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The map label for this gene is patB [H]

Identifier: 89052956

GI number: 89052956

Start: 464681

End: 465850

Strand: Reverse

Name: patB [H]

Synonym: Jann_0465

Alternate gene names: 89052956

Gene position: 465850-464681 (Counterclockwise)

Preceding gene: 89052966

Following gene: 89052952

Centisome position: 10.79

GC content: 60.51

Gene sequence:

>1170_bases
ATGTCATTTGATGAGATCATCGACCGCCGTGGCACCCATTGCACGAAATGGGACATGATGGAGACGCTGTACGGTGTCTC
GCCCGACGACGGGATCTCGATGTGGGTGGCTGACATGGACTTCCGCCCGCCGCAATGCGTGCAGGATGCGGTGGCCGACA
TGCACGCCCATGGCGTCTACGGCTATTTCGGCGATGACAGTAAATATCGCGCTGCCATCTGTTGGTGGATGCAGGAGCGT
CACGGGTGGAGCGTGGACCCCTCGCACATCTTCTCCACCCATGGGCTGGTGAACGGCACGTCCATGTGCATCGATGCTTT
CACCGCGCCGGGTGACGGGGTGGTCCTTTTCACCCCGGTCTATCATGCGTTCGCCAAGGTCATTAACGCCTCGGCCCGTG
ACCTGTGTGAGTTGGAGATGCCAATCGTGGACGGTCGCCTGACCCTCGATTTTGAGGCCTTTGATACGCAGATGAAGGGG
CATGAGAAGATGCTGGTGCTGTGTTCGCCGCATAATCCCGGGGGACGTGTCTGGACGCGCGAGGAGTTGGAAGGCATCGC
GGATTTCGCACGGCGTCATGACCTGATCCTTGTATCGGACGAGATTCACCATGACCTCACCATGCCCGGTCAGACCCACA
TTCCCATGGCCCATATCGACGGGATCGAAGACCGGCTGGTGATGATGACGGCGGCCACCAAGACCTTCAACATCGCGGGC
TCCCATATCGGGAATGTCATCATCGCCGACGACACCCTGCGCGCGACATTCGCGGGCCGAATGGCGGCGTTGGGCATGTC
ACCAAACTCATTTGGCCTGTTCATGGTCACCGCGGCCTATTCCCCCGAGGGGGCAGAGTGGCTGGACGAGTTGCGCGCTT
ATCTGGCCGAGAATGCCCGCGTCTTTGATGAGGGGATCAACGCCATTCCCGGACTTCGGTCCATGGCCCTCGAATCCACC
TACCTTGCGTGGGTCGACTTTTCCGGCACCGGGATGACCAAGGATGAGTTCACGGCGCGTGTCACCTCCTCCGCCAAGAT
CGCCGCAAACCATGGGCCCACCTTCGGCAAAGGGGGTGACAGCTTCCTGCGCTTCAACATCGCCGCGCCCCGTGCCGTGA
TTGAAGATGCCGTGACGCGCATGAAGGCGGCGTTCAGCGACCTGCAGTAA

Upstream 100 bases:

>100_bases
TCTGCCGTCCCGGGCTTCAATTATCTAATCCGAACGGACGCCGCCCTTGCAGCCCCACGACCAAACGCTAGGGTCGCCCT
AGGTATTCAAGGAGACGCCC

Downstream 100 bases:

>100_bases
GCCTTTGGTGGACCAGATACACCGATAGGCTGGCCACAACGATGGCCCCACCGCCAAGCATCATTGGCGTGGGGGCCTCG
CCGACCGCAAGCCAGACCCA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSFDEIIDRRGTHCTKWDMMETLYGVSPDDGISMWVADMDFRPPQCVQDAVADMHAHGVYGYFGDDSKYRAAICWWMQER
HGWSVDPSHIFSTHGLVNGTSMCIDAFTAPGDGVVLFTPVYHAFAKVINASARDLCELEMPIVDGRLTLDFEAFDTQMKG
HEKMLVLCSPHNPGGRVWTREELEGIADFARRHDLILVSDEIHHDLTMPGQTHIPMAHIDGIEDRLVMMTAATKTFNIAG
SHIGNVIIADDTLRATFAGRMAALGMSPNSFGLFMVTAAYSPEGAEWLDELRAYLAENARVFDEGINAIPGLRSMALEST
YLAWVDFSGTGMTKDEFTARVTSSAKIAANHGPTFGKGGDSFLRFNIAAPRAVIEDAVTRMKAAFSDLQ

Sequences:

>Translated_389_residues
MSFDEIIDRRGTHCTKWDMMETLYGVSPDDGISMWVADMDFRPPQCVQDAVADMHAHGVYGYFGDDSKYRAAICWWMQER
HGWSVDPSHIFSTHGLVNGTSMCIDAFTAPGDGVVLFTPVYHAFAKVINASARDLCELEMPIVDGRLTLDFEAFDTQMKG
HEKMLVLCSPHNPGGRVWTREELEGIADFARRHDLILVSDEIHHDLTMPGQTHIPMAHIDGIEDRLVMMTAATKTFNIAG
SHIGNVIIADDTLRATFAGRMAALGMSPNSFGLFMVTAAYSPEGAEWLDELRAYLAENARVFDEGINAIPGLRSMALEST
YLAWVDFSGTGMTKDEFTARVTSSAKIAANHGPTFGKGGDSFLRFNIAAPRAVIEDAVTRMKAAFSDLQ
>Mature_388_residues
SFDEIIDRRGTHCTKWDMMETLYGVSPDDGISMWVADMDFRPPQCVQDAVADMHAHGVYGYFGDDSKYRAAICWWMQERH
GWSVDPSHIFSTHGLVNGTSMCIDAFTAPGDGVVLFTPVYHAFAKVINASARDLCELEMPIVDGRLTLDFEAFDTQMKGH
EKMLVLCSPHNPGGRVWTREELEGIADFARRHDLILVSDEIHHDLTMPGQTHIPMAHIDGIEDRLVMMTAATKTFNIAGS
HIGNVIIADDTLRATFAGRMAALGMSPNSFGLFMVTAAYSPEGAEWLDELRAYLAENARVFDEGINAIPGLRSMALESTY
LAWVDFSGTGMTKDEFTARVTSSAKIAANHGPTFGKGGDSFLRFNIAAPRAVIEDAVTRMKAAFSDLQ

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=218, Percent_Identity=26.605504587156, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI56713256, Length=218, Percent_Identity=26.605504587156, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI95147551, Length=233, Percent_Identity=25.3218884120172, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI169881279, Length=233, Percent_Identity=25.3218884120172, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI169881281, Length=120, Percent_Identity=32.5, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787909, Length=381, Percent_Identity=31.758530183727, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788722, Length=355, Percent_Identity=25.6338028169014, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786816, Length=314, Percent_Identity=22.9299363057325, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=160, Percent_Identity=27.5, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994476, Length=167, Percent_Identity=25.748502994012, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=167, Percent_Identity=25.748502994012, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=298, Percent_Identity=22.8187919463087, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=327, Percent_Identity=23.8532110091743, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573069, Length=171, Percent_Identity=30.4093567251462, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646114, Length=171, Percent_Identity=30.4093567251462, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28573067, Length=171, Percent_Identity=30.4093567251462, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28573065, Length=171, Percent_Identity=30.4093567251462, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42915; Mature: 42784

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDEIIDRRGTHCTKWDMMETLYGVSPDDGISMWVADMDFRPPQCVQDAVADMHAHGVY
CCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEE
GYFGDDSKYRAAICWWMQERHGWSVDPSHIFSTHGLVNGTSMCIDAFTAPGDGVVLFTPV
EEECCCCCEEEEEEEEEHHCCCCCCCHHHHHHCCCCCCCHHHEEEEECCCCCCEEEEHHH
YHAFAKVINASARDLCELEMPIVDGRLTLDFEAFDTQMKGHEKMLVLCSPHNPGGRVWTR
HHHHHHHHCCCHHHHHEECCCEECCEEEEEHHHHHHCCCCCCEEEEEECCCCCCCCEEEH
EELEGIADFARRHDLILVSDEIHHDLTMPGQTHIPMAHIDGIEDRLVMMTAATKTFNIAG
HHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCEEEECCC
SHIGNVIIADDTLRATFAGRMAALGMSPNSFGLFMVTAAYSPEGAEWLDELRAYLAENAR
HHHCCEEEECCCHHHHHHHHHHEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCH
VFDEGINAIPGLRSMALESTYLAWVDFSGTGMTKDEFTARVTSSAKIAANHGPTFGKGGD
HHHHHCCCCCCHHHHHHCCEEEEEEEECCCCCCHHHHHEEECCCEEEEECCCCCCCCCCC
SFLRFNIAAPRAVIEDAVTRMKAAFSDLQ
CEEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFDEIIDRRGTHCTKWDMMETLYGVSPDDGISMWVADMDFRPPQCVQDAVADMHAHGVY
CHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEE
GYFGDDSKYRAAICWWMQERHGWSVDPSHIFSTHGLVNGTSMCIDAFTAPGDGVVLFTPV
EEECCCCCEEEEEEEEEHHCCCCCCCHHHHHHCCCCCCCHHHEEEEECCCCCCEEEEHHH
YHAFAKVINASARDLCELEMPIVDGRLTLDFEAFDTQMKGHEKMLVLCSPHNPGGRVWTR
HHHHHHHHCCCHHHHHEECCCEECCEEEEEHHHHHHCCCCCCEEEEEECCCCCCCCEEEH
EELEGIADFARRHDLILVSDEIHHDLTMPGQTHIPMAHIDGIEDRLVMMTAATKTFNIAG
HHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCEEEECCC
SHIGNVIIADDTLRATFAGRMAALGMSPNSFGLFMVTAAYSPEGAEWLDELRAYLAENAR
HHHCCEEEECCCHHHHHHHHHHEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCH
VFDEGINAIPGLRSMALESTYLAWVDFSGTGMTKDEFTARVTSSAKIAANHGPTFGKGGD
HHHHHCCCCCCHHHHHHCCEEEEEEEECCCCCCHHHHHEEECCCEEEEECCCCCCCCCCC
SFLRFNIAAPRAVIEDAVTRMKAAFSDLQ
CEEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]