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The map label for this gene is lktA [H]

Identifier: 89052501

GI number: 89052501

Start: 10410

End: 11687

Strand: Direct

Name: lktA [H]

Synonym: Jann_0010

Alternate gene names: 89052501

Gene position: 10410-11687 (Clockwise)

Preceding gene: 89052500

Following gene: 89052505

Centisome position: 0.24

GC content: 62.13

Gene sequence:

>1278_bases
ATGCCCGTCTTCCTGACCCTGACCAATGCCAATATCCTCGACCCCGCCTTCTGGGCAGCGCAGGTCGTCGACGGAAACAG
CACAATCAACGCCACAGCGGTCAGCGACACGTTGCAGATCACGCTGACGGGTGGGTCGATCACGATCACGGACACGACGA
CCAGCGTTTCCACCACATTCACCAACGCGGATTTAAGCGGGGGGGCCTTCAGCAACGTCGTGCAATTTCGCGGGAACGAC
GCTGACAACATTATCGGCGGCTCGGTGGGGCTAAACGGACAGGGATATCGCGGCGGCAGCGGGGACGATCAGCTTACCGA
TGACGGCAATCTCGGCGGTCAGATGCGCGGCGGGCGCGGCGACGATACCATCATCGGCGGAACCGGCGACAATCAGATCC
GAGGCAATGGCGGCGATGACCTGCTTATCGGTGGTTCAGGCAACAATAACCTGATTGGCGGCAGTGGCGACGATACGCTG
ATCGGCGATCAGGGGTCCGGCAACCTGATTGGTGGATCGGGGGACGACCTGATTATCACGTCCGAGTTGACGACATTCGT
GGATGGCGGCAGCGGCGACAACCAGATGATCATTCCCGAAAACGCAACGTTCACACCCTTTTCTCCTGGCTCCACCGGGG
GCGAGGTGACCGTAACCTTTCCCGATATGTCCACGAGAACCTTCACGTATCTCAACATCGCGGCTGAAAATATCACGACG
ATCTGCTTCGCTGCCGGCACCCGGATCGCGACGCCACGCGGGCAGGTCGCGGTGGAGGATTTGCGCGTGGGCGACAGGGT
CGTCACGCGCGACGGCGGCATTCAAGCTTTGCGCTGGATCGGTTTTCGGACCGTACCCGCCGACGGCCCGCTGGCGCCCA
TCCACATCACCAAAGGGGCCCTTGGCAATACCCGCGCCCTGACCGTGTCGCCGGAACACCGGATGCTGGTTCAAGGCTGG
CGCTGTCAGGTGCTGTTCGGCCGAGAGGAGGGGCTGTGCGCCGCAAAGCACCTGGTGGACGGGGACAGCATCTACCGCGA
TCCGCGCGAGTTGGTGACCTATTTCCACGTGATGTTTGATGCCCACCAGATCATCCTGGCCGAGGGGACCTGGGCGGAGA
GCCTTTATATTGGCGACTATCAAACCGCCCATGATCCCGAGCTGTACGCCGAGCTGTTCACCCTCTTCCCCGAGCTTGAG
GATACCGCGCACCCCGCGCGCCTTCTGGCGGCAGAGCCCCTTCGCGCGTTTGAGGCCACGGCCCTTCGGGACGCTTAA

Upstream 100 bases:

>100_bases
ACAGGCGGTTTGATGCCGAAACAAACTGTTTCCATGACGCCGCAGGGCGCGACAGCAGCCCTCTGGTACCCTTACATCTC
TCGCTGATGAGGTGCCCTAC

Downstream 100 bases:

>100_bases
TCGCCCGCGCCCAGATGCGCCTCGCCCCGGGCTTTCGCCAGGGCGATCTGCTTTTGCCGCTCCCGGAACCGCGCGCGGTC
TGCGTCTGAATGGACATCCA

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MPVFLTLTNANILDPAFWAAQVVDGNSTINATAVSDTLQITLTGGSITITDTTTSVSTTFTNADLSGGAFSNVVQFRGND
ADNIIGGSVGLNGQGYRGGSGDDQLTDDGNLGGQMRGGRGDDTIIGGTGDNQIRGNGGDDLLIGGSGNNNLIGGSGDDTL
IGDQGSGNLIGGSGDDLIITSELTTFVDGGSGDNQMIIPENATFTPFSPGSTGGEVTVTFPDMSTRTFTYLNIAAENITT
ICFAAGTRIATPRGQVAVEDLRVGDRVVTRDGGIQALRWIGFRTVPADGPLAPIHITKGALGNTRALTVSPEHRMLVQGW
RCQVLFGREEGLCAAKHLVDGDSIYRDPRELVTYFHVMFDAHQIILAEGTWAESLYIGDYQTAHDPELYAELFTLFPELE
DTAHPARLLAAEPLRAFEATALRDA

Sequences:

>Translated_425_residues
MPVFLTLTNANILDPAFWAAQVVDGNSTINATAVSDTLQITLTGGSITITDTTTSVSTTFTNADLSGGAFSNVVQFRGND
ADNIIGGSVGLNGQGYRGGSGDDQLTDDGNLGGQMRGGRGDDTIIGGTGDNQIRGNGGDDLLIGGSGNNNLIGGSGDDTL
IGDQGSGNLIGGSGDDLIITSELTTFVDGGSGDNQMIIPENATFTPFSPGSTGGEVTVTFPDMSTRTFTYLNIAAENITT
ICFAAGTRIATPRGQVAVEDLRVGDRVVTRDGGIQALRWIGFRTVPADGPLAPIHITKGALGNTRALTVSPEHRMLVQGW
RCQVLFGREEGLCAAKHLVDGDSIYRDPRELVTYFHVMFDAHQIILAEGTWAESLYIGDYQTAHDPELYAELFTLFPELE
DTAHPARLLAAEPLRAFEATALRDA
>Mature_424_residues
PVFLTLTNANILDPAFWAAQVVDGNSTINATAVSDTLQITLTGGSITITDTTTSVSTTFTNADLSGGAFSNVVQFRGNDA
DNIIGGSVGLNGQGYRGGSGDDQLTDDGNLGGQMRGGRGDDTIIGGTGDNQIRGNGGDDLLIGGSGNNNLIGGSGDDTLI
GDQGSGNLIGGSGDDLIITSELTTFVDGGSGDNQMIIPENATFTPFSPGSTGGEVTVTFPDMSTRTFTYLNIAAENITTI
CFAAGTRIATPRGQVAVEDLRVGDRVVTRDGGIQALRWIGFRTVPADGPLAPIHITKGALGNTRALTVSPEHRMLVQGWR
CQVLFGREEGLCAAKHLVDGDSIYRDPRELVTYFHVMFDAHQIILAEGTWAESLYIGDYQTAHDPELYAELFTLFPELED
TAHPARLLAAEPLRAFEATALRDA

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 44679; Mature: 44548

Theoretical pI: Translated: 4.12; Mature: 4.12

Prosite motif: PS50817 INTEIN_N_TER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFLTLTNANILDPAFWAAQVVDGNSTINATAVSDTLQITLTGGSITITDTTTSVSTTF
CCEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEECCEEEEEECCCEEEEEE
TNADLSGGAFSNVVQFRGNDADNIIGGSVGLNGQGYRGGSGDDQLTDDGNLGGQMRGGRG
ECCCCCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCC
DDTIIGGTGDNQIRGNGGDDLLIGGSGNNNLIGGSGDDTLIGDQGSGNLIGGSGDDLIIT
CCEEEECCCCCCEECCCCCEEEEECCCCCCEECCCCCCCEECCCCCCCEECCCCCCEEEE
SELTTFVDGGSGDNQMIIPENATFTPFSPGSTGGEVTVTFPDMSTRTFTYLNIAAENITT
ECEEEEEECCCCCCEEEECCCCEECCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCEEE
ICFAAGTRIATPRGQVAVEDLRVGDRVVTRDGGIQALRWIGFRTVPADGPLAPIHITKGA
EEEECCCEEECCCCCEEEEEECCCCEEEECCCCEEEEEEECEEECCCCCCEEEEEEECCC
LGNTRALTVSPEHRMLVQGWRCQVLFGREEGLCAAKHLVDGDSIYRDPRELVTYFHVMFD
CCCCEEEEECCCCCEEEECCEEEEEEECCCCCCHHHHCCCCHHHHCCHHHHHHHHHHHHC
AHQIILAEGTWAESLYIGDYQTAHDPELYAELFTLFPELEDTAHPARLLAAEPLRAFEAT
CEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHH
ALRDA
HCCCC
>Mature Secondary Structure 
PVFLTLTNANILDPAFWAAQVVDGNSTINATAVSDTLQITLTGGSITITDTTTSVSTTF
CEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEECCEEEEEECCCEEEEEE
TNADLSGGAFSNVVQFRGNDADNIIGGSVGLNGQGYRGGSGDDQLTDDGNLGGQMRGGRG
ECCCCCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCC
DDTIIGGTGDNQIRGNGGDDLLIGGSGNNNLIGGSGDDTLIGDQGSGNLIGGSGDDLIIT
CCEEEECCCCCCEECCCCCEEEEECCCCCCEECCCCCCCEECCCCCCCEECCCCCCEEEE
SELTTFVDGGSGDNQMIIPENATFTPFSPGSTGGEVTVTFPDMSTRTFTYLNIAAENITT
ECEEEEEECCCCCCEEEECCCCEECCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCEEE
ICFAAGTRIATPRGQVAVEDLRVGDRVVTRDGGIQALRWIGFRTVPADGPLAPIHITKGA
EEEECCCEEECCCCCEEEEEECCCCEEEECCCCEEEEEEECEEECCCCCCEEEEEEECCC
LGNTRALTVSPEHRMLVQGWRCQVLFGREEGLCAAKHLVDGDSIYRDPRELVTYFHVMFD
CCCCEEEEECCCCCEEEECCEEEEEEECCCCCCHHHHCCCCHHHHCCHHHHHHHHHHHHC
AHQIILAEGTWAESLYIGDYQTAHDPELYAELFTLFPELEDTAHPARLLAAEPLRAFEAT
CEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHH
ALRDA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]