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The map label for this gene is adhI [H]

Identifier: 89052535

GI number: 89052535

Start: 41642

End: 42754

Strand: Direct

Name: adhI [H]

Synonym: Jann_0044

Alternate gene names: 89052535

Gene position: 41642-42754 (Clockwise)

Preceding gene: 89052528

Following gene: 89052536

Centisome position: 0.96

GC content: 60.65

Gene sequence:

>1113_bases
ATGCGCACACGTGCAGCCGTTGCCCTTGAAGCGGGCAAGCCATTGGAAGTCATGGACGTGAACCTCGACGGTCCCCGTGA
AGGAGAAGTGCTGGTCGAAATCAAGGCCACTGGCATTTGCCACACCGATGAGTTCACCTTGTCGGGCGCTGACCCCGAAG
GGCTTTTTCCGGCCATCCTTGGCCACGAGGGCGCCGGTGTGGTGCTGGAGGTTGGACCCGGCGTGACGTCCTTGAAACCG
GGCGACCATGTGATCCCGCTTTACACGGCGGAATGTCGGGAGTGTGAATACTGCCTGAACCCCAAAACGAACCTTTGCCA
AAAGGTCCGCGCGACCCAGGGCCAGGGGTTGATGCCGGACGGGTCTTCCCGGTTCTCCATGCTCGATGGCACGCCGATCC
TGCATTACATGGGCTGTTCGACCTTCGCCAACCACACGGTGGTGCCAGAGGTGTCCCTTGCAAAGGTTCGCAATGACGCG
CCGTTCGACAAGATCTGCTATATTGGCTGCGGCGTGACGACGGGCATCGGCGCAGTGATCTACACCGCGAAGGTGGAAAT
CGGATCCCGCGCGATTGTCTTTGGCCTTGGCGGTATCGGCCTGAACGTGATCCAGGGTCTGCGGTTGGCAGGCGCGGATC
AGATCGTAGGTGTGGACCTCAACCCCGGCAAGGTCGAGATGGCCAAGCGCTTTGGTATGACTGATTTCGTGAATCCGTCA
GAGGTTACGGGTGATTTGGTCGGCCATCTGGTTGAACTGACCGGTGGCGGCGCAGACTATACGTTTGACGCTACGGGCAA
CGTAGACGTCATGCGCACCGCGCTGGAGGCCTGCCACAAGGGCTGGGGTGAGAGCATCATCATCGGCGTCGCACCTGCGG
GCGCGGAAATCAGCACGCGTCCGTTTCAGCTGGTCACCGGCCGCAGTTGGCGTGGCACAGCATTTGGCGGCGCGCGCGGG
CGCACTGATGTGCCGCAGATCGTGGATTGGTACATGGACGGCAAGATCGAGATCGACCCGATGATCACCCACACCTTGGC
GCTGGACAACATCAACGAAGGCTTTGACCTGATGCACCGGGGTGAATCGATCCGCTCCGTGGTGATCTACTGA

Upstream 100 bases:

>100_bases
ATCAGAAGCGTAAATCGCATGGTGGATATCCTTCCGTTGCGTTGTGCCCGAGTTTGTCCCAGTCTCGGGTGAAATCAAGT
CTCTGGGAGAAGACATAAAA

Downstream 100 bases:

>100_bases
GCGCCGATGTCCGATCACTACCTTTTTCATCTGACGTTCGACGTTCGCCACGACGCGCCGCCGCAGCTTATGGCCGCCTT
GGCAAAGCGGGCGGGCGGGG

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRTRAAVALEAGKPLEVMDVNLDGPREGEVLVEIKATGICHTDEFTLSGADPEGLFPAILGHEGAGVVLEVGPGVTSLKP
GDHVIPLYTAECRECEYCLNPKTNLCQKVRATQGQGLMPDGSSRFSMLDGTPILHYMGCSTFANHTVVPEVSLAKVRNDA
PFDKICYIGCGVTTGIGAVIYTAKVEIGSRAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVEMAKRFGMTDFVNPS
EVTGDLVGHLVELTGGGADYTFDATGNVDVMRTALEACHKGWGESIIIGVAPAGAEISTRPFQLVTGRSWRGTAFGGARG
RTDVPQIVDWYMDGKIEIDPMITHTLALDNINEGFDLMHRGESIRSVVIY

Sequences:

>Translated_370_residues
MRTRAAVALEAGKPLEVMDVNLDGPREGEVLVEIKATGICHTDEFTLSGADPEGLFPAILGHEGAGVVLEVGPGVTSLKP
GDHVIPLYTAECRECEYCLNPKTNLCQKVRATQGQGLMPDGSSRFSMLDGTPILHYMGCSTFANHTVVPEVSLAKVRNDA
PFDKICYIGCGVTTGIGAVIYTAKVEIGSRAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVEMAKRFGMTDFVNPS
EVTGDLVGHLVELTGGGADYTFDATGNVDVMRTALEACHKGWGESIIIGVAPAGAEISTRPFQLVTGRSWRGTAFGGARG
RTDVPQIVDWYMDGKIEIDPMITHTLALDNINEGFDLMHRGESIRSVVIY
>Mature_370_residues
MRTRAAVALEAGKPLEVMDVNLDGPREGEVLVEIKATGICHTDEFTLSGADPEGLFPAILGHEGAGVVLEVGPGVTSLKP
GDHVIPLYTAECRECEYCLNPKTNLCQKVRATQGQGLMPDGSSRFSMLDGTPILHYMGCSTFANHTVVPEVSLAKVRNDA
PFDKICYIGCGVTTGIGAVIYTAKVEIGSRAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVEMAKRFGMTDFVNPS
EVTGDLVGHLVELTGGGADYTFDATGNVDVMRTALEACHKGWGESIIIGVAPAGAEISTRPFQLVTGRSWRGTAFGGARG
RTDVPQIVDWYMDGKIEIDPMITHTLALDNINEGFDLMHRGESIRSVVIY

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=58.1521739130435, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=44, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=43.5135135135135, Blast_Score=334, Evalue=6e-92,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=43.2432432432432, Blast_Score=334, Evalue=7e-92,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=43.2432432432432, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=42.972972972973, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=42.972972972973, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=41.7344173441734, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=41.9889502762431, Blast_Score=313, Evalue=1e-85,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=59.7297297297297, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=25.065274151436, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790045, Length=378, Percent_Identity=24.8677248677249, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=22.5626740947075, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=355, Percent_Identity=26.4788732394366, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786518, Length=375, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=267, Percent_Identity=29.5880149812734, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081918, Length=352, Percent_Identity=27.5568181818182, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=221, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=55.3475935828877, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=55.0531914893617, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=55.8139534883721, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562584, Length=377, Percent_Identity=27.3209549071618, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=26.0752688172043, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=26.6081871345029, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=53.3692722371968, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319621, Length=377, Percent_Identity=29.973474801061, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=388, Percent_Identity=29.1237113402062, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=366, Percent_Identity=26.775956284153, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=364, Percent_Identity=26.9230769230769, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=364, Percent_Identity=26.9230769230769, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=373, Percent_Identity=25.7372654155496, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=374, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=375, Percent_Identity=25.0666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=279, Percent_Identity=27.9569892473118, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=57.9945799457995, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17137530, Length=344, Percent_Identity=25.8720930232558, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39290; Mature: 39290

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRAAVALEAGKPLEVMDVNLDGPREGEVLVEIKATGICHTDEFTLSGADPEGLFPAIL
CCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCHHHH
GHEGAGVVLEVGPGVTSLKPGDHVIPLYTAECRECEYCLNPKTNLCQKVRATQGQGLMPD
CCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCHHHCCCCHHHHHHHHHCCCCCCCCC
GSSRFSMLDGTPILHYMGCSTFANHTVVPEVSLAKVRNDAPFDKICYIGCGVTTGIGAVI
CCCCEEEECCCCEEEEECCHHHCCCEECCCCHHHHHCCCCCCCCEEEEECCHHHCCCEEE
YTAKVEIGSRAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVEMAKRFGMTDFVNPS
EEEEEECCCEEEEEEECCCHHHHHHHHEECCCCEEEEEECCCCHHHHHHHCCCCCCCCHH
EVTGDLVGHLVELTGGGADYTFDATGNVDVMRTALEACHKGWGESIIIGVAPAGAEISTR
HHHHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
PFQLVTGRSWRGTAFGGARGRTDVPQIVDWYMDGKIEIDPMITHTLALDNINEGFDLMHR
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCEEEEEEEECCCCCCHHHHHC
GESIRSVVIY
CCCCEEEEEC
>Mature Secondary Structure
MRTRAAVALEAGKPLEVMDVNLDGPREGEVLVEIKATGICHTDEFTLSGADPEGLFPAIL
CCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCHHHH
GHEGAGVVLEVGPGVTSLKPGDHVIPLYTAECRECEYCLNPKTNLCQKVRATQGQGLMPD
CCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCHHHCCCCHHHHHHHHHCCCCCCCCC
GSSRFSMLDGTPILHYMGCSTFANHTVVPEVSLAKVRNDAPFDKICYIGCGVTTGIGAVI
CCCCEEEECCCCEEEEECCHHHCCCEECCCCHHHHHCCCCCCCCEEEEECCHHHCCCEEE
YTAKVEIGSRAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVEMAKRFGMTDFVNPS
EEEEEECCCEEEEEEECCCHHHHHHHHEECCCCEEEEEECCCCHHHHHHHCCCCCCCCHH
EVTGDLVGHLVELTGGGADYTFDATGNVDVMRTALEACHKGWGESIIIGVAPAGAEISTR
HHHHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
PFQLVTGRSWRGTAFGGARGRTDVPQIVDWYMDGKIEIDPMITHTLALDNINEGFDLMHR
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCEEEEEEEECCCCCCHHHHHC
GESIRSVVIY
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]