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The map label for this gene is pepA [H]

Identifier: 89052597

GI number: 89052597

Start: 96570

End: 97940

Strand: Reverse

Name: pepA [H]

Synonym: Jann_0106

Alternate gene names: 89052597

Gene position: 97940-96570 (Counterclockwise)

Preceding gene: 89052598

Following gene: 89052596

Centisome position: 2.27

GC content: 64.19

Gene sequence:

>1371_bases
ATGCCGATGCAATTTGCCGGGGCGGAGCAGGACGCTCTGCCAATTTTTCTGGTCCGTGCGGGAGACGATGTGGGGGCGCT
TGCGCCATCCCATGCCGCCTGGGCCGAGGCCAATGGATTCACGGGCCGGTTGGGTCAGGCGCTGGTCTTGCCGGGGGACG
GTTTGGCGGGCGCTTTGGTTGGAATGGGGCAGCCATCCGACCGGCGGCGCAAACGGTTTGCCGTGGGGGCCGCGATCGCG
GGTTTGCCCGAGGCCACCTACGAGATTACCAACATGCCCGATGCGGGGCCCGAGGCCGATGAAATCGCCCTGGGGTATCT
GCTGTCGACGTATCGGTTCGAGCGTTATCGCAAGCAATCTGGTCCCAAGGCTCGGTTGCTTGCGCCGCTCGGCGTGAACG
CCGAACAGTTGGAGCGGATCGCCAAGGCGGAAGGTCTGATCCGCGATCTGATCAACACACCCGCCGAAGATATGGGCCCC
GATGCGCTGGAAGCGGTAGTTCGCACGCTGGGGGCCGAGTTTGGCGCAGATGTCTCCGTCATCGCGGGCGACGCGCTGCT
GGAGCAGAATTTTCCGCTGATCCACACCGTCGGACGGGCCGCCGCGAAAGCCCCGCGTCTGATCGAAATGACCTGGGGCG
CAAGCGGTCCCGCATTAACGCTGGTCGGCAAGGGCGTGTGCTTCGATACCGGCGGTCTGAACCTGAAACCCGGCGCGCCG
ATGGGGATCATGAAGAAGGATATGGGCGGGTCGGCCAATGTCCTGGGCCTGGCGCGGATGATCATGGCCAGTGCCATGGA
TGTGCAGCTGCGCGTGTTGATCCCCGCCGTTGAAAACAACGTGGCGGGCAATTCCTTCCGGCCCGGTGATATCTTCACCG
CGCGCAACGGGATGACGGTTGAAATCAACAACACCGATGCGGAGGGGCGTCTTGTGCTGGCCGATGCGCTGGCGCTGGCG
TCTGAAACGCCCCCCGATCTGCTGATATGTATGGCGACGCTGACCGGAGCCGCCCGCGTTGCCGTTGGCCCTGATCTTGC
GCCATTCTTCACCGATGATGATGGGTTTGCGACCGCGTTGAGTGCGGCAAGCGCGCGCGTTGCGGACCCGGTCTGGCGTC
TGCCGTTCCATGATGCCTATGAGCCGATGATCGAGCCGGGTATCGCTGATCTCGACAATGCACCCGCTGGCGGTATGGCG
GGGTCGATCACAGCGGCGCTGTTCCTGCGACGCTTCGCGCCCGTGCCCCGCTTCGCGCATTTTGACATTTACGGCTGGCA
GCGCACCACTGCGCCTGCCCGTCCCAAGGGTGGCGTGGGCCAAGGTATCCGCGCGATCTTTGACGCATTGCCCGAGGTTC
TTTCCCGATGA

Upstream 100 bases:

>100_bases
TCGATCCACGCCGTCTGGGATCTGGAGGATCTTTCGGTCTGATCTGACTTGCAGAGCAGGTGAGGAACGCTAGGCTGGCG
CGAAATCAATAGGTGCGCCA

Downstream 100 bases:

>100_bases
CCGACCCCCGCACCACCGCATTCAACGGCCGTGTCGCCCATGCATCGCTGAAAGGCGAGATCGAGGCCGAGCGGTATTCG
GAAGGCCGCTGGATGATGGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MPMQFAGAEQDALPIFLVRAGDDVGALAPSHAAWAEANGFTGRLGQALVLPGDGLAGALVGMGQPSDRRRKRFAVGAAIA
GLPEATYEITNMPDAGPEADEIALGYLLSTYRFERYRKQSGPKARLLAPLGVNAEQLERIAKAEGLIRDLINTPAEDMGP
DALEAVVRTLGAEFGADVSVIAGDALLEQNFPLIHTVGRAAAKAPRLIEMTWGASGPALTLVGKGVCFDTGGLNLKPGAP
MGIMKKDMGGSANVLGLARMIMASAMDVQLRVLIPAVENNVAGNSFRPGDIFTARNGMTVEINNTDAEGRLVLADALALA
SETPPDLLICMATLTGAARVAVGPDLAPFFTDDDGFATALSAASARVADPVWRLPFHDAYEPMIEPGIADLDNAPAGGMA
GSITAALFLRRFAPVPRFAHFDIYGWQRTTAPARPKGGVGQGIRAIFDALPEVLSR

Sequences:

>Translated_456_residues
MPMQFAGAEQDALPIFLVRAGDDVGALAPSHAAWAEANGFTGRLGQALVLPGDGLAGALVGMGQPSDRRRKRFAVGAAIA
GLPEATYEITNMPDAGPEADEIALGYLLSTYRFERYRKQSGPKARLLAPLGVNAEQLERIAKAEGLIRDLINTPAEDMGP
DALEAVVRTLGAEFGADVSVIAGDALLEQNFPLIHTVGRAAAKAPRLIEMTWGASGPALTLVGKGVCFDTGGLNLKPGAP
MGIMKKDMGGSANVLGLARMIMASAMDVQLRVLIPAVENNVAGNSFRPGDIFTARNGMTVEINNTDAEGRLVLADALALA
SETPPDLLICMATLTGAARVAVGPDLAPFFTDDDGFATALSAASARVADPVWRLPFHDAYEPMIEPGIADLDNAPAGGMA
GSITAALFLRRFAPVPRFAHFDIYGWQRTTAPARPKGGVGQGIRAIFDALPEVLSR
>Mature_455_residues
PMQFAGAEQDALPIFLVRAGDDVGALAPSHAAWAEANGFTGRLGQALVLPGDGLAGALVGMGQPSDRRRKRFAVGAAIAG
LPEATYEITNMPDAGPEADEIALGYLLSTYRFERYRKQSGPKARLLAPLGVNAEQLERIAKAEGLIRDLINTPAEDMGPD
ALEAVVRTLGAEFGADVSVIAGDALLEQNFPLIHTVGRAAAKAPRLIEMTWGASGPALTLVGKGVCFDTGGLNLKPGAPM
GIMKKDMGGSANVLGLARMIMASAMDVQLRVLIPAVENNVAGNSFRPGDIFTARNGMTVEINNTDAEGRLVLADALALAS
ETPPDLLICMATLTGAARVAVGPDLAPFFTDDDGFATALSAASARVADPVWRLPFHDAYEPMIEPGIADLDNAPAGGMAG
SITAALFLRRFAPVPRFAHFDIYGWQRTTAPARPKGGVGQGIRAIFDALPEVLSR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=416, Percent_Identity=30.5288461538462, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI47155554, Length=293, Percent_Identity=34.8122866894198, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=36.7088607594937, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1790710, Length=301, Percent_Identity=35.8803986710963, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=283, Percent_Identity=36.3957597173145, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=224, Percent_Identity=30.8035714285714, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21355725, Length=370, Percent_Identity=30.8108108108108, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24661038, Length=360, Percent_Identity=30.5555555555556, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21357381, Length=280, Percent_Identity=36.0714285714286, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=280, Percent_Identity=35.3571428571429, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379062, Length=280, Percent_Identity=35.3571428571429, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24662227, Length=291, Percent_Identity=28.8659793814433, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI20129969, Length=349, Percent_Identity=29.2263610315186, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161077148, Length=410, Percent_Identity=28.0487804878049, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130057, Length=410, Percent_Identity=28.0487804878049, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355645, Length=341, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662223, Length=341, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922386, Length=291, Percent_Identity=27.4914089347079, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI20129963, Length=410, Percent_Identity=25.609756097561, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646701, Length=233, Percent_Identity=31.7596566523605, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646703, Length=233, Percent_Identity=31.7596566523605, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21358201, Length=233, Percent_Identity=31.7596566523605, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 47703; Mature: 47572

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMQFAGAEQDALPIFLVRAGDDVGALAPSHAAWAEANGFTGRLGQALVLPGDGLAGALV
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCEEEECCCCHHHHHH
GMGQPSDRRRKRFAVGAAIAGLPEATYEITNMPDAGPEADEIALGYLLSTYRFERYRKQS
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPKARLLAPLGVNAEQLERIAKAEGLIRDLINTPAEDMGPDALEAVVRTLGAEFGADVSV
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCEEE
IAGDALLEQNFPLIHTVGRAAAKAPRLIEMTWGASGPALTLVGKGVCFDTGGLNLKPGAP
EECCHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCEEEECCCCCCCCCCC
MGIMKKDMGGSANVLGLARMIMASAMDVQLRVLIPAVENNVAGNSFRPGDIFTARNGMTV
CCHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEHHCCCCCCCCCCCCEEEECCCEEE
EINNTDAEGRLVLADALALASETPPDLLICMATLTGAARVAVGPDLAPFFTDDDGFATAL
EECCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCEECCCCHHHHH
SAASARVADPVWRLPFHDAYEPMIEPGIADLDNAPAGGMAGSITAALFLRRFAPVPRFAH
HHHHHHHCCCCEECCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
FDIYGWQRTTAPARPKGGVGQGIRAIFDALPEVLSR
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PMQFAGAEQDALPIFLVRAGDDVGALAPSHAAWAEANGFTGRLGQALVLPGDGLAGALV
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCEEEECCCCHHHHHH
GMGQPSDRRRKRFAVGAAIAGLPEATYEITNMPDAGPEADEIALGYLLSTYRFERYRKQS
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPKARLLAPLGVNAEQLERIAKAEGLIRDLINTPAEDMGPDALEAVVRTLGAEFGADVSV
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCEEE
IAGDALLEQNFPLIHTVGRAAAKAPRLIEMTWGASGPALTLVGKGVCFDTGGLNLKPGAP
EECCHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCEEEECCCCCCCCCCC
MGIMKKDMGGSANVLGLARMIMASAMDVQLRVLIPAVENNVAGNSFRPGDIFTARNGMTV
CCHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEHHCCCCCCCCCCCCEEEECCCEEE
EINNTDAEGRLVLADALALASETPPDLLICMATLTGAARVAVGPDLAPFFTDDDGFATAL
EECCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCEECCCCHHHHH
SAASARVADPVWRLPFHDAYEPMIEPGIADLDNAPAGGMAGSITAALFLRRFAPVPRFAH
HHHHHHHCCCCEECCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
FDIYGWQRTTAPARPKGGVGQGIRAIFDALPEVLSR
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]