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The map label for this gene is crtE [H]

Identifier: 89052673

GI number: 89052673

Start: 174719

End: 175591

Strand: Reverse

Name: crtE [H]

Synonym: Jann_0182

Alternate gene names: 89052673

Gene position: 175591-174719 (Counterclockwise)

Preceding gene: 89052680

Following gene: 89052672

Centisome position: 4.07

GC content: 61.97

Gene sequence:

>873_bases
ATGCCCTTGAAACCCCGGATTGAGCACGCAATTTCCGCGGCTATCACACAGGCGCAGGGCAATGTCGCGCCCACGAAGCT
GGCCTCCGCCCTTGAATATTCCGTGACCCCCGGTGGTGCTCGCATTCGTCCTACGATTTGCCTGTCCGTTGCCCTGGCAT
GCGGTGATCCACAACCCGCGATGGCTGATGCCGCGGCGACCGCGATCGAGCTGATCCACTGTGCCAGCCTTGTCCATGAT
GATATGCCCTGTTTTGACGACGCTGATGTGCGGCGGGGGAAGCCCTCCGTCCACAAGGCTTATTCCGAGCCGCTGGCGCT
TCTGGCGGGTGACAGCCTGATCATCGCATCCTTTGAGGTTCTGACCCGGGTCGCCCATCATGATCCGCTCCGCGCCATTG
AGTTGATGAAAATCCTTGGCCAATCCACCGGCATGCCCGGCGGCATCTGTGCCGGGCAGGGGTGGGAGAGTGAGGACAAG
ATCGACCTCTCCGCCTATCACCGCGCCAAGACCGGTGCGCTTTTTACCGCCGCCACGCGTATGGGCGCCGCGGCCGCCGG
GGAAGATCCGGAACCGTGGACCGAACTTGGGGCCCGTATTGGCGAAGCCTTTCAGGTCGCCGATGACTTGCGGGATGCGC
TTTATGATGAGGCGACACTTGGGAAGCCCGCCCATCAAGACGAAATCCATGACCGCCCCAATGCTGTGACCGAGTTTGGC
GTGCGTGGGGCCATCAGGCGGTTGGAAGATATCCTCTCCGGCGCGATTTCCTCCATTCCGGCTTGTCCGGGGGAGGCGAT
GCTGGCCGAAATGGTACGCAAAACTGCGGAACGTCTGACGCCCGTGATGCCTCCGGTTCAGGCCGCTGAATAA

Upstream 100 bases:

>100_bases
AGTGTCAGTCAATGTTGACACCTATCCCGTATATGTCCAGTCTGATTTACATATCGGGTGTCAGATCCGTGAACCGAATC
CCTTTGAGGAGGTGCAACCC

Downstream 100 bases:

>100_bases
ATGGCGCTCGCCGATCCGCAAGACACCAAAACATCCCTGAAAGACCGCTTCTATGCGTGGCGGACGGCTCTGATCGGGTC
GCGTCGCTTTCAACAGCGCG

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: GGPP synthase; Farnesyltranstransferase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MPLKPRIEHAISAAITQAQGNVAPTKLASALEYSVTPGGARIRPTICLSVALACGDPQPAMADAAATAIELIHCASLVHD
DMPCFDDADVRRGKPSVHKAYSEPLALLAGDSLIIASFEVLTRVAHHDPLRAIELMKILGQSTGMPGGICAGQGWESEDK
IDLSAYHRAKTGALFTAATRMGAAAAGEDPEPWTELGARIGEAFQVADDLRDALYDEATLGKPAHQDEIHDRPNAVTEFG
VRGAIRRLEDILSGAISSIPACPGEAMLAEMVRKTAERLTPVMPPVQAAE

Sequences:

>Translated_290_residues
MPLKPRIEHAISAAITQAQGNVAPTKLASALEYSVTPGGARIRPTICLSVALACGDPQPAMADAAATAIELIHCASLVHD
DMPCFDDADVRRGKPSVHKAYSEPLALLAGDSLIIASFEVLTRVAHHDPLRAIELMKILGQSTGMPGGICAGQGWESEDK
IDLSAYHRAKTGALFTAATRMGAAAAGEDPEPWTELGARIGEAFQVADDLRDALYDEATLGKPAHQDEIHDRPNAVTEFG
VRGAIRRLEDILSGAISSIPACPGEAMLAEMVRKTAERLTPVMPPVQAAE
>Mature_289_residues
PLKPRIEHAISAAITQAQGNVAPTKLASALEYSVTPGGARIRPTICLSVALACGDPQPAMADAAATAIELIHCASLVHDD
MPCFDDADVRRGKPSVHKAYSEPLALLAGDSLIIASFEVLTRVAHHDPLRAIELMKILGQSTGMPGGICAGQGWESEDKI
DLSAYHRAKTGALFTAATRMGAAAAGEDPEPWTELGARIGEAFQVADDLRDALYDEATLGKPAHQDEIHDRPNAVTEFGV
RGAIRRLEDILSGAISSIPACPGEAMLAEMVRKTAERLTPVMPPVQAAE

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=219, Percent_Identity=29.6803652968037, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786623, Length=258, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789578, Length=211, Percent_Identity=31.7535545023697, Blast_Score=87, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=243, Percent_Identity=27.9835390946502, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651612, Length=165, Percent_Identity=32.1212121212121, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.29 [H]

Molecular weight: Translated: 30611; Mature: 30480

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKPRIEHAISAAITQAQGNVAPTKLASALEYSVTPGGARIRPTICLSVALACGDPQPA
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCH
MADAAATAIELIHCASLVHDDMPCFDDADVRRGKPSVHKAYSEPLALLAGDSLIIASFEV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHCCHHHHCCCCHHHHHHHH
LTRVAHHDPLRAIELMKILGQSTGMPGGICAGQGWESEDKIDLSAYHRAKTGALFTAATR
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHH
MGAAAAGEDPEPWTELGARIGEAFQVADDLRDALYDEATLGKPAHQDEIHDRPNAVTEFG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHH
VRGAIRRLEDILSGAISSIPACPGEAMLAEMVRKTAERLTPVMPPVQAAE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PLKPRIEHAISAAITQAQGNVAPTKLASALEYSVTPGGARIRPTICLSVALACGDPQPA
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCH
MADAAATAIELIHCASLVHDDMPCFDDADVRRGKPSVHKAYSEPLALLAGDSLIIASFEV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHCCHHHHCCCCHHHHHHHH
LTRVAHHDPLRAIELMKILGQSTGMPGGICAGQGWESEDKIDLSAYHRAKTGALFTAATR
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHH
MGAAAAGEDPEPWTELGARIGEAFQVADDLRDALYDEATLGKPAHQDEIHDRPNAVTEFG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHH
VRGAIRRLEDILSGAISSIPACPGEAMLAEMVRKTAERLTPVMPPVQAAE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721699; 10648776 [H]