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The map label for this gene is dapL [H]

Identifier: 89052918

GI number: 89052918

Start: 430047

End: 431228

Strand: Direct

Name: dapL [H]

Synonym: Jann_0427

Alternate gene names: 89052918

Gene position: 430047-431228 (Clockwise)

Preceding gene: 89052917

Following gene: 89052919

Centisome position: 9.96

GC content: 60.66

Gene sequence:

>1182_bases
ATGGTGTTCCCTGAGCGGTTTTCGAACCTCCCAGACTATGCGTTTCCGCGTTTGCGGACCCTTTTGGATTCCCATGAACC
GGGCGCCGAGCCGATTGCCATGACCATTGGCGAGCCGCGCCATGATTTTCCGCCTTGGATCGCAGAGATCATTGGGCAGA
ACCTCCACGGTTTTGGAAAATACCCCGAAAACGATGGCACGTTGTCACTGCGCACGGCGCAGGCGGATTGGCTGGGGCGG
CGGTATGGCGTGGATGTTGATCCGGCGCGGCAGATCCTCGCTTTGAACGGCACGCGGGAGGGCTTGTATAATGCCTGCAT
GTCGCTGTGCCCTGAGCGCAAGAACGGCCAAAAGCCCGTGGTTCTGACGCCCAATCCGTTCTATCAGGTGTATGCCGTCG
CGGCTTTGTCCGTGGGCGCGGAGCCGATTTACCTGCCCGCCACGGAAGCCACTGGAGATCTGCCGGATTTCCACGCCGTG
GACCCTGCGATCCTGGATCGCACGGCCATTGCCTACATCTGTTCCCCCGCGAACCCGCAGGGCGCCGTGGCGTCTGAGGC
CTATTGGGAAGGCCTGATTGCGCTGGCCGAGCAGCATGATTTCAAGATCTTCGCTGATGAATGCTATTGTGAAATCTACC
GCGATAGCCCGCCCCCGGGTGCTTTGGAGATTGCGCACAAGATGGGTGCGGACCCGGAACGGGTGATGGTGTTTCACTCG
CTCTCCAAACGCTCCAATCTGCCCGGATTGCGCAGCGGCTTTTGCGCGGGTGGCCCAGAGAGTATCGCGCGGATGAAGAC
CTTGCGCGCCTATGCCGGTGCGCCCCTGCCGATGCCCCTGCAGGCGGTGGCAGAGGCGGTTTGGACCGATGAGGATCACG
TCATCGACAACCGCAACCTTTACCGGGTGAAATACAAGATTGCCGACGACATCCTTGGTGATGTCCAGGGCTACAAGGGC
CCCGAGGCGGGGTTTTTCCTGTGGCTTCCGGTCCAGGATGCGGAACAAGCCACATTGAAACTGTGGCAAGAGACCGGCGT
GCGTGTGCTGCCCGGATCCTATCTCGCGCGCGAAGTGGACGGGGTGACCCCCGGCCACGACAAGATCCGCGTCGCGATGG
TTGCTGAAAAAGAAGAAATGCGTCGGGGGCTGAAAACGCTCCGCAAGACGCTGTATGAGTGA

Upstream 100 bases:

>100_bases
ACACCTCCCTCAGAACAGGGCGCTTTTTCTGGACCCGGAGTCTCTCGTTCGCTATCATCATCGCTAACAGGGCATGAATG
ACCCTGAATATGAGGCAGTT

Downstream 100 bases:

>100_bases
GGAGGCACGACAATGGCCTATCAGACCCGCCAGCGAGAGCCGCTACTAGACGGCCACATGCAGGAAATCGTGTCTCGTCG
GGGACGAGAGATGTGTGGCA

Product: aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MVFPERFSNLPDYAFPRLRTLLDSHEPGAEPIAMTIGEPRHDFPPWIAEIIGQNLHGFGKYPENDGTLSLRTAQADWLGR
RYGVDVDPARQILALNGTREGLYNACMSLCPERKNGQKPVVLTPNPFYQVYAVAALSVGAEPIYLPATEATGDLPDFHAV
DPAILDRTAIAYICSPANPQGAVASEAYWEGLIALAEQHDFKIFADECYCEIYRDSPPPGALEIAHKMGADPERVMVFHS
LSKRSNLPGLRSGFCAGGPESIARMKTLRAYAGAPLPMPLQAVAEAVWTDEDHVIDNRNLYRVKYKIADDILGDVQGYKG
PEAGFFLWLPVQDAEQATLKLWQETGVRVLPGSYLAREVDGVTPGHDKIRVAMVAEKEEMRRGLKTLRKTLYE

Sequences:

>Translated_393_residues
MVFPERFSNLPDYAFPRLRTLLDSHEPGAEPIAMTIGEPRHDFPPWIAEIIGQNLHGFGKYPENDGTLSLRTAQADWLGR
RYGVDVDPARQILALNGTREGLYNACMSLCPERKNGQKPVVLTPNPFYQVYAVAALSVGAEPIYLPATEATGDLPDFHAV
DPAILDRTAIAYICSPANPQGAVASEAYWEGLIALAEQHDFKIFADECYCEIYRDSPPPGALEIAHKMGADPERVMVFHS
LSKRSNLPGLRSGFCAGGPESIARMKTLRAYAGAPLPMPLQAVAEAVWTDEDHVIDNRNLYRVKYKIADDILGDVQGYKG
PEAGFFLWLPVQDAEQATLKLWQETGVRVLPGSYLAREVDGVTPGHDKIRVAMVAEKEEMRRGLKTLRKTLYE
>Mature_393_residues
MVFPERFSNLPDYAFPRLRTLLDSHEPGAEPIAMTIGEPRHDFPPWIAEIIGQNLHGFGKYPENDGTLSLRTAQADWLGR
RYGVDVDPARQILALNGTREGLYNACMSLCPERKNGQKPVVLTPNPFYQVYAVAALSVGAEPIYLPATEATGDLPDFHAV
DPAILDRTAIAYICSPANPQGAVASEAYWEGLIALAEQHDFKIFADECYCEIYRDSPPPGALEIAHKMGADPERVMVFHS
LSKRSNLPGLRSGFCAGGPESIARMKTLRAYAGAPLPMPLQAVAEAVWTDEDHVIDNRNLYRVKYKIADDILGDVQGYKG
PEAGFFLWLPVQDAEQATLKLWQETGVRVLPGSYLAREVDGVTPGHDKIRVAMVAEKEEMRRGLKTLRKTLYE

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=333, Percent_Identity=23.1231231231231, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI169881279, Length=333, Percent_Identity=23.1231231231231, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1788722, Length=409, Percent_Identity=24.2053789731051, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786816, Length=386, Percent_Identity=25.1295336787565, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788627, Length=375, Percent_Identity=22.9333333333333, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43508; Mature: 43508

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFPERFSNLPDYAFPRLRTLLDSHEPGAEPIAMTIGEPRHDFPPWIAEIIGQNLHGFGK
CCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCC
YPENDGTLSLRTAQADWLGRRYGVDVDPARQILALNGTREGLYNACMSLCPERKNGQKPV
CCCCCCEEEEEECCHHHHHHHCCCCCCCCHHEEEECCCHHHHHHHHHHHCCCCCCCCCCE
VLTPNPFYQVYAVAALSVGAEPIYLPATEATGDLPDFHAVDPAILDRTAIAYICSPANPQ
EECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHEEEEEECCCCCC
GAVASEAYWEGLIALAEQHDFKIFADECYCEIYRDSPPPGALEIAHKMGADPERVMVFHS
CCCHHHHHHHHHHHHHHCCCCEEECCHHEEEEECCCCCCCHHHHHHHHCCCHHHEEEEHH
LSKRSNLPGLRSGFCAGGPESIARMKTLRAYAGAPLPMPLQAVAEAVWTDEDHVIDNRNL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEECCCCE
YRVKYKIADDILGDVQGYKGPEAGFFLWLPVQDAEQATLKLWQETGVRVLPGSYLAREVD
EEEEEEHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEECCHHHHHHHC
GVTPGHDKIRVAMVAEKEEMRRGLKTLRKTLYE
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVFPERFSNLPDYAFPRLRTLLDSHEPGAEPIAMTIGEPRHDFPPWIAEIIGQNLHGFGK
CCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCC
YPENDGTLSLRTAQADWLGRRYGVDVDPARQILALNGTREGLYNACMSLCPERKNGQKPV
CCCCCCEEEEEECCHHHHHHHCCCCCCCCHHEEEECCCHHHHHHHHHHHCCCCCCCCCCE
VLTPNPFYQVYAVAALSVGAEPIYLPATEATGDLPDFHAVDPAILDRTAIAYICSPANPQ
EECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHEEEEEECCCCCC
GAVASEAYWEGLIALAEQHDFKIFADECYCEIYRDSPPPGALEIAHKMGADPERVMVFHS
CCCHHHHHHHHHHHHHHCCCCEEECCHHEEEEECCCCCCCHHHHHHHHCCCHHHEEEEHH
LSKRSNLPGLRSGFCAGGPESIARMKTLRAYAGAPLPMPLQAVAEAVWTDEDHVIDNRNL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEECCCCE
YRVKYKIADDILGDVQGYKGPEAGFFLWLPVQDAEQATLKLWQETGVRVLPGSYLAREVD
EEEEEEHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEECCHHHHHHHC
GVTPGHDKIRVAMVAEKEEMRRGLKTLRKTLYE
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA