGCCTGGACCATGATGACGCGG
TGTTTCAACTGATCGAGGGGCAGGACGTGCCTTTGGCGCTGATGTGGAACTATTCCGAAGGCGCGCCCTACCCCTGCATC
GGGGCCGACAATGACCTTGCGGGCCGGATGATCGCGCAGCATGTCTTGGCGTTGGGCCACACGCAGATCGCCTGCATGTT
TCCACCCACCGGCGGCAATGACCGGGCCGAGGCGCGGCGCAATTCGGTGATGGAAACCCTTGCGGAGGCGGTCGTGGATG
TGCCTGACCGCTGGCAACTGACCACCGTTTACAGCGTCTCTTCCTCCAAACGCGAGACGATGGCGCTGTTGCGCGCAGGA
CCCCATCCCACCGCGTTGATCTGCGGCAATGACGTGCTGGCGACCGGAGCACTTTACGGGTCAGCCGCGATGGGCATCTC
GGTGCCGCGCGACCTGACAATCGTGGGCATCGGCGATTTTCGTGGCGCCGCCGAGATTGAGCCTGCCTTGACCACAGTCC
ATATCCCGGCACGTGAGATTGGTCGGGAAAGCGGCAAGGCACTGGCCGCTGCTATCACGGATCCGGATGAGCCGCGCCAT
AATATCCATTGTAGACCCAGCCTGCGCGTGCGGGCCTCGTGCCGCGCCCTTGCGTAG

Upstream 100 bases:

>100_bases
CTCCCAAACCAATCAGCGATTGACCAGTTACGCTACGCAATGAAAATAGTTTTGCAAATGTTTTCATAAACCACCCAAAT
ACGGGGTGCAAAGGTCTGAC

Downstream 100 bases:

>100_bases
ACTGTGGATAAGTCTGTGGATAATATGAATTAGTCGCTGATAATTCTTTGAAACAAAGGCCTTAGATGCGATCGGTCAGC
CACCACGTCTCCACGATCCC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVKKADIFSVSKAARVSPSTVSRYFNHPELVKLATRKKIDAAVRKQGYIRNRAAQTIHGIRSGTIGVVVPTLDHAIFAE
VVQAFSDTVADLGFTILLASHGYDQQREYAILRKMLEHRVDGVVLTGLDHDDAVFQLIEGQDVPLALMWNYSEGAPYPCI
GADNDLAGRMIAQHVLALGHTQIACMFPPTGGNDRAEARRNSVMETLAEAVVDVPDRWQLTTVYSVSSSKRETMALLRAG
PHPTALICGNDVLATGALYGSAAMGISVPRDLTIVGIGDFRGAAEIEPALTTVHIPAREIGRESGKALAAAITDPDEPRH
NIHCRPSLRVRASCRALA

Sequences:

>Translated_338_residues
MKVKKADIFSVSKAARVSPSTVSRYFNHPELVKLATRKKIDAAVRKQGYIRNRAAQTIHGIRSGTIGVVVPTLDHAIFAE
VVQAFSDTVADLGFTILLASHGYDQQREYAILRKMLEHRVDGVVLTGLDHDDAVFQLIEGQDVPLALMWNYSEGAPYPCI
GADNDLAGRMIAQHVLALGHTQIACMFPPTGGNDRAEARRNSVMETLAEAVVDVPDRWQLTTVYSVSSSKRETMALLRAG
PHPTALICGNDVLATGALYGSAAMGISVPRDLTIVGIGDFRGAAEIEPALTTVHIPAREIGRESGKALAAAITDPDEPRH
NIHCRPSLRVRASCRALA
>Mature_338_residues
MKVKKADIFSVSKAARVSPSTVSRYFNHPELVKLATRKKIDAAVRKQGYIRNRAAQTIHGIRSGTIGVVVPTLDHAIFAE
VVQAFSDTVADLGFTILLASHGYDQQREYAILRKMLEHRVDGVVLTGLDHDDAVFQLIEGQDVPLALMWNYSEGAPYPCI
GADNDLAGRMIAQHVLALGHTQIACMFPPTGGNDRAEARRNSVMETLAEAVVDVPDRWQLTTVYSVSSSKRETMALLRAG
PHPTALICGNDVLATGALYGSAAMGISVPRDLTIVGIGDFRGAAEIEPALTTVHIPAREIGRESGKALAAAITDPDEPRH
NIHCRPSLRVRASCRALA

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=331, Percent_Identity=28.3987915407855, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI48994940, Length=319, Percent_Identity=30.0940438871473, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1790369, Length=313, Percent_Identity=28.7539936102236, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790194, Length=332, Percent_Identity=26.5060240963855, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786540, Length=309, Percent_Identity=28.4789644012945, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787906, Length=329, Percent_Identity=26.1398176291793, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788474, Length=330, Percent_Identity=28.4848484848485, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790715, Length=326, Percent_Identity=22.0858895705521, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=26.4604810996564, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787580, Length=327, Percent_Identity=25.9938837920489, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789068, Length=301, Percent_Identity=24.5847176079734, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790689, Length=319, Percent_Identity=23.1974921630094, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36517; Mature: 36517

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKKADIFSVSKAARVSPSTVSRYFNHPELVKLATRKKIDAAVRKQGYIRNRAAQTIHG
CCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IRSGTIGVVVPTLDHAIFAEVVQAFSDTVADLGFTILLASHGYDQQREYAILRKMLEHRV
HCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHC
DGVVLTGLDHDDAVFQLIEGQDVPLALMWNYSEGAPYPCIGADNDLAGRMIAQHVLALGH
CCEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TQIACMFPPTGGNDRAEARRNSVMETLAEAVVDVPDRWQLTTVYSVSSSKRETMALLRAG
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCC
PHPTALICGNDVLATGALYGSAAMGISVPRDLTIVGIGDFRGAAEIEPALTTVHIPAREI
CCCEEEEECCCHHHHHHHHCCHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCHHHH
GRESGKALAAAITDPDEPRHNIHCRPSLRVRASCRALA
CCCCCCEEEEEECCCCCCCCCEECCCCCEEECCCCCCC
>Mature Secondary Structure
MKVKKADIFSVSKAARVSPSTVSRYFNHPELVKLATRKKIDAAVRKQGYIRNRAAQTIHG
CCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IRSGTIGVVVPTLDHAIFAEVVQAFSDTVADLGFTILLASHGYDQQREYAILRKMLEHRV
HCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHC
DGVVLTGLDHDDAVFQLIEGQDVPLALMWNYSEGAPYPCIGADNDLAGRMIAQHVLALGH
CCEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TQIACMFPPTGGNDRAEARRNSVMETLAEAVVDVPDRWQLTTVYSVSSSKRETMALLRAG
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCC
PHPTALICGNDVLATGALYGSAAMGISVPRDLTIVGIGDFRGAAEIEPALTTVHIPAREI
CCCEEEEECCCHHHHHHHHCCHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCHHHH
GRESGKALAAAITDPDEPRHNIHCRPSLRVRASCRALA
CCCCCCEEEEEECCCCCCCCCEECCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]