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The map label for this gene is cytR [H]

Identifier: 89053838

GI number: 89053838

Start: 1312134

End: 1313159

Strand: Reverse

Name: cytR [H]

Synonym: Jann_1347

Alternate gene names: 89053838

Gene position: 1313159-1312134 (Counterclockwise)

Preceding gene: 89053844

Following gene: 89053832

Centisome position: 30.41

GC content: 61.6

Gene sequence:

>1026_bases
ATGAACGACAGTCGCGCCATTCCTACATTGCAAGACGTTGCGGATCTGGCCGAGGTCTCGACGGCAACAGTCTCGCGGTG
CCTGAACCTGCCGGATCAGGTGTCCATGAAGACCCGCAAAAAAGTCGACAGCGCGATTGACGCCTTGGGCTATACTCCCA
ATTTCGGCGCGCGGGTGATGGCGGCGCAGCGCACCAAGACCATCGGTGCCATCATTCCGACGATGGAGAACGCGGTTTTC
GCGCGCGGCATCCAAGCCTTCCAGGAGGAGCTGGACGCCAACGGCTACACCCTCCTGGTGGCAAGCTCCTCCTACCAACA
GGACCTGGAGGAGCGGCAGATCAGGTCGCTGGTGGCCCGCGGCGCCGACGCGCTGTTGCTCATCGGCTACGAGCGGGACC
CCGAGATCTTCAAATACCTGCACTCCCGCAACATCCCAGCCCTTGTCACCTGGGCGTTTGACGCGTCGCAGTCCCGGCCC
TCTATCGGGTTCGACAATCGCGGCTCCATGCGAAGCCTGGCGCGCGAGGTTTTGCGCCTCGGTCACCGGCGGCTTGCGAT
GATTTCCGTGGACCGCGGGTCAAACGACCGTGTCGCAGCGCGCGAAGACGGCGTGTACGAAGCCATTCGCGAAATGGGCC
TGCCGGAGAAGGACCTCACCCTTGTCGTGACCAACTACAGTATCGAAACGGGGGCGAGCGCATTTGCCGATGTGATGCAG
ATGGCCAGACGCCCGACAGTCGTATTTTGCGCCAATGACGTGCTTGCGGTGGGCGCGCTGAGAGAGGCGCGGAAGATGGG
CATGATTGTCCCCGACGATGTATCAATCGTCGGTTTTGATGATATCGAGCTTACACAGGTCACCCATCCCGAACTGACGA
CCGTTCACGTCCCCCACAGCGAAATGGGGCGTCTTGCCGCAAAGGCGCTGATCGACCTTCTGGAGAACGGAACTCCCCTT
CGCCGCCATGAGCTTGTTGCGGATATTCGCCTCCGTGGATCCCTCAGCCCACCCGCGATCCGATGA

Upstream 100 bases:

>100_bases
TTTTAAAATGCAAGCGCTTACATTTCGTGTAGCATTGGAACCGTGGCGGTTTTGGCCGATTGTCATGCCATCCATGCTTT
CACCCCCAGGTTGAGCCCAG

Downstream 100 bases:

>100_bases
CTGGTTCGCGGGCCAGATCGCGGACGCGAAGGCGTCCCGCCGCAACCTCGTTGCAGACATTGGTCCACCGTTTGTGCGTC
GTGCCTGATTTGATCGCATT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNDSRAIPTLQDVADLAEVSTATVSRCLNLPDQVSMKTRKKVDSAIDALGYTPNFGARVMAAQRTKTIGAIIPTMENAVF
ARGIQAFQEELDANGYTLLVASSSYQQDLEERQIRSLVARGADALLLIGYERDPEIFKYLHSRNIPALVTWAFDASQSRP
SIGFDNRGSMRSLAREVLRLGHRRLAMISVDRGSNDRVAAREDGVYEAIREMGLPEKDLTLVVTNYSIETGASAFADVMQ
MARRPTVVFCANDVLAVGALREARKMGMIVPDDVSIVGFDDIELTQVTHPELTTVHVPHSEMGRLAAKALIDLLENGTPL
RRHELVADIRLRGSLSPPAIR

Sequences:

>Translated_341_residues
MNDSRAIPTLQDVADLAEVSTATVSRCLNLPDQVSMKTRKKVDSAIDALGYTPNFGARVMAAQRTKTIGAIIPTMENAVF
ARGIQAFQEELDANGYTLLVASSSYQQDLEERQIRSLVARGADALLLIGYERDPEIFKYLHSRNIPALVTWAFDASQSRP
SIGFDNRGSMRSLAREVLRLGHRRLAMISVDRGSNDRVAAREDGVYEAIREMGLPEKDLTLVVTNYSIETGASAFADVMQ
MARRPTVVFCANDVLAVGALREARKMGMIVPDDVSIVGFDDIELTQVTHPELTTVHVPHSEMGRLAAKALIDLLENGTPL
RRHELVADIRLRGSLSPPAIR
>Mature_341_residues
MNDSRAIPTLQDVADLAEVSTATVSRCLNLPDQVSMKTRKKVDSAIDALGYTPNFGARVMAAQRTKTIGAIIPTMENAVF
ARGIQAFQEELDANGYTLLVASSSYQQDLEERQIRSLVARGADALLLIGYERDPEIFKYLHSRNIPALVTWAFDASQSRP
SIGFDNRGSMRSLAREVLRLGHRRLAMISVDRGSNDRVAAREDGVYEAIREMGLPEKDLTLVVTNYSIETGASAFADVMQ
MARRPTVVFCANDVLAVGALREARKMGMIVPDDVSIVGFDDIELTQVTHPELTTVHVPHSEMGRLAAKALIDLLENGTPL
RRHELVADIRLRGSLSPPAIR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=334, Percent_Identity=32.3353293413174, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=31.7152103559871, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787948, Length=312, Percent_Identity=31.0897435897436, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790194, Length=333, Percent_Identity=31.2312312312312, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788474, Length=302, Percent_Identity=30.4635761589404, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789202, Length=295, Percent_Identity=29.8305084745763, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790715, Length=311, Percent_Identity=27.6527331189711, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789068, Length=322, Percent_Identity=27.3291925465839, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1786540, Length=344, Percent_Identity=28.7790697674419, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787580, Length=338, Percent_Identity=25.4437869822485, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790689, Length=304, Percent_Identity=25.6578947368421, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786268, Length=288, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787906, Length=310, Percent_Identity=25.1612903225806, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37487; Mature: 37487

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSRAIPTLQDVADLAEVSTATVSRCLNLPDQVSMKTRKKVDSAIDALGYTPNFGARVM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAQRTKTIGAIIPTMENAVFARGIQAFQEELDANGYTLLVASSSYQQDLEERQIRSLVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHC
GADALLLIGYERDPEIFKYLHSRNIPALVTWAFDASQSRPSIGFDNRGSMRSLAREVLRL
CCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
GHRRLAMISVDRGSNDRVAAREDGVYEAIREMGLPEKDLTLVVTNYSIETGASAFADVMQ
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHH
MARRPTVVFCANDVLAVGALREARKMGMIVPDDVSIVGFDDIELTQVTHPELTTVHVPHS
HHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEEECCCCCEEEECCHH
EMGRLAAKALIDLLENGTPLRRHELVADIRLRGSLSPPAIR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNDSRAIPTLQDVADLAEVSTATVSRCLNLPDQVSMKTRKKVDSAIDALGYTPNFGARVM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAQRTKTIGAIIPTMENAVFARGIQAFQEELDANGYTLLVASSSYQQDLEERQIRSLVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHC
GADALLLIGYERDPEIFKYLHSRNIPALVTWAFDASQSRPSIGFDNRGSMRSLAREVLRL
CCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
GHRRLAMISVDRGSNDRVAAREDGVYEAIREMGLPEKDLTLVVTNYSIETGASAFADVMQ
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHH
MARRPTVVFCANDVLAVGALREARKMGMIVPDDVSIVGFDDIELTQVTHPELTTVHVPHS
HHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEEECCCCCEEEECCHH
EMGRLAAKALIDLLENGTPLRRHELVADIRLRGSLSPPAIR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]