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The map label for this gene is tyrB [H]

Identifier: 89052519

GI number: 89052519

Start: 25771

End: 26970

Strand: Reverse

Name: tyrB [H]

Synonym: Jann_0028

Alternate gene names: 89052519

Gene position: 26970-25771 (Counterclockwise)

Preceding gene: 89052520

Following gene: 89052518

Centisome position: 0.62

GC content: 62.5

Gene sequence:

>1200_bases
ATGACAGGCTGTCTGATGTTTGAGCATTTGTTGCCCCCTGAACCGGACAAGATCTTCCGCCTGACAGGGCAATTCGCGGC
AGATCCGCGCGCCGATAAGGTTGATCTTCTGGTTGGTCTCTACCGTAATGCCCACGGTCTGACCCCCGTCTTGGGCGCGG
TGAAAGAGGCTGAGCGCCGGATCCTTGAGACGCAGACGACCAAGTCTTACCTCGGGTTTGAAGGCGATCGCGGTTTTATC
GCCGGGATGCGGTCCTTGCTGTTGGCAGATGCGGTGCCTGAGGCGCGGGTCGCGGGCATTGCCACCGTGGGCGGCACCAG
TGCCTTGCGTCAGATTTTTGAACTGGTGCGCACGCTTATGCCGGATGCACAGGTCTGGATCTCGGACCCGAGCTGGCCAA
TTCACGCAGGTATGGCAGAACATCTTGGCTTGGCGCACCGCAGCTATCGCTATCTGGACCGCGACAGCAATGGGCTGGAT
CGGGACGGCATGATGGAGGATCTTCGCGCCGCGCGTGCGGGTGATATCATCGTCTTGCATGGCTGTTGCCACAACCCCAG
CGGTGCGGATCTGACGCTTTCGGACTGGGAAGATGTGGCCCGGGTCTGCCTGGCAACGGGCGCAATTCCCCTTGTCGATA
TGGCGTATCAGGGCTTTGGGACCGGGCTGGACGAGGATGCGGCCGGTACGCGCCTGTTGGCACAGCGTGTGCCGACGCTG
TTCGTGGCGGCCAGTTGTTCCAAGAATTTCGGCCTTTACCGCGACCGCGCCGGTGTTGCCCTTGCGGTGACGTCCCAGGG
CGCTGCCCGCGACGCGGCGCAAGGGCATCTGATCGCGATGAACCGCAACAATTACTCCTTCCCGCCGGACCATGGTGCGC
GGACGGTCGATCTGATCCTGCACGATGCCGAACTTCGTCAGATGTGGGAGGCGGAGCTGACGTCGATGCGTGAAACGATC
ACCCGCAATCGCCGCGCCTTGGCTGAGAGTTTGCGGGCAGAGACCGGCTCCGACAGGTTCGGTGCGCTCGCCGCGCATCA
GGGCATGTTCTCACTGATCGGAGCGACGCCTGCGCAGGTCGATGCATTGCGAGAGGATCATGCCGTCTATGTGGTGGGCG
ACGGGCGCATGAATGTGGCCGGTCTGACGGAGCAGACGGTGCCTATTGTCGCGCGGGCAATGGCGCAGGTGCTGGGGTGA

Upstream 100 bases:

>100_bases
GTCAACACCTGCACCCTGGATCATCCAGCGGCGCTGCGTCTCTACCAAAAGATGGGATTCAAGCCGGTCGACAGGGAAGA
GAGAACGCGCGTCCTGGCCT

Downstream 100 bases:

>100_bases
CACGCCCGGGTTGACGGGCGCGTAAGACGGGCGTATCCGGCGCACGTGTTCGTGGGTTTGAAGCAAGCCGCGATAACCAA
GTCTCCGACTACCTTGCAAA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTGCLMFEHLLPPEPDKIFRLTGQFAADPRADKVDLLVGLYRNAHGLTPVLGAVKEAERRILETQTTKSYLGFEGDRGFI
AGMRSLLLADAVPEARVAGIATVGGTSALRQIFELVRTLMPDAQVWISDPSWPIHAGMAEHLGLAHRSYRYLDRDSNGLD
RDGMMEDLRAARAGDIIVLHGCCHNPSGADLTLSDWEDVARVCLATGAIPLVDMAYQGFGTGLDEDAAGTRLLAQRVPTL
FVAASCSKNFGLYRDRAGVALAVTSQGAARDAAQGHLIAMNRNNYSFPPDHGARTVDLILHDAELRQMWEAELTSMRETI
TRNRRALAESLRAETGSDRFGALAAHQGMFSLIGATPAQVDALREDHAVYVVGDGRMNVAGLTEQTVPIVARAMAQVLG

Sequences:

>Translated_399_residues
MTGCLMFEHLLPPEPDKIFRLTGQFAADPRADKVDLLVGLYRNAHGLTPVLGAVKEAERRILETQTTKSYLGFEGDRGFI
AGMRSLLLADAVPEARVAGIATVGGTSALRQIFELVRTLMPDAQVWISDPSWPIHAGMAEHLGLAHRSYRYLDRDSNGLD
RDGMMEDLRAARAGDIIVLHGCCHNPSGADLTLSDWEDVARVCLATGAIPLVDMAYQGFGTGLDEDAAGTRLLAQRVPTL
FVAASCSKNFGLYRDRAGVALAVTSQGAARDAAQGHLIAMNRNNYSFPPDHGARTVDLILHDAELRQMWEAELTSMRETI
TRNRRALAESLRAETGSDRFGALAAHQGMFSLIGATPAQVDALREDHAVYVVGDGRMNVAGLTEQTVPIVARAMAQVLG
>Mature_398_residues
TGCLMFEHLLPPEPDKIFRLTGQFAADPRADKVDLLVGLYRNAHGLTPVLGAVKEAERRILETQTTKSYLGFEGDRGFIA
GMRSLLLADAVPEARVAGIATVGGTSALRQIFELVRTLMPDAQVWISDPSWPIHAGMAEHLGLAHRSYRYLDRDSNGLDR
DGMMEDLRAARAGDIIVLHGCCHNPSGADLTLSDWEDVARVCLATGAIPLVDMAYQGFGTGLDEDAAGTRLLAQRVPTLF
VAASCSKNFGLYRDRAGVALAVTSQGAARDAAQGHLIAMNRNNYSFPPDHGARTVDLILHDAELRQMWEAELTSMRETIT
RNRRALAESLRAETGSDRFGALAAHQGMFSLIGATPAQVDALREDHAVYVVGDGRMNVAGLTEQTVPIVARAMAQVLG

Specific function: Shows activities toward both dicarboxylic and aromatic substrates [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504067, Length=404, Percent_Identity=33.4158415841584, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=31.1855670103093, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI117414139, Length=332, Percent_Identity=22.8915662650602, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=40.9090909090909, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=38.2871536523929, Blast_Score=264, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI71981858, Length=388, Percent_Identity=32.9896907216495, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147133, Length=401, Percent_Identity=32.9177057356608, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17569539, Length=390, Percent_Identity=32.0512820512821, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17569537, Length=385, Percent_Identity=26.4935064935065, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17550384, Length=247, Percent_Identity=29.9595141700405, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25147136, Length=215, Percent_Identity=29.7674418604651, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323055, Length=401, Percent_Identity=35.1620947630923, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322743, Length=423, Percent_Identity=29.0780141843972, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24654046, Length=384, Percent_Identity=35.15625, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI19922362, Length=384, Percent_Identity=35.15625, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24580972, Length=393, Percent_Identity=34.3511450381679, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24580970, Length=393, Percent_Identity=34.3511450381679, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI19920542, Length=393, Percent_Identity=34.3511450381679, Blast_Score=218, Evalue=6e-57,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43144; Mature: 43012

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGCLMFEHLLPPEPDKIFRLTGQFAADPRADKVDLLVGLYRNAHGLTPVLGAVKEAERR
CCCHHHHHHCCCCCCCHHEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ILETQTTKSYLGFEGDRGFIAGMRSLLLADAVPEARVAGIATVGGTSALRQIFELVRTLM
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEECCCHHHHHHHHHHHHHHC
PDAQVWISDPSWPIHAGMAEHLGLAHRSYRYLDRDSNGLDRDGMMEDLRAARAGDIIVLH
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEE
GCCHNPSGADLTLSDWEDVARVCLATGAIPLVDMAYQGFGTGLDEDAAGTRLLAQRVPTL
ECCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCE
FVAASCSKNFGLYRDRAGVALAVTSQGAARDAAQGHLIAMNRNNYSFPPDHGARTVDLIL
EEEECCCCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEE
HDAELRQMWEAELTSMRETITRNRRALAESLRAETGSDRFGALAAHQGMFSLIGATPAQV
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHH
DALREDHAVYVVGDGRMNVAGLTEQTVPIVARAMAQVLG
HHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TGCLMFEHLLPPEPDKIFRLTGQFAADPRADKVDLLVGLYRNAHGLTPVLGAVKEAERR
CCHHHHHHCCCCCCCHHEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ILETQTTKSYLGFEGDRGFIAGMRSLLLADAVPEARVAGIATVGGTSALRQIFELVRTLM
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEECCCHHHHHHHHHHHHHHC
PDAQVWISDPSWPIHAGMAEHLGLAHRSYRYLDRDSNGLDRDGMMEDLRAARAGDIIVLH
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEE
GCCHNPSGADLTLSDWEDVARVCLATGAIPLVDMAYQGFGTGLDEDAAGTRLLAQRVPTL
ECCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCE
FVAASCSKNFGLYRDRAGVALAVTSQGAARDAAQGHLIAMNRNNYSFPPDHGARTVDLIL
EEEECCCCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEE
HDAELRQMWEAELTSMRETITRNRRALAESLRAETGSDRFGALAAHQGMFSLIGATPAQV
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHH
DALREDHAVYVVGDGRMNVAGLTEQTVPIVARAMAQVLG
HHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9058208; 9665848; 9930977 [H]