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The map label for this gene is rnc

Identifier: 89053013

GI number: 89053013

Start: 514001

End: 514684

Strand: Direct

Name: rnc

Synonym: Jann_0522

Alternate gene names: 89053013

Gene position: 514001-514684 (Clockwise)

Preceding gene: 89053012

Following gene: 89053015

Centisome position: 11.9

GC content: 66.23

Gene sequence:

>684_bases
ATGAAACCCGCGCGGGAGCTGACGGCCTTCATGGACCGCCTGGGGTATGTCTTTGAGGACCCCGCATTGCTCGCGCGCGC
GCTGACCCATTCGTCCCTGTCCTCGCCCACGCGGGGCGATAACCAGCGGCTGGAGTTCCTGGGCGACCGCGTTCTGGGTT
TGGTGATGGCCGAGGCCGTCCTGGCCGCTGACACGGACGCGAAGGAAGGTACGCTTGCGCCGCGCTTCAACGCGCTGGTC
CGCAAAGAGGCCTGCGCTGACGTGGCCCGCCAGATTGATCTGGGTGCGGCCATGCGTCTTGGCAAATCCGAGATGTCCGC
AGGGGGCCGCCGCCGCATGGCGCTTTTGGGCGACGCGATGGAAGCGGTGATCGCCGCCGTCTATCTGGATGGGGGCTTTG
CAAGCGCGCGCGATCTGGTCCTACGCCTCTGGTCCGAGCGGGTGCAAAGCGTCGAGGAAGATGCGCGCGACGCCAAAACG
GCGCTTCAGGAATGGGCGCAGGCCCGTGGTATGGCGCCGCCGACATATACCGAAGTTGCCCGATCCGGCCCAGATCATGC
GCCCGTTTTTCGAGTCCGCGTGACGCTGTCCTCCGGCGAAAACGCGGAGGCTCAGGCCAAAGCCAAACGTCAGGCCGAGC
AGCAGGCGGCGAAAGACTTACTGGCGCAGCTGGCGGGCGAATGA

Upstream 100 bases:

>100_bases
TCGTGCGGACCGGGTGATTTTCTCGTCCGCGGGCCAGCGAATGATCTACTTCTGGACCTGGCGCTCGGACCGCTTCTTCC
GGGCGATCGAGTAGCCCGCG

Downstream 100 bases:

>100_bases
GGCGGCTCTAGCGGACCTCTTCATCCGGTTGCATCACGAAGATCAGCACGACCAGTATCGACATGTAGAACCGGAACGCG
GCTTGCTGGCCGTTCCAGAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKPARELTAFMDRLGYVFEDPALLARALTHSSLSSPTRGDNQRLEFLGDRVLGLVMAEAVLAADTDAKEGTLAPRFNALV
RKEACADVARQIDLGAAMRLGKSEMSAGGRRRMALLGDAMEAVIAAVYLDGGFASARDLVLRLWSERVQSVEEDARDAKT
ALQEWAQARGMAPPTYTEVARSGPDHAPVFRVRVTLSSGENAEAQAKAKRQAEQQAAKDLLAQLAGE

Sequences:

>Translated_227_residues
MKPARELTAFMDRLGYVFEDPALLARALTHSSLSSPTRGDNQRLEFLGDRVLGLVMAEAVLAADTDAKEGTLAPRFNALV
RKEACADVARQIDLGAAMRLGKSEMSAGGRRRMALLGDAMEAVIAAVYLDGGFASARDLVLRLWSERVQSVEEDARDAKT
ALQEWAQARGMAPPTYTEVARSGPDHAPVFRVRVTLSSGENAEAQAKAKRQAEQQAAKDLLAQLAGE
>Mature_227_residues
MKPARELTAFMDRLGYVFEDPALLARALTHSSLSSPTRGDNQRLEFLGDRVLGLVMAEAVLAADTDAKEGTLAPRFNALV
RKEACADVARQIDLGAAMRLGKSEMSAGGRRRMALLGDAMEAVIAAVYLDGGFASARDLVLRLWSERVQSVEEDARDAKT
ALQEWAQARGMAPPTYTEVARSGPDHAPVFRVRVTLSSGENAEAQAKAKRQAEQQAAKDLLAQLAGE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=29.2576419213974, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=29.2576419213974, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1788920, Length=187, Percent_Identity=37.4331550802139, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17506883, Length=226, Percent_Identity=29.2035398230088, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=226, Percent_Identity=29.2035398230088, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137682, Length=231, Percent_Identity=32.9004329004329, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_JANSC (Q28V23)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508464.1
- ProteinModelPortal:   Q28V23
- SMR:   Q28V23
- STRING:   Q28V23
- GeneID:   3932963
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0522
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q28V23
- ProtClustDB:   CLSK934087
- BioCyc:   JSP290400:JANN_0522-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 24482; Mature: 24482

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPARELTAFMDRLGYVFEDPALLARALTHSSLSSPTRGDNQRLEFLGDRVLGLVMAEAV
CCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAADTDAKEGTLAPRFNALVRKEACADVARQIDLGAAMRLGKSEMSAGGRRRMALLGDAM
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHH
EAVIAAVYLDGGFASARDLVLRLWSERVQSVEEDARDAKTALQEWAQARGMAPPTYTEVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RSGPDHAPVFRVRVTLSSGENAEAQAKAKRQAEQQAAKDLLAQLAGE
HCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPARELTAFMDRLGYVFEDPALLARALTHSSLSSPTRGDNQRLEFLGDRVLGLVMAEAV
CCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAADTDAKEGTLAPRFNALVRKEACADVARQIDLGAAMRLGKSEMSAGGRRRMALLGDAM
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHH
EAVIAAVYLDGGFASARDLVLRLWSERVQSVEEDARDAKTALQEWAQARGMAPPTYTEVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RSGPDHAPVFRVRVTLSSGENAEAQAKAKRQAEQQAAKDLLAQLAGE
HCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA