BacMap

Definition	Jannaschia sp. CCS1 chromosome, complete genome.
Accession	NC_007802
Length	4,317,977

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The map label for this gene is kduD [H]

Identifier: 89053951

GI number: 89053951

Start: 1429291

End: 1429998

Strand: Direct

Name: kduD [H]

Synonym: Jann_1460

Alternate gene names: 89053951

Gene position: 1429291-1429998 (Clockwise)

Preceding gene: 89053949

Following gene: 89053952

Centisome position: 33.1

GC content: 63.7

Gene sequence:

>708_bases
ATGACCTCAGCGGCGTTTCAGGACGCGGACGTGCTTGTGGTGGGGGCCAGCCGTGGCGGGATTGGTACGGCGATTGCCCG
TGCCTTTCGAGATGCCGGGGCGCAGGTGCGCATCACGGGCGTCGAGGCTGCGCCTGACCCAGATGACGGGTTCGACTACA
CGGCCCTCGACGTGACGGATACAGATGCCGTCCGCGCCTATGCCGATACGATCCAATACCTTGATATCCTGGTCAATTGT
GCCGCCATCACGCGGCGTGGAGAGGAGATGGATCCCGGCTTTTTCTCCCACGTACTGGACGTAAATTTAACGGGATCGCT
ACGGTGTGCGGAGGCTTTGCACGATGCCTTGAAGGGCGGCTGCGTCATCAATGTGGCCTCAATGTACGCACGCTTCGGCT
CGCCCCGGAACCCGGCCTATGGGGCGTCCAAGGCGGGGGTGGAGCAATTGACCAAGTCGCTCGCCATCGCATGGGCCGAG
GACGGCATCCGCGTCAACGCGATCGCGCCCGGCTTCATCGTAACGGAACAATCGGCCCGCGCGCGAGAAGACGCGACTTT
TGCTGAACGTGTGACGGCGCGAACCCCCATGGGTCGGTGGGGGCAACCCGACGATATAGCGGGGGTCGCGCTGTTTCTGG
CCAGTGACGCGGCCCGGTTCGTCACGGGGGCCACGATCCCGGTCGACGGGGGATATTCGGTTGTTTGA

Upstream 100 bases:

>100_bases
TGGTTCGAGTATGTAATCGATTTCAGAGCCGACAAAGAAGAAAATTCTAAGGGCGGAGATCAGGGAGAAGGGGGGCGGCT
TTGACCAGCCAGTCCAACAT

Downstream 100 bases:

>100_bases
GAGGGGCTTATGACGGATTTTGCAAATATCGGCGCGGTAATTGTCGGCACCGGCTTCATCGGCACGATCCACACGCAGGC
CCTGCGCCGTTTGGGTGTTC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTSAAFQDADVLVVGASRGGIGTAIARAFRDAGAQVRITGVEAAPDPDDGFDYTALDVTDTDAVRAYADTIQYLDILVNC
AAITRRGEEMDPGFFSHVLDVNLTGSLRCAEALHDALKGGCVINVASMYARFGSPRNPAYGASKAGVEQLTKSLAIAWAE
DGIRVNAIAPGFIVTEQSARAREDATFAERVTARTPMGRWGQPDDIAGVALFLASDAARFVTGATIPVDGGYSVV

Sequences:

>Translated_235_residues
MTSAAFQDADVLVVGASRGGIGTAIARAFRDAGAQVRITGVEAAPDPDDGFDYTALDVTDTDAVRAYADTIQYLDILVNC
AAITRRGEEMDPGFFSHVLDVNLTGSLRCAEALHDALKGGCVINVASMYARFGSPRNPAYGASKAGVEQLTKSLAIAWAE
DGIRVNAIAPGFIVTEQSARAREDATFAERVTARTPMGRWGQPDDIAGVALFLASDAARFVTGATIPVDGGYSVV
>Mature_234_residues
TSAAFQDADVLVVGASRGGIGTAIARAFRDAGAQVRITGVEAAPDPDDGFDYTALDVTDTDAVRAYADTIQYLDILVNCA
AITRRGEEMDPGFFSHVLDVNLTGSLRCAEALHDALKGGCVINVASMYARFGSPRNPAYGASKAGVEQLTKSLAIAWAED
GIRVNAIAPGFIVTEQSARAREDATFAERVTARTPMGRWGQPDDIAGVALFLASDAARFVTGATIPVDGGYSVV

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=187, Percent_Identity=33.1550802139037, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI19923817, Length=181, Percent_Identity=33.1491712707182, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4503301, Length=190, Percent_Identity=33.6842105263158, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI10190704, Length=192, Percent_Identity=32.2916666666667, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=30.9623430962343, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI7705925, Length=234, Percent_Identity=27.3504273504274, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI59889578, Length=224, Percent_Identity=35.2678571428571, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=33.4710743801653, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66933014, Length=244, Percent_Identity=29.9180327868852, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI126723750, Length=113, Percent_Identity=38.0530973451327, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=33.7301587301587, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=32.9218106995885, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87082160, Length=239, Percent_Identity=30.9623430962343, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=35.2226720647773, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=34.2857142857143, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=33.6, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=30.4, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI2367365, Length=237, Percent_Identity=31.2236286919831, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=28.0487804878049, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=30.5220883534137, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789378, Length=121, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789057, Length=175, Percent_Identity=29.7142857142857, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=33.7349397590361, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=32.1285140562249, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17561272, Length=194, Percent_Identity=35.0515463917526, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=32.4, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=32.4528301886792, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=233, Percent_Identity=31.7596566523605, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=32.5396825396825, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=31.4741035856574, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=31.8548387096774, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=259, Percent_Identity=30.5019305019305, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=27.7153558052434, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=30.8641975308642, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=29.7709923664122, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=31.1538461538462, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.1954887218045, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=29.2307692307692, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=268, Percent_Identity=27.9850746268657, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=26.615969581749, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=257, Percent_Identity=30.7392996108949, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=27.3408239700375, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=25.7462686567164, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=26.7657992565056, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=25.8426966292135, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=29.4339622641509, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=257, Percent_Identity=27.6264591439689, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=245, Percent_Identity=30.2040816326531, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=30.2238805970149, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=252, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=145, Percent_Identity=35.1724137931034, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=34.8360655737705, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24644337, Length=170, Percent_Identity=37.6470588235294, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=35.0806451612903, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24639444, Length=239, Percent_Identity=33.4728033472803, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24643142, Length=237, Percent_Identity=31.6455696202532, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=30.1960784313725, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=30.8, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=30.8641975308642, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 24608; Mature: 24477

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAAFQDADVLVVGASRGGIGTAIARAFRDAGAQVRITGVEAAPDPDDGFDYTALDVTD
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCC
TDAVRAYADTIQYLDILVNCAAITRRGEEMDPGFFSHVLDVNLTGSLRCAEALHDALKGG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHCC
CVINVASMYARFGSPRNPAYGASKAGVEQLTKSLAIAWAEDGIRVNAIAPGFIVTEQSAR
EEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEEEECCCEEEECCCHH
AREDATFAERVTARTPMGRWGQPDDIAGVALFLASDAARFVTGATIPVDGGYSVV
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCCEEECCCCCCCC
>Mature Secondary Structure 
TSAAFQDADVLVVGASRGGIGTAIARAFRDAGAQVRITGVEAAPDPDDGFDYTALDVTD
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCC
TDAVRAYADTIQYLDILVNCAAITRRGEEMDPGFFSHVLDVNLTGSLRCAEALHDALKGG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHCC
CVINVASMYARFGSPRNPAYGASKAGVEQLTKSLAIAWAEDGIRVNAIAPGFIVTEQSAR
EEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEEEECCCEEEECCCHH
AREDATFAERVTARTPMGRWGQPDDIAGVALFLASDAARFVTGATIPVDGGYSVV
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]