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The map label for this gene is ywfH [H]

Identifier: 89053698

GI number: 89053698

Start: 1167701

End: 1168480

Strand: Direct

Name: ywfH [H]

Synonym: Jann_1207

Alternate gene names: 89053698

Gene position: 1167701-1168480 (Clockwise)

Preceding gene: 89053696

Following gene: 89053699

Centisome position: 27.04

GC content: 66.03

Gene sequence:

>780_bases
ATGGATTTAGGGATCAAGGGACGCCGCGCACTGGTCTGCGCGTCATCAAAGGGTCTGGGCCGGGGCTGCGCGGAGGCGCT
GGCCGAGGCGGGCGTGGATCTGGTGCTGAATGCGCGCGGCGCGGAGGCGCTAGAGGAGACGGCGCAGGCCATCCGCGACA
CCTATGGCGTGTCGGTGACGGCTGCGGCCGCCGACATCACGTCAGAGAAGGGTCGCGCGCGCGTGCTGGCCGAGGCTGCT
GGCGTTGACATCCTGGTGACGAATGCGGGCGGACCGCCGCCGGGGCTGTGGTCCGACTGGGGCCGCGATGACTTCATCGC
CGCGCTGGACGCCAATATGCTGGCGCCCATTGCGCTGATGACCGAGTTGATGCCTGCGATGATCGACAACGGCTGGGGCC
GCGTCGTCAATATCACCTCGCAATCGGTAAAGGCACCGATCCCGGCACTGGGGCTGTCCAATGCCGCGCGCACCGGTCTG
ACCGGTTACGTGGCGGGCACCGCGCGCCAGGTCGCGCCCTTTGGGGTGAACGTCAACAATTTGCTTCCGGGCATTCATGC
CACGGACCGGGCCATACAACTGGACGGCGGCGTTTCCCAGAAAGAGGGCATTAGCATGGATAAGGCGAAGGCCCGCCGCG
AATTAACGATTCCCGCTCGCCGCTATGGCACCCGCGCCGAGTTCGGGGCGATGTGCGCGTTTTTATGCTCGGAACATGCG
GGCTTCATCGTGGGCCAGAACATCCTGTGCGACGGCGGCGGCACCAACGCGACAATCTAG

Upstream 100 bases:

>100_bases
TTTCCCGGTTAGACAGGCGCGGGGCAGGGCGGTCAAGGCTGGTGGCGGAGCAGGGGGGCTGGTAGGCAGATTTCAACGCT
GGATAGGAGGAGACTTGCTT

Downstream 100 bases:

>100_bases
GCGCGCCTTCGGCGCGGGGCACTCAGCGCACCTGCGGTGCTTTTCGTCGCGCGCACCTGCGGTGCGGCTGTCCATGGCAC
CTTCGGTGTGAGGGGCTGAT

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDLGIKGRRALVCASSKGLGRGCAEALAEAGVDLVLNARGAEALEETAQAIRDTYGVSVTAAAADITSEKGRARVLAEAA
GVDILVTNAGGPPPGLWSDWGRDDFIAALDANMLAPIALMTELMPAMIDNGWGRVVNITSQSVKAPIPALGLSNAARTGL
TGYVAGTARQVAPFGVNVNNLLPGIHATDRAIQLDGGVSQKEGISMDKAKARRELTIPARRYGTRAEFGAMCAFLCSEHA
GFIVGQNILCDGGGTNATI

Sequences:

>Translated_259_residues
MDLGIKGRRALVCASSKGLGRGCAEALAEAGVDLVLNARGAEALEETAQAIRDTYGVSVTAAAADITSEKGRARVLAEAA
GVDILVTNAGGPPPGLWSDWGRDDFIAALDANMLAPIALMTELMPAMIDNGWGRVVNITSQSVKAPIPALGLSNAARTGL
TGYVAGTARQVAPFGVNVNNLLPGIHATDRAIQLDGGVSQKEGISMDKAKARRELTIPARRYGTRAEFGAMCAFLCSEHA
GFIVGQNILCDGGGTNATI
>Mature_259_residues
MDLGIKGRRALVCASSKGLGRGCAEALAEAGVDLVLNARGAEALEETAQAIRDTYGVSVTAAAADITSEKGRARVLAEAA
GVDILVTNAGGPPPGLWSDWGRDDFIAALDANMLAPIALMTELMPAMIDNGWGRVVNITSQSVKAPIPALGLSNAARTGL
TGYVAGTARQVAPFGVNVNNLLPGIHATDRAIQLDGGVSQKEGISMDKAKARRELTIPARRYGTRAEFGAMCAFLCSEHA
GFIVGQNILCDGGGTNATI

Specific function: Along with the bacABCDE operon is involved in bacilysin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=33.596837944664, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=29.9212598425197, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI226371731, Length=187, Percent_Identity=29.9465240641711, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=31.9148936170213, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI126723750, Length=260, Percent_Identity=28.0769230769231, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI7705855, Length=191, Percent_Identity=27.7486910994764, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI126723191, Length=178, Percent_Identity=33.7078651685393, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=26.2548262548263, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=27.6381909547739, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=26.1044176706827, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=259, Percent_Identity=31.6602316602317, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=28.6821705426357, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=26.4, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=30.3846153846154, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787905, Length=258, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=27.8884462151394, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=27.5193798449612, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789057, Length=251, Percent_Identity=27.8884462151394, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.5343511450382, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=29.1187739463602, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=29.296875, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=29.4776119402985, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=269, Percent_Identity=29.7397769516729, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=26.2357414448669, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=28.7878787878788, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=27.3408239700375, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=28.3582089552239, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=272, Percent_Identity=26.8382352941176, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=28.030303030303, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=26.9662921348315, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=30.0380228136882, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=27.4131274131274, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=28.2442748091603, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=26.984126984127, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=26.171875, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=29.1338582677165, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=28.125, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=29.8850574712644, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=28.8537549407115, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24584744, Length=202, Percent_Identity=30.1980198019802, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=25.4901960784314, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574402, Length=202, Percent_Identity=30.1980198019802, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640442, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076933, Length=191, Percent_Identity=29.8429319371728, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24584748, Length=191, Percent_Identity=29.8429319371728, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26674; Mature: 26674

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGIKGRRALVCASSKGLGRGCAEALAEAGVDLVLNARGAEALEETAQAIRDTYGVSVT
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEE
AAAADITSEKGRARVLAEAAGVDILVTNAGGPPPGLWSDWGRDDFIAALDANMLAPIALM
EHHHHHHCCCCHHEEEEHHCCCEEEEECCCCCCCCCCCCCCCCCEEEHHCCHHHHHHHHH
TELMPAMIDNGWGRVVNITSQSVKAPIPALGLSNAARTGLTGYVAGTARQVAPFGVNVNN
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEECCCCHHCCCCCCCHHH
LLPGIHATDRAIQLDGGVSQKEGISMDKAKARRELTIPARRYGTRAEFGAMCAFLCSEHA
HCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHEECCCHHHCCCHHHHHHHHHHHHHCCC
GFIVGQNILCDGGGTNATI
CEEECCEEEECCCCCCCCC
>Mature Secondary Structure
MDLGIKGRRALVCASSKGLGRGCAEALAEAGVDLVLNARGAEALEETAQAIRDTYGVSVT
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEE
AAAADITSEKGRARVLAEAAGVDILVTNAGGPPPGLWSDWGRDDFIAALDANMLAPIALM
EHHHHHHCCCCHHEEEEHHCCCEEEEECCCCCCCCCCCCCCCCCEEEHHCCHHHHHHHHH
TELMPAMIDNGWGRVVNITSQSVKAPIPALGLSNAARTGLTGYVAGTARQVAPFGVNVNN
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEECCCCHHCCCCCCCHHH
LLPGIHATDRAIQLDGGVSQKEGISMDKAKARRELTIPARRYGTRAEFGAMCAFLCSEHA
HCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHEECCCHHHCCCHHHHHHHHHHHHHCCC
GFIVGQNILCDGGGTNATI
CEEECCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]