Click here to switch to the map view.

The map label for this gene is gabT [C]

Identifier: 89053612

GI number: 89053612

Start: 1080468

End: 1081829

Strand: Reverse

Name: gabT [C]

Synonym: Jann_1121

Alternate gene names: 89053612

Gene position: 1081829-1080468 (Counterclockwise)

Preceding gene: 89053613

Following gene: 89053611

Centisome position: 25.05

GC content: 63.8

Gene sequence:

>1362_bases
ATGAACACCTACGCCCCCAATTCCTGGGAAGCGCGCGCCGAGGAATACTCGCTCTATGGCTTCACCGATCTGCCGTCGAT
CCGCGACCGGGGAACCGTTGTCGTCACCCACGGTGAGGGTCCGTATATCTTTGACACCAATGGGAAAAAGTACCTCGATA
GCAATTCGGGCCTTTGGAACATGGTGGCGGGATTTGACCACAAAGGATTGGCCGAGGCCGCCAAGGCGCAATACGACCGC
TTCCCCGGCTATCACGCCTTCTTTGGCCGCATGTCCGACCAAACGGTGGCCTTGTCCGAGCGGTTGATCGACGTGTCACC
CTGGGACCGCGGCAAGGTGTTCTACACGAATTCCGGGTCCGAGGCGAACGACACCATGGTCAAGATGCTGTGGTTCATGG
CCCGCGCGGAAGGCACGCCGCAAAAGCGCAAAATCCTGACCCGGGGCAATGCTTATCATGGGGTCACGGCGGTCTCGGCC
TCCATGACCGCGAAGCCGTATAACGAGGTGTTCGGCCTGCCGCTCGACGGGTTCGTCCACCTCACCTGCCCGCATTACTG
GCGCGAGGGGCACGAGGGCGAGAGTGAGGCCGCGTTTACCGCCCGGCTGGCGCTTGAGTTGGAGGACGTCATCGCGCGCG
AGGGCGCGGAGACGATTGCGGGGTTCTTTGCGGAACCGGTTCTGGGCGCAGGCGGGGTGATCCCTCCGCCCGAGGGGTAC
TTTCAGGCGATGCAGGCGGTGCTGCGCCGGCATGGCATCCCGCTCATTTCCGATGAGGTGATCTGCGGGTTTGGCCGCAC
CGGAGAGGTCTGGGGCTGCGAGAGCTATGACTTCATCCCCGATGCCATCATATCCTCCAAAGCCCTGACAGCAGGGTATT
TTCCCATGGGCGCGGTGATGTTGGGGCCTCAGATGACGGACCGCCTGCAAGCGGCCATCGACCCGATCGAGGAATTCCCC
CACGGCTTCACCGCGTCGGGCCACCCGGTGGGTTGTGCGGTGGCCCTGAAGGCCATCGACGTGGTGCTGGAGGAGGGGCT
GCTGGATAGCGTCCGCGCGGGTGCGGGCCGGATGGAAGCGGGCTTGGCCGAGGTCGCAAAACACCCCAACATCGGAGAGC
TGCGCGGCATCGGCTACATGTGGGCGCTGGAGGCGGTGCGCGAGGGCAAGGTGCCGTTCGAGGGCGACCTGTCGGTCAGC
GAACGGATCGCCAATACCTGCACCGACCACGGGTTGATCTGCCGCCCACTGGGACAATCGGTGGTGCTCTGCCCCGCCTT
CACCCTGACCGACGGGCAGATGGATGAGATGTGCGAGAAGCTCGATGCGGCGCTGCGGCAGGTGTTTGCAGAGATCACAT
GA

Upstream 100 bases:

>100_bases
CGACTGGATCACGCGGGCCGAGCACCGAACCGACATCGCCTATTGAGCGCCACGGGACACGGGCGTAGCGTCAGCGACAA
GTACCACGGAGGTCCGCACC

Downstream 100 bases:

>100_bases
GTGACGCACGTCCGCTGCCCGACGGTTTTGAGCTGATCCCCCTGCGCTCCGCCACGCTGCACCTGCGGCCCATGGTGGCG
CAGGACTTGGCCGCACTCAC

Product: aminotransferase

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MNTYAPNSWEARAEEYSLYGFTDLPSIRDRGTVVVTHGEGPYIFDTNGKKYLDSNSGLWNMVAGFDHKGLAEAAKAQYDR
FPGYHAFFGRMSDQTVALSERLIDVSPWDRGKVFYTNSGSEANDTMVKMLWFMARAEGTPQKRKILTRGNAYHGVTAVSA
SMTAKPYNEVFGLPLDGFVHLTCPHYWREGHEGESEAAFTARLALELEDVIAREGAETIAGFFAEPVLGAGGVIPPPEGY
FQAMQAVLRRHGIPLISDEVICGFGRTGEVWGCESYDFIPDAIISSKALTAGYFPMGAVMLGPQMTDRLQAAIDPIEEFP
HGFTASGHPVGCAVALKAIDVVLEEGLLDSVRAGAGRMEAGLAEVAKHPNIGELRGIGYMWALEAVREGKVPFEGDLSVS
ERIANTCTDHGLICRPLGQSVVLCPAFTLTDGQMDEMCEKLDAALRQVFAEIT

Sequences:

>Translated_453_residues
MNTYAPNSWEARAEEYSLYGFTDLPSIRDRGTVVVTHGEGPYIFDTNGKKYLDSNSGLWNMVAGFDHKGLAEAAKAQYDR
FPGYHAFFGRMSDQTVALSERLIDVSPWDRGKVFYTNSGSEANDTMVKMLWFMARAEGTPQKRKILTRGNAYHGVTAVSA
SMTAKPYNEVFGLPLDGFVHLTCPHYWREGHEGESEAAFTARLALELEDVIAREGAETIAGFFAEPVLGAGGVIPPPEGY
FQAMQAVLRRHGIPLISDEVICGFGRTGEVWGCESYDFIPDAIISSKALTAGYFPMGAVMLGPQMTDRLQAAIDPIEEFP
HGFTASGHPVGCAVALKAIDVVLEEGLLDSVRAGAGRMEAGLAEVAKHPNIGELRGIGYMWALEAVREGKVPFEGDLSVS
ERIANTCTDHGLICRPLGQSVVLCPAFTLTDGQMDEMCEKLDAALRQVFAEIT
>Mature_453_residues
MNTYAPNSWEARAEEYSLYGFTDLPSIRDRGTVVVTHGEGPYIFDTNGKKYLDSNSGLWNMVAGFDHKGLAEAAKAQYDR
FPGYHAFFGRMSDQTVALSERLIDVSPWDRGKVFYTNSGSEANDTMVKMLWFMARAEGTPQKRKILTRGNAYHGVTAVSA
SMTAKPYNEVFGLPLDGFVHLTCPHYWREGHEGESEAAFTARLALELEDVIAREGAETIAGFFAEPVLGAGGVIPPPEGY
FQAMQAVLRRHGIPLISDEVICGFGRTGEVWGCESYDFIPDAIISSKALTAGYFPMGAVMLGPQMTDRLQAAIDPIEEFP
HGFTASGHPVGCAVALKAIDVVLEEGLLDSVRAGAGRMEAGLAEVAKHPNIGELRGIGYMWALEAVREGKVPFEGDLSVS
ERIANTCTDHGLICRPLGQSVVLCPAFTLTDGQMDEMCEKLDAALRQVFAEIT

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=366, Percent_Identity=30.327868852459, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=26.0869565217391, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI226442705, Length=366, Percent_Identity=30.6010928961749, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI226442709, Length=335, Percent_Identity=30.7462686567164, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI24119277, Length=370, Percent_Identity=28.1081081081081, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI4557809, Length=445, Percent_Identity=25.3932584269663, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI284507298, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI188536080, Length=385, Percent_Identity=22.3376623376623, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI38679950, Length=385, Percent_Identity=22.3376623376623, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI38679946, Length=385, Percent_Identity=22.3376623376623, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=28.9473684210526, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789759, Length=414, Percent_Identity=26.8115942028986, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788044, Length=414, Percent_Identity=27.2946859903382, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI145693181, Length=427, Percent_Identity=27.6346604215457, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=25.2983293556086, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=26.491646778043, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1786349, Length=434, Percent_Identity=24.4239631336406, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=374, Percent_Identity=29.9465240641711, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=24.3243243243243, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=377, Percent_Identity=25.1989389920424, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=177, Percent_Identity=29.3785310734463, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17541228, Length=444, Percent_Identity=22.0720720720721, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=435, Percent_Identity=26.8965517241379, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323470, Length=456, Percent_Identity=25, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=383, Percent_Identity=26.3707571801567, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=287, Percent_Identity=24.0418118466899, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28574759, Length=407, Percent_Identity=30.4668304668305, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161085790, Length=407, Percent_Identity=30.4668304668305, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21356575, Length=363, Percent_Identity=28.6501377410468, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357415, Length=435, Percent_Identity=26.6666666666667, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI281366494, Length=442, Percent_Identity=22.6244343891403, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667139, Length=442, Percent_Identity=22.6244343891403, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667143, Length=442, Percent_Identity=22.6244343891403, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 49311; Mature: 49311

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYAPNSWEARAEEYSLYGFTDLPSIRDRGTVVVTHGEGPYIFDTNGKKYLDSNSGLWN
CCCCCCCCCHHHHHHEEEECCCCCCCCCCCCEEEEECCCCCEEECCCCCEEECCCCCCEE
MVAGFDHKGLAEAAKAQYDRFPGYHAFFGRMSDQTVALSERLIDVSPWDRGKVFYTNSGS
HHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHEECCCCCCCEEEEECCCC
EANDTMVKMLWFMARAEGTPQKRKILTRGNAYHGVTAVSASMTAKPYNEVFGLPLDGFVH
CHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCCEEEEHHCCCCCHHHHCCCCCCCEEE
LTCPHYWREGHEGESEAAFTARLALELEDVIAREGAETIAGFFAEPVLGAGGVIPPPEGY
EECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHH
FQAMQAVLRRHGIPLISDEVICGFGRTGEVWGCESYDFIPDAIISSKALTAGYFPMGAVM
HHHHHHHHHHCCCCEECCCEEECCCCCCCEECCCCCCCCCHHHHCCCCCCCCCCCCCCEE
LGPQMTDRLQAAIDPIEEFPHGFTASGHPVGCAVALKAIDVVLEEGLLDSVRAGAGRMEA
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GLAEVAKHPNIGELRGIGYMWALEAVREGKVPFEGDLSVSERIANTCTDHGLICRPLGQS
HHHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCC
VVLCPAFTLTDGQMDEMCEKLDAALRQVFAEIT
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTYAPNSWEARAEEYSLYGFTDLPSIRDRGTVVVTHGEGPYIFDTNGKKYLDSNSGLWN
CCCCCCCCCHHHHHHEEEECCCCCCCCCCCCEEEEECCCCCEEECCCCCEEECCCCCCEE
MVAGFDHKGLAEAAKAQYDRFPGYHAFFGRMSDQTVALSERLIDVSPWDRGKVFYTNSGS
HHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHEECCCCCCCEEEEECCCC
EANDTMVKMLWFMARAEGTPQKRKILTRGNAYHGVTAVSASMTAKPYNEVFGLPLDGFVH
CHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCCEEEEHHCCCCCHHHHCCCCCCCEEE
LTCPHYWREGHEGESEAAFTARLALELEDVIAREGAETIAGFFAEPVLGAGGVIPPPEGY
EECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHH
FQAMQAVLRRHGIPLISDEVICGFGRTGEVWGCESYDFIPDAIISSKALTAGYFPMGAVM
HHHHHHHHHHCCCCEECCCEEECCCCCCCEECCCCCCCCCHHHHCCCCCCCCCCCCCCEE
LGPQMTDRLQAAIDPIEEFPHGFTASGHPVGCAVALKAIDVVLEEGLLDSVRAGAGRMEA
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GLAEVAKHPNIGELRGIGYMWALEAVREGKVPFEGDLSVSERIANTCTDHGLICRPLGQS
HHHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCC
VVLCPAFTLTDGQMDEMCEKLDAALRQVFAEIT
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]