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The map label for this gene is pbpC [H]

Identifier: 89052754

GI number: 89052754

Start: 265121

End: 267160

Strand: Reverse

Name: pbpC [H]

Synonym: Jann_0263

Alternate gene names: 89052754

Gene position: 267160-265121 (Counterclockwise)

Preceding gene: 89052755

Following gene: 89052750

Centisome position: 6.19

GC content: 64.9

Gene sequence:

>2040_bases
ATGATACGCAGGATCGCCGCCACCCTTGGCCTGTTGGTCACAGCGCTACTGTTTGGGGCCGCCCTGTGGCTCAACACCTG
GATAAACGAGACAGAACTCCCGCCCCTCACCCTTGAGACCGGCGTTGAAGTGTTGGACCGCGACGGTGATCTTCTGCGCG
CCTACACGGTTGAGAACGGGCGCTGGCGCCTGCCCGTGTCCTATGACGCTGTAGATCCCGGCTACATCGAGATGCTGGTC
GCCTATGAAGATCGTCGCTTCTGGACCCATCCCGGTGTTGACCTGCGCGCCTTTGCTCGCGCCGCCTGGCAACGAGTGAC
AACGGGTCGGGTCATTTCCGGCGGGTCAACGCTGACCATGCAGGTGGCGCGGTTGTTGGAGGATTCGGGCACCGGCGAAT
GGGGTGGCAAAATCCGCCAGATCCGGCTCGCGCTTGCGCTGGAAAGGCAATTGTCGAAGCAAGAGATACTGACCCTCTAC
CTCCATCTCGCGCCCTTTGGCGGCAACATCGAAGGGGTCCGTGCGGCGACGTTGACATGGTTCGGGACTGAACCACACCG
CCTCACCGCCGCGCAATCCGCGCTTCTGGTGGCCCTGCCGCAAGCGCCTAACTCTCGTCGTCCCGACCGCTTCCCCGACG
CCGCCGAAATCGCCCGCAACCGTGTGCTGTCGCGCGCCGTCACCTTCACCGAGCTGACGGAGGAGCAAATCGCCTGGGCG
CGAGAGGAACCGATTCCCACCACCCGCCGCGATTTCCCCGCCCTCGCCCCGCATCTTGCGGATCGCGCCATCGTCGAGCG
CCCCACGCAGGGCACCCATCATCTGACCCTCGATGTCGACCTGCAACGGCAGATGGAGCGTTTGACCTCCCGCGCGATCA
GTCAACTCGGCCCACAGATGTCAGCGGCGATTATGGTCATGGATCATGAAACCGGCGCGCTTTTGGCCTCCGTTGGATCG
CCGGACTACACCGATACGACCCGAGAGGGGTTTGTGGATATGACGCAGGCCGTGCGGTCTCCCGGGTCCACCCTGAAGCC
GCTGATCTATGGTCTCGCCTTTGACGCCGGCGTGCTGCACCCGCAGACGCTGATCCAGGATCGCCCGATCTCCATTTCCG
GCTATGCGCCGCAGAATTTCGACTCGGTCTTTCGGGGGGAGGTCACCGCGGCGCAAGCTCTGCAGCTGTCCCTGAACATC
CCAGCCGTAACGCTCCTGAATGATGTCGGACCCCACCACATGCTCGCCGCCATGGGGCGTGCCGGGATGGAGGTTTCCCT
TCCAGAAGGGGAGGAACCCGGCCTTGCCATCGCGCTGGGCGGGCTTGGGACCACGATGGAGGATCTGCTCGGCCTTTACG
CCGGGATCGCGCGGGGCGGTATCGCCACCCCACCCCATTGGCGGCAGGGCGAGGGGGCGGAGGGGCAACGCATCCTGTCA
GAGACGGCAGCCTGGTATCTGGGCGATATTCTGGGCGACGTGGCCCCACCACCCAACGCACCGCGCATCGGGCTCAGCTA
TAAGACGGGCACCAGCTACGGCCACCGTGACGCTTGGGCGTTTGGCTTCGATGGGCAGCATGTGGTCGGCATCTGGATGG
GCCGCGCGGATGGGGCGTCCGTCCCCGGCGCTTTCGGGGCCGCCCTCTCCGCGCCGCTGCTGTTCGAGGCCTTCTCTCGC
ATTGATGAACACACCACACCGCGCGCGGCTCCTCCGCCTGGCGCTTTGACGCTGGCCACCGCGCAGTTGCCCGGGCCACT
ACAGCACTTTGATCCGGGCGCGGATCTGGCAGATGCAGGTGGCCCGGCAATCACCTTCCCACCTGAGGGTGCGGTACTTG
CCTATCAACCCGGTCTGCCGATCATGGCCCGTGTCGCCGAGGGCACGCCGCCCTTCACATGGCTCTGGAATGGCGCGCCG
GTTGCGACCGGTTGGCATGACCGGGAAATTGCGCTTGAGGCGGATTTAGGGTTCGGGGAACTCACCGTCATCGACGCAAC
AGGCCTGGCGGAAAGTCGCGCTGTAGAGGTCTCAAACTAG

Upstream 100 bases:

>100_bases
TGTCGCCGGGCGAATTCCATCATCCCGCTGCAATGGTTGAGGATATGTACCGCCCGACATATCGCGCGCAGACGGCCTCT
GGCCGGATAAGCGTTGTGGA

Downstream 100 bases:

>100_bases
GCTCTAACCTGCGTGTTAGAGCCGCTCAATCGCCAAGGCGATCCCCTGTCCCCCGCCAATACACATCGTGATCAGCGCGC
GCTTGCCGCCAGTCCGCTCC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MIRRIAATLGLLVTALLFGAALWLNTWINETELPPLTLETGVEVLDRDGDLLRAYTVENGRWRLPVSYDAVDPGYIEMLV
AYEDRRFWTHPGVDLRAFARAAWQRVTTGRVISGGSTLTMQVARLLEDSGTGEWGGKIRQIRLALALERQLSKQEILTLY
LHLAPFGGNIEGVRAATLTWFGTEPHRLTAAQSALLVALPQAPNSRRPDRFPDAAEIARNRVLSRAVTFTELTEEQIAWA
REEPIPTTRRDFPALAPHLADRAIVERPTQGTHHLTLDVDLQRQMERLTSRAISQLGPQMSAAIMVMDHETGALLASVGS
PDYTDTTREGFVDMTQAVRSPGSTLKPLIYGLAFDAGVLHPQTLIQDRPISISGYAPQNFDSVFRGEVTAAQALQLSLNI
PAVTLLNDVGPHHMLAAMGRAGMEVSLPEGEEPGLAIALGGLGTTMEDLLGLYAGIARGGIATPPHWRQGEGAEGQRILS
ETAAWYLGDILGDVAPPPNAPRIGLSYKTGTSYGHRDAWAFGFDGQHVVGIWMGRADGASVPGAFGAALSAPLLFEAFSR
IDEHTTPRAAPPPGALTLATAQLPGPLQHFDPGADLADAGGPAITFPPEGAVLAYQPGLPIMARVAEGTPPFTWLWNGAP
VATGWHDREIALEADLGFGELTVIDATGLAESRAVEVSN

Sequences:

>Translated_679_residues
MIRRIAATLGLLVTALLFGAALWLNTWINETELPPLTLETGVEVLDRDGDLLRAYTVENGRWRLPVSYDAVDPGYIEMLV
AYEDRRFWTHPGVDLRAFARAAWQRVTTGRVISGGSTLTMQVARLLEDSGTGEWGGKIRQIRLALALERQLSKQEILTLY
LHLAPFGGNIEGVRAATLTWFGTEPHRLTAAQSALLVALPQAPNSRRPDRFPDAAEIARNRVLSRAVTFTELTEEQIAWA
REEPIPTTRRDFPALAPHLADRAIVERPTQGTHHLTLDVDLQRQMERLTSRAISQLGPQMSAAIMVMDHETGALLASVGS
PDYTDTTREGFVDMTQAVRSPGSTLKPLIYGLAFDAGVLHPQTLIQDRPISISGYAPQNFDSVFRGEVTAAQALQLSLNI
PAVTLLNDVGPHHMLAAMGRAGMEVSLPEGEEPGLAIALGGLGTTMEDLLGLYAGIARGGIATPPHWRQGEGAEGQRILS
ETAAWYLGDILGDVAPPPNAPRIGLSYKTGTSYGHRDAWAFGFDGQHVVGIWMGRADGASVPGAFGAALSAPLLFEAFSR
IDEHTTPRAAPPPGALTLATAQLPGPLQHFDPGADLADAGGPAITFPPEGAVLAYQPGLPIMARVAEGTPPFTWLWNGAP
VATGWHDREIALEADLGFGELTVIDATGLAESRAVEVSN
>Mature_679_residues
MIRRIAATLGLLVTALLFGAALWLNTWINETELPPLTLETGVEVLDRDGDLLRAYTVENGRWRLPVSYDAVDPGYIEMLV
AYEDRRFWTHPGVDLRAFARAAWQRVTTGRVISGGSTLTMQVARLLEDSGTGEWGGKIRQIRLALALERQLSKQEILTLY
LHLAPFGGNIEGVRAATLTWFGTEPHRLTAAQSALLVALPQAPNSRRPDRFPDAAEIARNRVLSRAVTFTELTEEQIAWA
REEPIPTTRRDFPALAPHLADRAIVERPTQGTHHLTLDVDLQRQMERLTSRAISQLGPQMSAAIMVMDHETGALLASVGS
PDYTDTTREGFVDMTQAVRSPGSTLKPLIYGLAFDAGVLHPQTLIQDRPISISGYAPQNFDSVFRGEVTAAQALQLSLNI
PAVTLLNDVGPHHMLAAMGRAGMEVSLPEGEEPGLAIALGGLGTTMEDLLGLYAGIARGGIATPPHWRQGEGAEGQRILS
ETAAWYLGDILGDVAPPPNAPRIGLSYKTGTSYGHRDAWAFGFDGQHVVGIWMGRADGASVPGAFGAALSAPLLFEAFSR
IDEHTTPRAAPPPGALTLATAQLPGPLQHFDPGADLADAGGPAITFPPEGAVLAYQPGLPIMARVAEGTPPFTWLWNGAP
VATGWHDREIALEADLGFGELTVIDATGLAESRAVEVSN

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=551, Percent_Identity=44.464609800363, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1786343, Length=550, Percent_Identity=27.6363636363636, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI87082258, Length=270, Percent_Identity=31.8518518518519, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789601, Length=147, Percent_Identity=34.0136054421769, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 72987; Mature: 72987

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRIAATLGLLVTALLFGAALWLNTWINETELPPLTLETGVEVLDRDGDLLRAYTVENG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHCCHHHHCCCCCEEEEEEECCC
RWRLPVSYDAVDPGYIEMLVAYEDRRFWTHPGVDLRAFARAAWQRVTTGRVISGGSTLTM
EEEEEEECCCCCCCCEEEEEEEECCEEECCCCCCHHHHHHHHHHHHCCCEEECCCCHHHH
QVARLLEDSGTGEWGGKIRQIRLALALERQLSKQEILTLYLHLAPFGGNIEGVRAATLTW
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCEEEEEEEE
FGTEPHRLTAAQSALLVALPQAPNSRRPDRFPDAAEIARNRVLSRAVTFTELTEEQIAWA
ECCCCCHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REEPIPTTRRDFPALAPHLADRAIVERPTQGTHHLTLDVDLQRQMERLTSRAISQLGPQM
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
SAAIMVMDHETGALLASVGSPDYTDTTREGFVDMTQAVRSPGSTLKPLIYGLAFDAGVLH
EEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
PQTLIQDRPISISGYAPQNFDSVFRGEVTAAQALQLSLNIPAVTLLNDVGPHHMLAAMGR
HHHHHCCCCEEEECCCCCCHHHHHHCCCCCEEEEEEEECCCEEEEHHCCCHHHHHHHHCC
AGMEVSLPEGEEPGLAIALGGLGTTMEDLLGLYAGIARGGIATPPHWRQGEGAEGQRILS
CCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
ETAAWYLGDILGDVAPPPNAPRIGLSYKTGTSYGHRDAWAFGFDGQHVVGIWMGRADGAS
HHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCEEEEEEEECCCCCC
VPGAFGAALSAPLLFEAFSRIDEHTTPRAAPPPGALTLATAQLPGPLQHFDPGADLADAG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCC
GPAITFPPEGAVLAYQPGLPIMARVAEGTPPFTWLWNGAPVATGWHDREIALEADLGFGE
CCEEEECCCCCEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCE
LTVIDATGLAESRAVEVSN
EEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MIRRIAATLGLLVTALLFGAALWLNTWINETELPPLTLETGVEVLDRDGDLLRAYTVENG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHCCHHHHCCCCCEEEEEEECCC
RWRLPVSYDAVDPGYIEMLVAYEDRRFWTHPGVDLRAFARAAWQRVTTGRVISGGSTLTM
EEEEEEECCCCCCCCEEEEEEEECCEEECCCCCCHHHHHHHHHHHHCCCEEECCCCHHHH
QVARLLEDSGTGEWGGKIRQIRLALALERQLSKQEILTLYLHLAPFGGNIEGVRAATLTW
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCEEEEEEEE
FGTEPHRLTAAQSALLVALPQAPNSRRPDRFPDAAEIARNRVLSRAVTFTELTEEQIAWA
ECCCCCHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REEPIPTTRRDFPALAPHLADRAIVERPTQGTHHLTLDVDLQRQMERLTSRAISQLGPQM
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
SAAIMVMDHETGALLASVGSPDYTDTTREGFVDMTQAVRSPGSTLKPLIYGLAFDAGVLH
EEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
PQTLIQDRPISISGYAPQNFDSVFRGEVTAAQALQLSLNIPAVTLLNDVGPHHMLAAMGR
HHHHHCCCCEEEECCCCCCHHHHHHCCCCCEEEEEEEECCCEEEEHHCCCHHHHHHHHCC
AGMEVSLPEGEEPGLAIALGGLGTTMEDLLGLYAGIARGGIATPPHWRQGEGAEGQRILS
CCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
ETAAWYLGDILGDVAPPPNAPRIGLSYKTGTSYGHRDAWAFGFDGQHVVGIWMGRADGAS
HHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCEEEEEEEECCCCCC
VPGAFGAALSAPLLFEAFSRIDEHTTPRAAPPPGALTLATAQLPGPLQHFDPGADLADAG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCC
GPAITFPPEGAVLAYQPGLPIMARVAEGTPPFTWLWNGAPVATGWHDREIALEADLGFGE
CCEEEECCCCCEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCE
LTVIDATGLAESRAVEVSN
EEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]