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The map label for this gene is aroE

Identifier: 89052687

GI number: 89052687

Start: 187014

End: 187850

Strand: Reverse

Name: aroE

Synonym: Jann_0196

Alternate gene names: 89052687

Gene position: 187850-187014 (Counterclockwise)

Preceding gene: 89052688

Following gene: 89052686

Centisome position: 4.35

GC content: 58.9

Gene sequence:

>837_bases
ATGACCAGAGACACCATTCCCCTCGCCGGTGTGATCGGTGATCCGATTTCTCACTCCCTGTCGCCGCGTTTGCACGGTCA
TTGGTTGCGGCGGTACGGGCTGCAGGGCCATTATGTTCCTTTGCACGTTAATCATGCCAATCTGGAGACGGTCCTAAGAA
CGTTACCGCTAATGGGGTTCGTCGGGGTGAACGTGACCCTGCCGCACAAGGAACATGTCCTGTCCATCGCTGATTCTGTC
ACGGACCGGGCCGCGTTGATCGGCGCGGCCAATACTCTGACCTTCACCGCAAACGAACAGATACAGGCAGACAACACTGA
TGGTATGGGGTTCCTGTCCAATATTCGCCAAGCCTTGCCTGGTTGGTCCGCCTCCGCGGGGCCAGCGCTTGTCTTGGGGT
CCGGCGGTGCGGCGAAAGCCATCGTGTCTGCGCTTGTGTCCGACGGGGCTCCGGTCGTTCATGTGGCCAACAGGACGCGG
GCCCGGGCCGATGGACTGAAAGAACAGTTTGGGGCCCGGGTGTCTCCATCCGATTGGACCCATATTCCAGACCTCATCGG
CGATGCGGCCCTGATCGTGAATACCACGTCCCTGGGAATGGCGGGCCAAAGTCCTCTGTCTTTAGACTTGTCACGACTTT
CGCCGCCCACTGTGGTGACAGACATCGTTTACGCCCCGCTACAAACGAACCTTCTGAGAGACGCGAGCATACGCGGATGT
GAGACAGTCGATGGCCTCGGTATGCTGCTTCATCAAGCGGTTCCCGGGTTTGAGCGATGGTTCAATTACACGCCGACCGT
TGATGAGGACCTTCGCGAAGCTGTGCTGGCCGGATGA

Upstream 100 bases:

>100_bases
CGCAGCTCTTCTCCCGGATCGAGGGTGATTGGTTCTCCGTTCTCGGCTTGCCGCTGCTCCAGGTCTTGTCCTATCTCCGA
ATGCGCGGGATGGTAGCGCC

Downstream 100 bases:

>100_bases
GTTTTGCTCTCGGTCTCACGGGCTCCATCGGGATGGGTAAAAGCACGACAGCCGCGATGTTTCGTGACCTTGATGTGCCG
GTATGGGACGCTGATGCCAC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTRDTIPLAGVIGDPISHSLSPRLHGHWLRRYGLQGHYVPLHVNHANLETVLRTLPLMGFVGVNVTLPHKEHVLSIADSV
TDRAALIGAANTLTFTANEQIQADNTDGMGFLSNIRQALPGWSASAGPALVLGSGGAAKAIVSALVSDGAPVVHVANRTR
ARADGLKEQFGARVSPSDWTHIPDLIGDAALIVNTTSLGMAGQSPLSLDLSRLSPPTVVTDIVYAPLQTNLLRDASIRGC
ETVDGLGMLLHQAVPGFERWFNYTPTVDEDLREAVLAG

Sequences:

>Translated_278_residues
MTRDTIPLAGVIGDPISHSLSPRLHGHWLRRYGLQGHYVPLHVNHANLETVLRTLPLMGFVGVNVTLPHKEHVLSIADSV
TDRAALIGAANTLTFTANEQIQADNTDGMGFLSNIRQALPGWSASAGPALVLGSGGAAKAIVSALVSDGAPVVHVANRTR
ARADGLKEQFGARVSPSDWTHIPDLIGDAALIVNTTSLGMAGQSPLSLDLSRLSPPTVVTDIVYAPLQTNLLRDASIRGC
ETVDGLGMLLHQAVPGFERWFNYTPTVDEDLREAVLAG
>Mature_277_residues
TRDTIPLAGVIGDPISHSLSPRLHGHWLRRYGLQGHYVPLHVNHANLETVLRTLPLMGFVGVNVTLPHKEHVLSIADSVT
DRAALIGAANTLTFTANEQIQADNTDGMGFLSNIRQALPGWSASAGPALVLGSGGAAKAIVSALVSDGAPVVHVANRTRA
RADGLKEQFGARVSPSDWTHIPDLIGDAALIVNTTSLGMAGQSPLSLDLSRLSPPTVVTDIVYAPLQTNLLRDASIRGCE
TVDGLGMLLHQAVPGFERWFNYTPTVDEDLREAVLAG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=266, Percent_Identity=30.4511278195489, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789675, Length=268, Percent_Identity=32.4626865671642, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320332, Length=273, Percent_Identity=28.2051282051282, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_JANSC (Q28VZ9)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508138.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q28VZ9
- SMR:   Q28VZ9
- STRING:   Q28VZ9
- GeneID:   3932633
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0196
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   GHYIPMD
- PhylomeDB:   Q28VZ9
- ProtClustDB:   PRK00258
- BioCyc:   JSP290400:JANN_0196-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29474; Mature: 29343

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRDTIPLAGVIGDPISHSLSPRLHGHWLRRYGLQGHYVPLHVNHANLETVLRTLPLMGF
CCCCCCCCHHHHCCCHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHE
VGVNVTLPHKEHVLSIADSVTDRAALIGAANTLTFTANEQIQADNTDGMGFLSNIRQALP
ECCEEECCCHHHHHHHHHHHHHHHHHEECCCEEEEECCCCEECCCCCCHHHHHHHHHHCC
GWSASAGPALVLGSGGAAKAIVSALVSDGAPVVHVANRTRARADGLKEQFGARVSPSDWT
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCC
HIPDLIGDAALIVNTTSLGMAGQSPLSLDLSRLSPPTVVTDIVYAPLQTNLLRDASIRGC
CCHHHHCCCEEEEEECCCCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ETVDGLGMLLHQAVPGFERWFNYTPTVDEDLREAVLAG
CHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TRDTIPLAGVIGDPISHSLSPRLHGHWLRRYGLQGHYVPLHVNHANLETVLRTLPLMGF
CCCCCCCHHHHCCCHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHE
VGVNVTLPHKEHVLSIADSVTDRAALIGAANTLTFTANEQIQADNTDGMGFLSNIRQALP
ECCEEECCCHHHHHHHHHHHHHHHHHEECCCEEEEECCCCEECCCCCCHHHHHHHHHHCC
GWSASAGPALVLGSGGAAKAIVSALVSDGAPVVHVANRTRARADGLKEQFGARVSPSDWT
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCC
HIPDLIGDAALIVNTTSLGMAGQSPLSLDLSRLSPPTVVTDIVYAPLQTNLLRDASIRGC
CCHHHHCCCEEEEEECCCCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ETVDGLGMLLHQAVPGFERWFNYTPTVDEDLREAVLAG
CHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA