Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 89053589

GI number: 89053589

Start: 1058300

End: 1060246

Strand: Reverse

Name: thrS

Synonym: Jann_1098

Alternate gene names: 89053589

Gene position: 1060246-1058300 (Counterclockwise)

Preceding gene: 89053591

Following gene: 89053588

Centisome position: 24.55

GC content: 63.17

Gene sequence:

>1947_bases
ATGGCCCAAATCTCTCTCACCTTCCCCGATGGCAACGCGCGCTCTTACGACGCCGGGATCACTCCCGCTGCCGTCGCCGC
CGACATCTCCAATTCGCTGGCCAAGAAGGCCATTTCCGCCACGGTCGACGGCGCGCATCATGATTTGCAATGGCCCATCG
ACGCGGACGCGCAAATCGCGATCCATACCCTCAAGGATGACGATCAGGCGCTTGAGCTGATCCGCCACGACTGCGCCCAC
ATCATGGCCCGCGCGGTGCAGGAAATCTGGCCGGACGTCAAAGTCACCATCGGCCCGGTGCGCGACAAGGGCTGGTTCTA
CGATTTCGACCGGCCGGAGCCGTTCACGCCCGAGGATCTGGGCGCGATCGAGGCGAAGATGAAAGAGATCATCAACGCCC
GCGACGCCGTGCGCACCGAAATCTGGGACCGCGACCGCGTCCGCGCCCATTATGAGGCGACGGATGAGCCCTATAAGATC
GAGCTCCTCGACCGCATTCCGGGCGACGAGCCGATCCGCATGTATTGGCACGGCGATTGGCAGGACATGTGCCGCGGCCC
GCATCTGCAACATACCGGTCAGGTGCCCGCCGATGCCTTCAAGCTGATGTCCGTGGCCGCCGCCTACTGGCTTGGCGACA
ACACGCGCCCTATGCTGCAACGCATCTACGGCGTCGCCTTCAAGAACCGCGACGACCTGCGCAAGTATCTGAATTTCCTG
GAGGAAGCCGAGAAGCGCGATCACCGTCGTCTGGGCCGCGAGATGGACCTGTATCACATGCAGGAAGAGGCGCCGGGGCA
GGTGTTCTGGCACCCCAACGGCTGGACCATCTACACCACGTTGCAGGATTACATGCGCCGCAAGCAACGCGCCGATGGCT
ATGTGGAGGTGAACACCCCGCAGGTCGTGGACCGCGCCTTGTGGGAAAAGTCCGGCCATTGGGACAAGTATCAGGAGCAT
ATGTTCATCGTCGAAGTGGATGAGGAACACGCCCAGACCAAGGCCATCAACGCGCTCAAGCCGATGAACTGCCCCTGCCA
CGTGGAGGTGTTCAATCAGGGGCTGAAATCTTATCGCGACCTGCCCCTGCGGATGGCGGAATTCGGCTCCTGCTCACGGT
ATGAGCCCTCGGGCGCTTTGCATGGCATCATGCGCGTGCGCGGGTTTACCCAGGACGACGCCCACATCTTCTGCACCGAA
GATCAGATCGAGGCCGAATGCGCCAAGTTCATCACCTTCCTCTCGGGCGTCTACAAGGATTTGGGGTTTGAGAGCTTCGA
CATTGCCTTCGCCACCCGCCCCGAAAAGCGCGTGGGCACCGATGAGGCGTGGGATCACGTCGAAGGCGCGCTGGAGGCGG
CGATCAAATCCGTGGGCAATCCCTACCGGATCGAGGAGGGCGACGGCGCGTTTTACGGCCCCAAACTGGACTTCTACCTG
ACCGACGCCATCGGGCGCGTATGGCAGTGTGGAACGTTCCAGGTCGACCCCAACCTGCCCGAGCGTCTGGGCGCCAGCTA
TGTCGGCCAGGACGGCGACAAGCATCGCCCCTACATGCTGCACCGCGCCTGCCTTGGCTCGTTCGAGCGGTTCATCGGCA
TCCTGATCGAGAACTCGGAAGGTCGTCTGCCGTTCTGGCTGGCCCCGCGTCAGGTGGTCGTGGCCTCCATCGTGTCGGAC
GCCGATGAGTTCGTACACGAGGTCGTCGCCGCCCTGAAGGCCACCGGCATCCGGGCCGAGGCCGACACCCGCAACGAGAA
GATCAACTACAAGGTTCGCGAACATTCCGTCGGCAAGGTCCCCGCGATCCTCGCCATCGGCAAGCAGGAGGTCGAGAACC
GCACCGTCACCCTGCGTCGTCTGGGCGAAAAGCAAACCCGCGTTGTGCCCCTGGCCGAAGTGGTGGAAGCCCTGGCCGCT
GAGGCCGTCGCGCCGGACCTGCGCTGA

Upstream 100 bases:

>100_bases
CCGCCCGTTGACATGGGCCCGAAGCCTCGCCAAAGAGCACCGGAAGACATACCCGCAACCGGGCGTTTTGTAGGCGCCAA
ACTGACGAGGAGCCCTTTTG

Downstream 100 bases:

>100_bases
CCCGAAAACCAGTCGCGCGCCCCTCCTGCCCCGGGCGCGCGACCCTTAACGCCCTGTTAATAATCTTTCCTTGAATTGCC
ACAGTTTTGCCGGGCAAGTG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MAQISLTFPDGNARSYDAGITPAAVAADISNSLAKKAISATVDGAHHDLQWPIDADAQIAIHTLKDDDQALELIRHDCAH
IMARAVQEIWPDVKVTIGPVRDKGWFYDFDRPEPFTPEDLGAIEAKMKEIINARDAVRTEIWDRDRVRAHYEATDEPYKI
ELLDRIPGDEPIRMYWHGDWQDMCRGPHLQHTGQVPADAFKLMSVAAAYWLGDNTRPMLQRIYGVAFKNRDDLRKYLNFL
EEAEKRDHRRLGREMDLYHMQEEAPGQVFWHPNGWTIYTTLQDYMRRKQRADGYVEVNTPQVVDRALWEKSGHWDKYQEH
MFIVEVDEEHAQTKAINALKPMNCPCHVEVFNQGLKSYRDLPLRMAEFGSCSRYEPSGALHGIMRVRGFTQDDAHIFCTE
DQIEAECAKFITFLSGVYKDLGFESFDIAFATRPEKRVGTDEAWDHVEGALEAAIKSVGNPYRIEEGDGAFYGPKLDFYL
TDAIGRVWQCGTFQVDPNLPERLGASYVGQDGDKHRPYMLHRACLGSFERFIGILIENSEGRLPFWLAPRQVVVASIVSD
ADEFVHEVVAALKATGIRAEADTRNEKINYKVREHSVGKVPAILAIGKQEVENRTVTLRRLGEKQTRVVPLAEVVEALAA
EAVAPDLR

Sequences:

>Translated_648_residues
MAQISLTFPDGNARSYDAGITPAAVAADISNSLAKKAISATVDGAHHDLQWPIDADAQIAIHTLKDDDQALELIRHDCAH
IMARAVQEIWPDVKVTIGPVRDKGWFYDFDRPEPFTPEDLGAIEAKMKEIINARDAVRTEIWDRDRVRAHYEATDEPYKI
ELLDRIPGDEPIRMYWHGDWQDMCRGPHLQHTGQVPADAFKLMSVAAAYWLGDNTRPMLQRIYGVAFKNRDDLRKYLNFL
EEAEKRDHRRLGREMDLYHMQEEAPGQVFWHPNGWTIYTTLQDYMRRKQRADGYVEVNTPQVVDRALWEKSGHWDKYQEH
MFIVEVDEEHAQTKAINALKPMNCPCHVEVFNQGLKSYRDLPLRMAEFGSCSRYEPSGALHGIMRVRGFTQDDAHIFCTE
DQIEAECAKFITFLSGVYKDLGFESFDIAFATRPEKRVGTDEAWDHVEGALEAAIKSVGNPYRIEEGDGAFYGPKLDFYL
TDAIGRVWQCGTFQVDPNLPERLGASYVGQDGDKHRPYMLHRACLGSFERFIGILIENSEGRLPFWLAPRQVVVASIVSD
ADEFVHEVVAALKATGIRAEADTRNEKINYKVREHSVGKVPAILAIGKQEVENRTVTLRRLGEKQTRVVPLAEVVEALAA
EAVAPDLR
>Mature_647_residues
AQISLTFPDGNARSYDAGITPAAVAADISNSLAKKAISATVDGAHHDLQWPIDADAQIAIHTLKDDDQALELIRHDCAHI
MARAVQEIWPDVKVTIGPVRDKGWFYDFDRPEPFTPEDLGAIEAKMKEIINARDAVRTEIWDRDRVRAHYEATDEPYKIE
LLDRIPGDEPIRMYWHGDWQDMCRGPHLQHTGQVPADAFKLMSVAAAYWLGDNTRPMLQRIYGVAFKNRDDLRKYLNFLE
EAEKRDHRRLGREMDLYHMQEEAPGQVFWHPNGWTIYTTLQDYMRRKQRADGYVEVNTPQVVDRALWEKSGHWDKYQEHM
FIVEVDEEHAQTKAINALKPMNCPCHVEVFNQGLKSYRDLPLRMAEFGSCSRYEPSGALHGIMRVRGFTQDDAHIFCTED
QIEAECAKFITFLSGVYKDLGFESFDIAFATRPEKRVGTDEAWDHVEGALEAAIKSVGNPYRIEEGDGAFYGPKLDFYLT
DAIGRVWQCGTFQVDPNLPERLGASYVGQDGDKHRPYMLHRACLGSFERFIGILIENSEGRLPFWLAPRQVVVASIVSDA
DEFVHEVVAALKATGIRAEADTRNEKINYKVREHSVGKVPAILAIGKQEVENRTVTLRRLGEKQTRVVPLAEVVEALAAE
AVAPDLR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=641, Percent_Identity=38.2215288611544, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=37.375415282392, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI20070344, Length=640, Percent_Identity=36.71875, Blast_Score=416, Evalue=1e-116,
Organism=Escherichia coli, GI1788013, Length=646, Percent_Identity=47.9876160990712, Blast_Score=627, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=620, Percent_Identity=36.7741935483871, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71984192, Length=619, Percent_Identity=36.3489499192246, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322112, Length=640, Percent_Identity=37.96875, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322654, Length=416, Percent_Identity=35.0961538461538, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24583839, Length=641, Percent_Identity=37.9095163806552, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24583842, Length=641, Percent_Identity=37.9095163806552, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI28574141, Length=641, Percent_Identity=37.9095163806552, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73664; Mature: 73533

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00024 HEMOPEXIN ; PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQISLTFPDGNARSYDAGITPAAVAADISNSLAKKAISATVDGAHHDLQWPIDADAQIA
CCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
IHTLKDDDQALELIRHDCAHIMARAVQEIWPDVKVTIGPVRDKGWFYDFDRPEPFTPEDL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCCHHH
GAIEAKMKEIINARDAVRTEIWDRDRVRAHYEATDEPYKIELLDRIPGDEPIRMYWHGDW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCCEEEEEECCCCCCCCEEEEECCCH
QDMCRGPHLQHTGQVPADAFKLMSVAAAYWLGDNTRPMLQRIYGVAFKNRDDLRKYLNFL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
EEAEKRDHRRLGREMDLYHMQEEAPGQVFWHPNGWTIYTTLQDYMRRKQRADGYVEVNTP
HHHHHHHHHHHCCCCCHHHHHCCCCCCEEECCCCCEEEHHHHHHHHHHHCCCCEEEECCH
QVVDRALWEKSGHWDKYQEHMFIVEVDEEHAQTKAINALKPMNCPCHVEVFNQGLKSYRD
HHHHHHHHHCCCCCCCHHCCEEEEEECHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHC
LPLRMAEFGSCSRYEPSGALHGIMRVRGFTQDDAHIFCTEDQIEAECAKFITFLSGVYKD
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
LGFESFDIAFATRPEKRVGTDEAWDHVEGALEAAIKSVGNPYRIEEGDGAFYGPKLDFYL
CCCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEE
TDAIGRVWQCGTFQVDPNLPERLGASYVGQDGDKHRPYMLHRACLGSFERFIGILIENSE
EHHHHHHEECCCEEECCCCHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
GRLPFWLAPRQVVVASIVSDADEFVHEVVAALKATGIRAEADTRNEKINYKVREHSVGKV
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
PAILAIGKQEVENRTVTLRRLGEKQTRVVPLAEVVEALAAEAVAPDLR
CHHEEECHHHHHCHHHHHHHHCCHHHCEECHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AQISLTFPDGNARSYDAGITPAAVAADISNSLAKKAISATVDGAHHDLQWPIDADAQIA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
IHTLKDDDQALELIRHDCAHIMARAVQEIWPDVKVTIGPVRDKGWFYDFDRPEPFTPEDL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCCHHH
GAIEAKMKEIINARDAVRTEIWDRDRVRAHYEATDEPYKIELLDRIPGDEPIRMYWHGDW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCCEEEEEECCCCCCCCEEEEECCCH
QDMCRGPHLQHTGQVPADAFKLMSVAAAYWLGDNTRPMLQRIYGVAFKNRDDLRKYLNFL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
EEAEKRDHRRLGREMDLYHMQEEAPGQVFWHPNGWTIYTTLQDYMRRKQRADGYVEVNTP
HHHHHHHHHHHCCCCCHHHHHCCCCCCEEECCCCCEEEHHHHHHHHHHHCCCCEEEECCH
QVVDRALWEKSGHWDKYQEHMFIVEVDEEHAQTKAINALKPMNCPCHVEVFNQGLKSYRD
HHHHHHHHHCCCCCCCHHCCEEEEEECHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHC
LPLRMAEFGSCSRYEPSGALHGIMRVRGFTQDDAHIFCTEDQIEAECAKFITFLSGVYKD
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
LGFESFDIAFATRPEKRVGTDEAWDHVEGALEAAIKSVGNPYRIEEGDGAFYGPKLDFYL
CCCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEE
TDAIGRVWQCGTFQVDPNLPERLGASYVGQDGDKHRPYMLHRACLGSFERFIGILIENSE
EHHHHHHEECCCEEECCCCHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
GRLPFWLAPRQVVVASIVSDADEFVHEVVAALKATGIRAEADTRNEKINYKVREHSVGKV
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
PAILAIGKQEVENRTVTLRRLGEKQTRVVPLAEVVEALAAEAVAPDLR
CHHEEECHHHHHCHHHHHHHHCCHHHCEECHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA